Digital Commons Network^™

Clinical And Microbiologic Efficacy Of A Water Filter Program In A Rural Honduran Community, Jaclyn Arquiette, Michael P. Stevens, Jean M. Rabb, Kakotan Sanogo, Patrick Mason, Gonzalo Bearman

VCU Health Publications

Water purification in the rural Honduras is a focus of the nonprofit organization Honduras Outreach Medical Brigade Relief Effort (HOMBRE). We assessed water filter use and tested filter microbiologic and clinical efficacy. A 22-item questionnaire assessed water sources, obtainment/storage, purification, and incidence of gastrointestinal disease. Samples from home clay-based filters in La Hicaca were obtained and paired with surveys from the same home. We counted bacterial colonies of four bacterial classifications from each sample. Sixty-five surveys were completed. Forty-five (69%) individuals used a filter. Fifteen respondents reported diarrhea in their home in the last 30 days; this incidence was higher …

Neuropathological Responses To Chronic Nmda In Rats Are Worsened By Dietary N-3 Pufa Deprivation But Are Not Ameliorated By Fish Oil Supplementation, Vasken L. Keleshian, Matthew Kellom, Hyung-Wook Kim, Ameer Y. Taha, Yewon Cheon, Miki Igarashi, Stanley I. Rapoport, Jagadeesh S. Rao

Anatomy and Neurobiology Publications

Background

Dietary long-chain n-3 polyunsaturated fatty acid (PUFA) supplementation may be beneficial for chronic brain illnesses, but the issue is not agreed on. We examined effects of dietary n-3 PUFA deprivation or supplementation, compared with an n-3 PUFA adequate diet (containing alpha-linolenic acid [18:3 n-3] but not docosahexaenoic acid [DHA, 22:6n-3]), on brain markers of lipid metabolism and excitotoxicity, in rats treated chronically with NMDA or saline.

Methods

Male rats after weaning were maintained on one of three diets for 15 weeks. After 12 weeks, each diet group was injected i.p. daily with saline (1 ml/kg) or a subconvulsive dose …

Calorie Labeling, Edward F. Ansello

Director's Editorials from Age in Action

As required by the Affordable Care Act, chain restaurants with 20 or more locations in the US will soon have to display calorie information on their menus. Does knowing this information translate to changing our eating behavior and improving our nutritional intake? Will this change affect older adults in a meaningful way? Menu labeling should be viewed as an early approach in governmental policy to address the obesity epidemic.

Dietary Regimens Modify Early Onset Of Obesity In Mice Haploinsufficient For Rai1, Joseph T. Alaimo, Natalie H. Hahn, Sureni V. Mullegama, Sarah H. Elsea

Human and Molecular Genetics Publications

Smith-Magenis syndrome is a complex genomic disorder in which a majority of individuals are obese by adolescence. While an interstitial deletion of chromosome 17p11.2 is the leading cause, mutation or deletion of the RAI1 gene alone results in most features of the disorder. Previous studies have shown that heterozygous knockout of Rai1 results in an obese phenotype in mice and that Smith-Magenis syndrome mouse models have a significantly reduced fecundity and an altered transmission pattern of the mutant Rai1 allele, complicating large, extended studies in these models. In this study, we show that breeding C57Bl/6J Rai1+/−mice with FVB/NJ to …

A Placebo-Controlled, Double-Blind, Randomized, Multicenter Study To Assess The Effects Of Dronedarone 400 Mg Twice Daily For 12 Weeks On Atrial Fibrillation Burden In Subjects With Permanent Pacemakers, Michael D. Ezekowitz, Kenneth Ellenbogen , M.D., John P. Dimarco, Karoly Kaszala, Alexander Boddy, Gregory Geba P., Andrew Koren

Human and Molecular Genetics Publications

Purpose

Dronedarone is a benzofuran derivative with a pharmacological profile similar to amiodarone but has a more rapid onset of action and a much shorter half-life (13–19 h). Our goal was to evaluate the efficacy of dronedarone in atrial fibrillation (AF) patients using dual-chamber pacemakers capable of quantifying atrial fibrillation burden.

Methods

Pacemakers were adjusted to optimize AF detection. Patients with AF burden >1 % were randomized to dronedarone 400 mg twice daily (BID) or placebo. Pacemakers were interrogated after 4 and 12 weeks of treatment. The primary endpoint was the change in AF burden from baseline over the 12-week …

Impaired Bone Formation In Pdia3 Deficient Mice, Yun Wang, Alexandr Nizkorodov, Kelsie Riemenschneider, Christopher S. D. Lee, Rene Olivares-Navarrete, Zvi Schwartz, Barbara D. Boyan

Biomedical Engineering Publications

1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] is crucial for normal skeletal development and bone homeostasis. Protein disulfide isomerase family A, member 3 (PDIA3) mediates 1α,25(OH)2D3initiated-rapid membrane signaling in several cell types. To understand its role in regulating skeletal development, we generated Pdia3-deficient mice and examined the physiologic consequence of Pdia3-disruption in embryos and Pdia3+/− heterozygotes at different ages. No mice homozygous for the Pdia3-deletion were found at birth nor were there embryos after E12.5, indicating that targeted disruption of the Pdia3 gene resulted in early embryonic lethality.Pdia3-deficiency also resulted in skeletal manifestations as revealed by µCT analysis …

Evolution Of Our Understanding Of Myeloid Regulatory Cells: From Mdscs To Mregs, Masoud H. Manjili

Microbiology and Immunology Publications

The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions. Emerging evidence suggests that MDSCs suppress CTL and Th1 responses in malignant diseases while they regulate effective immune responses in parasitic and helminth infections as well as Th17 inflammatory response during autoimmune diseases. Based on these data, the term myeloid regulatory cells (Mregs) more accurately reflects their function and interactions with different cells of the immune system during diseased conditions. Here, we provide evidence on the multifaceted function of Mregs …

Annual Report Of The Officers, Trustees, Boards, Committees, And Agents For The Town Of Nottingham, New Hampshire For The Year Ending December 31, 2013., Nottingham Town Representatives

Nottingham, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Promise Vs. Performance: Why Public Subsidies Of Private Development Are Not Likely To Produce Fair Returns To The Taxpaying Public, Marc Knapp

University of Baltimore Journal of Land and Development

On September 10, 2013, the Baltimore City Council gave final approval to Harbor Point, a $1 billion multi-use project to be built on a vacant, remediated brownfield that juts into Baltimore's Inner Harbor. Like many urban development or redevelopment projects, Harbor Point will be supported by significant taxpayer subsidies. Between a $107 million direct investment in project-related infrastructure largely parks that will surround the to-be-built offices, shops and residences, and a waterfront promenade - along with a mixed bag of real estate and income tax incentives, the visible public support to Harbor Point will exceed $200 million, 20% of projected …

Rna-Seq Analysis Reveals A Six-Gene Soxr Regulon In Streptomyces Coelicolor, Nawar Naseer, Joshua A. Shapiro, Monica Chander

Biology Faculty Research and Scholarship

The redox-regulated transcription factor SoxR is conserved in diverse bacteria, but emerging studies suggest that this protein plays distinct physiological roles in different bacteria. SoxR regulates a global oxidative stress response (involving >100 genes) against exogenous redox-cycling drugs in Escherichia coli and related enterics. In the antibiotic producers Streptomyces coelicolor and Pseudomonas aeruginosa, however, SoxR regulates a smaller number of genes that encode membrane transporters and proteins with homology to antibiotic-tailoring enzymes. In both S. coelicolor and P. aeruginosa, SoxR-regulated genes are expressed in stationary phase during the production of endogenously-produced redox-active antibiotics. These observations suggest that SoxR evolved …

Shape Evolution And Sexual Dimorphism In The Mandible Of The Dire Wolf, Canis Dirus, At Rancho La Brea, Alexandria L. Brannick

Theses, Dissertations and Capstones

The Rancho La Brea tar pits are a classic fossil lagerstätten, famous for the deposition of episodic accumulations of large numbers of fossils over short intervals in the late Pleistocene. I analyzed 157 Canis dirus (dire wolf) hemi-mandibles from Rancho La Brea through a 2D landmark-based morphometric analysis to test for size and shape changes through time. I scored 16 landmarks on each mandible gathered from four pits of different ages: 61/67 (~13-14 thousand years ago [ka]), 13 (~17-18 ka), 2051 (~26 ka), and 91 (~28 ka). Analyses indicate size does change through time, and shares a broad correlation with …

The Geography Of Stuck: Exceptions To Brain Drain In West Virginia, Lindsay Heinemann

Theses, Dissertations and Capstones

Brain drain, also known as “human capital flight,” can be defined as “the mass emigration of technically skilled people from one country to another country” (Weeks, 2008, p. 250) or one state to another state. This theory surmises that highly skilled people or those with high education levels are more likely to migrate from places with little to no economic opportunities to places with better economic and job opportunities. West Virginia has largely been a state with few high paying or prestigious job opportunities. So why do highly educated people stay in West Virginia? Using census data and personal interviews, …

Examination Of Two Hydration Protocols During Simulated Forced Marching Under Acute Heat Stress, David Alan Cottrill

Theses, Dissertations and Capstones

The purpose of this study was to identify and compare the effects of ingesting either water or 6% solution of carbohydrates, electrolytes, and water on hydration status during simulated military road marching in hot environmental conditions. Five volunteer male subjects completed two 60 minute experimental trials exercising at a high intensity (RER .90-.95) in an improvised environmental chamber (29.7 ^{_{+ or -}} .18^oC, 11.3 + or - 2.13% relative humidity) in full army combat uniform carrying 18.18kg of equipment. Random assignment of either water or solution was completed prior to trial 1, and consumption of the unselected protocol …

Subthreshold Toxic Effects Of Atrazine And Three Degradates On Behavior In Procambarus Clarkii, Carol B. Starkey

Theses, Dissertations and Capstones

Atrazine is among the most heavily applied pesticides worldwide, and recent evidence suggests that it may be unsafe at environmental levels. It is a known endocrine disruptor and a suggested neurotoxin. The US EPA Maximum Contaminant Level (MCL) is 3 μg/L for human ingestion and 200 μg/L for limited human exposure. Several environmentally persistent degradates have been identified, including deethylatrazine (DEA), deisopropylatrazine (DIA) and hydroxyatrazine (HA). No MCLs have been established for these degradates, although some are suggested toxins. Thus, there remains concern for the risk associated with the presence of atrazine and its degradates in the environment. Currently little …

Using Ailuropoda Melanoleuca As A Model Species For Studying The Ecomorphology Of Paranthropus, Ryan Andrew King

Theses, Dissertations and Capstones

Giant pandas (Ailuropoda melanoleuca) have cranial morphology similar to the extinct hominin genus Paranthropus which makes them an excellent model species when studying Paranthropus diet. Both species have wide skulls with flared zygomatic arches adapted for chewing. To gain insight into possible food sources of Paranthropus, I investigated the giant panda’s specialized diet of bamboo. The toughness, hardness, and stiffness of various bamboo species was determined to assess mechanical challenges facing giant pandas during feeding. Bamboo is thought to be tough, but studies on such properties and how they apply to mastication of giant pandas are largely …

Associated Students Annual Report 2013-2014, San Jose State University, Associated Students

Associated Students Annual Reports

No abstract provided.

West Virginia State Documents Inventory, Marshall University Special Collections

Miscellaneous Inventories

Marshall University is an official repository for West Virginia State Documents. The West Virginia State Documents are a collection of documents published by various state entities from the state’s inception to today. This includes publications from a variety of public departments as well as the state legislature. The collection includes newsletters, maps, pamphlets, legislative bills, reports, and more.

A Case Study Of A Priority Middle School Involved In The North Carolina Turnaround Initiative, Jo Beth Clark

Education Dissertations and Projects

In 2007, the North Carolina Department of Public Instruction included low-performing middle schools in its Turnaround Initiative. The purpose of this initiative was to offer support and guidance to designated low-performing middle schools across the state. This research study was a descriptive case study that involved a North Carolina priority middle school located in the north central part of the Piedmont, which served a diverse, low socioeconomic population. This research study investigated how the implementation of the North Carolina Turnaround Initiative impacted the school's culture and reviewed student achievement trends for the years 2007-2010, covering 3 school years.

This descriptive …

Eury Value-Added Experience Model: A Case Study On The Collective Learning Culture Of A Suburban Middle School In The Southeastern Region Of The United States, Timothy Merrell Reed

Education Dissertations and Projects

This dissertation was designed to test the Eury Value-Added Experience Model as a theoretical model to measure and evaluate the collective learning culture of a school organization. The Eury Value-Added Experience Model is based upon five domains of the theoretical model: (1) dispositions, (2) professional experiences, (3) structure, (4) shared decision making, and (5) assessment and reflection skills. This mixed-method case study used the five domains to focus on the collective learning culture of a suburban middle school in the western region of the State of North Carolina. Limited research exists on the use of the Eury Value-Added Experience Model …

Discharge Education In The Emergency Department: Are We Effectively Teaching Chest Pain Patients?, Emily Edwards Nishiyama

Nursing Theses and Capstone Projects

Millions of individuals visit the emergency department (ED) each year with complaints of chest pain. Many chest pain patients do not have an underlying condition of Acute Coronary Syndrome (ACS) but the health and well-being of these patients is indispensable. Research has indicated soaring costs, an increased demand in medical resources, and an increasingly poor quality of life for these patients after discharge. Although research encourages quality education at discharge, very few studies have been conducted on ED discharge education for non-ACS chest pain patients. Using a cross-sectional descriptive research design, this quantitative study discovered the frequency of education provided …

Community And Global Public Health Curriculum Map 2013-2014, Sean M. Stone, Char Booth, Dani Brecher, M. Sara Lowe, Natalie Tagge

Curriculum Maps

This map displays degree requirements, courses, faculty information, clubs & organizations, and Library resources associated with community and global public health across the seven Claremont Colleges (7Cs) for the 2013-14 academic year. It was compiled using public information drawn from Colleges websites, course schedules and catalogs, and the Claremont Colleges Library website.

This project was completed as part of an IMLS Sparks! Ignition grant in 2013-14.

Neuroscience Curriculum Map 2013-2014, Sean M. Stone, Char Booth, Dani Brecher, M. Sara Lowe, Natalie Tagge

Curriculum Maps

This map displays degree requirements, courses, faculty information, clubs & organizations, and Library resources associated with neuroscience across the seven Claremont Colleges (7Cs) for the 2013-14 academic year. It was compiled using public information drawn from Colleges websites, course schedules and catalogs, and the Claremont Colleges Library website.

This project was completed as part of an IMLS Sparks! Ignition grant in 2013-14.

Chemistry Curriculum Map 2013-2014, Sean M. Stone, Char Booth, Dani Brecher, M. Sara Lowe, Natalie Tagge

Curriculum Maps

This map displays degree requirements, courses, faculty information, clubs & organizations, and Library resources associated with chemistry across the seven Claremont Colleges (7Cs) for the 2013-14 academic year. It was compiled using public information drawn from Colleges websites, course schedules and catalogs, and the Claremont Colleges Library website.

This project was completed as part of an IMLS Sparks! Ignition grant in 2013-14.

Center For Grassland Studies, Winter-Spring 2014, Volume 20, No. 1

Center for Grassland Studies: Newsletters

Bringing Back Grazing Lands in the Rainwater Basin

From the Director

Turfgrass Phosphorus Requirements Are Lower than Previously Thought

Landscape Changes to Grassland Ecosystems

Worldwide Study Finds that Fertilizer Destabilizes Grasslands

On the Land Is Now Online

2014 Nebraska Grazing Conference Features New Venues

CGS Associates

Opportunities for Livestock Expansion in Nebraska

PGA Golf Management Alumni Earn Awards

Breastfeeding Infants With Phenylketonuria In The United States And Canada, Sandra Banta-Wright, Nancy Press, Kathleen Knafl, Robert Steiner, Gail Houck

Faculty Publications - College of Nursing

Objective: This study described the prevalence and duration of mothers’ breastfeeding infants with phenylketonuria (PKU) and explored factors related to duration of breastfeeding as a surrogate for breastfeeding success. Subjects and

Methods: Descriptive analysis as performed from an international Internet survey of mothers (n = 103) who met the inclusion criteria: (1) at least 21 years of age, (2) able to read and write in English, (3) child with PKU, and (4) living in the United States or Canada.

Results: Of the 103 mothers, 89 (86%) initiated breastfeeding immediately following delivery, whereas 14 (14%) chose bottle feeding. In comparison to …

The Dual Burden Of Malnutrition: Quetzaltenango, Guatemala, Nisha Punatar, Robert C. Morrow

GW Research Days 2014

No abstract provided.

A Pilot Academic-Community Partnership To Advance The D.C. Healthy Schools Act, Nisha Narayanan, Jonathan Tatum, Margarita Ramos, Jessica Kim, Nisha Punatar, Michele L. Mietus-Snyder

GW Research Days 2014

No abstract provided.

Guardian Engagement, Rachel Baywal, Jessica Carag, Laura Johns, John-Hanson Machado, Sarah Rothenberg, Indira Singh, Christie Toolin, Meghana Vijaysimha

ISCOPES Posters and Presentations

No abstract provided.

Fusion, 2014, George Washington University, William H. Beaumont Medical Research Honor Society

Fusion

No abstract provided.

Thiamine Pyrophosphokinase Deficiency Causes A Leigh Disease Like Phenotype In A Sibling Pair: Identification Through Whole Exome Sequencing And Management Strategies, Jamie L. Fraser, Adeline Vanderver, Sandra Yang, Taeun Chang, Laura Cramp, Gilbert Vezina, Uta Lichter-Konecki, Kristina Cusmano-Ozog, Patroula Smpokou, Kimberly A. Chapman, Dina Zand

Neurology Faculty Publications

We present a sibling pair with Leigh-like disease, progressive hypotonia, regression, and chronic encephalopathy. Whole exome sequencing in the younger sibling demonstrated a homozygous thiamine pyrophosphokinase (TPK) mutation. Initiation of high dose thiamine, niacin, biotin, α-lipoic acid and ketogenic diet in this child demonstrated improvement in neurologic function and re-attainment of previously lost milestones. The diagnosis of TPK deficiency was difficult due to inconsistent biochemical and diagnostic parameters, rapidity of clinical demise and would not have been made in a timely manner without the use of whole exome sequencing. Molecular diagnosis allowed for attempt at dietary modification with cofactor supplementation …