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Antidepressants And Melanoma: Is There A Link?, Stephanie Douglas

Yale Medicine Thesis Digital Library

ANTIDEPRESSANTS AND MELANOMA: IS THERE A LINK? Stephanie R. Douglas, Deepak Narayan. Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT.

Cutaneous melanoma is the sixth most common cancer in the United States, and its incidence continues to rise steadily at a rate of 2-3% per year. Meanwhile nearly 11% of the general population is treated with antidepressant medication. Laboratory studies suggest a number of theoretical links between antidepressants and melanoma. Serotonin is a growth factor for melanocytes, and antidepressants upregulate components of the Wnt/beta-catenin, mTOR, and MAP kinase signaling pathways, all …

A Restatement Of Health Care Law, David Orentlicher

Scholarly Works

No abstract provided.

Aging Populations And Physician Aid In Dying: The Evolution Of State Government Policy, David Orentlicher

Scholarly Works

Professor David Orentlicher explores the evolution of physician assisted suicide from illegal taboo to the passage of Death with Dignity legislation and caselaw.

Health Care Reform And Efforts To Encourage Healthy Behavior By Individuals, David Orentlicher

Scholarly Works

No abstract provided.

The Future Of The Affordable Care Act: Protecting Economic Health More Than Physical Health?, David Orentlicher

Scholarly Works

No abstract provided.

Medicine@Yale July/August 2014 Volume 10, Issue 2, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Lifelong Learning: Established Concepts And Evolving Values, Jamsheer J Jehangir Talati Professor

Section of Urology

Objective: To summarise the concepts critical for understanding the content and value of lifelong learning (LL).
Methods: Ideas generated by personal experience were combined with those of philosophers, social scientists, educational institutions, governments and UNESCO, to facilitate an understanding of the importance of the basic concepts of LL.
Results: Autopoietic, continuous, self-determined, informal, vicarious, biographical, lifelong reflexive learning, from and for society, when supported by self-chosen formal courses, can build capacities and portable skills that allow useful responses to challenges and society’s new structures of governance. The need for LL is driven by challenges. LL flows continuously in pursuit of …

Effect Of Heme Oxygenase-1 On Matrix Metalloproteinase-3 Expression In Human Fibroblasts, Theresa A. Stangl

PCOM Biomedical Studies Student Scholarship

Heme oxygenase-1(HO-1) is an enzyme that plays a very important role in the resolution of inflammation. HO-1-based therapies are effective in a number of disease conditions. However, HO-1 also increases tumor growth, angiogenesis, metastasis and chemoresistance. Matrix metalloproteinase-3 (MMP-3) is an enzyme involved in physiological and pathophysiological tissue remodeling. Unbalanced expression of MMPs is a key feature of connective tissue destruction in chronic inflammatory conditions. Previously shown in this laboratory, the HO-1 inducer, hemin, increased MMP-3 mRNA expression in some HGF cultures. To assess whether HO-1 and/or its products regulate expression of MMP-3 in human fibroblasts, the effect of HO-1 …

2014 January Newsletter, Nancy Rockey

Human Subject Research Archive

No abstract provided.

A Foreign Text In A Foreign Land, Dylan A. Vernon

Honors Projects

The Bible has passed through different languages and cultures, and in the process the words of the text lose their original meaning and gain new meanings. This process influences the way that commentators interpret the biblical text. This study looks at the Hebrew verb פתה that appears in Hosea 2:16, the Greek verb πλανω that translates פתה in Hosea 2:16, and the Latin verb lacto that translates פתה in Hosea 2:16. This study then looks at the interpretations of Hosea 2:16 by three commentators, Rabbi Shlomo ben Issac (Rashi), Theodore of Mopsuestia, and Nicholas of Lyra. Rashi read the Hebrew …

Community Gardens Around The World: Successes And Benefits For Healthy Communities, 2014, Mia Rizzi, Jillian Miller

Monteverde Institute: Culture, Community, and Health

Our research focused on the ways in which community gardens can foster ecological and social sustainability. We first completed a literature review in order to identify the benefits of community gardens. We then assessed several case studies in order to ascertain what makes a community garden successful and the ways in which projects have positively altered communities. Finally, we conducted an interview with Sergio Aray who is involved with a community garden project in the Monteverde area, in order to gain an understanding of what he is hoping to accomplish through the creation and maintenance of a community garden.

Evaluating The Role Of Hypoglycemia & Comorbid Illness On Diabetes Management Behaviors, Saumitra Vijay Rege

Open Access Dissertations

Over the recent years, the incidence of diabetes has significantly increased. Use of preventive services and treatment with oral antidiabetic drugs (OAD) has remained cornerstone in the management of type 2 diabetes (T2DM). Despite strong evidence that treating diabetes using these disease management strategies decreases morbidity, mortality and complications, glycemic control as well as other diabetes related outcomes remain unsatisfactory. The prevalence of diabetes in the United States has grown vastly in proportion over the last few years with the American Diabetes Association estimating that 9.3% of the population suffered from diabetes in the year 2012. These estimates are expected …

The Psychometric Utility Of The Drug Abuse Screening Test Among Treatment-Seeking, Homeless Men, Brittany N. Winters

Theses and Dissertations

Homelessness in the United States is recognized as a grave societal problem with longstanding and pervasive implications. A substantial body of research has shown that substance use disorders occur at higher rates among homeless adults than among housed persons. Mental disorders, particularly depressive disorders, are also known to occur at substantially higher rates among the homeless. Given the prevalence of these conditions, it is important that clinicians working with homeless adults have access to reliable and valid assessment tools. The purpose of this study was to examine the usefulness of the Drug Abuse Screening Test-20 (DAST-20) in a sample of …

Governing For Health As The World Grows Older: Healthy Lifespans In Aging Societies, Lawrence O. Gostin, Anna Garsia

Georgetown Law Faculty Publications and Other Works

So much of global health governance focuses intensely on a brief moment in the human lifespan—from a safe birth to infant and child survival. Yet, with all the attention to this early window of life (infancy to age five), the opposite end of the life spectrum is comparatively neglected. The Millennium Development Goals (MDGs) do not mention a healthy lifespan or a healthy old age. This inadequate attention to the older years of the life appears to be a glaring omission given the universal challenges posed by aging societies. Aging is a demographic fact in almost all countries, but it …

Challenges On The Road To School Success For Low Socio-Economic And Minority Students School Dropout And Parent Involvement, Rose A. Hall

Graduate Student Dissertations, Theses, Capstones, and Portfolios

As the United States struggles to keep its students competitive in a global society, dropout rate reduction has been a priority for large urban school districts. Students have a less than a 50-50 chance of graduating from high school with their peers in big-city school districts like New York City and Chicago, where far fewer than half graduate each spring, according to a 2006 research study (Toppo, 2006). The promotion and implementation of parent involvement is a major key to confronting school dropout, especially low-income, minority students leaving school early without graduating. "Minority, low income families are repeatedly found to …

Establishing A Positive Right To Migrate As A Solution To Food Scarcity, Douglas Stephens

Emory International Law Review

Food scarcity is a dire matter impacting parts of our world such from Paraguay to Somalia. In these nations, the issue is serious enough to force individuals to leave their homeland for another country. However, under the current regime of human rights law, these individuals are left without protection. While international conventions guarantee them the freedom of movement, they are not promised the right to enter other countries. Likewise, though refugee law covers sudden, violent, or extreme deprivations, it does not account for slow degradation of the environment, or social, political, or economic issues that lead to food scarcity. Under …

Conceptualizing Social Determinants Of Maternal And Infant Health Disparities, Susanne Klawetter

School of Social Work Faculty Publications and Presentations

Research demonstrates that women and children within marginalized ethnic and racial groups and those living in poverty experience disparate health outcomes. These disparities have immediate and long-term consequences. Exploring two theories used to examine social determinants of health— life course perspective and historical trauma response, this article will explain the major premises of each, provide application examples, compare and examine utility for practice, and highlight areas for future research. A theoretical critique will be included, as well as insight into how these theories together might address gaps as an approach to maternal and infant health research and practice.

The African American Community In Multnomah County: An Unsettling Profile, Lisa K. Bates, Ann Curry-Stevens, Coalition Of Communities Of Color

School of Social Work Faculty Publications and Presentations

This report covers topics of importance for the African-American community, highlighting critical areas of disparity and disproportionate representation. The areas of analysis include: economic opportunity, housing and neighborhoods, education, health, child welfare, the criminal justice system, and civic engagement. In each area, we provide history and context, followed by data analysis that demonstrates the extent of racial disparity.

Taken together, the data on inequities show a community facing real and persistent challenges. These data point to a need for fundamental change and help to focus attention on some key drivers of that change. The depth and breadth of disparities profiled …

Investigations On The Gut Microbiota Of Salmonids And The Applications Of Probiotics-Based Feed Additives, Ali Atia Abid

School of Biological and Marine Sciences Theses

A series of investigations were conducted in order to characterise the GIT microbiota of salmonids and to determine the effect of microbial modulating feed additives on the intestinal microbiota, immunity and growth of salmonids. The first experiment, Chapter three, used PCR-DGGE and 16S rRNA gene sequence analysis of cultivable bacteria were used to investigate the GIT microbiota of brown trout. 16S rRNA gene sequence analysis demonstrated that Citrobacter freundii and Carnobacterium maltaromaticum were the predominant culturable viable bacteria and lactic acid bacteria, respectively in all regions of the GIT. DGGE revealed complex communities with a diverse range of microbes from …

Bioaccumulation And Sub-Lethal Effects Of Intermittent And Continuous Exposure To Metals On The Marine Mussel, Mytilus Galloprovincialis, Dokuboba Amachree

School of Biological and Marine Sciences Theses

Aquatic organisms experience intermittent exposure to contaminants. The hazard from such discontinuous exposure may not simply be predicted from existing continuous exposure. Little is known about the bioaccumulation responses of shellfish to metals during intermittent compared to the continuous exposure counterparts. This study was designed to compare the bioaccumulation responses of two metals (Cd and Hg) singly (Chapters 3 and 4) or mixtures (Chapters 5 and 6) during continuous and intermittent exposure. Responses were examined using a multi-assay approach in areas of oxidative stress, osmoregulation, haematology and organ pathology. Tissue metal concentrations were highest in the gill and digestive gland …

The Genetics And Physiology Of Abiotic Stress Disorder In Swede (Brassica Napus Var. Napobrassica), Faiz Fadhel

School of Biological and Marine Sciences Theses

Swedes are extremely common as a root vegetable in Europe, USA, and Canada but are affected by the occasional presence of Brown Heart (BH) disorder affecting the marketable swede root. The incidence of BH has been reported worldwide however it is very difficult to breed resistance due to its sporadic occurrence with no external symptoms to select for. BH has been attributed to boron availability but attempts to link BH appearance definitively with boron deficiency have been difficult. Anecdotal evidence from breeders and growers highlighted the recent co-appearance of BH and frost injury in the field and it was postulated …

Terebella Lapilloides Münster, 1833 From The Upper Jurassic-Lower Cretaceous İnaltı Carbonates, Northern Turkey: Its Taxonomic Position And Paleoenvironmental-Paleoecological Significance, Mustafa Yücel Kaya, Demi̇r Altiner

Turkish Journal of Earth Sciences

The agglutinating annelid Terebella lapilloides Münster, 1833 is commonly encountered in reefal deposits from the Late Jurassic. This annelid is described and documented for the first time from the Upper Jurassic-Lower Cretaceous carbonates of the İnaltı Formation in the Central Pontides, Turkey. The whole İnaltı formation, 395 m in thickness, was studied near Bürnük village and 105 samples were collected along the section. The investigated thin sections reveal the shallow water and the reefal/fore-reefal character of the carbonates with coral-sponge frame-builders. The bioconstituents are accompanied by various microencrusters and microproblematica (such as Lithocodium aggregatum, Bacinella-type structures, Koskinobullina socialis, Radiomura cautica, …

Liver Enzymes, Mean Platelet Volume, And Red Cell Distribution Width In Gestational Diabetes, Serpi̇l Erdoğan, Özhan Özdemi̇r, Halef Okan Doğan, Sevi̇lay Sezer, Cemal Reşat Atalay, Fatma Meri̇ç Yilmaz, Yüksel Koca

Turkish Journal of Medical Sciences

To investigate the value of measuring liver enzymes, red cell distribution width (RDW), and mean platelet volume (MPV) in predicting the development of gestational diabetes mellitus (GDM). Materials and methods: The medical records of all pregnant women followed by the obstetrics clinic between January 2010 and November 2012 were systematically evaluated, and patients with a diagnosis of GDM were identified. A total of 68 patients with GDM and 61 healthy controls were included in the study. Results of relevant laboratory parameters were recorded. Results: Out of all the parameters evaluated, mean values for platelet distribution width (PDW) and mean activities …

Effect Of Process Mixing On The Size Distribution And Mean Diameter Of The Thiol-Triacrylate Microcapsules, Rubaiyet Abedin

LSU Master's Theses

An important limitation in the development of the microparticles is the difficulty to develop a precise size distribution. Microparticles have a wide spread applicability in different fields including medical, pharmaceutical, textile, cosmetics, pesticide, printing industry, etc. The large and growing impact of microencapsulation in different fields of technology has made this process important. Microparticle size is a primary determinant of control release mechanism and the reaction kinetics and also impacts the allowable routes of administration, The main objective of this research work is to evaluate the effect of the process mixing on the size and size distribution of the trithiol-triacrylate …

Participation In Personal Training Services Among University Clientele, Ethan R. Crawford

Graduate Research Papers

This study examined the reasons previous clientele chose to utilize personal training services at a University in the Midwest. The purpose of this study was to distinguish why individuals acquire a personal trainer, and if those reasons varied by sub-groups. This information can be used to better understand and market to people who may be potential clients for certified personal trainers. The primary research questions of this study are: (a) What are the most reported reasons for the hiring of a personal trainer? (b) Are there gender differences 9 among the variables examined? ( c) Is there any relationship between …

Heterotic Grouping And Patterning Of Quality Protein Maize Inbreds Based On Genetic And Molecular Marker Studies, Ambika Rajendran, Arunachalam Muthiah, John Joel, Ponnusamy Shanmugasundaram, Dhandapani Raju

Turkish Journal of Biology

An investigation was done to study the heterotic grouping and patterning in quality protein maize inbreds. Biochemical screening resulted in the choice of 3 inbreds each with high (UQPM 2, UQPM 4, and UQPM 21) and low (UQPM 18, UQPM 19, and UQPM 20) lysine and tryptophan contents respectively for genetic studies using diallel analysis. UQPM 20 × UQPM 18 was notable as it possessed high standard heterosis and specific combining (sca) effect for grain yield, protein, tryptophan, and lysine. Based on yield sca, the 6 parental inbreds were classified into 3 heterotic groups. Intergroup cross UQPM 20 × UQPM …

Ex Situ Conservation Of Dianthus Giganteus D’Urv. Subsp. Banaticus (Heuff.) Tutin By In Vitro Culture And Assessment Of Somaclonal Variability By Molecular Markers, Liliana Jarda, Anca Butiuc Keul, Maria Hohn, Andrzej Pedryc, Victoria Cristea

Turkish Journal of Biology

Ex situ conservation of Dianthus giganteus subsp. banaticus was obtained by in vitro culture on different culture media supplemented with phytohormones. Assessment of somaclonal variability over a period of preservation by in vitro culture is required prior to introduction and acclimatization in natural habitats. In this study we used 2 types of molecular markers, ISSR and multilocus SSR markers, which allow comparison of different alleles, to assess the somaclonal variability of endemic taxa Dianthus giganteus subsp. banaticus after a period of 24 months of preservation by in vitro culture. The assessment of somaclonal variability of D. giganteus subsp. banaticus shows …

Temperature-Induced Stress Response In Lymantria Dispar Neurosecretory Neurons, Larisa Ilijin, Milena Vlahovic, Vesna Peric Mataruga, Ivana Kmetic, Anja Gavrilovic, Dragana Matic, Marija Mrdakovic

Turkish Journal of Biology

The release of neurosecretory material from A2 neurosecretory neurons (NSNs) was stimulated in Lymantria dispar fourth instar caterpillars exposed to a temperature of 35 °C for 1, 12, and 24 h, as well as those allowed recover after exposure (12 h at 35 °C, then 12 h at 23 °C). The levels of 2 protein forms with the same molecular mass as bombyxin (3-4 and 4-5 kDa) increased with prolonged exposure to 35 °C. The second band was present only in the groups exposed to this stressor. There was intensified synthetic activity and a low level of secretion in L2' …

Inhibitory Effect Of Enterocin Kp In Combination With Sublethal Factors On Escherichia Coli O157:H7 Or Salmonella Typhimurium In Bhi Broth And Uht Milk, Zeli̇ha Yildirim, Yaseli̇n İlk, Meti̇n Yildirim, Kader Tokatli, Ni̇lgün Öncül

Turkish Journal of Biology

The effects of physical and chemical sublethal treatments on the antibacterial activity of enterocin KP produced by Enterococcus faecalis KP against Escherichia coli O157:H7 and Salmonella Typhimurium were investigated. Enterocin KP was not active against intact cells of E. coli O157:H7 or S. Typhimurium. However, the use of enterocin KP together with ethylenediaminetetraacetic acid (50 mM), sodium tripolyphosphate (50 mM), sublethal heating (60 °C for 10 min), cold shock (-20 °C for 2 h), or acid stress (mixture of 40% lactic acid, 16% propionic acid, 16% acetic acid) in BHI medium decreased the cell number of E. coli O157:H7 by …

Potential Of Moringa Oleifera L. As Livestock Fodder Crop: A Review, Wasif Nouman, Shahzad Maqsood Ahmed Basra, Muhammad Tahir Siddiqui, Azra Yasmeen, Tehseen Gull, Maria Angelica Cervantes Alcayde

Turkish Journal of Agriculture and Forestry

Dairy and meat production in dry regions is very complex due to low quality and shortage of fodder, especially in dry periods. Livestock scientists are eager to explore and investigate good-quality fodders that can boost milk and meat production in an organic and economical way. Some organic meals like soybean, cotton seed cake, and range grasses are being utilized to overcome the fodder shortage. These have some limitations, however, like unavailability in December through May as currently green fodder is least available after wheat, alfalfa, brassica, and maize harvesting. This leads towards reduced livestock production and low-quality milk and meat …