Digital Commons Network^™

Cd100 Up-Regulation Induced By Interferon-Α On B Cells Is Related To Hepatitis C Virus Infection, Yu He, Yonghong Guo, Yun Zhou, Ying Zhang, Chao Fan, Guangxi Ji, Yu Wang, Zhiyuan Ma, Jianqi Lian, Chunqiu Hao, Zhi Q. Yao, Zhansheng Jia

ETSU Faculty Works

Objectives: CD100, also known as Sema4D, is a member of the semaphorin family and has important regulatory functions that promote immune cell activation and responses. The role of CD100 expression on B cells in immune regulation during chronic hepatitis C virus (HCV) infection remains unclear. Materials and Methods: We longitudinally investigated the altered expression of CD100, its receptor CD72, and other activation markers CD69 and CD86 on B cells in 20 chronic HCV-infected patients before and after treatment with pegylated interferon-alpha (Peg-IFN-α) and ribavirin (RBV) by flow cytometry. Results: The frequency of CD5+ B cells as well as the expression …

Synthesis And Characterization Of Complex Molecular Assemblies On Surfaces, Nitesh Madaan

Theses and Dissertations

The research presented in this dissertation is focused on the construction of complex molecular structures on planar gold and silicon dioxide surfaces using a variety of surface modification techniques, along with thorough surface characterization at each modification step. The dissertation is structured into six separate chapters. In Chapter 1, an introduction to the importance and implications of molecular level surface modification, commonly employed surface modification methods, and available surface characterization techniques is presented. Chapter 2 shows applications of novel methodologies for the functionalization of gold surfaces using alkane dithiol self-assembled monolayers and thiol-ene click chemistry. The resulting functionalized gold substrates …

Chaperone-Mediated Folding And Assembly Of Β-Propeller Proteins Into Cellular Signaling Complexes, Rebecca L. Plimpton

Theses and Dissertations

G protein signaling depends on the ability of the individual subunits of the G protein heterotrimer to assemble into a functional complex. Formation of the G protein βγ (Gβγ) dimer is particularly challenging because it is an obligate dimer in which the individual subunits are unstable on their own. Recent studies have revealed an intricate chaperone system that brings the Gβ and Gγ subunits together. This system includes the cytosolic chaperonin containing TCP-1 (CCT) and a co-chaperone phosducin-like protein 1 (PhLP1). Two key intermediates in the Gβγ assembly process, the Gβ-CCT and the PhLP1-Gβ-CCT complexes, were isolated and their structures …

A Comparison Of Learning In Dual Credit Introductory College Physics, Eric L. Thies

Boise State University Theses and Dissertations

Dual credit courses have been offered for over fifty years and have helped students save time and money during their college education. However, little has been done to study the quality of the dual credit courses themselves. The literature is unclear about whether students in dual credit programs learn the same material as the students enrolled in the same course at the university level.

The purpose of my study was to determine whether students in a concurrent enrollment introductory physics course achieve the same knowledge growth as university students enrolled in the same physics course. I used the Force Concept …

Development And Application Of Tools For Avalanche Forecasting, Avalanche Detection, And Snowpack Characterization, Scott Christopher Havens

Boise State University Theses and Dissertations

Avalanche formation is a complex interaction between the snowpack, weather, and terrain. However, detailed observations typically can only be made at a single point and must be extrapolated over the slope or regional scale. This study aims to provide avalanche forecasters with tools to evaluate the snowpack, avalanche hazard, and avalanche occurrence when manual observations are not feasible.

Avalanches that occur within the new storm snow are a prevalent problem for the avalanche forecasters with the Idaho Transportation Department (ITD) along Highway 21. We have implemented a real time SNOw Slope Stability (SNOSS) model that provides an index to the …

A Comparison Of Fifth Grade Mathematics Curriculum Materials, Michael E. Starks Sr.

Dissertations

In the USA, the No Child Left Behind Act of 2001 resulted in requirements placed on school districts to show student achievement in mathematics, based on measured adequate yearly progress. This caused school districts to search for standards based programs that improve mathematics learning. A quantitative multi-year study was used to compare the state-assessed achievement levels of 1,695 fifth-grade Midwestern children in the state of Missouri, who learned mathematics from two different curriculum-delivery programs, EveryDay Mathematics and EnVision Mathematics. A 2 by 2 by 8 research design was used through the choice of two elementary schools using EveryDay Mathematics and …

Bard Free Press, Vol. 16, No. 3 (December 2014), Bard College

Bard Free Press - All Issues (2000-2018)

No abstract provided.

Enzyme, Cosolvent, And Substrate Interactions In Ple Hydrolysis Reactions And Evaluation Of The Stability Of An Unnatural Glutathione Analogue, Maureen Elizabeth Smith

Dissertations

Prochiral diester malonates have been hydrolyzed in the presence of Pig Liver Esterase (PLE). Several of the diesters produced the respective half-ester in moderate to high enantioselectivity. A series of cosolvent assays were performed to evaluate the ability of the cosolvent to influence the enantioselective outcome of the hydrolysis reactions. Ethanol produced the largest changes in enantioselectivity of all solvents evaluated. The isoenzymes of PLE were also evaluated and provided very different enantioselective outcomes than that of crude PLE. A series of NMR titrations was performed to explore the interactions between the substrates and ethanol cosolvents.

Improvements to our previously …

Normal Fault Block Or Giant Landslide? Baldy Block, Wasatch Range, Utah, Eric R. Meyer

Theses and Dissertations

Understanding the interplay between surficial and tectonic processes in the development of Utah's Wasatch Range is vital to evaluating geologic hazards along the Wasatch Front. Baldy is a large (6.125 km3) block of limestone and sandstone structurally overlying shale on the western flank of Mount Timpanogos. It has been mapped as a downdropped normal fault block of Permian units, but no other trace of such a fault exists along the range. The Baldy block structurally overlies the weak Manning Canyon shale, which has produced a regional geomorphology replete with faceted spurs, landslide scarps and deposits. Structural, bio- and litho-stratigrahic mapping …

Impact Of Peer Praise Notes Issued During Recess: Effects On Office Disciplinary Referrals, Elise Ann Teerlink

Theses and Dissertations

School recess can be a problematic setting due to inadequate safety, supervision, and structure. Peer praise notes (PPNs) is a school-wide positive behavior support strategy that was implemented during recess to address these concerns at a Title I elementary school. An ABAB reversal design across all students was employed to evaluate the effectiveness of PPNs. Overall changes in office disciplinary referrals (ODRs) in each phase of the design, an effect size that reflects a highly effective treatment, and a moderately strong and statistically significant negative correlation suggest that PPNs decreased ODRs. Results from social validity surveys completed by eight recess …

Tincr: Integrating Custom Cad Tool Frameworks With The Xilinx Vivado Design Suite, Brad S. White

Theses and Dissertations

The field programmable gate array (FPGA) is appealing as a computational platform because of its ability to be repurposed for a number of different applications and its relatively low design cost. Traditionally, FPGA vendors provide a set of electronic design automation (EDA) tools to assist customers with the implementation of their designs. These tools are necessarily general purpose, and the resulting tool flow does not provide the user much in the way of customization. Frameworks such as RapidSmith and Torc allow for the creation of custom CAD tools that are able to target actual Xilinx FPGA devices. However, they are …

Design And Implementation Of An Inverse Modeling Framework Using The Method Of Anchored Distributions, Carlos Andres Osorio Murillo

Theses and Dissertations

Estimation of spatial random fields (SRFs) such as transmissivity or porosity is required for predicting groundwater flow and subsurface contaminant movement. Similarly, distributed parameter fields such as terrain roughness and evapotranspiration coefficients are required by other areas of environmental and earth sciences modeling. This dissertation presents an inverse modeling framework for characterizing SRFs called MAD#, which is an end-user software implementation of the Bayesian inverse modeling technique Method of Anchored Distributions (MAD). The MAD# framework allows modelers to “wrap” existing simulation modeling tools using an extensible driver architecture that exposes model parameters to the inversion engine. A compelling aspect of …

The Word Problem Factor: Assessing The Ability Of Utah High School Career And Technical Education Students To Do The Math Involved In Formulating And Calculating Energy Cost Factors, Kristen Bentley

Theses and Dissertations

Much research has been done showing the difficulty people have with word problems. This has been shown to be true for many types of word problems and for different demographics. Questions have remained unanswered regarding the reasons for this difficulty. It has been unclear if the word problems were hard because the people had forgotten or had not yet learned how to do the math calculations involved or for some other reason. This study deals with high school students who are currently in a high school level math class. They were given an assessment involving word problems and number-only problems. …

Spatial Heterogeneity Of Ecosystem Metabolism In A Shallow Wetland, Daniel Riley Rackliffe

Theses and Dissertations

Spatial heterogeneity in ecosystem metabolism may play a critical role in determining ecosystem functions. Variation in ecosystem metabolism between macrophyte patches in shallow wetlands at the extremes of freshwater habitats has not been investigated. We estimated ecosystem metabolism in mesocosms containing different macrophytes using 24-hour oxygen curves to test our hypotheses: (1) net aquatic production (NAP) during spring and summer would be similar among algal patches (metaphyton and Chara), (2) NAP in algal patches would be greater than patches dominated by the vascular plant Potamogeton foliosus, (3) heterotrophy and anaerobiosis would be greatest in patches dominated by Lemna, and (4) …

A Proposed Change Leadership Plan For Bimmer Elementary School, Nicole Villaverde

Dissertations

My paper details a Change Leadership Plan (CLP) for a school with the fictious name of Bimmer Elementary School (BME). My study's purpose is to enhance student learning by collaborating with staff to explore ways to maximize time-on-task (TOT) for all subjects. Currently BME has a reading achievement problem and is using pull-out programs for 4th and 5th grade students that take needed instructional time from core academic programs. I used Wagner's As-Is and To-Be charts (see Appendix A) for BME to identify and present the current status and future desired state of the school's culture, context, conditions, and competencies. …

Cross-Loop Optimization Of Arithmetic Intensity For Finite Element Local Assembly, Fabio Luporini, Ana Lucia Varbanescu, Florian Rathgeber, Gheorghe Teodor Bercea, J. Ramanujam, David A. Ham, Paul H.J. Kelly

Faculty Publications

We study and systematically evaluate a class of composable code transformations that improve arithmetic intensity in local assembly operations, which represent a significant fraction of the execution time in finite element methods. Their performance optimization is indeed a challenging issue. Even though affine loop nests are generally present, the short trip counts and the complexity of mathematical expressions, which vary among different problems, make it hard to determine an optimal sequence of successful transformations. Our investigation has resulted in the implementation of a compiler (called COFFEE) for local assembly kernels, fully integrated with a framework for developing finite element methods. …

Early Bilingual Education: An Examination Of Purposely Selected Teacher Viewpoints: South East China And San Francisco Area, Shan Chen

Dissertations, Masters Theses, Capstones, and Culminating Projects

In the coming years, an increasing number of children in urban Chinese areas are taking a second language at an early age. It leads to an argument about whether it is appropriate for children to learn a second language in an early age Some people disagree that idea, because children are not developed enough to receive foreign language learning.

Learning a second language early is disadvantageous for young children because they should first learn to speak the primary language well. Whereas, other people support that children should start learning second language early for three main reasons: children’s talent for language …

Opportunity And Access: High School Coursework And Its Impact On Student Self-Perceptions, Cassie K. Ferguson

Dissertations, Masters Theses, Capstones, and Culminating Projects

The skills taught and the courses offered to the United States’ public high school students have changed drastically over the past 20 years. Career-based electives have given way to college preparatory classes. Gone are the auto shops, construction and home economics classes—courses that many view as outdated, dangerous or unnecessary at the high school level. Arts and humanities-based courses have also disappeared; even courses that can train students to enter the robust fields of healthcare or technology are diminishing (Dare, 2006).

The communities in which many of these courses are disappearing are often diverse and economically disadvantaged. This “second-generation segregation” …

The Sciences Of Learning, Instruction, And Assessment As Underpinnings Of The Morningside Model Of Generative Instruction, Elizabeth M. Street, Kent Johnson

All Faculty Scholarship for the College of the Sciences

This paper focuses on a subset of the practices that have created the powerful learning technology developed and disseminated by Morningside Academy in Seattle, Washington, U.S.A. We briefly describe this technology, known as the Morningside Model of Generative Instruction, and tell how it builds on the selectionist approach of B. F. Skinner and the pragmatic approach of John Dewey. We also describe the critical role Precision Teaching plays at Morningside Academy and its dependence on findings from the science of learning and the science of instruction, including placement of learners, task analysis, content analysis, instructional protocols, and principles of instructional …

Prognostic Value Of Elevated Serum Ceruloplasmin Levels In Patients With Heart Failure, Muhammad Hammadah, Yiying Fan, Yuping Wu, Stanley L. Hazen, W.H. Wilson Tang

Mathematics and Statistics Faculty Publications

Background: Ceruloplasmin (Cp) is a copper-binding acute-phase protein that is increased in inflammatory states and deficient in Wilson's disease. Recent studies demonstrate that increased levels of Cp are associated with increased risk of developing heart failure. Our objective was to test the hypothesis that serum Cp provides incremental and independent prediction of survival in stable patients with heart failure. Methods and Results: We measured serum Cp levels in 890 patients with stable heart failure undergoing elective cardiac evaluation that included coronary angiography. We examined the role of Cp levels in predicting survival over 5 years of follow-up. Mean Cp level …

Robust Geotechnical Design - Methodology And Applications, Lei Wang

All Dissertations

This dissertation is aimed at developing a novel robust geotechnical design methodology and demonstrating this methodology for the design of geotechnical systems. The goal of a robust design is to make the response of a system insensitive to, or robust against, the variation of uncertain geotechnical parameters (termed noise factors in the context of robust design) by carefully adjusting design parameters (those that can be controlled by the designer such as geometry of the design). Through an extensive investigation, a robust geotechnical design methodology that considers explicitly safety, robustness, and cost is developed. Various robustness measures are considered in this …

The Challenges And Opportunities Throughout The Life Cycle Of Landscape-Scale Collaborative Conservation Organizations: Case Studies In The Southern Appalachians And The Northern Rockies Ecosystems, Jennifer Thomsen

All Dissertations

Currently our natural environment is threatened by climate change, habitat fragmentation, and other transboundary issues. To address these problems, it is thought that conservation organizations and land management agencies should attempt to manage at larger geographic scales and across political boundaries. The Crown Managers Partnership (CMP) and the Southern Appalachian Man and the Biosphere Cooperative (SAMAB) are two such organizations that work at an ecoregional scale to support collaboration among agencies, aboriginal groups, conservationists, scientists, and other stakeholders for the conservation and restoration of the Northern Rocky Mountain and the Southern Appalachian regions in North America. Over the past decades, …

The Update, December 2014, University Of Northern Iowa. College Of Humanities, Arts And Sciences.

Update

Inside this issue:

-- Harlem Hellfighters: UNI Alumnus Publishes Award Winning Book
-- Department News
-- School of Music Events
-- Science Students Travel to Minneapolis: 50th Anniversary of the Nobel Conference
-- Faculty Research, Scholarship and Creative Activity Awards
-- Graphic Design Students Create Work for the Community: Students Created Work for the Hearst Center for the Arts and Cedar Rock State Park
-- Alumni Spotlight: Department of Chemistry & Biochemistry: Dane Jacobson
-- Alumni Spotlight: Department of Physics: Jack Dostal
-- Alumni Spotlight: Department of Earth Science: Cara Wright
-- Student Spotlight: Department of Philosophy & World Religions: …

Development Of A Digital Controller For Motor Control Experiments In The Ee472 Lab, Jeffrey David D'Amelio

Master's Theses

A digital motor controller for student lab use is designed, built, and tested. The controller uses an encoder for position measurement, and an H-bridge to drive the electromechanical plant.

A user interface is created to enhance usability of the device. The user interface is able to display key parameters of the control algorithm as well as the state of the system. It is also used to modify the gains and sample rate of the control algorithm.

The design of the system is refined, and 10 units are built for the EE472 Digital Controls Lab. The lab manuals for the first …

Tme Volume 11, Number 3

The Mathematics Enthusiast

No abstract provided.

Editorial: Is Every Tme Issue Special?, Bharath Sriraman

The Mathematics Enthusiast

No abstract provided.

The Miracle Of Applied Mathematics, Frank Blume

The Mathematics Enthusiast

We provide an outline of a college-level lecture on systems of differential equations that is intended to offer an alternative, integrative view of the subject. Particular emphasis is placed on the fact that very elementary concepts and insights can be employed to gain access to a very wide range of important applications, including the Schr¨odinger equation, the Klein-Gordon equation, the Laplace equation, and the Poisson equation.

Generalizing Cantor-Schroeder-Bernstein: Counterexamples In Standard Settings, Tien Chih

The Mathematics Enthusiast

The Cantor-Schroeder-Bernstein theorem states that any two sets that have injections into each other have the same cardinality, i.e. there is a bijection between them. Another way to phrase this is if two sets A;B have monomorphisms from A to B and B to A, then they are isomorphic in the setting of sets. One naturally wonders if this may be extended to other commonly studied systems of sets with structure and functions which preserve that structure. Given two objects with injective structure preserving maps between them are the structures of these objects the same? In other words, would these …

A Study On Malaysian Mathematicians’ Way Of Knowing, Lim Chap Sam

The Mathematics Enthusiast

“Can you name me a mathematician?” “Einstein??”

“Do you wish to become a mathematician one day?”

If these questions were asked to the public or any school students, the most likely answer to both questions might be a big ‘No!’. Why is this so?

The director of the Public Understanding of Mathematics Forum, Gene Kloz (1996) claims that the mathematics profession is the most misunderstood in all of academia. According to him, the public thinks that mathematicians contemplate ancient proofs and work as lonely recluses. Moreover, the most common public image of a mathematician has been furnished by a physicist …

Reasoning-And-Proving Within Ireland’S Reform-Oriented National Syllabi, Jon Davis

The Mathematics Enthusiast

As educational systems around the world attempt to reform their mathematics programs to increase students’ opportunities to engage in processes central to the practice of mathematics such as proof, it is important to understand how this mathematical act is portrayed in national curriculum documents that drive that change. This study examined the presence of reasoning-and-proving (RP) in Ireland’s national reform-oriented secondary syllabi for junior cycle (ages 12-15) and senior cycle (ages 15-18) students. The analyses reveal that there were no differences among direct and indirect RP learning outcomes within each syllabus, but statistically significant differences did exist across syllabi in …