Digital Commons Network^™

High-Level Relatedness Among Mycobacterium Abscessus Subsp. Massiliense Strains From Widely Separated Outbreaks, Hervé Tettelin, Rebecca M. Davidson, Sonia Agrawal, Moira L. Aitken, Shamira Shallom, Nabeeh A. Hasan, Michael Strong, Vinicius Calado Nogueira De Moura, Mary Ann De Groote, Rafael S. Duarte, Erin Hine, Sushma Parankush, Qi Su, Sean C. Daugherty, Claire M. Fraser, Barbara A. Brown-Elliott, Richard J. Wallace Jr., Steven M. Holland, Elizabeth P. Sampaio, Kenneth N. Olivier, Mary Jackson, Adrian M. Zelazny

School of Medicine Faculty Publications and Presentations

Three recently sequenced strains isolated from patients during an outbreak of Mycobacterium abscessus subsp. massiliense infections at a cystic fibrosis center in the United States were compared with 6 strains from an outbreak at a cystic fibrosis center in the United Kingdom and worldwide strains. Strains from the 2 cystic fibrosis outbreaks showed high-level relatedness with each other and major-level relatedness with strains that caused soft tissue infections during an epidemic in Brazil. We identified unique single-nucleotide polymorphisms in cystic fibrosis and soft tissue outbreak strains, separate single-nucleotide polymorphisms only in cystic fibrosis outbreak strains, and unique genomic traits for …

In With New Families, Out With Bad Law: Determining The Rights Of Known Sperm Donors Through Intent-Based Written Agreements, Maria E. Garcia

Duke Journal of Gender Law & Policy

No abstract provided.

Shealy Among Six Honored For 40 Years Of Service To Uab, Natalie Wade

Browse All News

No abstract provided.

Gender-Based Screening For Chlamydial Infection And Divergent Infection Trends In Men And Women, Susan M. Rogers, Charles F. Turner, William C. Miller, Emily Erbelding, Elizabeth Eggleston, Sylvia Tan, Anthony Roman, Marcia Hobbs, James Chromy, Ravikiran Muvva, Laxminarayana Ganapathi

Publications and Research

Objectives: To assess the potential impact of chlamydial screening policy that recommends routine screening of women but not men.

Methods: Population surveys of probability samples of Baltimore adults aged 18 to 35 years in 1997–1998 and 2006–2009 collected biospecimens to estimate trends in undiagnosed chlamydial infection. Survey estimates are compared to surveillance data on diagnosed chlamydial infections reported to the Health Department.

Results: Prevalence of undiagnosed chlamydial infection among men increased from 1.6% to 4.0%, but it declined from 4.3% to 3.1% among women (p = 0.028 for test of interaction). The annual (average) number of diagnosed infections was substantially …

Report On Status Of Mycobacterium Ulcerans (Buruli Ulcer), David R. Nielsen, Dr. Warner Woodworth

Journal of Undergraduate Research

First discovered in 1947 in a small community in Australia, the Buruli Ulcer (Mycobacterium Ulcerans) has become the third largest mycobacterial disease in the world, next to leprosy and tuberculosis. Dobos et al. estimate that the severity of the Buruli Ulcer will soon reach that of leprosy. In a 10-year study conducted in Ivory Coast, villages were surveyed to assess the degree of infection. In some communities, the rate was shown to be as high as 16%, with current estimates as high as 22%.

Bacterial Fingerprints, Kristilyn Rogers, Dr. Ron W. Leavitt

Journal of Undergraduate Research

Bordetellosis, or turkey coryza, is a highly contagious respiratory disease in poultry caused by Bordetella avium. Turkey growers worldwide are concerned with this disease which results in millions of dollars in losses annually to the turkey industry. Bordetellosis is readily transmitted through close contact with those already infected, or by exposure to contaminated litter or water. Infected turkeys experience, among other things, stunted growth and a predisposition for other infectious diseases. The mortality rate for bordetellosis is less than 10%. However, morbidity rates can reach 80-100% in young poults. Moreover, with concurrent infection of B. avium and Escherichia coli …

February 18, 2014 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Immature Myeloid Cells Promote Tumor Formation Via Non-Suppressive Mechanism, Myrna Lillian Ortiz

USF Tampa Graduate Theses and Dissertations

ABSTRACT

Although there is ample evidence linking chronic inflammation with cancer, the cellular mechanisms involved in early events leading to tumor development remain unclear. Myeloid cells are an intricate part of inflammation. They consist of mature cells represented by macrophages, dendritic cells and granulocytes and a population of Immature Myeloid Cells (IMC), which in healthy individuals are cells in transition to mature cells. There is a substantial expansion of IMC in cancer and many other pathological conditions which is associated with pathologic activation of these cells. As a result, these cells acquire the ability to suppress immune responses and are …

Capillary Electrophoresis-Based Assay Of Phosphofructokinase-1, Andrew Malina, Sherrisse K. Bryant, Simon H. Chang, Grover L. Waldrop, S. Douglass Gilman

Faculty Publications

An assay was developed for phosphofructokinase-1 (PFK-1) using capillary electrophoresis (CE). In the glycolytic pathway, this enzyme catalyzes the rate-limiting step from fructose-6-phosphate and magnesium-bound adenosine triphosphate (Mg-ATP) to fructose-1,6-bisphosphate and magnesium-bound adenosine diphosphate (Mg-ADP). This enzyme has recently become a research target because of the importance of glycolysis in cancer and obesity. The CE assay for PFK-1 is based on the separation and detection by ultraviolet (UV) absorbance at 260 nm of Mg-ATP and Mg-ADP. The separation was enhanced by the addition of Mg 2+ to the separation buffer. Inhibition studies of PFK-1 by aurintricarboxylic acid and palmitoyl coenzyme …

Shrimp Immune System -Special Focus On Penaeidin, Yen-Ling Song, Ching-Yu Li

Journal of Marine Science and Technology–Taiwan

In this review paper, we summarize the immune system of penaeid shrimp. This review includes the clotting system comprising clot protein and clotting enzyme (transglutaminase II), as well as the prophenoloxidase (proPO) activation system including proPO-activating enzyme (PPAE), proPO and clip domain serine protease homolog (c-SPH). In addition, several shrimp cytokines or cytokine-like molecules found in tiger shrimp Penaeus monodon participating in the defense responses are also discussed. C-SPH could enhance hemocyte adhesion. Shrimp astakine promoted hemocyte proliferation in the hematopoietic tissues and could be down-regulated at the post-transcriptional level by the binding of intracellular molecules such as transglutaminase I …

The Status Of Public Health Services & Systems Research In The Us: Implications For British Columbia, Glen P. Mays

Health Management and Policy Presentations

Research on the organization, financing, and delivery of public health services has accelerated in the U.S. in recent years. This applied scholarship has been fueled in part by the changes and natural experiments created by global economic recession and by comprehensive federal and state health reforms. Co-occuring changes in public health organization and financing have occurred in Canada and more specifically in British Columbia, where valuable scholarship on public health delivery is also underway. This presentation reviews the progress and current directions of PHSSR scholarship in the U.S., and identifies opportunities and implications for British Columbia.

Computational Design Of The Affinity And Specificity Of A Therapeutic T Cell Receptor, Brian G. Pierce, Lance M. Hellman, Moushumi Hossain, Nishant K. Singh, Craig W. Vander Kooi, Zhiping Weng, Brian M. Baker

Molecular and Cellular Biochemistry Faculty Publications

T cell receptors (TCRs) are key to antigen-specific immunity and are increasingly being explored as therapeutics, most visibly in cancer immunotherapy. As TCRs typically possess only low-to-moderate affinity for their peptide/MHC (pMHC) ligands, there is a recognized need to develop affinity-enhanced TCR variants. Previous in vitro engineering efforts have yielded remarkable improvements in TCR affinity, yet concerns exist about the maintenance of peptide specificity and the biological impacts of ultra-high affinity. As opposed to in vitro engineering, computational design can directly address these issues, in theory permitting the rational control of peptide specificity together with relatively controlled increments in affinity. …

Ah1n1 Virus Reappears In Mexico In Early 2014; No Health Emergency Declared, Carlos Navarro

SourceMex

No abstract provided.

The Underutilization Of Primary Care Providers In Treating Opiate Addiction, Jennifer Jenkinson

Student Works

Opioid abuse is a worldwide problem and there are not enough care providers or treatment programs available to treat the opioid abuse epidemic. Many primary-care nurse practitioners care for patients who are dependant and/or abuse opioids. Under current legislation, nurse practitioners are not allowed to prescribe the schedule III medications necessary to treat them, even though they have been made available to primary-care physicians with some additional training. This paper discusses the effectiveness of opioid substitution therapy in a primary care setting, the patient population best suited for this therapy, patient satisfaction with primary care service, and the barriers preventing …

Cholera Transmission Dynamic Models For Public Health Practitioners, Isaac Chun-Hai Fung

Epidemiology: Faculty Publications (2002-2018)

Great progress has been made in mathematical models of cholera transmission dynamics in recent years. However, little impact, if any, has been made by models upon public health decision-making and day-to-day routine of epidemiologists. This paper provides a brief introduction to the basics of ordinary differential equation models of cholera transmission dynamics. We discuss a basic model adapted from Codeço (2001), and how it can be modified to incorporate different hypotheses, including the importance of asymptomatic or inapparent infections, and hyperinfectious V. choleraeand human-to-human transmission. We highlight three important challenges of cholera models: (1) model misspecification and parameter uncertainty, …

February 11, 2014 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Methamphetamine Use Among Suburban Women: Implications For Nurse Practitioners, Annette Bairan, Miriam Boeri, Janice Morian

Faculty Articles

Purpose The purpose of this article is to provide nurse practitioners (NPs) with more effective strategies to diagnose methamphetamine (MA) use and assess healthcare needs of MA-using women. Data sources The researchers collected data from 65 suburban women who were MA users living in the suburbs of a large southeastern city in the United States. We conducted in-depth interviews and focus groups examining their life history, drug history, risk behaviors, and access to health care. The qualitative findings are examined here. Conclusions Three main themes emerged from the data: (a) gendered stigmatization of MA use; (b) MA-related health risk behaviors; …

The Permissibility Of Routine Aids Testing In The Health Care Context, Ziyad I. Naccasha

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Prohibiting Aids Testing In The Health Insurance Context: Patching Up A Patchwork System, Suzanne M. Russell

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Distress Among The Legal Profession: What Law Schools Can Do About It, Bridget A. Maloney

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

In The Ghetto: The State's Duty To Protect Inner-City Children From Violence, Aileen M. Bigelow

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Human Papillomavirus Genotype Prevalence In Invasive Penile Cancers From A Registry-Based United States Population, Brenda Y. Hernandez, Marc T. Goodman, Elizabeth R. Unger, Martin Steinau, Amy Powers, Charles F. Lynch, Wendy Cozen, Maria Sibug Saber, Edward S. Peters, Edward J. Wilkinson, Glenn Copeland, Claudia Hopenhayn, Youjie Huang, Meg Watson, Sean F. Altekruse, Christopher Lyu, Mona Saraiya, The Hpv Typing Of Cancer Workgroup

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: Human papillomavirus (HPV) is estimated to play an etiologic role in 40-50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited.

METHODS: HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998-2005 within the catchment areas of seven U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review.

RESULTS: HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral …

National Animal Health Monitoring Survey For Toxoplasma Gondii And Trichinella Spiralis – Npb #12-121, Dolores Hill

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

The United States Department of Agriculture (USDA) initiated the National Animal Health Monitoring System (NAHMS) in 1983 to collect, analyze, and disseminate data on animal health, management, and productivity in U.S. domestic livestock populations. The purpose of this study was to determine the national seroprevalence of Toxoplasma gondii and Trichinella spiralis in grower/finisher pigs using sera collected during the 5th National Swine Study (NAHMS Swine 2012). Sera was collected during the voluntary survey of 202 grower/finisher swine production sites located in 13 states accounting for ~90% of U.S. swine production (Iowa, Illinois, Indiana, Kansas, Minnesota, Missouri, Nebraska, North Carolina, Ohio, …

New 'Living Document' Provides Real-Time Hepatitis C Treatment Guidance, Jim Bakken

Browse All News

No abstract provided.

Politics And The Culture Of Life - Why I Am Still A Democrat, Kristen Day

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

The Collegian (2014-02-03), Cleiri Quezada

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 66, No. 18

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Human Trafficking: An Issue Of Human And National Security, Roza Pati

University of Miami National Security & Armed Conflict Law Review

No abstract provided.

Skeleton Found In A Rhode Island Cave, Possibility Of Lyme Disease, Tooba Ghafoor

2014 Honors Council of the Illinois Region Papers

A skeleton of a member of the Wampanoag tribe was recently found in a cave near the eastern shore of Narragansett Bay, Rhode Island. Examination of the skeleton revealed the individual was most likely a male in his late 40s. Six Amblyomma americanum and nine Xodes scapalaris ticks were found in the fur cloth of the individual. These ticks, as well as abnormalities of the skeleton, including a missing arm and broken rib, raise the possibility of the individual suffering and dying from Lyme disease. Carbon-14 dated the remains and ticks to the year 1600.

Utility Of Serodiagnostics Designed For Use In The United States For Detection Of Lyme Borreliosis Acquired In Europe And Vice Versa, Gary P. Wormser, Aimee T. Tang, Natasha R. Schimmoeller, Susan Bittker, Denise Cooper, Paul Visintainer, Maria E. Aguero-Rosenfeld, Katarina Ogrinc, Franc Strle, Gerold Stanek

NYMC Faculty Publications

Although two-tier testing is standard practice in both the United States and Europe for the serologic diagnosis of Lyme borreliosis (LB), the test kits generally differ. The purpose of this study was to determine if the testing used in the United States will detect LB acquired in Europe and vice versa. Testing was performed on a convenience sample of archived sera from 40 LB patients from Austria and 39 from the United States, using first- and second-tier test kits from both the United States and Europe. The sensitivity of four first-tier tests from Europe and two first-tier tests from the …