Digital Commons Network^™

Reclaiming The Efficacy Of Β-Lactam–Β-Lactamase Inhibitor Combinations: Avibactam Restores The Susceptibility Of Cmy-2-Producing Escherichia Coli To Ceftazidime, Krisztina M. Papp-Wallace, Marisa L. Winkler, Julian A. Gatta, Magdalena A. Taracila, Sujatha Chilakala, Yan Xu, J. Kristie Johnson, Robert A. Bonomo

Chemistry Faculty Publications

CMY-2 is a plasmid-encoded Ambler class C cephalosporinase that is widely disseminated in Enterobacteriaceae and is responsible for expanded-spectrum cephalosporin resistance. As a result of resistance to both ceftazidime and β-lactamase inhibitors in strains carrying blaCMY, novel β-lactam–β-lactamase inhibitor combinations are sought to combat this significant threat to β-lactam therapy. Avibactam is a bridged diazabicyclo [3.2.1]octanone non-β-lactam β-lactamase inhibitor in clinical development that reversibly inactivates serine β-lactamases. To define the spectrum of activity of ceftazidime-avibactam, we tested the susceptibilities of Escherichia coli clinical isolates that carry blaCMY-2 or blaCMY-69 and investigated the inactivation kinetics of CMY-2. Our analysis showed that …

The Globalization Of Maternal Healthcare In Western Africa, Maura T. Magistrali

Celebration

Maternal healthcare is one of the most important global issues in today’s world, reflected in its inclusion in the Millennium Development Goals. Globalization, through increased acceleration and movement, has improved maternal healthcare in Western Africa, as observed through the spread of Westernized medicines and treatments and improved technology in prenatal and obstetric care. Another remarkable effect of globalization is the hybridity manifested in both women’s healthcare choices and in the pluralistic training of midwives. However, the same forces of movement and exchange can also bring negative consequences, visible through health-access inequalities, brain drain, and the exploitation West African countries.

Human Disease - Unintended Globalization, Christopher J. Dellana

Celebration

Before man was exchanging goods and ideas, he was exchanging germs. As such, the spread of infectious disease constitutes the first truly global phenomenon and, therefore, marks the beginnings—primitive though they may have been—of what today we have finally termed ‘globalization.’ The global spread of disease, then, proves that globalization is not new and that its origins were the result of a different narrative than the ones we read from globalization theorists; it further demonstrates that the modern conception of the phenomenon is only now so well recognized because the accelerated and efficient processes that inform its daily activities have …

Uncompromising Spirits: The Entwined Careers Of William Lloyd Garrison And Josephine Butler, Anne A. Salter, Charles O. Boyd

Oglethorpe Journal of Undergraduate Research

William Lloyd Garrison and Josephine Butler challenged the political structures of their times. Both employed similar strategies to turn the mind set of American and British citizens. Garrison’s work as an American abolitionist inspired Butler and her work to repeal the Contagious Diseases Acts in Great Britain. Their life long commitment to liberty and justice was successful proving that one person can make a difference. Brief character sketches of each serve to revive interest in these important but somewhat neglected individuals.

Hiv Infection: Solitary Work, Silent Suffering Beliefs About Responsibility For Health And The Ability To Impact Disease Progression, Cynthia A. Frank

Doctoral Dissertations

HIV Infection: Solitary Work, Silent Suffering

Beliefs about Responsibility for Health

and the Ability to Impact Disease Progression

Cynthia Frank, PhD

University of Connecticut 2014

In contemporary Western society, health has become a personal and moral responsibility. People are blamed for their unhealthy or risky behavior and for acquiring certain diseases according to socially and culturally constructed norms. HIV is an infectious disease that is imbued with moral overtones and stigma, often multidimensional, creating an illness in which responsibility (for acquisition, transmission, and viral suppression) is an overarching theme. Thus, it represents a unique vehicle for exploring belief systems related …

The Effects Of Anthropogenic Nitrogen On Public Health, Grace Fowler, John Sears

CLAS: Colby Liberal Arts Symposium

Human activities that add nitrogen to the environment are dramatically affecting the nitrogen cycle. Advancements in the production of reactive nitrogen in the 1950s rapidly increased the production of nitrogen fertilizers used in agricultural food production, a significant source of nitrogen in the cycle. Increased crop yields have been tied to the rapidly ascending human population and associated environmental impacts, and the alteration of the nitrogen cycle itself is associated with documented environmental detriment. A review of the history of ascending anthropogenic nitrogen production in agricultural and industrial processes also reveals its role in negatively altering greenhouse gas levels, spreading …

Cyanide Toxicokinetics: The Behavior Of Cyanide, Thiocyanate And 2-Amino-2-Thiazoline-4-Carboxylic Acid In Multiple Animal Models, Raj K. Bhandari, Robert P. Oda, Ilona Petrikovics, David E. Thompson, Matthew Brenner, Sari B. Mahon, Vikhyat S. Bebarta, Gary A. Rockwood, Brian A. Logue

Chemistry and Biochemistry Faculty Publications

Cyanide causes toxic effects by inhibiting cytochrome c oxidase, resulting in cellular hypoxia and cytotoxic anoxia, and can eventually lead to death. Cyanide exposure can be verified by direct analysis of cyanide concentrations or analyzing its metabolites, including thiocyanate (SCN⁻) and 2-amino-2-thiazoline-4-carboxylic acid (ATCA) in blood. To determine the behavior of these markers following cyanide exposure, a toxicokinetics study was performed in three animal models: (i) rats (250–300 g), (ii) rabbits (3.5–4.2 kg) and (iii) swine (47–54 kg). Cyanide reached a maximum in blood and declined rapidly in each animal model as it was absorbed, distributed, metabolized and …

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Numerical Simulation For The Fractional Sirc Model And Influenza A, M. M. Khader, N. H. Sweilam, A. M. S. Mahdy, N. K. Abdel Moniem

Applied Mathematics & Information Sciences

In this paper, A Chebyshev spectral method is presented to study the deals with the fractional SIRC model associated with the evolution of influenza A disease in human population. The properties of the Chebyshev polynomials are used to derive an approximate formula of the Caputo fractional derivative. This formula reduces the SIRC model to the solution of a system of algebraic equations which is solved using Newton iteration method. The convergence analysis and an upper bound of the error of the derived formula are given. We compared our numerical solutions with those numerical solutions using fourth-order Runge-Kutta method. The obtained …

Mathematical Modeling Towards The Dynamical Interaction Of Leptospirosis, Muhammad Altaf Khan, Saeed Islam, Sher Afzal Khan

Applied Mathematics & Information Sciences

In this work, we extend the mathematical model of leptospirosis disease by taking into account the exposed individuals, the related death rate and the transmission coefficients between susceptible human and infected vector. Initially, we present the local asymptotical stability of both the disease-free and endemic equilibrium. We use the Lyapunov function theory with some sufficient conditions. This shows the global stability of both the disease-free and endemic equilibrium. Further, we present the bifurcation of the model and exhibit that the local asymptotical stability of the disease-free and endemic equilibrium co-exists with the threshold quantity. Finally, we discuss the numerical results.

Lg Ms 032 Marty Sabol Papers Finding Aid, Christina E. Walker

Search the Manuscript Collection (Finding Aids)

Description:

Marty Sabol manages the Infectious Disease Program at the Public Health Division of the Portland Department of Health and Human Services. He oversees prevention efforts and healthcare services related to sexually transmitted and vaccine preventable diseases in the Portland area. He has served as vice-president of the Maine Public Health Association, as an advisor to the Equity Fund of the Maine Community Foundation and as a member of the GLBT Caucus of Public Health Workers with the American Public Health Association. In 1984, Sabol co-founded the Maine Lesbian and Gay Political Alliance (MLGPA), now known as EqualityMaine, serving as …

Undergraduate And Graduate Course Descriptions, 2014 Summer, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Summer 2014.

Impact Of Siblings On Pragmatic Development In Children With Cochlear Implants, Caitlin R. Mcafee

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

The purpose of this study was to investigate the development of pragmatics in young children who have received cochlear implants (CI). There are limited studies that focus specifically on the pragmatic development of these children. This led to the questions of this study that focused on the development of early pragmatics and the possible role of older siblings on this development. Three children and their families participated in this study, one with bilateral cochlear implants, one with a unilateral implant, and one with hearing aids in both ears (who was a cochlear implant candidate). The child with bilateral cochlear implants …

The Effect Of A Group Lifestyle Coaching Model On Hba1c And Psychosocial Constructs In Low-Income Patients With Type 2 Diabetes, Lillian Tryon, D.N.P.

Faculty Works

The epidemic of diabetes and its complications is concerning, and new approaches need to be explored for fostering better patient outcomes in a cost effective way. This exploratory study examined the effectiveness of a group coaching model on glycemic control, diabetes knowledge, diabetes empowerment, and diabetes self-management compared to usual care or participation in a 90-minute diabetes education class. A convenience sample of 34 patients with type 2 diabetes mellitus was recruited at a clinic providing services to the uninsured. Participants self-selected into the coaching group (n= 12), class group (n = 10), or control group ( …

College Of Health Sciences Newsletter, May 2014, College Of Health Sciences, Odu

Ellmer College of Health Sciences Newsletters

May 2014 issue of Old Dominion University's College of Health Sciences Newsletter.

Pharmacy Matters - May 2014, University Of Mississippi. School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: "School names new Distinguished Teaching Scholars," "Partners land technology transfer prize," "Two students inducted into Hall of Fame," "Pharmacy students recognize faculty for teaching excellence," "Scholarship supports pharmaceutical marketing students," "UM's chief research officer champions competitiveness"

Fact Sheet: The Environmental, Public Health, And Social Impacts Of Pig Factory Farming

Agribusiness Reports

No abstract provided.

In Vitro Validation Of Patient-Specific Hemodynamic Simulations In Coronary Aneurysms Caused By Kawasaki Disease, Ethan Kung, Andrew M. Kahn, Jane C. Burns, Alison Marsden

Publications

To perform experimental validation of computational fluid dynamics (CFD) applied to patient specific coronary aneurysm anatomy of Kawasaki disease. We quantified hemodynamics in a patient-specific coronary artery aneurysm physical phantom under physiologic rest and exercise flow conditions. Using phase contrast MRI (PCMRI), we acquired 3-component flow velocity at two slice locations in the aneurysms. We then performed numerical simulations with the same geometry and inflow conditions, and performed qualitative and quantitative comparisons of velocities between experimental measurements and simulation results. We observed excellent qualitative agreement in flow pattern features. The quantitative spatially and temporally varying differences in velocity between PCMRI …

Diverse Gastropod Hosts Of Angiostrongylus Cantonensis, The Rat Lungworm, Globally And With A Focus On The Hawaiian Islands, Jaynee Kim, Kenneth Hayes, Norine Norine W Yeung, Robert Cowie

Department of Biology Faculty Publications

Eosinophilic meningitis caused by the parasitic nematode Angiostrongylus cantonensis is an emerging infectious disease with recent outbreaks primarily in tropical and subtropical locations around the world, including Hawaii. Humans contract the disease primarily through ingestion of infected gastropods, the intermediate hosts of Angiostrongylus cantonensis. Effective prevention of the disease and control of the spread of the parasite require a thorough understanding of the parasite's hosts, including their distributions, as well as the human and environmental factors that contribute to transmission. The aim of this study was to screen a large cross section of gastropod species throughout the main Hawaiian Islands …

Investigating Antibiotic Resistance Levels Of Salmonella Internalized In Lettuce Leaves, Jason B. Thomas

McNair Scholars Research Journal

Contamination of food crops by the human pathogen Salmonella is a food safety threat worldwide. Though using treated wastewater for irrigation is a sustainable practice, it may introduce trace levels of Salmonella that may contaminate food crops. Salmonella could develop resistance to antibiotics present in wastewater. The overall goal of the project is to increase the understanding of the public health risk associated with the use of treated wastewater to irrigate food crops. The objective of this particular study is to determine the antibiotic resistance level of Salmonella internalized in lettuce leaves. In this experiment, thirty-six plants of the lettuce …

Phthalates And Phthalate Alternatives: Effects On Proliferative And Estrogenic Target Genes In Ishikawa Cells, Ranjani Sundar '15, Ping Yin, Serdar E. Bulun

Student Publications & Research

Phthalates are used as plasticizers in many of the products found in medical, household, and industrial applications. Much research has not been completed on the effects of these phthalates as potential endocrine disrupting chemicals (EDCs). As these chemicals are ingested, the mechanism by which they affect the reproductive system is largely unknown. The purpose of this study was to observe how 2 phthalates, Di-n-butyl phthalate (DBP) and Diisononyl phthalate (DINP), and 2 phthalate alternatives, Dioctyl terephthalate (DOTP) and BHT (butylated hydroxytoluene)affect uterine cells in comparison to a vehicle treatment and 17β-Estradiol treatment. Changes in expression of mRNA were observed using …

The Effect Of Small Molecule 390 On Cxcr4 Receptors, Selam B. Zenebe-Gete '14, Shruti R. Topudurti '14, Shum Andrew, Richard J. Miller

Student Publications & Research

CXCR4 is the chemokine receptor which aids in chemotaxis of stem cells, such as those in the bone marrow or the brain. SDF-1 is the natural ligand for the CXCR4 receptor. Similarities between novel molecule 390 synthesized by the Miller Lab and SDF-1 make this novel small molecule a possible agonist of the CXCR4 receptor. To determine whether 390 is an agonist to the CXCR4 receptor, we transfected cells with CXCR4 and exposed them to no agonist [vehicle control], SDF-1, or varying concentrations of our agonist drug. Next, we took calcium images using the dye fura-2, which indicates changes in …

Characterization Of A Putative Cephalotoxin From The Hemocytes Of Euprymna Scolopes, Jessie E. Scott

University Scholar Projects

Many organisms have beneficial microbial symbionts, and complex interactions between the immune system and the bacteria must occur to allow these symbioses to persist. The host immune system must recognize and preferentially tolerate the beneficial microorganisms, while simultaneously eliminating harmful pathogens. The Hawaiian bobtail squid, Euprymna scolopes, is a model organism for host-microbe interactions because of the unique light organ symbiosis. Hemocytes, the squid’s primary immune cell, infiltrate and patrol the light organ and continuously interact with the symbiont Vibrio fischeri. Using this model, several innate immunity genes have been shown to be differentially expressed in the hemocytes …

Modeling The Adaptive Immune Response To Mutation-Generated Antigens, Rory J. Geyer

University Scholar Projects

Somatic mutations may drive tumorigenesis or lead to new, immunogenic epitopes (neoantigens). The immune system is thought to represses neoplastic growths through the recognition of neoantigens presented only by tumor cells. To study mutations as well as the immune response to mutation-generated antigens, we have created a conditional knockin mouse line with a gene encoding, 5’ to 3’, yellow fluorescent protein (YFP), ovalbumin (which is processed to the immunologically recognizable peptide, SIINFEKL), and cyan fluorescent protein (CFP), or, YFP-ovalbumin-CFP. A frame shift mutation has been created at the 5’ end of the ovalbumin gene, hence YFP should always be expressed, …

"Nursing Contamination: Wearing Scrubs In Public", Kemble Green

Undergraduate Honors Theses

Nurses are frequently seen in public in their “scrubs,” which could mean that contaminated clothing is being brought into the community, thereby posing an infection risk. The purpose of this study is to investigate if and which contaminants are present on the fabrics and the actions nurses are taking to eliminate contamination risks.

Eleven scrub tops were worn on hospital units over one twelve-hour shift. The contaminated scrubs and three control tops were then swabbed and used to inoculate agar plates. After incubation, colonies were counted, streaked onto nutrient and Mannitol-salt agar for isolation, and incubated. Using API Staph strips …

Bat Flight And Zoonotic Viruses, Thomas J. O’Shea, Paul M. Cryan, Andrew A. Cunningham, Anthony R. Fooks, David T.S. Hayman, Angela D. Luis, Alison J. Peel, Raina K. Plowright, James L.N. Wood

KIP Articles

No abstract provided.

Isoflupredone Acetate As Ancillary Therapy For Bovine Respiratory Disease In High-Risk Stocker Calves, Claire E. Crews

Animal Science Undergraduate Honors Theses

Bovine respiratory disease (BRD) is the leading cause of illness and death in U.S. feedlot cattle. This study evaluated the use of isoflupredone acetate in the treatment of BRD. Crossbred male beef calves (n = 192; BW = 221 ± 3.9 kg) were acquired in two blocks from regional auction markets and transported to the University of Arkansas Stocker and Receiving Cattle Unit. Calves were observed daily for signs of respiratory illness. Antibiotic treatment was administered if calves displayed signs of respiratory illness and rectal temperature was ≥ 40 °C. Calves (n = 72) requiring antibiotic treatment were assigned randomly …

Regulation Of Macrophage Inflammatory Signaling Pathways By Amp-Activated Protein Kinase., Yanfang Zhu

Electronic Theses and Dissertations

AMP-activated protein kinase, AMPK, is a conserved serine/threonine kinase with a critical function in the regulation of metabolic pathways in eukaryotic cells. Recently, AMPK has been shown to play an additional role as a regulator of inflammatory activity in leukocytes. Treatment of macrophages with chemical AMPK activators, or forced expression of a constitutively active form of AMPK, results in polarization to an antiinflammatory phenotype. Additionally, we reported previously that stimulation of macrophages with antiinflammatory cytokines such as IL-10, IL-4 and TGF-ß results in rapid activation of AMPK, suggesting that AMPK contributes to the suppressive function of these cytokines. In the …

Quality Of Primary Care From The Patient Perspective In Saudi Arabia : A Multi-Level Study., Khalid Awad Alahmary

Electronic Theses and Dissertations

Objectives: To assess primary care performance for measures of patients’ experience in Community-based Primary Care (CPC) and Employer-based Primary Care (EPC) systems in Saudi Arabia, to examine variations in performance across the two systems, and to explore factors at both the individual-level and the organizational-level that explain variations in primary care performance. Design and Methods: This is an observational and cross-sectional study, using comparative design and survey research methods. The newly revised and re-translated Arabic version of the Primary Care Assessment Survey (PCAS) was used to measure patients’ experience of primary care. PCAS operationalizes the IOM definition of primary care, …

Early Detection And Control Of Potential Pandemics., Shengpeng Jin

Electronic Theses and Dissertations

Over the centuries, human beings have been inflicted with a variety of contagious diseases, resulting in tens of millions of respiratory illnesses and deaths worldwide. Early detection of disease spread facilitates timely responses that can greatly reduce its impact on a population. Therefore, this early information is a major public health objective and is crucial for policy makers and public health officials responsible for protecting the public from the spread of contagious diseases. Current indicators of the spread of contagious outbreaks lag behind its actual spread, leaving no time for a planned response. The studies of Christakis et al. in …