Digital Commons Network^™

The Role Of Stem Cells In Adipose Tissue Remodeling., Candice Reshay Holden 1988-

Electronic Theses and Dissertations

The work presented in this dissertation outlines the role of stem cells in the remodeling of adipose tissue under conditions of nutrient excess. Obesity-induced variations in adipose tissue stem cell distribution were uncovered by analysis of the stromal vascular fraction isolated from mice fed a high fat diet for several weeks. Bone marrow cell transplantation was used to determine the derivation of progenitor cells found in adipose tissue; and supplementation of depleted progenitor cell populations achieved via direct cell transplantation, helped to determine the contribution of these progenitor cells to the remodeling process. The dissertation is presented in five chapters …

Boundary Contour Based Surface Representation., Yong Su

Electronic Theses and Dissertations

We receive most information about our surrounding space and objects through the eyes. To reconstruct the 3D space and objects in the visual system from the 2D retinal images, surface representation must be a critical intermediate stage in the visual processing stream. It is hypothesized in the dissertation that the visual system represents textured surface by a border-to-interior strategy: boundary contours would be encoded first and then border-ownership assignments would be resolved. This process would solve the related problems such as figure-ground segregation, surface depth relationship, occlusion, transparency, etc. As a result, the boundary contours of the surfaces would be …

Development Of A Thin-Film Porous-Microelectrode Array (P-Mea) For Electrical Stimulation Of Engineered Cardiac Tissue., Hiren Vrajlal Trada 1977-

Electronic Theses and Dissertations

Electrical stimulation has been increasingly used by research groups to enhance and increase maturation of cells in an engineered cardiac tissue (ECT). Current methods are based on using off-the-shelf wires or electrodes to deliver a stimulus voltage to the in-vitro tissue in culture medium. A major issue with this approach is the generation of byproducts in the medium due to the voltage levels required, which are typically in the range of 5V-10V. No solution currently exists that can accomplish electrical stimulation of cells in an ECT at a low voltage level. Therefore, in this study a novel, porous, thinfilm, microelectrode …

Project Management And Its Relation To Long-Term Project Success : An Empirically Based Theoretical Framework., Youssef Ait Boudlal 1969-

Electronic Theses and Dissertations

Companies implement effective project management to successfully operate in turbulent market cycles and ensure the success of their endeavors. Project management is indispensable for most industrial sectors and is employed in a variety of for-profit and non-profit organizations. It can be considered as a management method that contributes value to a variety of organizations. Many practitioners and researchers have attempted to identify the causes of project failure, the factors of project success, and the criteria to gauge this success. There has been little agreement on what constitutes project success. In response to the widespread debate surrounding project success, several lists …

Predictors Of Lifestyle Behaviors, Trust Of Health Care Provider, And Utilization Of Health Services Among Adolescents Living In A Rural Area., Heather Karolyne Hardin

Electronic Theses and Dissertations

Background: Adolescents have elevated morbidity and mortality rates associated with risk-taking behaviors, but utilize health services at low levels. There is little evidence concerning health behavior, trust of health care provider, or utilization of health services among adolescents living in rural areas. Purpose: The purpose of this study was to examine individual characteristic variables and determine the extent to which these variables influence lifestyle behaviors, trust of health care provider (HCP), and utilization of health services among adolescents attending public high school in rural Indiana. Methods: This study used a cross-sectional, quantitative design. Instruments used in this study were …

The Effect Of Spinal Cord Injury On Vagal Afferents., April N. Herrity

Electronic Theses and Dissertations

Spinal cord injury (SCI) is a significant public health concern that leaves patients with a multitude of life-long disabilities. Major complications of SCI apart from paralysis, include deficits in bladder and bowel function. Lower urinary tract dysfunction continues to remain a top priority issue affecting quality of life for this population. The majority of visceral organs receive a dual sensory innervation from both spinal nerves as well as the vagus nerve. Following SCI, the vagus nerve is a potential pathway through which information from regions below the level of a spinal injury can travel directly to the brainstem, bypassing the …

Signaling Mechanisms In Regenerative Myogenesis., Sajedah M. Hindi 1986-

Electronic Theses and Dissertations

Skeletal muscle constitutes a highly plastic and malleable tissue that rapidly and profoundly adapts to various environmental and physiological stimuli. This response takes place by means of regulated signaling transduction which elicits changes in gene expression, biochemical, and metabolic properties. Adult muscle is composed by alignment of multinucleated, post mitotic muscle fibers formed during embryonic and neonatal development. Residing in the niche of mature muscle fibers is a small population of undifferentiated muscle progenitors termed satellite cells. Satellite cells are muscle stem cells that carry out regenerative response in adult myofibers. Coordinated signaling emitting from terminally differentiated muscle fibers and …

An Evaluation Of A Brief, Theatre-Based Intervention For The Prevention Of Adolescent Cyberbulllying And Suicide., Kathryn Laurel Hopkins

Electronic Theses and Dissertations

Quality program evaluation investigates both the process and the outcomes of an intervention in order to accurately determine its effectiveness and impact. In the present study, the effectiveness of CHOICES, a brief, applied-theatre intervention that addresses cyberbullying and suicide was evaluated. The fidelity of implementation of the intervention was assessed to determine whether the delivery of CHOICES was consistent with the original goals of the program, as well as consistent across multiple deliveries. Investigation of the fidelity of implementation revealed that CHOICES was not implemented with high levels of fidelity. The study also determined whether exposure to CHOICES led to …

Evaluating The Effectiveness And Hydrological Performance Of Green Infrastructure Stormwater Control Measures., Hamidreza Kazemi

Electronic Theses and Dissertations

The Louisville and Jefferson County Metropolitan Sewer District (MSD) has developed a Long-Term Control Plan (LTCP) to address the combined sewer overflow (CSO) issue through a combination of gray and green infrastructure (GI) stormwater management practices in the city of Louisville. In support of this effort, the MSD installed a series of GI stormwater control measures (SCMs) to abate the CSO volumes in an urban sewershed basin. This research is focused on monitoring and evaluating the individual hydrological performance, which included infiltration and exfiltration processes, of two permeable pavement systems over a two year study period. It also assess the …

Post-Transcriptional Regulation Of The Type Iia Sodium-Phosphate Cotransporter By Parathyroid Hormone., Rebecca Dale Murray

Electronic Theses and Dissertations

The type IIa sodium-phosphate cotransporter (Npt2a) is expressed in the apical membrane of the renal proximal tubule and is responsible for the reabsorption of the majority of the filtered load of phosphate. Parathyroid hormone (PTH) is secreted by the parathyroid gland in response to a decrease in serum calcium or an increase in serum phosphorus, and acutely induces phosphaturia through the rapid stimulation of endocytosis of Npt2a and its subsequent lysosomal degradation. Chronic PTH stimulation leads to sustained phosphaturia, but the mechanisms for the chronic regulation of Npt2a by PTH remain unclear. We hypothesize that PTH decreases Npt2a mRNA levels …

An Examination Of The Relationship Between Sense Of Coherence, Engagement In Health Behaviors, And Individual Coping Style., Dean Todd Misener 1973-

Electronic Theses and Dissertations

Stress is a pervasive issue among traditional college students; affecting their choice in health behaviors, and overall academic performance. What is not clear is why some students, despite the pervasiveness of stressors are able to do well in school and maintain/improve their health, while other students struggle to maintain their health and do poorly in school. Aaron Antonovsky theorized that when confronted with a stressor a person with a high sense of coherence (SOC) will be motivated to cope, believe the challenge is understood and that the necessary resources to cope with the stressor are available. Overall, Antonovsky theorized that …

Aminooxy Reagents In Nanomedicine And Bioanalysis., Stephanie Mattingly

Electronic Theses and Dissertations

The development of nanomaterials as medical diagnostic and therapeutic agents is a rapidly expanding field. A brief search of the literature revealed that roughly half of all articles related to nanoparticle-based drug delivery were published after the onset of this thesis research, over the past 4 years. A few nano-based formulations have entered into clinical use, including liposomal drug formulations, protein-linked drugs, and nanoparticle-based MRI contrast agents. The chemistry that enables conjugation of a functional cargo, whether a drug, a targeting element, or a radionucleotide, to a nanocarrier is thus a critical component for development. Oximation is one of the …

A Discourse On Entrepreneurial Identity : Three Essays., Krishna P. Poudel

Electronic Theses and Dissertations

My dissertation provides theoretical insights on individual level entrepreneurial identity in three inter-related essays, drawing on multiple theories and disciplines. In the first essay, I advance a dual-process model of identity development, contributing to the debates in the broad identity literature. I articulate that the intrinsic prospection of identity is another fundamental process of identity formation, besides the social construction of identity, the prevalent notion in the literature. I propose a comprehensive conceptual framework of entrepreneurial identity. On the basis of this conceptual framework, I explain that there are within-group and between-group variations in the entrepreneurial identity of different types …

Extracellular Matrix Proteins And The Liver-Lung Axis In Disease., Veronica L. Massey

Electronic Theses and Dissertations

No abstract provided.

Effects Of Step Training On The Kidneys Following Spinal Cord Injury In Rats., Pradeepa Poudyal

Electronic Theses and Dissertations

Detrusor-sphincter dyssynergia after chronic spinal cord injury (SCI) leads to over-distention, high bladder pressures and vesico-ureteric reflux into the kidney, resulting in repeated infections and pyelonephritis. Given the importance/limited knowledge of SCI effects on the upper urinary tract, this study assessed expression of two proteins in the kidneys of contused (T9) male rats relative to controls that are indicative of tissue stress/damage (TGFβ, CD11b). The impact of two therapeutic rehabilitation strategies, 60 minutes of step training and general exercise, was then assessed on these protein levels relative to non-trained SCI controls, plus the effectiveness of a shorter training duration (30 …

The Effect Of A Controlled Frequency Breath Holding Training Program On Running Economy Among Elite College Swimmers., Patrick Sims 1988-

Electronic Theses and Dissertations

Running economy (RE) is the amount of oxygen consumed while running at a submaximal intensity. Along with aerobic capacity (VO2max), RE is an important predictor of running performance. Little research has investigated changes in RE with restricted breathing training [i.e. controlled breath-holding (CFB)] during exercise. RE may improve ~6% amongst a novice swimming cohort through CFB training, but this has not been established in elite swimmers. The purpose was to further establish that CFB training (16 sessions of 12 x 50-m with ~15 seconds rest between each 50-m, using only ~2 breaths per 50-m) can improve RE in 25 elite …

The Role Of Porphyromonas Gingivalis In The Regulation Of Epithelial-Mesenchymal Transition Markers In Migration., Akintunde Ojo 1981-

Electronic Theses and Dissertations

A relationship between periodontal disease and oral squamous cell carcinoma (OSCC) has been demonstrated in recent studies. Porphyromonas gingivalis’ antigen have been found in oral cancer cells. The embryonic program “epithelial-mesenchymal transition” (EMT) is thought to trigger cancer invasion by allowing tumor cell propagation. The objective of this study was to examine the role of P. gingivalis in the expression of ZEB1, vimentin, and repression of miRNA-200 family as EMT prognostic markers in cancer cell metastasis. Human telomerase immortalized gingival keratinocytes (TIGK) cells were challenged with P. gingivalis strain ATCC 33277 in vitro for 24h at MOI 50 and 100. …

The Tracker: A Proximity Alarm System, Derek Van Riper

Electrical Engineering

No abstract provided.

Transimpedance Amplifier For Polymer Photodiodes, Sheridan Knighton

Electrical Engineering

Dr. Braun’s students in the Polymer Electronics Lab currently have a way to measure the light intensity from their light emitting devices however it consumes an unnecessary amount of space and power. I offer to improve upon the existing transimpedance circuit that Dr. Braun currently uses, reducing the total space occupied by the circuit and the power consumption of the current setup. The transimpedance circuit measures the incidence light intensity from the polymer-based photo detector and outputs an accurate, discrete, and measurable voltage. The current setup however utilizes two 20V wall warts for the positive and negative rails of the …

Microprocessor Management Of Energy Harvesting Buck Boost Converters, Timothy O'Sullivan

Electrical Engineering

No abstract provided.

High Voltage Pulse-Width Generator For The Algae Biofuel Project, Philip Yu, Stephen Leung

Electrical Engineering

This purpose of this project, sponsored by Boeing and advised by Dr. Arakaki and Dr. Taufik, is to build a high voltage pulse width generator that lyses algae cells to harvest the biofuel within. This project uses Emmanuel Loza's thesis on a cascaded high voltage converter with variable control to build a portable pulse width generator with independent control on the peak voltage, pulse width, and frequency. The project focuses on creating a pulse width generator capable of finding the most optimal pulsed electric field to lyse algae. The pulse width module ranges from 10V-80V peak voltage, 60Hz-100 kHz frequency, …

Trade Secret Fair Use, Deepa Varadarajan

Fordham Law Review

Trade secret law arose to help companies protect confidential information (e.g., the Coca-Cola formula) from competitors seeking to copy their innovative efforts. But companies increasingly use trade secret law to block a wide swath of information from the scrutinizing eyes of consumers, public watchdog groups, and potential improvers. Companies can do this, in part, because trade secret law lacks clear limiting doctrines that consider the social benefits of unauthorized use. For example, trade secret law makes no allowance for the departing employee that uses proprietary information to create a substantially improved product or disclose public health risks.

This Article argues …

December 2014 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Genetic Parameter Estimates And Breed Effects For Calving Difficulty And Birth Weight In A Multi-Breed Population, Cashley Ahlberg

Department of Animal Science: Dissertations, Theses, and Student Research

There are multiple breeds of beef cattle available to utilize in breeding systems to maximize production and economics. Calving difficulty (dystocia) is a significant cost to beef production and is more prevalent in first-calf heifers. The objectives of this study were to estimate genetic parameters and breed differences for calving difficulty and birth weight as a first step towards the development of across-breed adjustment factors for calving difficulty.

Two models were employed to analyze birth weight (BWT) and calving difficulty (CD) recorded on 4,579 first parity females from the Germplasm Evaluation program at the United States Meat Animal Research Center …

Suppression Of Invasion And Metastasis Of Triple-Negative Breast Cancer Lines By Pharmacological Or Genetic Inhibition Of Slug Activity., Giovanna Ferrari-Amorotti, Claudia Chiodoni, Fei Shen, Sara Cattelani, Angela Rachele Soliera, Gloria Manzotti, Giulia Grisendi, Massimo Dominici, Francesco Rivasi, Mario Paolo Colombo, Alessandro Fatatis, Bruno Calabretta

Department of Cancer Biology Faculty Papers

Most triple-negative breast cancers (TNBCs) exhibit gene expression patterns associated with epithelial-to-mesenchymal transition (EMT), a feature that correlates with a propensity for metastatic spread. Overexpression of the EMT regulator Slug is detected in basal and mesenchymal-type TNBCs and is associated with reduced E-cadherin expression and aggressive disease. The effects of Slug depend, in part, on the interaction of its N-terminal SNAG repressor domain with the chromatin-modifying protein lysine demethylase 1 (LSD1); thus, we investigated whether tranylcypromine [also known as trans-2-phenylcyclopropylamine hydrochloride (PCPA) or Parnate], an inhibitor of LSD1 that blocks its interaction with Slug, suppresses the migration, invasion, and metastatic …

Forage News [2014-12], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentuckians at AFGC
• Forages at KCA
• Select Forage Varieties Wisely
• How Good is Your Hay?
• 35th Kentucky Alfalfa Conference
• Vegetative Identification of Small Grains
• 2014 UK Robinson Center Mountain Ag Week a Success
• Transgenic Reduced-Lignin Alfalfa Gains Deregulation

Factors That Affect Attachment Between The Employed Mother And The Child, Infancy To Two Years, Naureen Kassamali, Salma Amin Rattani

School of Nursing & Midwifery

To explore a mother's feeling of attachment and the affects her working status on the attachment relationship with her child, upon ethical clearance from the institutional ethics committee, in-depth interviews of nine participants were conducted. Mothers enrolled were those who resumed the employment within the first year of post-delivery and were having a child up to two years of age. Results revealed that maternal employment itself does not enhance or deteriorate attachment with the child. It is combinations of factors that revolve around it impact on their bond. Overall, maternal integration or the balance of the dual roles of employment …

Gossypiboma: An Unrecognized And Under-Reported Problem In Pakistan, Abdul Rehman, Noor-Ul-Ain Baloch, Muhammad Awais

Department of Biological & Biomedical Sciences

No abstract provided.

The Influence Of Underlying Factors And The Relationship Of Hiv/Aids Among African Americans In Shreveport, Louisiana And Surrounding Areas, Frederick T. Ellis Sr.

All-Inclusive List of Electronic Theses and Dissertations

The significance of this study was to evaluate multiple underlying factors among African Americans in Shreveport, Louisiana and the influence of those factors on their relationship with HIV/AIDS. This is extremely important for two very reasons. First, in the past 30 years since the initial presentation of HIV/AIDS into society, a shift in the demographic of the infected individuals has resulted in African Americans becoming the new face of HIV/AIDS in the United States. Secondly, African Americans are only 12 to 13% of the United States population, but they represent more than 45% of all new HIV/AIDS cases reported annually. …

Online Experiences Of Adolescents With Asperger’S Syndrome And High-Functioning Autism, Shin Ruu Ko

All-Inclusive List of Electronic Theses and Dissertations

This study investigated the online experiences of 10 adolescents with Asperger's Disorder (AD). This study was exploratory in nature and employed a qualitative approach. Three research questions guided this study: (a) What are the positive and negative online experiences of youth with ASD?, (b) What are the perceptions of online interactions in comparison to offline interactions held by youth with ASD?, and (c) What experiences with social connectedness and cyberbullying do youth with ASD have as a result of Internet usage? Four themes and 14 subthemes emerged during the process of analyzing the data: (a) Benefits of Internet Usage (Social, …