Digital Commons Network^™

Translocation Of Shed Syndecan-1 To The Nucleus: A Novel Mechanism Of Tumor-Host Crosstalk, Mark Stewart

All ETDs from UAB

Multiple myeloma is a hematological malignancy of plasma cells that disseminates throughout the body. Crosstalk between myeloma and host cells is critical to the establishment of a microenvironment conducive to tumor growth and progression. An important mediator of this crosstalk is syndecan-1, a heparan sulfate proteoglycan. Syndecan-1 is proteolytically shed from the surface of myeloma cells and is abundant in the bone marrow microenvironment and serum of myeloma patients. Shed syndecan-1 facilitates tumor-host crosstalk within the microenvironment to drive tumor growth, angiogenesis, and metastasis. We now report for the first time that shed syndecan-1 can be taken up by a …

Statistical Analysis In Genomic Studies, Guodong Wu

All ETDs from UAB

Next-generation sequencing (NGS) technologies reveal unprecedented insights about genome, transcriptome, and epigenome. However, existing quantification and statistical methods are not well prepared for the coming deluge of NGS data. In this dissertation, we propose to develop powerful new statistical methods in three aspects. First, we propose a Hidden Markov Model (HMM) in Bayesian framework to quantify methylation levels at base-pair resolution by NGS. Second, in the context of exome-based studies, we develop a general simulation framework that distributes total genetic effects hierarchically into pathways, genes, and individual variants, allowing the extensive evaluation of existing pathway-based methods. Finally, we develop a …

Usp16 And Histone H2a Deubiquitination In Mouse Embryonic Stem Cell Function, Wei Yang

All ETDs from UAB

In eukaryotic cells, genomic DNA is packaged into a chromatin structure by association with histone and non-histone proteins. Posttranslational modifications of histones play important roles in the regulation of chromatin structure and function. Ubiquitination of histone H2A (ubH2A) represents a predominate modification, occurring on ~10% of total cellular H2A. While H2A ubiquitination is primarily conferred by Polycomb Repressive Complex 1 (PRC1), H2A deubiquitination has been attributed to multiple H2A deubiquitinases. Our laboratory previously reported the purification and functional characterization of a H2A-specific deubiquitinase, USP16 (initially named as Ubp-M) in human cells. However, whether USP16 represents a general and important regulator …

The Roles Of Mammalian Tribbles Homolog 3 (Trib3) In Coordinating Energy Metabolism And Development Of Insulin Resistance, Wei Zhang

All ETDs from UAB

Insulin resistance in diabetics comprises of a reversible component treatable with intensive glycemic control and a non-reversible component present in pre-diabetes that may lead to the development of overt diabetes. The reversible component is induced and exacerbated by hyperglycemia in both uncontrolled type 1 and type 2 diabetes, a process known as glucose-induced insulin resistance (GIIR) or glucose toxicity. The tribbles homolog 3 (TRIB3) has been identified as a pseudokinase that inhibits Akt activity by physically blocking its phosphorylation site. Expression of TRIB3 has been associated with various signals such as endoplasmic reticulum (ER) stress and nutrient availability in pancreatic …

Multiple Human Itgam Variants Alter Mac-1, Fcgamma Receptor And Tlr Functions On Neutrophils, Yebin Zhou

All ETDs from UAB

Multiple studies have demonstrated that single-nucleotide polymorphisms (SNPs) in the ITGAM locus (including the non-synonymous SNPs rs1143679, rs1143678 and rs1143683) are associated with SLE. ITGAM encodes the protein CD11b, a subunit of the ß2 integrin Mac-1. The purpose of this work was to determine the effects of ITGAM genetic variation on the biological functions of neutrophil Mac-1. Neutrophils from ITGAM genotyped and sequenced healthy donors were isolated for functional studies. The phagocytic capacity of neutrophil ITGAM variants was probed with complement coated erythrocytes, serum treated zymosan, heat treated zymosan and IgG coated erythrocytes. The adhesion capacity of ITGAM variants, in …

The Small Sample Inferences Of Cluster-Randomized Trials, Peng Li

All ETDs from UAB

Generalized estimating equation (GEE) and generalized linear mixed model (GLMM) are two statistical modeling methods commonly used in the analyses of correlated outcomes from cluster-randomized trials (CRTs). The fact that most CRTs involve only a small number of clusters makes the small sample adjustment critical to preserve the type I error rates in testing the null hypothesis of intervention effects. To improve the small sample performance of GEE, some bias-corrected sandwich estimators have been proposed. To improve the small sample performance of GLMM, the approximated Wald F test is used to replace the asymptotic ÷^2 test and the denominator degrees …

A Low-Power Multichannel Telemetry System For High-Speed Wireless Neural Recordings, Yang-Guo Li

All ETDs from UAB

The advances in microelectronics and wireless communication are going to change our lifestyles and benefit our healthcare system in the foreseeable future. New conception named "Ubiquitous Healthcare" has been proposed. It envisions a continuous, real-time, remote monitoring on the health conditions of people through the wireless communication network. Traditional biosignal monitoring devices need wire-connections for the recording, which may cause skin rupture and body infection. The physical connections also limited the number of the integrated recording channels. A low-power implantable multichannel telemetry system which can be implanted in the body and transmit recordings wirelessly can solve the problem of the …

Cutting Effectiveness Of Diamond Burs On Dental Zirconia., Ching-Kai Lin

All ETDs from UAB

Monolithic zirconia restorations are popular but removing these crowns is difficult. The purpose of the study is to measure and compare the cutting effectiveness of 10 types of diamond burs through monolithic sintered zirconia. Ten types of diamond burs (n=8) were compared for the cutting effectiveness in Zirconia (CERCON; DeguDent) using a high speed computer controlled cutting device with water spray (5.45L/min). The turbine used to cut the blocks rotated at 150,000 rpm and with the burs at a depth of 2mm into the zirconia during cutting. A 100 gm load was applied during cutting for each bur which made …

Expression Of The Influenza Protein M2 During Viral Infection Inhibits Cftr Activity, James David Londino

All ETDs from UAB

The purpose of these dissertation studies was to 1) determine whether influenza infection alters CFTR activity in polarized epithelium; 2) measure CFTR expression and activity in cells co-expressing influenza M2 protein; and 3) examine the role of M2 on the alteration of CFTR during viral infection. We determined that infection of polarized primary epithelial cells with influenza decreases CFTR expression and activity. In addition, individual cells infected with influenza had decreased CFTR conductance as measured by whole-cell patch clamp. We also found that the influenza ion channel, matrix protein 2 (M2), alone reduced CFTR expression and activity. M2 is expressed …

Interaction Between A Low-Iron Diet And Early-Life Methylmercury Exposure In Daphnia Pulex, Sherri Hudson

All ETDs from UAB

Methylmercury (MeHg) is a known neurotoxicant and bioaccumulates in fish, with exposure to humans in utero being of highest concern. Iron deficiency (ID) accounts for approximately 50% of anemia cases. Anemia is estimated to affect 1.62 billion people worldwide, and is particularly problematic during pregnancy and early life. Previous studies have shown that ID exacerbates toxicity associated with exposure to metals, including lead, manganese, and cadmium. The overall purpose of this thesis research is to investigate the interaction between a low-iron (Fe) diet and early-life exposure to MeHg in Daphnia pulex. I hypothesized when D. pulex are fed a low-Fe …

Starlings Fell On Alabama, Sarah Hayden Jennings

All ETDs from UAB

Starlings Fell on Alabama is a collection of stories that explores the impact of relationships. The characters in this collection have been deeply affected by another person or are affecting another person. They are all in the grip of deep psychological and emotional turmoil as they deal with loss, desire, illness, and grief. And in order to find themselves, Walter, Louise, Robin, and Rose must confront their invisible tethers. Some will find a way to exist without those tethers, those relationships, and others will find themselves pulled deeper into the connections that sustain them.

New Niosh Headforms: Developing Novel Methods For Fabricating A More Realistic Physical Headform And Custom Facepieces And Evaluating Existing Commercially-Available Respirators, Paula Susanne Joe

All ETDs from UAB

For over 30 years, respirator sizing has been based on an anthropometric survey performed by LANL using the young and predominantly Caucasian US Air Force personnel. NIOSH, having observed the increase in diversity in the workplace, began a new survey in 2003 weighted to the US census. Finding that the LANL panel was no longer representative of the modern workforce, a new fit test panel recommending five sizing categories was created in 2007. Anthropometrically accurate headforms three-dimensional models for the average face in each size were designed in 2010. While these headforms are intended for use in respirator design, it …

Understanding Internal, External, And Relational Attributions For Abusive Supervision., James P. Burton, Shannon G. Taylor, Larissa K. Barber

Faculty Articles, Papers, and Other Scholarship

Despite abundant research on the consequences of perceived abusive supervision, less is known about how employees develop perceptions of supervisory abuse. Across two studies, we integrate classic and recent theoretical work on attributions to understand the causal explanations underlying employee perceptions of and reactions to abusive supervision. In the first study, we develop measures of internal, external, and relational attributions for perceived supervisor abuse. In the second study, we demonstrate that internal and external attributions are indirectly related to aggressive and citizenship behaviors through employees’ perceptions of interactional justice. Theoretical and practical implications are also discussed.

The Legal Profession’S Monopoly: Failing To Protect Consumers, Laurel A. Rigertas

Faculty Articles, Papers, and Other Scholarship

This article explores the implication of the legal monopoly that occurs through the current attorney regulation system used in most states. Through the lens of consumer protection, the author discusses how the current regulatory regime, limiting the practice of law to only those who have law licenses and law degrees, effects a landscape where many potential legal consumers' needs are not being met. First, the author provides a general discussion of consumer protection and the public interest. Then, the author focuses specifically on the legal profession, discussing the historical justification for the legal profession's monopoly: consumer protection, advancing the integrity …

The Immigrant “Other”: Racialized Identity And The Devaluation Of Immigrant Family Relations, Anita Maddali

Faculty Articles, Papers, and Other Scholarship

This Article explores how current terminations of undocumented immigrants’ parental rights are reminiscent of historical practices that removed early immigrant and Native American children from their parents in an attempt to cultivate an Anglo-American national identity. Today, children are separated from their families when courts terminate the rights of parents who have been, or who face, deportation. Often, biases toward undocumented parents affect determinations concerning parental fitness in a manner that, while different, reaps the same results as the removal of children from their families over a century ago. This Article examines cases in which courts terminated the parental rights …

Constitutional Constraints On Second Parent Laws, Jeffrey A. Parness

Faculty Articles, Papers, and Other Scholarship

American state parentage laws have traditionally required biological or adoptive ties and no more than two parents for any one child at any one time. Biological ties were demonstrated by giving birth or sperm. Adoptive ties were established by completion of formal procedures by those desiring to parent, where prospective adopters were assessed for parental worthiness by the state. While the two parent policy largely continues, increasingly for children with only one parent there are recognized long after birth second parents with no biological or formal adoptive ties and with no rights under a valid child creation pact predating birth …

How Do You Rate Your Lawyer?: Lawyers’ Responses To Online Reviews Of Their Services, Laurel A. Rigertas

Faculty Articles, Papers, and Other Scholarship

With the proliferation of opportunities for consumers to review a variety of services on the Internet, it is probably only a matter of time until more clients review their attorneys’ services on the Internet. This raises a variety of potential ethical and public policy issues that will be discussed in this article. First, what can attorneys do to try to control their on-line reputations? Second, if a client posts negative comments about an attorney’s services on a public Internet forum, can the attorney respond on that forum without breaching the duty of confidentiality and, if so, how? Finally, when settling …

Applying Insights From Behavioral Economics To Policy Design, Brigitte C. Madrian

Faculty Publications

The premise of this article is that an understanding of psychology and other social science disciplines can inform the effectiveness of the economic tools traditionally deployed in carrying out the functions of government, which include remedying market failures, redistributing income, and collecting tax revenue. An understanding of psychology can also lead to the development of different policy tools that better motivate desired behavior change or that are more cost-effective than traditional policy tools. The article outlines a framework for thinking about the psychology of behavior change in the context of market failures. It then describes the research on the effects …

What Makes Annuitization More Appealing?, John Beshears, James J. Choi, David Laibson, Brigitte C. Madrian, Stephen P. Zeldes

Faculty Publications

We conduct and analyze two large surveys of hypothetical annuitization choices. We find that allowing individuals to annuitize a fraction of their wealth increases annuitization relative to a situation where annuitization is an “all or nothing” decision. Very few respondents choose declining real payout streams over flat or increasing real payout streams of equivalent expected present value. Highlighting the effects of inflation increases demand for cost of living adjustments. Frames that highlight flexibility, control, and investment significantly reduce annuitization. A majority of respondents prefer to receive an extra “bonus” payment during one month of the year that is funded by …

A Critical Examination Of Couple Leisure And The Application Of The Core And Balance Model, Peter J. Ward, Keith W. Barney, Neil R. Lundberg, Ramon Zabriskie

Faculty Publications

This study further clarified the relationship between couple leisure involvement, couple leisure satisfaction, and marital satisfaction through examining the core and balance framework as it has been applied to the relationship between couple leisure and marital satisfaction. The sample consisted of 1,187 couples across the United States (N = 2,374). SEM analyses supported previous findings, indicating satisfaction with couple leisure involvement was far more important when predicting marital satisfaction than the amount of leisure involvement. Furthermore, while core marital leisure satisfaction was the driving force in the explanation of variance in marital satisfaction, findings suggested before that can happen there …

Effect Of Local Materials On The Silver Sorption And Strength Of Ceramic Water Filters, Vinka Oyanedel-Craver, Sophia Narkiewicz, Richard Genovesi, Aaron Bradshaw, Dawn Cardace

Civil & Environmental Engineering Faculty Publications

In this paper, we present a systematic evaluation of the effects of local clays and the manufacturing process on the performance of ceramic water filters (CWFs) impregnated with silver compounds, which are used for point-of-use water treatment in developing countries. Mineral composition, silver sorption/desorption, and strength are the important characteristics that influence effectiveness and durability of CWFs during transport and use. Laboratory tests were conducted on ceramic samples obtained from five CWF factories around the world to determine their mineral composition, silver sorption/desorption, and flexural strength. The results of this study showed that clays that contain traces of crystalline albite …

Validation Of The Brzycki And Epley Equations For The 1 Repetition Maximum Back Squat Test In Division I College Football Players, Thomas J. Distasio

Research Papers

No abstract provided.

The Effects Of Myofascial Release Vs Static Stretching On Hamstrings Range Of Motion, Patrick M. Keys

Research Papers

The purpose of this study was to investigate the effects of three days of foam rolling on the hamstrings range of motion in comparison with static stretching. Lower extremity injuries are prevalent in strength training and sports today. Poor flexibility has been found to increase the risk of overuse injuries and significantly affect the individual’s level of function and performance. Self myofascial release (SMR), foam rolling, is a recent modality clinically used to increase flexibility. On the other hand, there are few research studies on the technique.

Twenty college students participated in this study. Ten participants were in the static …

Standoff Methods For The Detection Of Threat Agents: A Review Of Several Promising Laser-Based Techniques, J. Bruce Johnson, Susan D. Allen, Jonathan Merten, Lewis Johnson, Daniel Pinkham, Scott W. Reeve

Publications

Detection of explosives, explosive precursors, or other threat agents presents a number of technological challenges for optical sensing methods. Certainly detecting trace levels of threat agents against a complex background is chief among these challenges; however, the related issues of multiple target distances (from standoff to proximity) and sampling time scales (from passive mines to rapid rate of march convoy protection) for different applications make it unlikely that a single technique will be ideal for all sensing situations. A number of methods for spanning the range of optical sensor technologies exist which, when integrated, could produce a fused sensor system …

The Language Flagship Model And The Humanities, Sam Eisen

Russian Language Journal

The Language Flagship program provides a model that strengthens and deepens cultural engagement within the humanities and creates bridges to collaboration across disciplines. Flagship addresses needs for national security and global competitiveness and integrates professional and life experience into the humanities and other fields for the students who engage in this course of study. The cross-disciplinary nature of the Flagship program and the level of personal, cultural and professional engagement required to complete the program are successfully changing the undergraduate study experience in ways that address significant issues in the ongoing discussion of a crisis in the humanities. The Language …

The University Of Rhode Island International Engineering Program: A Model For The Merger Of Technology And The Humanities, John M. Grandin, Sigrid Berka

Russian Language Journal

Contrary to a long-established and seemingly irrefutable tradition, American parents, educators, private and public sector leaders, and students are beginning to doubt the value of a university education. Charges have been leveled, for example, that students today are spending substantially less time on academics than their predecessors and are making little progress during their undergraduate years in their ability to read, write, speak, or think analytically and critically (see, for example, Arum and Roksa 2011, Vedder and Denhart 2011). Others have argued that college is burdening young people with lifelong debt to the degree that it is stifling their creativity …

Thoughts On High Level Proficiency In Arabic, Russian And English With A Platitudinous Postlude, James Bernhardt

Russian Language Journal

In the present paper, I look at the top of the Interagency Language Roundtable (ILR) Skill Level Descriptions and critique several of their assumptions. As I do this, I speak for myself and not for the Government in general or the U.S. Department of State in particular. I also do not pretend that my conclusions are not uncontroversial. I also discuss the 2012 ACTFL proficiency standards, but note that we do not train to those standards at the Foreign Service Institute.

Full Issue

Russian Language Journal

No abstract provided.

Research Data Management On A Shoestring Budget, Margaret Henderson, Regina Raboin, Yasmeen Shorish, Steve Van Tuyl

VCU Libraries Faculty and Staff Publications

In response to mandates from the federal government, many academic librarians face a new challenge to become service providers for research data management. A panel at RDAP14 convened representatives from Virginia Commonwealth University, James Madison University and a collaboration of seven New England libraries to discuss their strategies in response to the regulations when faced with limited resources. A common theme was to take advantage of work already done by others, including faculty surveys and existing data management resources such as DMPTool and Data Curation and Profiles Toolkit. Spreading the word on data issues to spark collaboration and gaining the …

Universalism And Civil Rights (With Notes On Voting Rights After Shelby), Samuel R. Bagenstos

Articles

After the Supreme Court’s decision in Shelby County v. Holder, voting rights activists proposed a variety of legislative responses. Some proposals sought to move beyond measures that targeted voting discrimination based on race or ethnicity. They instead sought to eliminate certain problematic practices that place too great a burden on voting generally. Responses like these are universalist, because rather than seeking to protect any particular group against discrimination, they formally provide uniform protections to everyone. As Bruce Ackerman shows, voting rights activists confronted a similar set of questions—and at least some of them opted for a universalist approach—during the campaign …