Digital Commons Network^™

Focusing On Drug Versus Disease Mechanisms And On Clinical Subgrouping To Advance Personalised Medicine In Psychiatry, Jose De Leon

Psychiatry Faculty Publications

Personalised medicine has finally been featured in psychiatric journals, but psychiatrists have mainly focused on the promise of using disease mechanisms to personalise treatment. Psychiatric disorders such as schizophrenia and depression are not diseases, in the medical sense, and are probably more like syndromes. Instead of spending much time and effort focusing on the mechanisms of diseases that may instead be syndromes, the author believes that psychiatrists should (1) learn more about personalising prescription via drug mechanisms, a pharmacological approach to personalised medicine; and (2) reconsider prior attempts by traditional clinical psychopharmacologists to use sophisticated clinical approaches that try to …

On The Symbolism Of The White Coat, David A. Nash

Oral Health Science Faculty Publications

The white coat ceremony has become an academic ritual in the health professions: a ceremony that signals a transformation of status from ordinary student to that of one studying to become a health professional. While donning the white coat is a sign of a changed role, the white coat is also a powerful symbol of transformation. White is a symbol of purity, and the white coat symbolizes the purity of purpose being affirmed in becoming a health professional. Dentistry is afforded the status of a learned profession as a result of the power dentists possess over patients seeking care; this …

Brief For The National Black Law Students Association As Amicus Curiae In Support Of Respondent, Deborah N. Archer, Erika L. Wood, New York Law School Racial Justice Project, Impact Center For Public Interest Law

Briefs, Court Filings, and Testimonies

December 2014

The National Black Law Students Association (NBLSA), submits this brief as amicus curiae in support of Respondents, urging this Court to affirm the ruling of the United States Court of Appeals for the Fifth Circuit upholding the recognition of disparate impact claims under the Fair Housing Act.1 NBLSA is a membership organization formed in 1968 to promote the educational, professional, political, and social objectives of Black law students. Today, NBLSA is the largest student-­run organization in the United States, with nearly 6,000 members, over 200 chapters in our nation's law schools, a growing pre-­law division, and six international …

A Holistic Look At Agency Enforcement, David L. Markell, Robert L. Glicksman

North Carolina Law Review

No abstract provided.

First Choice, December 2014, Wusf Public Media

First Choice Monthly Newsletter

The December 2014 issue of WUSF's newsletter "First Choice."

Retrotransposon-Based Profiling Of Mammalian Epigenomes: Dna Methylation Of Iap Ltrs In Embryonic Stem, Somatic And Cancer Cells, Arundhati Bakshi, Joomyeong Kim

Faculty Publications

© 2014 Elsevier Inc. In the current study, we have used HT-TREBS to individually analyze the DNA methylation pattern of 4799 IAP LTR retrotransposons in embryonic stem, somatic and Neuro2A cells. According to the results, half of the loci within this family show constant methylation patterns between the three cell types whereas the remaining half display variable levels of methylation. About half of the variably methylated IAP LTRs tend to be hypomethylated in ES cells, and nearly all in this group are hypomethylated in Neuro2A cells. The observed hypomethylation in both cell types occur in a non-uniform, locus-specific manner and …

The Collegian (2014-12-01), Cleiri Quezada

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 67, No. 14

Aret: A Novel Regulator Of Alternative Splicing In The Flight Muscle Transcripts In Drosophila Melanogaster, Sandy Thi Oas

Biology ETDs

Drosophila melanogaster has been used as a model organism for understanding muscle development. Drosophila flight and jump muscles are distinct functionally and biochemically. This distinction is due to differentially expressed genes and differentially spliced mRNA transcripts. The exact mechanism of alternative splicing in somatic muscles is not well characterized. Aret was previously shown to be a transcriptional repressor, and has been implicated in splicing regulation based upon literature analysis and preliminary work. This study aims to define the regulatory role of Aret and the impact of alternative splicing on determining muscle diversification and fiber choice. We indicate the importance of …

A Librarian As A Managing Editor, Erin E. Rushton

Library Scholarship

Four years ago, Binghamton University Libraries was presented with an unique proposal. The School of Nursing was planning to take ownership of the OA journal,Online Journal of Rural Nursing and Health Care, and the new editor asked if the Libraries would assist with the editorial and managerial process. Erin Rushton, Web Services and Nursing Librarian, was named Managing Editor. She helps support the publishing system and prepares the pdfs for publication. She also ensures the journal is indexed and preserved in the Libraries’ preservation system. Many research libraries support alternative publication models through membership and through scholarly communications …

Physicocehmical Properties And Pre-Exposure Processes Govern Gold Nanoparticle Accumulation In Freshwater Species, Austin Thomas Wray

All Dissertations

Monitoring the distribution and subsequent effects of nanoparticle (NP) contaminants in aquatic ecosystems will be pivotal to developing regulations that minimize their environmental footprint. Regulators are in a unique position to take a proactive role in shaping how we produce and consume nanomaterials as opposed to the reactive role they have had to adopt with other contaminants. Over the last few decades, researchers have made great strides in describing the fate, behavior, and toxicity of NPs in environmental systems. Recent initiatives have made the transition to scenarios with greater environmental relevance, yet important aspects of fate and behavior remain unexplored. …

American "Declinism": A Review Of Recent Literature, Michael Daniels

The US Army War College Quarterly: Parameters

No abstract provided.

Basic And Computation Of Rebased Gross Domestic Product (Gdp) Nigeria's Experience, Emeka Godwin Ofili

Bullion

The paper looks at the basic concepts in GDP compilation and the computational processes for the rebased GDP. The paper is structured into four sections. The first section deals with the introduction while section two explains some basic concepts and mathematics for GDP compilation. Section three takes a look at the GDP Rebasing while section four deals with the Recent Development from the rebasing exercise.

The Scoop, Vol. 1 Issue 9, December 2014, Health Sciences Library

Volume 1

Latest news and events from the Health Sciences Library in our monthly newsletter for December 2014.

Long-Acting Antituberculous Therapeutic Nanoparticles Target Macrophage Endosomes., Benson J. Edagwa, Dongwei Guo, Pavan Puligujja, Han Chen, Joellyn Mcmillan, Xinming Liu, Howard Gendelman, Prabagaran Narayanasamy

Journal Articles: Pharmacology & Experimental Neuroscience

Eradication of Mycobacterium tuberculosis (MTB) infection requires daily administration of combinations of rifampin (RIF), isoniazid [isonicotinylhydrazine (INH)], pyrazinamide, and ethambutol, among other drug therapies. To facilitate and optimize MTB therapeutic selections, a mononuclear phagocyte (MP; monocyte, macrophage, and dendritic cell)-targeted drug delivery strategy was developed. Long-acting nanoformulations of RIF and an INH derivative, pentenyl-INH (INHP), were prepared, and their physicochemical properties were evaluated. This included the evaluation of MP particle uptake and retention, cell viability, and antimicrobial efficacy. Drug levels reached 6 μg/10(6) cells in human monocyte-derived macrophages (MDMs) for nanoparticle treatments compared with 0.1 μg/10(6) cells for native drugs. …

Intellectual Origins Of (Modern) Substantive Due Process, The, Joshua D. Hawley

Faculty Publications

Almost fifty years after the Supreme Court revived the doctrine, substantive due process remains a puzzle. Detractors insist it is nothing more than judicial policy making. Defenders say it accords with the deepest values of the Constitution. But on all sides, the present scholarly debate suffers from an impoverished understanding of modern substantive due process's intellectual history, which has led to an impoverished understanding of the doctrine's core normative content. It is time for a revisionist turn. This Article supplies that turn by excavating the intellectual origins of modern substantive due process and relating that history to the doctrine's development. …

A Novel Method For Simulating Insulin Mediated Glut4 Translocation, Andrew Jezewski, Joshua Larson, Beata Wysocki, Paul H. Davis, Tadeusz Wysocki

Biology Faculty Publications

Glucose transport in humans is a vital process which is tightly regulated by the endocrine system. Specifically, the insulin hormone triggers a cascade of intracellular signals in target cells mediating the uptake of glucose. Insulin signaling triggers cellular relocalization of the glucose transporter protein GLUT4 to the cell surface, which is primarily responsible for regulated glucose import. Pathology associated with the disruption of this pathway can lead to metabolic disorders, such as type II diabetes mellitus, characterized by the failure of cells to appropriately uptake glucose from the blood. We describe a novel simulation tool of the insulin intracellular response, …

A Qualitative Study Evaluating Bedside Reporting And The Impact On Nurse Satisfaction And Communication Barriers With Washington Regional Medical Center, Win Szeto, Sarah Wren, Molly Milborn

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Nursing care occurs on a continuum that involves transferring the responsibility of a patient’s care from one nurse to another during shift change. Hand-off reports are a vital part of the communication cycle to ensure safe and effective care. Studies have shown bedside reporting increases patient and nurse satisfaction as well as the nurse-patient relationship (Agency for Healthcare Research and Quality, 2013b). The aim of this study was to educate nurses on the importance of bedside reporting and to implement a standardized hand-off. This study was evaluated through two measures. The first measure involved a survey/interview on nurses' perception before …

Recycling Wastewater For Hydraulic Fracturing By Use Of Nanofiltration Membranes, Haley D. Cleous

Chemical Engineering Undergraduate Honors Theses

Hydraulic fracturing creates large volumes of produced water, contaminated with organics, suspended solids, and dissolved minerals. This water must either be disposed of in injection wells or treated for reuse. One option is to use a combination of ultrafiltration and nanofiltration to treat this water and reuse it in future hydraulic fracturing wells. The object of this study was to test and characterize commercial nanofiltration membranes. The work done for this project will lead to future work in modifying membranes to improve the rejection of desired components.

Data Sources Regarding The Nonmedical Use Of Pharmaceutical Opioids In The United States, Teresa D. Schmidt, Amanuel Zimam, Alexandra Nielsen, Wayne Wakeland

Complex Systems Faculty Publications and Presentations

Objective—Recent increases in the nonmedical use of pharmaceutical opioids and the adverse outcomes associated with them have stimulated a large amount of research and data collection on this public health problem. Systematic organization of the available data sources is needed to facilitate ongoing research, analysis, and evaluation. This work offers a systematic categorization of data sources regarding the nonmedical use of pharmaceutical opioids in the United States.

Methods—A list of keywords regarding the nonmedical use of pharmaceutical opioids was used to conduct systematic searches in PubMed®. Filtration of search results generated 92 peer-reviewed academic articles, published between January 1995 and …

Faculty Senate Monthly Packet December 2014, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The December 2014 Monthly packet includes the December agenda and appendices and the Faculty Senate minutes and attachments from the meeting held November 3, 2014.

Economic And Emissions Impacts Of A Clean Air Tax Or Fee In Oregon (Sb306), Jenny H. Liu, Jeff Renfro, Christopher Butenhoff, Mike Paruszkiewicz

Northwest Economic Research Center Publications and Reports

Analysis on how a carbon pricing policy would affect different Oregon industry sectors and regions.

Named Entity Recognition In Chinese Clinical Text, Jianbo Lei

Dissertations and Theses (Open Access)

Objective: Named entity recognition (NER) is one of the fundamental tasks in natural language processing (NLP). In the medical domain, there have been a number of studies on NER in English clinical notes; however, very limited NER research has been done on clinical notes written in Chinese. The goal of this study is to develop corpora, methods, and systems for NER in Chinese clinical text.

Materials and methods: To study entities in Chinese clinical text, we started with building annotated clinical corpora in Chinese. We developed an NER annotation guideline in Chinese by extending the one used in the 2010 …

Focusing On The Negative: Cultural Differences In Expressions Of Sympathy, Birgit Koopmann-Holm, Jeanne L. Tsai

Psychology

Feeling concern about the suffering of others is considered a basic human response, and yet we know surprisingly little about the cultural factors that shape how people respond to the suffering of another person. To this end, we conducted 4 studies that tested the hypothesis that American expressions of sympathy focus on the negative less and positive more than German expressions of sympathy, in part because Americans want to avoid negative states more than Germans do. In Study 1, we demonstrate that American sympathy cards contain less negative and more positive content than German sympathy cards. In Study 2, we …

Saturated Free Fatty Acids Induce Cholangiocyte Lipoapoptosis, Sathish Kumar Natarajan, Sally A. Ingham, Ashley M. Mohr, Cody J. Wehrkamp, Anuttoma Ray, Sohini Roy, Sophie C. Cazanave, Mary A. Smith, Justin L. Mott

Journal Articles: Biochemistry & Molecular Biology

Recent studies have identified a cholestatic variant of nonalcoholic fatty liver disease (NAFLD) with portal inflammation and ductular reaction. Based on reports of biliary damage, as well as increased circulating free fatty acids (FFAs) in NAFLD, we hypothesized the involvement of cholangiocyte lipoapoptosis as a mechanism of cellular injury. Here, we demonstrate that the saturated FFAs palmitate and stearate induced robust and rapid cell death in cholangiocytes. Palmitate and stearate induced cholangiocyte lipoapoptosis in a concentration-dependent manner in multiple cholangiocyte-derived cell lines. The mechanism of lipoapoptosis relied on the activation of caspase 3/7 activity. There was also a significant up-regulation …

Study On Teacher Absenteeism In Indonesia 2014, Phillip Mckenzie, Dita Nugroho, Clare Ozolins, Julie Mcmillan, Sudarno Sumarto, Nina Toyamah, Vita Febriany, R Justin Sodo, Luhur Bima, Armand Arief Sim

Shaping educational policy

The Study on Teacher Absenteeism is a large-scale research project for the Republic of Indonesia Education Sector Analytical and Capacity Development Partnership (ACDP).The key objective of the study is to provide reliable, valid, nationally representative, and up-to-date information on the rates and determinants of teacher absenteeism in Indonesian primary and junior secondary schools. In addition, the study examines how schools are dealing with teacher absence and assesses the impact of teacher absenteeism on students. Finally, policies and programs already in place are analysed in order to ascertain the extent they are related to teacher attendance in schools and classrooms and …

Check Up, Lehigh Valley Health Network

Checkup

No abstract provided.

Foia Vs. Ferpa/Scalia Vs. Posner, Kristin Knotts

Southern Illinois University Law Journal

Two different Illinois newspapers have sued the University of Illinois-Springfield (UIS) and the University of Illinois at Urbana-Champaign (UIUC) for the release of documents pursuant to Illinois’ Freedom of Information Act (FOIA).  These cases present somewhat new, interesting, and developing problems in the law, including, but not limited to:  the public’s right to information, student privacy rights, and whether a federal law like the Federal Education Rights and Privacy Act (FERPA) can override any state’s FOIA.  If the universities are forced to violate FERPA, or if the newspapers appeal a negative decision and file for certiorari, their cases could end …

Review Of Methods To Assign The Nuclear Magnetic Resonance Peaks Of Reductively Methylated Proteins, Kevin J. Roberson, Megan A. Macnaughtan

Faculty Publications

© 2014 Elsevier Inc. Reductive methylation of lysyl side-chain amines has been a successful tool in the advancement of high-resolution structural biology. The utility of this method has continuously gained ground as a protein chemical modification, first as a tool to aid protein crystallization and later as a probe in protein nuclear magnetic resonance (NMR) spectroscopy. As an isotope-labeling strategy for NMR studies, reductive methylation has contributed to the study of protein-protein interactions and global conformational changes. Although more detailed structural studies using this labeling strategy are possible, the hurdle of assigning the NMR peaks to the corresponding reductively methylated …

Neurocognitive Underpinnings Of Language Disorder: Contrasting Schizophrenia And Mood Disorders, Alex S. Cohen, Tracey Auster, Dallas Callaway, Rebecca K. Macaulay, Kyle S. Minor

Faculty Publications

Language disorder is a deleterious, but poorly understood, symptom of schizophrenia. Burgeoning research suggests that it also occurs in depression and bipolar disorders. Building on prior research, the present study evaluated the degree to which language disorder was associated with neurocognitive deficits in a sample of patients with schizophrenia and mood disorders. Employed in this study were a standard neurocognitive battery and a behavior-based analysis of language disorder from natural speech. Speech samples were collected from two separate counterbalanced conditions administered a week apart. During an “activity” speech condition, participants discussed their daily activities, hobbies and interests. During a “social” …

Americanized Catholicism? A Response To Thomas Schärtl, Dennis M. Doyle

Theology and Religious Studies Faculty Publications

I stand in fundamental agreement with what Thomas Schärtl has said in his article describing recent trends in US Catholicism. I am a lifelong Catholic and a lifelong Democrat. I felt personally distressed and discouraged by the support given to Mitt Romney and the Republicans by some leading US Catholic bishops. Most of this support may have technically passed the legal test of being nonpartisan, but undeniably it functioned in a partisan manner, as did the attacks launched on President Obama in the midst of a campaign to defend religious liberty. Schärtl’s analysis of these trends as reflecting marketing strategies …