Digital Commons Network^™

Multi-Drug Resistant Gram Negative Infections And Use Of Intravenous Polymyxin B In Critically Ill Children Of Developing Country: Retrospective Cohort Study, Naveed-Ur-Rehman Siddiqui, Farah Naz Qamar, Humaira Jurair, Anwarul Haque

Department of Paediatrics and Child Health

Background: Patients in pediatric intensive care Units (PICU) are susceptible to infections with antibiotic resistant organisms which increase the morbidity, mortality and cost of care. To describe the clinical characteristics and mortality in patients with Multi-Drug Resistant (MDR) gram negative organisms. We also report safety of Polymyxin B use in these patients.
Methods: Files of patients admitted in PICU of Aga Khan University Hospital, from January 2010 to December 2011, one month to 15 years of age were reviewed. Demographic and clinical features of patients with MDR gram negative infections, antibiotic susceptibility pattern of isolates, discharge disposition and adverse effects …

The Omega-3 Fatty Acid Docosahexaenoic Acid Attenuates Organic Dust-Induced Airway Inflammation., Tara M. Nordgren, Taylor D. Friemel, Art J. Heires, Jill A. Poole, Todd A. Wyatt, Debra J. Romberger

Journal Articles: Pulmonary & Critical Care Med

Workers exposed to organic dusts from concentrated animal feeding operations (CAFOs) are at risk for developing airway inflammatory diseases. Available preventative and therapeutic measures for alleviating dust-induced lung disease are inadequate. Because omega-3 fatty acids can mitigate inflammatory processes, we aimed to determine whether nutritional supplementation with the omega-3 fatty acid docosahexaenoic acid (DHA) could reduce the airway inflammatory consequences of exposures to organic dust. Aqueous extracts of organic dusts from swine CAFOs (ODE) were utilized. In DHA-pretreated human bronchial epithelial cells, lung fibroblasts, monocyte cell cultures, and precision-cut murine lung slices, we found that DHA pretreatment dose-dependently decreased ODE-induced …

The Weekly Challenger, November 27, 2014, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The November 27, 2014, issue of The Weekly Challenger.

Aquatic Hazard Assessment Of A Commercial Sample Of Naphthenic Acids., James P. Swigert, Carol Lee, Diana C.L. Wong, Russell White, Alan G. Scarlett, Charles E. West, Steven J. Rowland

More Faculty of Science and Engineering Research

This paper presents chemical composition and aquatic toxicity characteristics of a commercial sample of naphthenic acids (NAs). Naphthenic acids are derived from the refining of petroleum middle distillates and can contribute to refinery effluent toxicity. NAs are also present in oil sands process-affected water (OSPW), but differences in the NAs compositions from these sources precludes using a common aquatic toxicity dataset to represent the aquatic hazards of NAs from both origins. Our chemical characterization of a commercial sample of NAs showed it to contain in order of abundance, 1-ring>2-ring>acyclic>3-ring acids (∼84%). Also present were monoaromatic acids (7%) …

The Cord (November 26, 2014)

The Cord

No abstract provided.

Aspartate Β-Hydroxylase Expession Promotes A Malignant Pancreatic Cellular Phenotype, Xiaoqun Dong, Qiushi Lin, Arihiro Aihara, Gregory Gabriel

Faculty Articles

Pancreatic cancer (PC) is one of the leading causes of cancer related deaths due to aggressive progression and metastatic spread. Aspartate β-hydroxylase (ASPH), a cell surface protein that catalyzes the hydroxylation of epidermal growth factor (EGF)-like repeats in Notch receptors and ligands, is highly overexpressed in PC. ASPH upregulation confers a malignant phenotype characterized by enhanced cell proliferation, migration, invasion and colony formation in vitro as well as PC tumor growth in vivo. The transforming properties of ASPH depend on enzymatic activity. ASPH links PC growth factor signaling cascades to Notch activation. A small molecule inhibitor of β-hydroxylase activity was …

Aspartate Β-Hydroxylase Expression Promotes A Malignant Pancreatic Cellular Phenotype, Xiaoqun Dong, Qiushi Lin, Arihiro Aihara, Yu Li, Chiung-Kuei Huang, Waihong Chung, Qi Tang, Xuesong Chen, Rolf Carlson, Christina Nadolny, Gregory Gabriel, Mark Olsen, Jack Wands

Biomedical and Pharmaceutical Sciences Faculty Publications

Pancreatic cancer (PC) is one of the leading causes of cancer related deaths due to aggressive progression and metastatic spread. Aspartate β-hydroxylase (ASPH), a cell surface protein that catalyzes the hydroxylation of epidermal growth factor (EGF)-like repeats in Notch receptors and ligands, is highly overexpressed in PC. ASPH upregulation confers a malignant phenotype characterized by enhanced cell proliferation, migration, invasion and colony formation in vitro as well as PC tumor growth in vivo. The transforming properties of ASPH depend on enzymatic activity. ASPH links PC growth factor signaling cascades to Notch activation. A small molecule inhibitor of β-hydroxylase activity …

November 26, 2014 Cal Poly Report, Public Affairs Office

Cal Poly Report

No abstract provided.

The Role Of Second-Year College Students' Mindset On Finances And Its Impact On Welness, Susan Koukounas, Steven B. Jubert Jr., Cheryl A. Howell, Elsa-Sofia Morote, Albert Inserra

New York Journal of Student Affairs

This study examined the differentiation among second-year college students from a small urban religious affiliated college in New York City and their four beliefs about household money on five constructs of wellness. Ninety-two participants completed the “TestWell: Wellness Inventory-College Edition” questionnaire. Discriminant analysis evaluated the differences among groups. It was found that students who believed they have plenty of money revealed higher scores for emotional awareness and physical fitness. Student services on college campuses may use this research to offer student financial planning to support and set short and long term budgeting goals that increase retention rates.

Culture In Crisis: The English Novel In The Late Twentieth Century, Michael F. Harper

Scripps Faculty Books

Culture in Crisis begins with political and social history at the moment of the election of Margaret Thatcher. Many saw in this event the dissolution of the ideal of the liberal State once believed to be shared by both the Left and the Right. Ranging widely over such writers as Anthony Powell, John LeCarre, Samuel Selvon, Salman Rushdie, and Margaret Drabble, Harper examines various responses to this “crisis” which he shows to have roots in a pernicious ideal of “Englishness” going back many generations. With considerable skill and a masterful grasp of books and ideas, he presents the novel as …

The Anchor, Volume 128.12: November 26, 2014, Hope College

The Anchor: 2014

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

P-I-N Heterojunctions With Bifeo3 Perovskite Nanoparticles And P- And N-Type Oxides: Photovoltaic Properties., Soumyo Chatterjee, Abhijit Bera, Amlan J Pal

Medical Biophysics Publications

We formed p-i-n heterojunctions based on a thin film of BiFeO3 nanoparticles. The perovskite acting as an intrinsic semiconductor was sandwiched between a p-type and an n-type oxide semiconductor as hole- and electron-collecting layer, respectively, making the heterojunction act as an all-inorganic oxide p-i-n device. We have characterized the perovskite and carrier collecting materials, such as NiO and MoO3 nanoparticles as p-type materials and ZnO nanoparticles as the n-type material, with scanning tunneling spectroscopy; from the spectrum of the density of states, we could locate the band edges to infer the nature of the active semiconductor materials. The energy level …

Norc Researchers Find Behavioral Response To Health Interventions Leads To Less Weight Change Than Often Predicted, Jim Bakken

Browse All News

No abstract provided.

2014-11-26-Ross-Sheehy’S Research Garners Gates Foundation Gce Grant, University Marketing And Communications, East Tennessee State University

Accent [newsletter]

No abstract provided.

2014-11-26-Roan Scholar Alumnus Participating In Solar Decathlon Europe 2014, University Marketing And Communications, East Tennessee State University

Accent [newsletter]

No abstract provided.

2014-11-26-Barton, Haslam To Speak At Commencement, University Marketing And Communications, East Tennessee State University

Accent [newsletter]

No abstract provided.

Saying Thanks Isn’T Always Simple, Melody Bowdon

UCF Forum

Tomorrow is Thanksgiving, and people all over the country will gather around tables with loved ones to express thanks for time together, getting through another year, and green bean casserole.

Microbial Diversity In A Venezuelan Orthoquartzite Cave Is Dominated By The Chloroflexi (Class Ktedonobacterales) And Thaumarchaeota Group I.1c, Hazel A. Barton, Juan G. Giarrizzo, Paula Suarez

KIP Articles

The majority of caves are formed within limestone rock and hence our understanding of cave microbiology comes from carbonate-buffered systems. In this paper, we describe the microbial diversity of Roraima Sur Cave (RSC), an orthoquartzite (SiO4) cave within Roraima Tepui, Venezuela. The cave contains a high level of microbial activity when compared with other cave systems, as determined by an ATP-based luminescence assay and cell counting. Molecular phylogenetic analysis of microbial diversity within the cave demonstrates the dominance of Actinomycetales and Alphaproteobacteria in endolithic bacterial communities close to the entrance, while communities from deeper in the cave are dominated (82–84%) …

Today - November 26, 2014, Loma Linda University Health

TODAY

Inside this issue:

-- Nichole Nordeman headlines ThankSharing Concert and Food Drive held in Redlands
-- Loma Linda University receives national grant to train entry-level health care workers
-- Reunion celebrates School of Dentistry's five years of successful PNAM-augmented cleft lip and palate repairs
-- 'Hiring blitz' brings 128 nurses on board
-- Grateful mother and March of Dimes volunteer thanks LLUMC
-- Pedestrian bridge over Campus Street opens
-- LLU dental hygiene students run Relay for Life
-- Annual colloquium trains faculty to enhance learning
-- Last flight of the big gray owl disrupts Southwestern adventure for Global Health …

Volume 52, Number 15: November 26, 2014, University Of North Dakota

University Letter Archive

No abstract provided.

Unraveling Cultural Knots: Exploring Narratives Of Intercultural Marriages Between Mexicans And Americans, Adrianna Renata Valenzuela

Theses and Dissertations

Narratives function to help us make decisions about what we do in our lives and in the lives of others. This study focuses on the intercultural marriages of three women who share Mexican and American cultures. Being a wife of a native Mexican, I proceed to examine the stories of how these three women were able to preserve or merge their cultural identity in the marriage and how they coped with the differences based on the following themes: culture, religion, and traditions. I composed three narratives based on the experiences of these women and incorporated an analysis of my findings …

Dove V. Parham: Desegregation In The Dollarway School District, Kevin Sinclair

Theses and Dissertations

This study examines the Dove v. Parham school desegregation case that was heard on December 16, 1959, in the United States District Court, Eastern District of Arkansas, Western Division with Judge J. Smith Henley presiding. Attorney George Howard Jr. had brought forth the lawsuit on behalf of three African American students who were denied transfer to the all-white Dollarway School District. The tactic of massive resistance had failed to stop any integration attempts in the state and was replaced by minimal compliance. The Dollarway School District chose to use pupil placement laws to avoid integration. By using transcripts from the …

Reflective Assessment: Using Reflection And Portfolios To Assess Student Learning In A Writing Center, Kelsie Hope Walker

Theses and Dissertations

As writing centers continue to petition for status, funding, and authority on university and college campuses, writing center research and assessment practices continue to evolve. Within the last 10 years, writing center administrators have turned to assessing the writing center based on student learning outcomes (SLOs). This research summarizes the assessment history of writing centers and then proposes a pilot study that uses portfolios and reflection as a way to assess student learning in a writing center on a metropolitan, four-year university campus. This research also discusses the pilot study in terms of future research and implications.

Factors Impacting Information Security Noncompliance When Completing Job Tasks, Martha Nanette Harrell

CCAC Theses and Dissertations

Work systems are comprised of the technical and social systems that should harmoniously work together to ensure a successful attainment of organizational goals and objectives. Information security controls are often designed to protect the information system and seldom consider the work system design. Using a positivist case study, this research examines the user's perception of having to choose between completing job tasks or remaining compliant with information security controls. An understanding of this phenomenon can help mitigate the risk associated with an information system security user's choice. Most previous research fails to consider the work system perspective on this issue. …

2014-November-26-Two Etsu Faculty Members Co-Author Book Chapter On Depression, Suicide, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Lifespan-Extending Caloric Restriction Or Mtor Inhibition Impair Adaptive Immunity Of Old Mice By Distinct Mechanisms, Emily L. Goldberg, Melissa J. Romero-Aleshire, Kristin R. Renkema, Melissa S. Ventevogel, Wade M. Chew, Jennifer L. Uhrlaub, Megan J. Smithey, Kirsten H. Limesand, Gregory D. Sempowski, Heddwen L. Brooks, Janko Nikolich-Zugich

Peer Reviewed Articles

Aging of the world population and a concomitant increase in age-related diseases and disabilities mandates the search for strategies to increase healthspan, the length of time an individual lives healthy and productively. Due to the age-related decline of the immune system, infectious diseases remain among the top 5–10 causes of mortality and morbidity in the elderly, and improving immune function during aging remains an important aspect of healthspan extension. Calorie restriction (CR) and more recently rapamycin (rapa) feeding have both been used to extend lifespan in mice. Preciously few studies have actually investigated the impact of each of these interventions …

2014-November-26-Dr. Alison Barton, Gov. Bill Haslam To Speak At Etsu Fall Commencement, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Structure-Based Network Analysis Of Activation Mechanisms In The Erbb Family Of Receptor Tyrosine Kinases: The Regulatory Spine Residues Are Global Mediators Of Structural Stability And Allosteric Interactions, Kevin A. James, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

The ErbB protein tyrosine kinases are among the most important cell signaling families and mutation-induced modulation of their activity is associated with diverse functions in biological networks and human disease. We have combined molecular dynamics simulations of the ErbB kinases with the protein structure network modeling to characterize the reorganization of the residue interaction networks during conformational equilibrium changes in the normal and oncogenic forms. Structural stability and network analyses have identified local communities integrated around high centrality sites that correspond to the regulatory spine residues. This analysis has provided a quantitative insight to the mechanism of mutation-induced ‘‘superacceptor’’ activity …

An Integrated Transcriptome And Expressed Variant Analysis Of Sepsis Survival And Death., Ephraim L. Tsalik, Raymond J. Langley, Darrell L. Dinwiddie, Neil A. Miller, Byunggil Yoo, Jennifer C. Van Velkinburgh, Laurie D. Smith, Isabella Thiffault, Anja K. Jaehne, Ashlee M. Valente, Ricardo Henao, Xin Yuan, Seth W. Glickman, Brandon J. Rice, Micah T. Mcclain, Lawrence Carin, G Ralph Corey, Geoffrey S S. Ginsburg, Charles B. Cairns, Ronny M. Otero, Vance G. Fowler, Emanuel P. Rivers, Christopher W. Woods, Stephen F. Kingsmore

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor outcomes, though current clinical characterizations fail to identify those at greatest risk of progression and mortality.

METHODS: The Community Acquired Pneumonia and Sepsis Outcome Diagnostic study enrolled 1,152 subjects with suspected sepsis. We sequenced peripheral blood RNA of 129 representative subjects with systemic inflammatory response syndrome (SIRS) or sepsis (SIRS due to infection), including 78 sepsis survivors and 28 sepsis non-survivors who had previously undergone plasma proteomic and metabolomic profiling. Gene …

Leo P. Mclaughlin: Undisputed Boss Of Hot Springs, John H. Jones

Theses and Dissertations

This project involves exploring the life of Leo Patrick McLaughlin, especially his time as mayor of Hot Springs, by web exhibit, http://leopmclaughlin.omeka.net/exhibits/show/leo-patrick-mclaughlin--the-un. The goal is to inform readers of this colorful character in Arkansas history. This has been achieved by examining the gambling syndicate and political machine that McLaughlin created, as well as his connections with underworld figures such as Al Capone, Bugs Moran, and other criminals on the Most Wanted list. Upon examination of these connections, it will become clear to readers that Mayor McLaughlin began to think himself untouchable, demonstrated by his attempts to take on Governor Carl …