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2014

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Articles 49291 - 49320 of 49333

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Minimal Effects Of Waterborne Exposure To Single-Walled Carbon Nanotubes On Behaviour And Physiology Of Juvenile Rainbow Trout (Oncorhynchus Mykiss)., D Boyle, Je Fox, Jm Akerman, Ka Sloman, Tb Henry, Rd Handy Jan 2014

Minimal Effects Of Waterborne Exposure To Single-Walled Carbon Nanotubes On Behaviour And Physiology Of Juvenile Rainbow Trout (Oncorhynchus Mykiss)., D Boyle, Je Fox, Jm Akerman, Ka Sloman, Tb Henry, Rd Handy

School of Biological and Marine Sciences

Fish behaviours are often considered to be sensitive endpoints of waterborne contaminants, but little attention has been given to engineered nanomaterials. The present study aimed to determine the locomotor and social behaviours of rainbow trout (Oncorhynchus mykiss) during waterborne exposure to single-walled carbon nanotubes (SWCNTs), and to ascertain the physiological basis for any observed effects. Dispersed stock suspensions of SWCNTs were prepared by stirring in sodium dodecyl sulphate (SDS), an anionic surfactant, on an equal w/w basis. Trout were exposed to control (no SWCNT or SDS), 0.25 mg L(-1) SDS (dispersant control), or 0.25 mg L(-1) of SWCNT for 10 …

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Uptake Epithelia Behave In A Cell-Centric And Not Systems Homeostatic Manner In Response To Zinc Depletion And Supplementation, D Zheng, Gp Feeney, Rd Handy, C Hogstrand, P Kille Jan 2014

Uptake Epithelia Behave In A Cell-Centric And Not Systems Homeostatic Manner In Response To Zinc Depletion And Supplementation, D Zheng, Gp Feeney, Rd Handy, C Hogstrand, P Kille

School of Biological and Marine Sciences

No abstract provided.

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Moving Beyond Too Little, Too Late: Managing Emerging Infectious Diseases In Wild Populations Requires International Policy And Partnerships, Jamie Voyles, A. Marm Kilpatrick, James P. Collins, Matthew C. Fisher, Winifred F. Frick, Hamish Mccallum, Craig K.R. Willis, David S. Blehert, Kris A. Murray, Robert Puschendorf, Erica Bree Rosenblum, Benjamin M. Bolker, Tina L. Cheng, Kate E. Langwig, Daniel L. Lindner, Mary Toothman, Mark Q. Wilber, Cheryl J. Briggs Jan 2014

Moving Beyond Too Little, Too Late: Managing Emerging Infectious Diseases In Wild Populations Requires International Policy And Partnerships, Jamie Voyles, A. Marm Kilpatrick, James P. Collins, Matthew C. Fisher, Winifred F. Frick, Hamish Mccallum, Craig K.R. Willis, David S. Blehert, Kris A. Murray, Robert Puschendorf, Erica Bree Rosenblum, Benjamin M. Bolker, Tina L. Cheng, Kate E. Langwig, Daniel L. Lindner, Mary Toothman, Mark Q. Wilber, Cheryl J. Briggs

School of Biological and Marine Sciences

Emerging infectious diseases (EIDs) are on the rise due to multiple factors, including human facilitated movement of pathogens, broad-scale landscape changes, and perturbations to ecological systems (Jones et al. 2008; Fisher et al. 2012). Epidemics in wildlife are problematic because they can lead to pathogen spillover to new host organisms, erode biodiversity and threaten ecosystems that sustain human societies (Fisher et al. 2012; Kilpatrick 2011). There have been recent calls for large-scale research approaches to combat the threats EIDs pose to wildlife (Sleeman 2013). While it is true that developing new analytical models, diagnostic assays and molecular tools will significantly …

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Steps Toward A Shared Governance Response For Achieving Good Environmental Status In The Mediterranean Sea, Sergio Cinnirella, R Sarda, Suarez De Vivero J Luis, Ruth Brennan, Alberto Barausse, John Icely, Tiziana Luisetti, David March, Carla Murciano, Alice Newton, T O'Higgins, Luca Palmeri, Maria Giovanna Palmieri, Pascal Raux, Sian Rees, J Albaiges, Nicola Pirrone, Kerry Turner Jan 2014

Steps Toward A Shared Governance Response For Achieving Good Environmental Status In The Mediterranean Sea, Sergio Cinnirella, R Sarda, Suarez De Vivero J Luis, Ruth Brennan, Alberto Barausse, John Icely, Tiziana Luisetti, David March, Carla Murciano, Alice Newton, T O'Higgins, Luca Palmeri, Maria Giovanna Palmieri, Pascal Raux, Sian Rees, J Albaiges, Nicola Pirrone, Kerry Turner

School of Biological and Marine Sciences

No abstract provided.

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The Deep Sea Is A Major Sink For Microplastic Debris, Lucy C. Woodall, Anna Sanchez-Vidal, Miquel Canals, Gordon L.J. Paterson, Rachel Coppock, Victoria Sleight, Antonio Calafat, Alex D. Rogers, Bhavani E. Narayanaswamy, Richard C. Thompson Jan 2014

The Deep Sea Is A Major Sink For Microplastic Debris, Lucy C. Woodall, Anna Sanchez-Vidal, Miquel Canals, Gordon L.J. Paterson, Rachel Coppock, Victoria Sleight, Antonio Calafat, Alex D. Rogers, Bhavani E. Narayanaswamy, Richard C. Thompson

School of Biological and Marine Sciences

Marine debris, mostly consisting of plastic, is a global problem, negatively impacting wildlife, tourism and shipping. However, despite the durability of plastic, and the exponential increase in its production, monitoring data show limited evidence of concomitant increasing concentrations in marine habitats. There appears to be a considerable proportion of the manufactured plastic that is unaccounted for in surveys tracking the fate of environmental plastics. Even the discovery of widespread accumulation of microscopic fragments (microplastics) in oceanic gyres and shallow water sediments is unable to explain the missing fraction. Here, we show that deep-sea sediments are a likely sink for microplastics. …

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A Biological, Latent Variable Model Of Health (Earlybird 68)., Michael E. Hyland, Alison N. Jeffery, Terence J. Wilkin Jan 2014

A Biological, Latent Variable Model Of Health (Earlybird 68)., Michael E. Hyland, Alison N. Jeffery, Terence J. Wilkin

School of Psychology

OBJECTIVE: To determine whether factor analysis of a set of health-related biomarkers provides evidence of an underlying common dimension of variation, and to explore the relationship between this dimension of variation with positive and negative affect. METHOD: Twelve health-related metabolic, immune and body-composition biomarkers at ages 5, 7, 9, 11, 14 and 16years were obtained from the EarlyBird longitudinal cohort of 347 children and supplemented by positive affect (PA) and negative affect (NA) measured at age 16years. RESULTS: At each age, principal factor analysis revealed that nine of the 12 biomarkers consistently loaded on the first extracted factor, accounting for …

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Planning-Related Motor Processes Underlie Mental Practice And Imitation Learning., Patric Bach, Bassem Khalaf Allami, Mike Tucker, Rob Ellis Jan 2014

Planning-Related Motor Processes Underlie Mental Practice And Imitation Learning., Patric Bach, Bassem Khalaf Allami, Mike Tucker, Rob Ellis

School of Psychology

It is still controversial whether mental practice-the internal rehearsal of movements to improve later performance-relies on processes engaged during physical motor performance and, if so, which processes these are. We report data from 5 experiments, in which participants mentally practiced complex rhythms with either feet or hands while using the same or different body parts to respond to unrelated sounds. We found that responses were impaired for those body parts that were concurrently used in mental practice, suggesting a binding of body-part-specific motor processes to action plans. This result was found when participants mentally trained to memorize the rhythms, to …

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Gaba-Mediated Changes In Inter-Hemispheric Beta Frequency Activity In Early-Stage Parkinson's Disease, S. D. Hall, E. J. Prokic, C. J. Mcallister, K. C. Ronnqvist, A. C. Williams, N. Yamawaki, C. Witton, G. L. Woodhall, I. M. Stanford Jan 2014

Gaba-Mediated Changes In Inter-Hemispheric Beta Frequency Activity In Early-Stage Parkinson's Disease, S. D. Hall, E. J. Prokic, C. J. Mcallister, K. C. Ronnqvist, A. C. Williams, N. Yamawaki, C. Witton, G. L. Woodhall, I. M. Stanford

School of Psychology

No abstract provided.

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Development Of Sampling Efficiency And Internal Noise In Motion Detection And Discrimination In School-Aged Children, Hk Falkenberg, Wa Simpson, Gn Dutton Jan 2014

Development Of Sampling Efficiency And Internal Noise In Motion Detection And Discrimination In School-Aged Children, Hk Falkenberg, Wa Simpson, Gn Dutton

School of Psychology

The aim of this study was to use an equivalent noise (EN) to investigate the development and maturation of motion perception, and how the underlying limitations of sampling efficiency and internal noise effect motion detection and direction discrimination in school-aged children (5-14 years) and adults. Contrast energy thresholds of a 2 c/deg sinusoidal grating drifting at 1.0 or 6.0 Hz were measured as a function of added dynamic noise in three tasks: detection of a drifting grating; detection of the sum of two oppositely drifting gratings and direction discrimination of oppositely drifting gratings. Compared to the ideal observer, in both …

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From Services To Civilian: The Geographies Of Veterans' Post-Military Lives, Agatha Herman, Richard Yarwood Jan 2014

From Services To Civilian: The Geographies Of Veterans' Post-Military Lives, Agatha Herman, Richard Yarwood

School of Geography, Earth and Environmental Sciences

No abstract provided.

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Parasitism In Early Life: Environmental Conditions Shape Within‐Brood Variation In Responses To Infection, Hmv Granroth‐Wilding, Sarah J. Burthe, Sue Lewis, Thomas E. Reed, Katherine A. Herborn, Mark A. Newell, Emi A. Takahashi, Francis Daunt, Emma J.A. Cunningham Jan 2014

Parasitism In Early Life: Environmental Conditions Shape Within‐Brood Variation In Responses To Infection, Hmv Granroth‐Wilding, Sarah J. Burthe, Sue Lewis, Thomas E. Reed, Katherine A. Herborn, Mark A. Newell, Emi A. Takahashi, Francis Daunt, Emma J.A. Cunningham

School of Biological and Marine Sciences

AbstractParasites play key ecological and evolutionary roles through the costs they impose on their host. In wild populations, the effect of parasitism is likely to vary considerably with environmental conditions, which may affect the availability of resources to hosts for defense. However, the interaction between parasitism and prevailing conditions is rarely quantified. In addition to environmental variation acting on hosts, individuals are likely to vary in their response to parasitism, and the combined effect of both may increase heterogeneity in host responses. Offspring hierarchies, established by parents in response to uncertain rearing conditions, may be an important source of variation …

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Oculometric Variations During Mind Wandering, R Grandchamp, C Braboszcz, A Delorme Jan 2014

Oculometric Variations During Mind Wandering, R Grandchamp, C Braboszcz, A Delorme

School of Psychology

A significant body of literature supports the contention that pupil size varies depending on cognitive load, affective state, and level of drowsiness. Here we assessed whether oculometric measures such as gaze position, blink frequency and pupil size were correlated with the occurrence and time course of self-reported mind-wandering episodes. We recorded the pupil size of two subjects engaged in a monotonous breath counting task while keeping their eyes on a fixation cross. This task is conducive to producing mind-wandering episodes. Each subject performed ten 20-min sessions, for total duration of about 4 h. Subjects were instructed to report spontaneous mind-wandering …

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Qualified Doctor And Medical Students' Use Of Resources For Accessing Information: What Is Used And Why?, Nicola Brennan, Sarah Edwards, Narcie Kelly, Alice Miller, Lucy Harrower, Karen Mattick Jan 2014

Qualified Doctor And Medical Students' Use Of Resources For Accessing Information: What Is Used And Why?, Nicola Brennan, Sarah Edwards, Narcie Kelly, Alice Miller, Lucy Harrower, Karen Mattick

Peninsula Medical School

BACKGROUND: Learning to access information using resources such as books and search engines is an important and fast changing challenge for doctors and medical students. Many resources exist to support evidence-based clinical decision-making, but a wide range of factors influences their use. OBJECTIVE: To explore qualified doctor and medical students' use of resources for accessing information and to determine what is used and why. METHODS: A stratified sample of 46 participants was recruited in Devon, UK. Participants kept a self-report diary of resources used over a week. The diaries were then used to stimulate recall within a semi-structured interview. Diary …

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Development Of A Prototype Lateral Flow Immunoassay (Lfi) For The Rapid Diagnosis Of Melioidosis., Raymond L. Houghton, Dana E. Reed, Mark A. Hubbard, Michael J. Dillon, Hongjing Chen, Bart J. Currie, Mark Mayo, Derek S. Sarovich, Vanessa Theobald, Direk Limmathurotsakul, Gumphol Wongsuvan, Narisara Chantratita, Sharon J. Peacock, Alex R. Hoffmaster, Brea Duval, Paul J. Brett, Mary N. Burtnick, David P. Aucoin Jan 2014

Development Of A Prototype Lateral Flow Immunoassay (Lfi) For The Rapid Diagnosis Of Melioidosis., Raymond L. Houghton, Dana E. Reed, Mark A. Hubbard, Michael J. Dillon, Hongjing Chen, Bart J. Currie, Mark Mayo, Derek S. Sarovich, Vanessa Theobald, Direk Limmathurotsakul, Gumphol Wongsuvan, Narisara Chantratita, Sharon J. Peacock, Alex R. Hoffmaster, Brea Duval, Paul J. Brett, Mary N. Burtnick, David P. Aucoin

Peninsula Medical School

Burkholderia pseudomallei is a soil-dwelling bacterium and the causative agent of melioidosis. Isolation of B. pseudomallei from clinical samples is the "gold standard" for the diagnosis of melioidosis; results can take 3-7 days to produce. Alternatively, antibody-based tests have low specificity due to a high percentage of seropositive individuals in endemic areas. There is a clear need to develop a rapid point-of-care antigen detection assay for the diagnosis of melioidosis. Previously, we employed In vivo Microbial Antigen Discovery (InMAD) to identify potential B. pseudomallei diagnostic biomarkers. The B. pseudomallei capsular polysaccharide (CPS) and numerous protein antigens were identified as potential …

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Hydroxyapatite, Fluor-Hydroxyapatite And Fluorapatite Produced Via The Sol–Gel Method: Dissolution Behaviour And Biological Properties After Crystallisation, Cj Tredwin, Am Young, Ea Abou Neel, G Georgiou, Jc Knowles Jan 2014

Hydroxyapatite, Fluor-Hydroxyapatite And Fluorapatite Produced Via The Sol–Gel Method: Dissolution Behaviour And Biological Properties After Crystallisation, Cj Tredwin, Am Young, Ea Abou Neel, G Georgiou, Jc Knowles

Peninsula Dental School

Hydroxyapatite (HA), fluor-hydroxyapatite (FHA) with varying levels of fluoride ion substitution and fluorapatite (FA) were synthesised by the sol-gel method as possible implant coating or bone-grafting materials. Calcium nitrate and triethyl phosphite were used as precursors under an ethanol-water based solution. Different amounts of ammonium fluoride were incorporated for the preparation of the FHA and FA sol-gels. After heating and powdering the sol-gels, dissolution behaviour was assessed using ion chromatography to measure Ca(2+) and PO4 (3-) ion release. Biological behaviour was assessed using cellular proliferation with human osteosarcoma cells and alamarBlue™ assay. Statistical analysis was performed with a two way …

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Phonitalia: A Phonological Lexicon For Italian., Jeremy Goslin, Claudia Galluzzi, Cristina Romani Jan 2014

Phonitalia: A Phonological Lexicon For Italian., Jeremy Goslin, Claudia Galluzzi, Cristina Romani

School of Psychology

In this article, we present the first open-access lexical database that provides phonological representations for 120,000 Italian word forms. Each of these also includes syllable boundaries and stress markings and a comprehensive range of lexical statistics. Using data derived from this lexicon, we have also generated a set of derived databases and provided estimates of positional frequency use for Italian phonemes, syllables, syllable onsets and codas, and character and phoneme bigrams. These databases are freely available from phonitalia.org. This article describes the methods, content, and summarizing statistics for these databases. In a first application of this database, we also demonstrate …

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Modeling Causal Conditional Reasoning Data Using Sdt: Caveats And New Insights., Dries Trippas, Michael F. Verde, Simon J. Handley, Matthew E. Roser, Nicolas A. Mcnair, Jonathan St B.T. Evans Jan 2014

Modeling Causal Conditional Reasoning Data Using Sdt: Caveats And New Insights., Dries Trippas, Michael F. Verde, Simon J. Handley, Matthew E. Roser, Nicolas A. Mcnair, Jonathan St B.T. Evans

School of Psychology

No abstract provided.

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Public Perceptions Of The Uk Marine Environment, Rl Jefferson, I Bailey, Dd Laffoley, Jp Richards, Mj Attrill Jan 2014

Public Perceptions Of The Uk Marine Environment, Rl Jefferson, I Bailey, Dd Laffoley, Jp Richards, Mj Attrill

School of Geography, Earth and Environmental Sciences

The damaging effects of human activities on marine health suggest that a major shift is required in the way marine systems are used by individuals. Identifying how to engage society in this shift is an ongoing debate. This includes strengthening the positive connections between society and the sea. This study uses a survey (n¼1047) to investigate UK public perceptions of subtidal species and marine health to assess whether it is possible to build more positive connections between society and the sea. Respondents showed considerable interest in traditionally charismatic species (puffins, seals and seahorses) although many respondents thought these species did …

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Insulin Acutely Improves Mitochondrial Function Of Rat And Human Skeletal Muscle By Increasing Coupling Efficiency Of Oxidative Phosphorylation., Raid B. Nisr, Charles Affourtit Jan 2014

Insulin Acutely Improves Mitochondrial Function Of Rat And Human Skeletal Muscle By Increasing Coupling Efficiency Of Oxidative Phosphorylation., Raid B. Nisr, Charles Affourtit

School of Biomedical Sciences

Insulin is essential for the regulation of fuel metabolism and triggers the uptake of glucose by skeletal muscle. The imported glucose is either stored or broken down, as insulin stimulates glycogenesis and ATP synthesis. The mechanism by which ATP production is increased is incompletely understood at present and, generally, relatively little functional information is available on the effect of insulin on mitochondrial function. In this paper we have exploited extracellular flux technology to investigate insulin effects on the bioenergetics of rat (L6) and human skeletal muscle myoblasts and myotubes. We demonstrate that a 20-min insulin exposure significantly increases (i) the …

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Heat-Killed Probiotic Bacteria Differentially Regulate Colonic Epithelial Cell Production Of Human Β-Defensin-2: Dependence On Inflammatory Cytokines., N. Habil, W. Abate, J. Beal, A. D. Foey Jan 2014

Heat-Killed Probiotic Bacteria Differentially Regulate Colonic Epithelial Cell Production Of Human Β-Defensin-2: Dependence On Inflammatory Cytokines., N. Habil, W. Abate, J. Beal, A. D. Foey

School of Biomedical Sciences

The inducible antimicrobial peptide human β-defensin-2 (hBD-2) stimulated by pro-inflammatory cytokines and bacterial products is essential to antipathogen responses of gut epithelial cells. Commensal and probiotic bacteria can augment such mucosal defences. Probiotic use in the treatment of inflammatory bowel disease, however, may have adverse effects, boosting inflammatory responses. The aim of this investigation was to determine the effect of selected probiotic strains on hBD-2 production by epithelial cells induced by pathologically relevant pro-inflammatory cytokines and the role of cytokine modulators in controlling hBD-2. Caco-2 colonic intestinal epithelial cells were pre-incubated with heat-killed probiotics, i.e. Lactobacillus casei strain Shirota (LcS) …

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The Bacterial Skin Microbiome In Psoriatic Arthritis, An Unexplored Link In Pathogenesis: Challenges And Opportunities Offered By Recent Technological Advances., Madhura Castelino, Stephen Eyre, Mathew Upton, Pauline Ho, Anne Barton Jan 2014

The Bacterial Skin Microbiome In Psoriatic Arthritis, An Unexplored Link In Pathogenesis: Challenges And Opportunities Offered By Recent Technological Advances., Madhura Castelino, Stephen Eyre, Mathew Upton, Pauline Ho, Anne Barton

School of Biomedical Sciences

The resident microbial community, harboured by humans in sites such as the skin and gastrointestinal tract, is enormous, representing a candidate environmental factor affecting susceptibility to complex diseases, where both genetic and environmental risk factors are important. The potential of microorganisms to influence the human immune system is considerable, given their ubiquity. The impact of the host-gene-microbe interaction on the maintenance of health and the development of disease has not yet been assessed robustly in chronic inflammatory conditions. PsA represents a model inflammatory disease to explore the role of the microbiome because skin involvement and overlap with IBD implicates both …

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Galleria Mellonella Infection Model Demonstrates High Lethality Of St69 And St127 Uropathogenic E. Coli., Majed F. Alghoribi, Tarek M. Gibreel, Andrew R. Dodgson, Scott A. Beatson, Mathew Upton Jan 2014

Galleria Mellonella Infection Model Demonstrates High Lethality Of St69 And St127 Uropathogenic E. Coli., Majed F. Alghoribi, Tarek M. Gibreel, Andrew R. Dodgson, Scott A. Beatson, Mathew Upton

School of Biomedical Sciences

Galleria mellonella larvae are an alternative in vivo model for investigating bacterial pathogenicity. Here, we examined the pathogenicity of 71 isolates from five leading uropathogenic E. coli (UPEC) lineages using G. mellonella larvae. Larvae were challenged with a range of inoculum doses to determine the 50% lethal dose (LD50) and for analysis of survival outcome using Kaplan-Meier plots. Virulence was correlated with carriage of a panel of 29 virulence factors (VF). Larvae inoculated with ST69 and ST127 isolates (10(4) colony-forming units/larvae) showed significantly higher mortality rates than those infected with ST73, ST95 and ST131 isolates, killing 50% of the larvae …

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Differentially Expressed Micrornas In Maternal Plasma For The Noninvasive Prenatal Diagnosis Of Down Syndrome (Trisomy 21), J Kamhieh-Milz, Reham Fadl Hassan Moftah, Gürkan Bal, Matthias Futschik, Viktor Sterzer, Omid Khorramshahi, Martin Burow, Gundula Thiel, Annegret Stuke-Sontheimer, Rabih Chaoui, S Kamhieh-Milz, Abdulgabar Salama Jan 2014

Differentially Expressed Micrornas In Maternal Plasma For The Noninvasive Prenatal Diagnosis Of Down Syndrome (Trisomy 21), J Kamhieh-Milz, Reham Fadl Hassan Moftah, Gürkan Bal, Matthias Futschik, Viktor Sterzer, Omid Khorramshahi, Martin Burow, Gundula Thiel, Annegret Stuke-Sontheimer, Rabih Chaoui, S Kamhieh-Milz, Abdulgabar Salama

School of Biomedical Sciences

Objectives. Most developmental processes are under the control of small regulatory RNAs called microRNAs (miRNAs). We hypothesize that different fetal developmental processes might be reflected by extracellular miRNAs in maternal plasma and may be utilized as biomarkers for the noninvasive prenatal diagnosis of chromosomal aneuploidies. In this proof-of-concept study, we report on the identification of extracellular miRNAs in maternal plasma of Down syndrome (DS) pregnancies.Methods. Using high-throughput quantitative PCR (HT-qPCR), 1043 miRNAs were investigated in maternal plasma via comparison of seven DS pregnancies with age and fetal sex matched controls.Results. Six hundred and ninety-five miRNAs were identified. Thirty-six significantly differentially …

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Nuclear Her4 Mediates Acquired Resistance To Trastuzumab And Is Associated With Poor Outcome In Her2 Positive Breast Cancer, Snm Nafi, D Generali, G Kramer-Marek, M Gijsen, Et Al Jan 2014

Nuclear Her4 Mediates Acquired Resistance To Trastuzumab And Is Associated With Poor Outcome In Her2 Positive Breast Cancer, Snm Nafi, D Generali, G Kramer-Marek, M Gijsen, Et Al

School of Biomedical Sciences

The role of HER4 in breast cancer is controversial and its role in relation to trastuzumab resistance remains unclear. We showed that trastuzumab treatment and its acquired resistance induced HER4 upregulation, cleavage and nuclear translocation. However, knockdown of HER4 by specific siRNAs increased trastuzumab sensitivity and reversed its resistance in HER2 positive breast cancer cells. Preventing HER4 cleavage by a γ-secretase inhibitor and inhibiting HER4 tyrosine kinase activity by neratinib decreased trastuzumab-induced HER4 nuclear translocation and enhanced trastuzumab response. There was also increased nuclear HER4 staining in the tumours from BT474 xenograft mice and human patients treated with trastuzumab. Furthermore, …

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Evidence That Duplications Of 22q11.2 Protect Against Schizophrenia, E Rees, G Kirov, Mc O'Donovan, Wellcome Trust Case Control Consortium, Et Al Jan 2014

Evidence That Duplications Of 22q11.2 Protect Against Schizophrenia, E Rees, G Kirov, Mc O'Donovan, Wellcome Trust Case Control Consortium, Et Al

School of Biomedical Sciences

A number of large, rare copy number variants (CNVs) are deleterious for neurodevelopmental disorders, but large, rare, protective CNVs have not been reported for such phenotypes. Here we show in a CNV analysis of 47 005 individuals, the largest CNV analysis of schizophrenia to date, that large duplications (1.5-3.0 Mb) at 22q11.2--the reciprocal of the well-known, risk-inducing deletion of this locus--are substantially less common in schizophrenia cases than in the general population (0.014% vs 0.085%, OR=0.17, P=0.00086). 22q11.2 duplications represent the first putative protective mutation for schizophrenia.

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Herbal And Microbial Products For The Management Of Obesity, Maha Salama, Soheir El Zalabani, Essam Abdel Sattar Jan 2014

Herbal And Microbial Products For The Management Of Obesity, Maha Salama, Soheir El Zalabani, Essam Abdel Sattar

Pharmacy

Obesity is a global epidemic and one of the major health burdens of modern times. The prevalence of obesity is increasing worldwide; it constitutes a serious problem in developed as well as developing countries. Beside adults, the number of obese teenagers and children in particular has dramatically increased. Obesity is characterized by accumulation of excess fat in adipose tissues in an extent to produce adverse effects on health, leading to a reduction in life expectancy and/or a raise in health hazards. People are classified as overweight (pre-obese) and obese on the basis of the Body Mass Index (BMI), crude measure …

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Lte Based E-Health Monitoring System, Muayad Sadik Jan 2014

Lte Based E-Health Monitoring System, Muayad Sadik

Iraqi Journal of Computers, Communications, Control and Systems Engineering

Recently, the on-line health monitoring have been considered in the research to obtain pragmatic e-health systems with low cost and high efficiency. In this paper, a mobile e-health system is proposed based on an algorithm over long terms eVolution (LTE) technology that can be called as fourth generation (4G). This system controls the receiving of the transmitted health data from the patients under supervision and replies the responses of the considered algorithm. The responded signals include the required actions that should be performed by the patient and the hospital. The proposed system utilizes the LTE based mobile networks for the …

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Post-School Adult Life For Young People With Down Syndrome, Kitty Rose Foley Jan 2014

Post-School Adult Life For Young People With Down Syndrome, Kitty Rose Foley

Theses: Doctorates and Masters

Down syndrome is a chromosomal birth disorder affecting one in 650 to 1000 live births in Western Australia. The life expectancy for people with Down syndrome has increased dramatically over the past two generations leading to these young people having changing needs in terms of social, economic and personal life. Encompassed within this, is the successful transition from school to post-school, a time of upheaval, stress and important decisions for young people with intellectual disabilities. The International classification of functioning, disability and health (ICF) is a world renowned framework which provides a scientific basis and standardised language for describing and …

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Enhancing Teaching Through Professional Learning: Case Studies Of Professional Learning To Improve Reading Instruction For Year 2 Students With Reading Difficulties In One Australian State, Susan Main Jan 2014

Enhancing Teaching Through Professional Learning: Case Studies Of Professional Learning To Improve Reading Instruction For Year 2 Students With Reading Difficulties In One Australian State, Susan Main

Theses: Doctorates and Masters

Reading is internationally recognised as a mediating factor in the life outcomes of individuals and the continuing failure of Australian children to attain the same level of literacy as children in other Western countries is an ongoing concern. Within the continuum of reading development, there are some children who experience more difficulty than their peers in acquiring reading skills and these children are at even greater risk of poor life outcomes if they do not receive appropriate instruction. Research demonstrates that professional learning is an effective way of enhancing teachers’ knowledge and practice and, therefore, the purpose of this study …

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Understanding And Building Resilience With Art: A Socio-Ecological Approach, Meagan Shand Jan 2014

Understanding And Building Resilience With Art: A Socio-Ecological Approach, Meagan Shand

Theses: Doctorates and Masters

Resilience is a widely researched phenomenon, it means different things to different people and is perceived and measured according to the theoretical lens being applied. The following thesis reviews the theoretical development of resilience that has led to contemporary understandings, to establish a platform for the research topic - understanding and building resilience with Art. Narrative research methods are combined with art processes to illuminate the stories of eight culturally diverse women participating in a community based mental health art program, in Western Australia. Fifteen resilience themes emerged from the collective experience, and are presented in a socio-ecological framework to …

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