Digital Commons Network^™

Competency-Based Medical Education In Two Sub-Saharan African Medical Schools., Elsie Kiguli-Malwadde, E Oluwabunmi Olapade-Olaopa, Sarah Kiguli, Candice Chen, Nelson K. Sewankambo, Adesola O. Ogunniyi, Solome Mukwaya, Francis Omaswa

Health Services Management and Leadership Faculty Publications

Background

Relatively little has been written on Medical Education in Sub-Saharan Africa, although there are over 170 medical schools in the region. A number of initiatives have been started to support medical education in the region to improve quality and quantity of medical graduates. These initiatives have led to curricular changes in the region, one of which is the introduction of Competency-Based Medical Education (CBME).

Institutional reviews

This paper presents two medical schools, Makerere University College of Health Sciences and College of Medicine, University of Ibadan, which successfully implemented CBME. The processes of curriculum revision are described and common themes …

An Implementation Plan For Integrated Dual Diagnosis Treatment, Mary Jean Dunn

Theses and Graduate Projects

Recovery from substance abuse or mental illness can be a long and difficult process. lndividuals attempting to recover from both issues face an even more complex road to healing. Research shows that treatment models, which address both illnesses simultaneously, in the same setting, have the best success. Treatment models that address both issues at once are called Integrated Dual Diagnosis Treatment (IDDT). There are a number of IDDT models around the country and Minnesota has recently finalized its framework for IDDT certification. This paper examines the most corlmonly used components of IDDT models and will study the process of implementation …

Healthy Choice, Healthy Life, Dawn M. Sanderman

Theses and Graduate Projects

According to the U.S. Department of Health and Human Services, unhealthy eating and inactivity cause any where from 310,000 to 580,000 deaths every year. How and what a child eats today will have a significant impact on his/her health throughout adolescence and adulthood. Consuming nutritious foods helps children grow, develop, do well academically and also prevents health issues, such as obesity, Type 2 diabetes, nutrient deficiencies and poor bone health. A project to empower middle school children to make healthy food choices was designed. An after school educational “Health Fair” was created using the theoretical framework of Watson’s Theory of …

Utilizing Watson's Theory Of Caring To Develop A Palliative Care Proposal For Olmsted Medical Center, Tammie Johnson

Theses and Graduate Projects

Palliative care is aimed at alleviating the suffering of patients with serious or chronic illnesses. Literature examined to determine the needs of seriously or chronically ill patients and their farnilies found patients to have physical, psychosocial, and spiritual needs while coping with their illness. In addition, patients' family needed support in physical care of their loved ones, as well as information and psychosocial needs for themselves. The purpose of this project is to develop a proposal for an inpatient palliative care program for Olmsted Medical Center's (OMC's) consideration, Watson's Theory of Caring was utilized in the development of a palliative …

Hepatitis B Serology Testing: An Educational Module For Nurses In Outpatient Dialysis, Kristi Hanson

Theses and Graduate Projects

For nurses in outpatient dialysis, an accidental needle stick could result in contracting the Hepatitis B virus. It is recommended that all individuals receive the series of three Hepatitis B vaccinations. To determine if immunity is developed as a result of the vaccinations, Hepatitis B serology testing is performed and a positive antibody and titer level above 10 mIU/mL is indicative of immunity. Without awareness of their personal Hepatitis B serology, nurses working with Hepatitis B positive patients in the outpatient dialysis setting lack knowledge to protect their health. The implementation of an educational module, influenced by Knowles' principles of …

Vaccinating Vulnerable Populations, Paula B. Mcnabb

Theses and Graduate Projects

Influenza vaccination rates for all minority groups in Minnesota are lower than rates for Caucasians of all age groups. Since 2006, a collaborative partnership called Minnesota Immunization Networking Initiative (MINI) has provided free influenza vaccinations in convenient and trusted community settings throughout the Twin Cities metropolitan area of Minnesota in an attempt to address this health disparity. The literature highlights a number of barriers that negatively influence individuals' choices regarding acceptance of influenza vaccination but also highlights motivators, facilitators and processes that positively impact these decisions. Thirteen focus group interviews were conducted with individuals from the Ethiopian, Latino, Native American …

2014 Intersession Catalog, Illinois Mathematics And Science Academy

Intersession Catalogs

No abstract provided.

University Of Malaya Research Bulletin, Volume 1, 2014, Institute Of Research Management & Monitoring University Of Malaya

Archival Material (2010s)

Previously known as IPPP UM Research Bulletin

2013-2014 Annual Report, Southern Illinois University Board Of Trustees

Annual Report Archive

No abstract provided.

Parameterization Of Pharmaceutical Emissions And Removal Rates For Use In Uk Predictive Exposure Models: Steroid Estrogens As A Case Study., J. D. Heffley, S. D.W. Comber, B. W. Wheeler, C. H. Redshaw

School of Geography, Earth and Environmental Sciences

Newly available prescription data has been used along with census data to develop a localised method for predicting pharmaceutical concentrations in sewage influent and effluent for England, and applied to a case study: the steroid estrogens estrone, 17β-estradiol, and 17α-ethinylestradiol in a selected catchment. The prescription data allows calculation of the mass consumed of synthetic estrogens, while use of highly localised census data improves predictions of naturally excreted estrogens by accounting for regional variations in population demographics. This serves two key purposes; to increase the accuracy of predictions in general, and to call attention to the need for more accurate …

Receptor Of Advanced Glycation Endproducts (Rage) Is Positively Correlated With Tumor Necrosis Factor-Α In Adolescents With Obesity, Tasnim Rahman, Daniel H. Conrad, Anshu Gupta

UROP Posters

Introduction: Obesity in childhood is associated with an increased prevalence of diabetes and other traditional cardiometabolic risk factors, suggesting an epidemic of premature cardiovascular disease among today’s youth. Glycotoxins, known as advanced glycationend products (AGE’s), activating via the membrane-bound receptors (mRAGE), have been implicated in the pathophysiology of inflammation, (increased tumor necrosis factor-α [TNF-α ]), insulin resistance and vascular dysfunction in adults, but the role of RAGE in the early stages of metabolic disorders is unknown. In this study, we assessed relationship of cardiometabolicrisk factors, mRNA expression of TNF-α and RAGE in peripheral monocytes in adolescents with obesity.

Methods: Thirty …

Integrating Phage Therapy Into Western Medicine, Jacob B. Jaminet

UROP Posters

The World Health Organization has described the rise of antibiotic use as a “global heath security emergency” (who.int). With the growing concern about antibiotic resistant bacteria, there has been an increased interest in bacteriophages. Bacteriophages are high-specific viruses that only infect bacteria. The use of bacteriophages medicinally to treat bacteria is called phage therapy. Research in phage therapy gained momentum until the introduction of antibiotics. While the USA and other Western countries accepted antibiotics, the Soviet Union and their satellite nations still continued to research phages. Since the funding for research was supplied by the Soviet military, the results of …

Community Based Interventions For The Prevention And Control Of Non-Helmintic Ntd, Jai K. Das, Rehana A. Salam, Ahmed Arshad, Hasina Maredia, Zulfiqar A. Bhutta

Department of Paediatrics and Child Health

In this paper, we aim to systematically analyze the effectiveness of community based interventions (CBI) for the prevention and control of non-helminthic diseases including dengue, trypanosomiasis, chagas, leishmaniasis, buruli ulcer, leprosy and trachoma. We systematically reviewed literature published up to May 2013 and included 62 studies in this review. Findings from our review suggest that CBI including insecticide spraying; insecticide treated bednets and curtains; community education and cleanliness campaigns; chemoprophylaxis through mass drug administration; and treatment have the potential to reduce the incidence and burden of non-helminthic diseases. Lack of data limited the subgroup analysis for integrated and non-integrated delivery …

January 2014 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Retention Of Adolescents Living With Hiv In Care, Treatment, And Support Programs In Uganda, Livingstone Ssali, Sam Kalibala, Josephine Birungi, Aggrey Egessa, Jonathan Wangisi, Joanne Lyavala Okullu, Celestin Bakanda, Stephen Okoboi, Francis Obare

HIV and AIDS

Understanding the extent to which adolescents aged 10–19 years who are living with HIV are retained in HIV care, treatment, and support is important for informing the design of effective services for this population to better meet their needs across three main areas of HIV and AIDS programming: treatment; care and support; and prevention. Retention in HIV programs is, in turn, important for positive clinical outcomes including viral suppression and survival. In 2013–2014, The AIDS Support Organization and the Population Council undertook a study to generate evidence on factors associated with retention of adolescents in HIV and AIDS programs in …

Cigarettes Vs. Soda: The Argument For Similar Public Health Regulation Of Smoking And Obesity Response, Katherine Pratt

Connecticut Law Review

This Article critiques Professor David Friedman’s article, Public Health Regulation and the Limits of Paternalism, and sets forth an alternative view of the limits of anti-obesity public health paternalism. Specifically, it critiques Friedman’s classification of public health interventions based on how coercive the intervention is, and offers an alternative construct to analyze paternalistic public health interventions. The alternative approach, developed by Mark Hall, distinguishes between (1) “old” public health interventions that target specific pathogens or toxins, and (2) “new” public health interventions that target upstream behavioral risk factors and ecological factors. This Article then elaborates on the main example that …

Limiting Liberty To Prevent Obesity: Justifiability Of Strong Hard Paternalism In Public Health Regulation Response, Thaddeus Mason Pope

Connecticut Law Review

Because of the largely self-regarding nature of obesity, many current and proposed public health regulatory measures are paternalistic. That is, these measures interfere with a person’s liberty with the primary goal of improving that person’s own welfare. Paternalistic public health measures may be effective in reducing obesity. They may even be the only sufficiently effective type of regulation. But many commentators argue that paternalistic public health measures are not politically viable enough to get enacted. After all, paternalism is repugnant in our individualistic culture. It is “wrong” for the government to limit our liberty for our own good. In this …

Racecadotril For The Treatment Of Severe Acute Watery Diarrhoea In Children Admitted To The Kenyatta National Hospital - A Randomised Double Blinded Placebo Controlled Trial, Jaspreet Singh Gharial

Master of Medicine in Paediatrics and Child Health

Background: Diarrhoeal disease is the second most common cause of death in children under 5 years of age in Kenya. Treatment with Oral Rehydration Solution (ORS), elemental zinc and continued feeding (as recommended by the World Health Organisation) led to a significant reduction in mortality in the 1970s and 1980s, which has slowed since then. Adjunctive treatments have however, not gained much popularity either due to modest improvements in morbidity and mortality or unacceptable adverse effect profiles. Racecadotril, an enkephalinase inhibitor, has been used for over 2 decades in parts of Europe but is only recently gaining recognition in other …

New Carbohydrate-Based Anti-Cancer And Anti-Bacterial Vaccines, Zhifang Zhou

Wayne State University Dissertations

The unique carbohydrates expressed on the surface of cancer, bacterial, viral and fungal cells are excellent target antigens for the design of therapeutic or preventive vaccines. However, as antigens carbohydrates have problems. First, carbohydrates usually have low immunogenicity. Second, even if immunogenic, carbohydrates typically elicit T cell-independent immune responses. To overcome these problems and design useful vaccines based on carbohydrate antigens, they are usually coupled with carrier proteins to form conjugates to enhance the immunogenicity of the antigens. However, there are still some issues existing in glycoprotein vaccines, such as poor reproducibility of the conjugates, difficulties in quality control and …

Delayed-Type Hypersensitivity And Hepatitis B Vaccine Responses, In Vivo Markers Of Cellular And Humoral Immune Function, And The Risk Of Aids Or Death, Shane B. Patterson, Michael L. Landrum, Jason F. Okulicz

Uniformed Services University of the Health Sciences

Background: Delayed-type hypersensitivity (DTH) test responsiveness is associated with HIV disease progression; however it is unknown whether other immune markers, such as hepatitis B virus (HBV) vaccine seroresponse, also predict HIV outcomes. Methods: Eligible participants received HBV vaccine after HIV diagnosis, had non-anergic DTH testing at the time of last HBV vaccination, and available post-vaccine HBV antibody responses. The risk of progression to AIDS or death from the time of last HBV vaccination was evaluated. Results: Of 369 eligible participants with non-anergic DTH responses, 148 (40%) were HBV vaccine responders. In a multivariate model adjusted for age, CD4 count, …

What Can Medicine Teach The Social Sciences?, Lee Mcintyre

UC Law Science and Technology Journal

In a field as slow to change as the law, it is often helpful to inject fresh perspectives from other disciplines. As different as legal analysis might be from that found in the medical and social sciences, they are all ultimately concerned with the pursuit of objectivity. Furthermore, in each of these fields, the pursuit of academic and practical goals are permeated and influenced by the values of those that seek to achieve them. Indeed, both the law and the social sciences in particular are fundamentally concerned with finding ways of distilling logic and order from the complexities of human …

Limiting Liberty To Prevent Obesity: Justifiability Of Strong Hard Paternalism In Public Health Regulation, Thaddeus Mason Pope

Faculty Scholarship

Because of the largely self-regarding nature of obesity, many current and proposed public health regulatory measures are paternalistic. That is, these measures interfere with a person’s liberty with the primary goal of improving that person’s own welfare.

Paternalistic public health measures may be effective in reducing obesity. They may even be the only sufficiently effective type of regulation. But many commentators argue that paternalistic public health measures are not politically viable enough to get enacted. After all, paternalism is repugnant in our individualistic culture. It is "wrong" for the government to limit our liberty for our own good.

In this …

The Current State Of Drug Discovery And A Potential Role For Nmr Metabolomics, Robert Powers

Robert Powers Publications

The pharmaceutical industry has significantly contributed to improving human health. Drugs have been attributed to both increasing life expectancy and decreasing health care costs. Unfortunately, there has been a recent decline in the creativity and productivity of the pharmaceutical industry. This is a complex issue with many contributing factors resulting from the numerous mergers, increase in out-sourcing, and the heavy dependency on highthroughput screening (HTS). While a simple solution to such a complex problem is unrealistic and highly unlikely, the inclusion of metabolomics as a routine component of the drug discovery process may provide some solutions to these problems. Specifically, …

Metabolomics Analysis Identifies D-Alanine-D-Alanine Ligase As The Primary Lethal Target Of D-Cycloserine In Mycobacteria, Steven M. Halouska, Robert J. Fenton, Denise K. Zinniel, Darrell D. Marshall, Raul G. Barletta, Robert Powers

Robert Powers Publications

D-cycloserine is an effective second line antibiotic used as a last resort to treat multi (MDR)- and extensively (XDR)- drug resistant strains of Mycobacterium tuberculosis. D-cycloserine interferes with the formation of peptidoglycan biosynthesis by competitive inhibition of Alanine racemase (Alr) and D-Alanine-D-alanine ligase (Ddl). Although, the two enzymes are known to be inhibited, the in vivo lethal target is still unknown. Our NMR metabolomics work has revealed that Ddl is the primary target of DCS, as cell growth is inhibited when the production of D-alanyl-Dalanine is halted. It is shown that inhibition of Alr may contribute indirectly by lowering …

The Neuropeptide Regulation Of Host-Seeking Behavior In Aedes Aegypti Mosquitoes, Jeff Liesch

Student Theses and Dissertations

Aedes aegypti mosquitoes are the principal vectors for several human diseases including Dengue Fever, which causes ~400 million cases and ~24,000 deaths per year (Bhatt et al., 2013; WHO, 2002). Novel strategies to combat mosquito-borne diseases are needed for A. aegypti and other mosquitoes such as the malaria vector Anopheles gambiae. Our goal was to discover new ways to interfere with the ability of a mosquito to locate a human host for a blood meal. Currently, the mechanistic basis of host-seeking and its regulation remain incompletely understood. Although it is known that mosquitoes require human odor cues to locate a …

The Origin Of Multiple Sclerosis Revisited: The Case For A Soluble Toxin, Kareem Rashid Rumah

Student Theses and Dissertations

After nearly two hundred years of scientific inquiry, the cause of Multiple Sclerosis (MS) remains unknown. Although generally considered an autoimmune disease, recent pathological findings have challenged the longstanding autoimmune view of MS. Indeed, lesions that are just hours past their initial onset display evidence of cellular degeneration in the absence of an inflammatory infiltrate. This seminal finding begs the fundamental question, if immune cells do not participate in early tissue damage in MS, what is the mysterious triggering agent? In the first half of this thesis, I will propose that a soluble bacterial toxin, Clostridium perfringens epsilon toxin (ETX), …

Benchmarks 2014, January 31, The Rockefeller University

BenchMarks 2014

BenchMarks. Friday, January 31, 2014

The community newsletter of The Rockefeller University

BenchMarks is published monthly and is distributed on the campus of The Rockefeller University. It produced by the Office of Communications and Public Affairs

Medicine@Yale December 2014 Volume 10, Issue 3, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

The Case For Flexible Intellectual Property Protections In The Trans-Pacific Partnership , Matthew E. Silverman

Journal of Law and Health

The United States and eleven other countries are currently in the end stages of negotiating the Trans-Pacific Partnership (TPP)—the largest free trade agreement (FTA) in U.S. history—which incorporates a range of trade topics, including the protection and enforcement of intellectual property rights (IPRs). Although the negotiations have been highly secretive, negotiating texts of the agreement leaked as recently as November 2013 have suggested that the United States is proposing IPR provisions, specifically relating to patent protection, that are stronger and less flexible than IPR provisions included within three of the four most recent U.S. FTAs. This paper addresses and analyzes …

Predictors Of Hiv Testing Among Individuals Diagnosed With Bipolar Disorder, Marie Denise Decoline

Walden Dissertations and Doctoral Studies

Research on rates of HIV testing among individuals diagnosed with Bipolar Disorder (BPD) is limited, while HIV infection continues to rise among BPD individuals. The problem is that BPD individuals are at high risk for HIV infection due to non-adherence to treatment for bipolar disorder and manic episodes that can lead to high-risk behaviors. The goal of the study was to examine the association between selected demographic variables, having a bipolar diagnosis, engaging in high-risk behaviors, inability to afford treatment for bipolar disorder, non-adherence to treatment for bipolar disorder, and substance abuse, and their relationship to obtaining an HIV test …