Digital Commons Network^™

The Study Of Au(Iii) Compounds And Their Interaction With Zinc Finger Proteins, Sarah Spell

Theses and Dissertations

Gold compounds have been used in medicine dating back as early as 2500 BC. Over the years gold(I) and gold(III) compounds have been used and designed to target rheumatoid arthritis, cancer, and viral diseases. New drug targets have been found for gold compounds that give insight into their mechanisms of action. Here we focus on the synthesis of Au(III) compounds designed to selectively target zinc finger (ZF) proteins. ZF proteins exhibit a variety of functions, including transcription, DNA repair, and apoptosis. Displacement of the central zinc ion, along with mutation of coordinated amino acids can result in a loss of …

If It's Not Mixed-Income, It Won't Be Transit-Oriented: Ensuring Our Future Developments Are Equitable & Promote Transit, M. Tanner Clagett

Transportation Law Journal

No abstract provided.

Long Life Electrochemical Diodes For Continuous Electrowetting, Mehdi Khodayari, Ben Hahne, Nathan B. Crane

Faculty Publications

The rate of electrochemical reactions in some systems varies with the polarity of the overpotential on the working electrode, introducing diode-like behavior at the electrode/electrolyte interface. However, with repeated bipolar cycling, the electrochemical current damages the electrodes. We have connected electrochemical diodes in series with opposing polarities to reduce the diode current while charging a capacitive circuit. We have previously used this capacitive circuit arrangement to actuate aqueous droplets continuously using the electrowetting (EW) effect. In this study, the performance of electrochemical diodes under repeated voltage cycles is investigated. Aluminum and titanium electrodes in contact with three electrolyte solutions (0.1 …

The Troubling Metaphor Of Foundations In Art Education: What Foundations Affords Or Limits In High School And College Art Programs, Mark Graham, Daniel T. Barney

Faculty Publications

No abstract provided.

Characterization Of Individual Charged Au25(Sg)18 Clusters And Their Enhancement Of Single Molecule Mass Spectrometry, Christopher Angevine

Theses and Dissertations

Metallic quantum clusters are stable structures that can exhibit many useful magnetic, chemical, and optical properties. Developing clusters for specific applications requires accurate methods for characterizing their physical and chemical properties. Most cluster characterization methods are ensemble-based measurements that can only measure the average values of the cluster properties. Single cluster measurements improve upon this by yielding information about the distribution of cluster parameters. This investigation describes the initial results on a new approach to detecting and characterizing individual gold nanoclusters (Au25(SG)18) in an aqueous solution with nanopore-based resistive pulse sensing. We also present a new application where the clusters …

Modeling Change In The Presence Of Non-Randomly Missing Data: Evaluating A Shared Parameter Mixture Model, Scott A. Baldwin, Nisha C. Gottfredson, Daniel J. Bauer

Faculty Publications

In longitudinal research, interest often centers on individual trajectories of change over time. When there is missing data, a concern is whether data are systematically missing as a function of the individual trajectories. Such a missing data process, termed random coefficient-dependent missingness, is statistically non-ignorable and can bias parameter estimates obtained from conventional growth models that assume missing data are missing at random. This paper describes a shared-parameter mixture model (SPMM) for testing the sensitivity of growth model parameter estimates to a random coefficient-dependent missingness mechanism. Simulations show that the SPMM recovers trajectory estimates as well as or better than …

"Mining" For A Reference Condition In Southern West Virginia Streams, Matthew Rouch

Theses and Dissertations

Quarterly samples were used to estimate assemblage-level (all species combined) fish production within three minimally-impacted, southern West Virginia streams. The total annual fish production estimate was highest in Slaunch Fork (37.52 kg∙ha^-1∙y^-1), a tributary of the Tug Fork River, and lowest in Cabin Creek (10.59 kg∙ha^-1∙y^-1), a Guyandotte River tributary. Creek Chub Semotilus atromaculatus, Mottled Sculpin Cottus bairdii and Blacknose Dace Rhinicthys atratulus were the most abundant species among sites, accounting for >90% of all sampled individuals. Reference condition criteria were also selected and metrics calculated for each of the three …

How Well Does Multiple Ocr Error Correction Generalize?, William B. Lund, Eric K. Ringger, Daniel D. Walker

Faculty Publications

As the digitization of historical documents, such as newspapers, becomes more common, the need of the archive patron for accurate digital text from those documents increases. Building on our earlier work, the contributions of this paper are: 1. in demonstrating the applicability of novel methods for correcting optical character recognition (OCR) on disparate data sets, including a new synthetic training set, 2. enhancing the correction algorithm with novel features, and 3. assessing the data requirements of the correction learning method. First, we correct errors using conditional random fields (CRF) trained on synthetic training data sets in order to demonstrate the …

Toward A Theory Of Equitable Federated Regionalism In Public Education, Erika K. Wilson

Faculty Publications

No abstract provided.

Pt-Symmetric Acoustics, Xuefeng Zhu, Hamidreza Ramezani, Chengzhi Shi, Jie Zhu, Xiang Zhang

Physics & Astronomy Faculty Publications

We introduce here the concept of acoustic parity-time (PT) symmetry and demonstrate the extraordinary scattering characteristics of the acoustic PT medium. On the basis of exact calculations, we show how an acoustic PT -symmetric medium can become unidirectionally transparent at given frequencies. Combining such a PT -symmetric medium with transformation acoustics, we design two-dimensional symmetric acoustic cloaks that are unidirectionally invisible in a prescribed direction. Our results open new possibilities for designing functional acoustic devices with directional responses.

Application Of A Hough Search For Continuous Gravitational Waves On Data From The Fifth Ligo Science Run, J. Aasi, J. Abadie, B. P. Abbott, Teviet Creighton, H. Daveloza, Mario C. Diaz, Soma Mukherjee, Volker Quetschke, Malik Rakhmanov, Robert Stone, A. S. Stroeer, Lappoon R. Tang, Cristina V. Torres

Physics & Astronomy Faculty Publications

We report on an all-sky search for periodic gravitational waves in the frequency range 50–1000 Hz with the first derivative of frequency in the range −8.9 × 10−10 Hz s−1 to zero in two years of data collected during LIGO's fifth science run. Our results employ a Hough transform technique, introducing a χ2 test and analysis of coincidences between the signal levels in years 1 and 2 of observations that offers a significant improvement in the product of strain sensitivity with compute cycles per data sample compared to previously published searches. Since our search yields no surviving candidates, we present …

Implementation Of An F-Statistic All-Sky Search For Continuous Gravitational Waves In Virgo Vsr1 Data, J. Aasi, B. P. Abbott, R. Abbott, T. Abbott, M. R. Abernathy, Mario C. Diaz, Malik Rakhmanov, Joseph D. Romano, Soma Mukherjee, Volker Quetschke, Teviet Creighton, Robert Stone

Physics & Astronomy Faculty Publications

We present an implementation of the -statistic to carry out the first search in data from the Virgo laser interferometric gravitational wave detector for periodic gravitational waves from a priori unknown, isolated rotating neutron stars. We searched a frequency f0 range from 100 Hz to 1 kHz and the frequency dependent spindown f1 range from Hz s−1 to zero. A large part of this frequency–spindown space was unexplored by any of the all-sky searches published so far. Our method consisted of a coherent search over two-day periods using the -statistic, followed by a search for coincidences among the …

Washington Avenue Bridge : A Technocentric Approach To Celebrating The Mississippi River Through Rhythm And Space, Adam Boole

Landscape Architecture Theses

There is a measurable, scientifically proven link between space and memory (Hoelscher, 2004). This means that education is highly sensitive towards the quality of the study environment, especially when it is a space that students average six years in developing their intellectual growth (Students, 2013). Many difficult problems can be solved through creative solutions by the university offering to support and give resources to intelligent minds. It is not just highly relevant, it is critical for a university to have a strong campus design that encourages and inspires thought process. This thesis demonstrates through research and design that the environment …

A Mathematical Model Of Collagen Lattice Contraction, J. C. Dallon, Emily J. Evans, H Paul Erhlich

Faculty Publications

Two mathematical models for fibroblast-collagen interaction are proposed which reproduce qualitative features of fibroblast populated collagen lattice contraction in time. Both models are force based and model the cells as individual entities with discrete attachment sites however the collagen lattice is modeled differently for each model. In the collagen lattice model the lattice is more interconnected and formed by triangulating nodes to form the fibrous structure. In the collagen fiber model the nodes are not triangulated, are less interconnected, and the collagen fibers are modeled as a string of nodes. Both models suggest that the overall increase in stress of …

Spatial Moment Analysis Of Reactive And Radioactive Solute In River System With Layered Porous Bed, Shadab Anwar

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Mass exchange between river stream and riverbed is critical towards remediation of contaminated river system. Spatial moment analysis of reactive and radioactive solute in river channel with underlying porous bed is applied to understand the qualitative description of solute plume in riverbed and river stream. Semi-analytical solutions for zeroth-, first- and second-order spatial moment of reactive and radioactive solute are derived in Laplace domain. The spatial moments of concentration are numerically inverted. Parabolic velocity in river channel and exponentially decaying velocity in porous bed are linked using a slip velocity at the interface. The model is verified against the semi-analytical …

Global Assessment Of Radiocarbon Isotopic Analysis For Particulate And Dissolved Organic Carbon In Riverine Systems, Ashley Tucker

Theses and Dissertations

Rivers are a significant source of particulate and dissolved organic carbon (POC, DOC) into inland waters and coastal systems and provide a fundamental linkage between the terrestrial, oceanic, and atmospheric carbon reservoirs. Recent studies have examined the relationship between the quantity and form (POC vs. DOC) of carbon delivered to the aquatic system; however, little is known about the age of POC and DOC exported and how the radiocarbon age may vary with latitude, topographic gradient, vegetation, and land use. I provide the first global synthesis of published radiocarbon values of POC and DOC (∆14C). Inclusion of DOC and POC …

Increasing And Generalizing Self-Efficacy: The Effects Of Adventure Recreation On The Academic Efficacy Of Early Adolescents, Mark A. Widmer, Mat D. Duerden, Stacy T. Taniguchi

Faculty Publications

This quasi-experimental study examined the impact of an adventure recreation program on adolescent participants’ outdoor recreation and academic self-efficacy. The study also explored the transferability of efficacy beliefs across non-related domains. The sample included 262 adolescents, 194 who served as participants in the program and 68 who served as comparisons. The average age for each group was 13.6 years. The intervention, a two-week, theory-based program, involved a variety of outdoor recreation activities. Pre-/post-instruments measured perceived levels of outdoor efficacy and academic efficacy, attitudes, and motivations. Results indicated participants experienced significantly more growth than comparisons on both outdoor and academic measures …

Modelling The Subsurface Geomorphology Or An Active Landslide Using Lidar, Norbert H. Maerz

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

No abstract provided.

High-Resolution Magnetic Susceptibility Measurements For Investigating Magnetic Mineral Formation During Microbial Mediated Iron Reduction, Estella A. Atekwana, Farag M. Mewafy, Gamal Z. Abdel Aal, D. Dale Werkema, Andre Revil, Lee D. Slater

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Disimilatory iron-reducing bacteria play an important role in the reduction of Fe(hydr)oxides and the production of secondary solid-iron mineral phases that can have magnetic properties. Magnetic susceptibility can therefore play an important role in identifying zones where microbial-mediated iron reduction is occurring. We investigated the magnetic susceptibility variations in a hydrocarbon-contaminated aquifer where methanogenesis and iron reduction are the main biogeochemical processes. Our objectives are to (1) determine the variability of magnetic susceptibility, (2) determine the hydrobiogeochemical controls on the magnetic susceptibility variability, and (3) evaluate the use of magnetic susceptibility as a viable technique for identifying zones where the …

Imsa 2014 Profile, Office Of College And Academic Counseling

IMSA Profile

The internationally recognized Illinois Mathematics and Science Academy ® (IMSA) develops creative, ethical leaders in science, technology, engineering and mathematics. As a teaching and learning laboratory created by the State of Illinois, IMSA enrolls academically talented Illinois students (grades 10-12) in its advanced, residential college preparatory program, and it serves thousands of educators and students in Illinois and beyond through innovative instructional programs that foster imagination and inquiry. IMSA also advances education through research, groundbreaking ventures and strategic partnerships. (www.imsa.edu) IMSA employs 56 full-time teaching faculty members, all of whom have advanced degrees, with 44% holding doctorate degrees. In addition, …

Following Suit With The Second Circuit: Defining Gambling In The Illegal Gambling Business Act, Kaitlyn Dunphy

Brooklyn Law Review

No abstract provided.

A Lawyer's Hidden Persuader: Genre Bias And How It Shapes Legal Texts By Constraining Writer's Choices And Influencing Readers' Perceptions, Bret Rappaport

Journal of Law and Policy

No abstract provided.

Moving Past A "Pocket Change" Settlement: The Threat Of Preemption And How The Loss Of Chance Doctrine Can Help Nfl Concussion Plaintiffs Prove Causation, John Guccione

Journal of Law and Policy

No abstract provided.

Probability, Confidence, And Matsushita: The Misunderstood Summary Judgement Revolution, Luke Meier

Journal of Law and Policy

No abstract provided.

Thousands Of Half-Lives To Go: Weighing The Risks Of Spent Nuclear Fuel Storage, Amanda Matos

Journal of Law and Policy

No abstract provided.

Role Of Feedstock And Process Conditions On Biomass Gasification For Synthesis Gas Production, Mayoorey Murugathasan

Masters Theses

In this study gasification of three different biomasses were performed to study the impact of process conditions and different feed stocks on final syngas composition. Final composition of the syngas determines the energy value of the resulting syngas and the suitability of syngas in chemical synthesis applications. Three kinds of feedstocks studied include switch grass pellets:wood chips 50:50 mixture, wood pellets:wood chips 50:50 mixture and wood pellets.

The effect of process conditions including temperature and feed stock composition on syngas composition were studied. Gas chromatography was used to analyze the final gas composition of syngas samples collected at five different …

Low Resolution Examination Of Cool-Water Carbonate Foraminifera Around Tasmania During The Pleistocene, Sara Jane Hughes

Masters Theses

Benthic foraminifera from nine sediment samples recovered during Ocean Drilling Program (ODP) Leg 189: The Tasman Gateway were examined to determine how changing Southern Ocean conditions affect benthic foraminiferal populations. All samples come from Site 1168 situated 70km from the coast of Tasmania on the western continental slope (2463 m below the surface) and are spaced at roughly 150,000 years apart. Identifications of benthic foraminifera were done with a dissecting microscope and several reference books. Foraminifera were correlated with environmental proxy data obtained from Brughmans (2003) (total organic carbon, carbonate, siliciclastics, coarse fractions, chlorin, barium, aluminum, iron, and titanium) and …

Computational And Experimental Studies Of Non-Covalent Interactions: Characterization Of Ch...Π Interactions And Structure Of 1,1-Difluoroethylene...Carbon Dioxide, Ashley M. Anderton

Masters Theses

Weakly bound CH/π interactions, due to the abundance of C-H bonds and π systems that exist in larger organic molecules, are an important driving force in the construction of biomacromolecules, supramolecular assemblies and crystal packing of organic compounds. To assist in the characterization of CH/π interactions, a density functional theory (DFT) study has been conducted to determine a quick and cheap method for accurate determination of the binding energy and rotational constants for CH/π interactions. Seven complexes were used in this study: five benzene-HY complexes (where Y= C≡CH, Cl, F, Br and C≡N) and two fluorobenzene-HY complexes (where Y= C≡CH …

Investigations Towards Synthesis Of Cinnamaldehyde Semicarbazone Derivatives And Their Photochromicity By Modifying The Ring, The Linker, And The Semicarbazone, Xiao Xiao

Masters Theses

Cinnamaldehyde semicarbazone was varied in three ways, by altering the ring, the conjugated linker, and the semicarbazone, to investigate how changing the structure affects the photochomicity. The synthesis of 7 hetero- and 2 polycyclic- aromatic semicarbazone variants involved three steps, (a Wittig reaction, hydrolysis, and condensation to the semicarbazone) with cumulative yields of 15% to 52%. Generally, the pyridine series gave lower yields than other synthesized semicarbazones. The Wittig reaction gave cis/trans mixtures in ratios of 2 : 1 to 1 : 7 for the 6 acetals, except for the 3 that went directly to the aldehyde, due to the …

Synthesis And Characterization Of Molecular Components For The Preparation Of Poly-Rotaxanes, Austin P. Welti

Masters Theses

The self-sorting ability of certain crown ethers make them important players in the field of supramolecular chemistry, especially those studying mechanically interlocked molecules (MIMs). Of these MIMs, rotaxanes and catenanes are the most common. Our approach in the synthesis of poly-rotaxane systems involves the preparation of axles containing multiple recognition motifs to determine the self-sorting principles that each motif shows. These principles include narcissistic self-sorting, and also type I and type II social self-sorting principles. Using these techniques, poly-rotaxane formation can be made readily available.

A hetero-poly-rotaxane equipped with a naphthalene diimide (NDI) site and two ammonium salt sites has …