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Nmp-7 Inhibits Chronic Inflammatory And Neuropathic Pain Via Block Of Cab3.2 T-Type Calcium Channels And Activation Of Cb2 Receptors, N. Daniel Berger, Vinicius M. Gadotti, Ravil R. Petrov, Kevin Chapman, Philippe Diaz, Gerald W. Zamponi

Biological Sciences Faculty Publications

Background: T-type calcium channels and cannabinoid receptors are known to play important roles in chronic pain, making them attractive therapeutic targets. We recently reported on the design, synthesis and analgesic properties of a novel T-type channel inhibitor (NMP-7), which also shows mixed agonist activity on CB₁ and CB₂ receptors in vitro. Here, we analyzed the analgesic effect of systemically delivered NMP-7 (intraperitoneal (i.p.) or intragstric (i.g.) routes) on mechanical hypersensitivity in inflammatory pain induced by Complete Freund’s Adjuvant (CFA) and neuropathic pain induced by sciatic nerve injury.

Results: NMP-7 delivered by either i.p. or i.g. routes produced …

Free-Breathing Pulmonary (1)H And Hyperpolarized (3)He Mri: Comparison In Copd And Bronchiectasis., Dante P I Capaldi, Khadija Sheikh, Fumin Guo, Sarah Svenningsen, Roya Etemad-Rezai, Harvey O Coxson, Jonathon A Leipsic, David G Mccormack, Grace Parraga

Medical Biophysics Publications

RATIONALE AND OBJECTIVES: In this proof-of-concept demonstration, we aimed to quantitatively and qualitatively compare pulmonary ventilation abnormalities derived from Fourier decomposition of free-breathing (1)H magnetic resonance imaging (FDMRI) to hyperpolarized (3)He MRI in subjects with chronic obstructive pulmonary disease (COPD) and bronchiectasis.

MATERIALS AND METHODS: All subjects provided written informed consent to a protocol approved by a local research ethics board and Health, Canada, and they underwent MRI, computed tomography (CT), spirometry, and plethysmography during a single 2-hour visit. Semiautomated segmentation was used to generate ventilation defect measurements derived from FDMRI and (3)He MRI, and these were compared using analysis …

The Murray Ledger And Times, December 6-7, 2014, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

El Mate En La Cultura Rioplatense: Un Ritual., Christian Ambrosioni

Spanish Model Lesson Plans

Esta lección se enfoca sobre el ritual del mate en la cultura rioplatense, y cómo este ritual se traduce en un fenómeno de adhesión popular. A según de los ingredientes escogidos para adornar o hacer más sencillo el mate, se pueden comunicar distintos estados de ánimo.

Retrospective Study To Identify Predictors Of Withdrawal In Pediatric Intensive Care Patients On Long-Term Sedation, Lindsay Fakete Pharmd, Jenny Boucher Pharmd, Jd, Bcps, Scott Wheatley Md

Department of Pharmacy

No abstract provided.

Vawa @ 20: The Politics Of Pretext: Vawa Goes Global, Deborah M. Weissman

City University of New York Law Review

No abstract provided.

Effectiveness Of Tailored Lifestyle Interventions, Using Web-Based And Print-Mail, For Reducing Blood Pressure Among Rural Women With Prehypertension: Main Results Of The Wellness For Women: Dashing Towards Health Clinical Trial., Patricia A. Hageman, Carol H. Pullen, Melody A. Hertzog, Linda Boeckner

Journal Articles: Physical Therapy

Background Lifestyle modification is recommended for management of prehypertension, yet finding effective interventions to reach rural women is a public health challenge. This community-based clinical trial compared the effectiveness of standard advice to two multi-component theory-based tailored interventions, using web-based or print-mailed delivery, in reducing blood pressure among rural women, ages 40–69, with prehypertension.

Methods 289 women with prehypertension enrolled in the Wellness for Women: DASHing towards Health trial, a 12-month intervention with 12-month follow-up. Women were randomly assigned to groups using a 1:2:2 ratio, comparing standard advice (30-minute counseling session) to two interventions (two 2-hour counseling sessions, 5 phone …

Mrs. Alma Jones Smith

African American Funeral Programs

No abstract provided.

The Evolution Of Judicial Power: How The Supreme Court Effectively Legalized Rape On Indian Reservations, Clara Martinez

Quercus: Linfield Journal of Undergraduate Research

According to the 2010 National Intimate Partner and Sexual Violence Survey, nearly one in five women in the United States have experienced sexual violence. While the statistics are staggering, the rate of sexual assault on Indian reservations is more than twice the national average. According to the Department of Justice, one in three American Indian and Alaska Native women have been raped or have experienced an attempted rape during their lifetime. Moreover, the primary assailants are males who are not members of tribal communities. Why has rape, perpetrated by non-Indian males, become effectively legalized on reservations? What explains tribal courts’ …

Learning Styles And Learning Preferences Of Higher Diploma Students, Man Wai, Janet Cheung, Kar Wai, Joanna Cheng, Nga Lun Alan Wong

Practical Social and Industrial Research Symposium

No abstract provided.

Stress, Burnout And Resilience Of Teachers Of Students With Emotional Behavioural Challenges, Lai Kuen Brenda Lo

Practical Social and Industrial Research Symposium

No abstract provided.

Educating He Women Of The Nation: Priscilla Wakefield And The Construction Of National Identity, 1798, Camilla Leach, Joyce Goodman

Quaker Studies

This article examines the views of the Quaker educationist, Priscilla Wakefield, on the role of women in the construction of British national identity at the end of the eighteenth century. Priscilla Wakefield wrote children's texts in late-eighteenth and early-nineteenth century England, was interested in the question of women and science and published on the education of women. This article analyses the way in which in Reflections on the Present Condition of the Female Sex, with Suggestions for its Improvement (1798) , she based her arguments for a 'useful' education for women on her views of what constituted the virtues and …

Challenges Facing The Elderly Care Industry In Hong Kong: The Shortage Of Frontline Workers, Sin Tung, Stella Kwok, Wai Ning Kris Wong, Shun Lai Yang

Practical Social and Industrial Research Symposium

No abstract provided.

Tvet As An Important Factor In Country’S Economic Development, Margarita Pavlova

Practical Social and Industrial Research Symposium

In this keynote speech, Dr Pavlova will bring together a number of strategic development areas for Hong Kong as stated in the 2014 Chief Executive’s Policy Address. These areas include economic development, innovation and technology industries, vocational education and environmental protection.

On Translating Technology Research Into Industrial Applications, Stephen T.C. Wong

Practical Social and Industrial Research Symposium

Using personal cases he previously experienced, Prof Wong will share with colleagues the influence of environments and market forces that drive the applied technology research into practice. The speech will be delivered in an informal, interactive format, rather than didactic.

Things I Am Curious To Learn, Marylouise Miles

Manuscripts

Like every other child I started out with a burning curiosity. At five that unextinguishable fire was a horrible thing. Horrible, that is, to those coming within hearing distance. "Why" was the only word in my vocabulary, and every moment made me more masterful in its use. Why do ants build their houses like that? Why is grass green instead of some other color? Why are you dusting, Mama? Why do I have to wear my coat today? Why? Why? Why? Of course those sentences, are exasperating; so was I.

Just For Fun, Tom Stump

Manuscripts

The first book that I remember having read for myself was A. A. Milne's Winnie the Pooh. I read and re-read this book many times, as well as its twin, House at Pooh Corner. Whenever I grew tired of reading one of these books, I would skim through the pages and look at the winsome little pictures of Pooh, or Ear, the donkey, or Kanga, the kangaroo. Although as I grew up I soon considered myself above such juvenile literature, I was amazed not very long to find that I still enjoyed reading about the exploits of Pooh, the amiable …

Physical Therapy Management Of A Patient With A Transtibial Amputation Using An Over-Ground Body Weight Support System: A Case Report, Elizabeth Kelly

Case Report Posters

Background: Peripheral Arterial Disease (PAD): Narrowing of the vessels secondary to atherosclerotic plaque buildup, results in ischemia to extremities which can lead to intermittent claudication, decreased distal pulses, impaired healing. Lower Extremity Amputation: 54% of amputations in the USA are due to PAD, either alone or in conjunction with diabetes (Kalapatapau V. et al), transtibial and transfemoral most common, best outcomes with multidisciplinary approach. Body Weight Support (BWS) Systems: Commonly used in patients after stroke or incomplete spinal cord injury; methods: treadmill or over-ground, over-ground allows for assistive device training and varying terrains; parameters: high-intensity, high-repetition, task-specific; lack of research …

Physical Therapy For A Patient With Poor Balance Secondary To Charcot-Marie Tooth Disease And Chronic Low Back Pain: A Case Report, Nicole Christine

Case Report Posters

Background: Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neuromuscular disorders with a prevalence rate of 1 in 2,500 in the United States. CMT is a form of muscular dystrophy, and is an umbrella term for certain inherited genetic disorders that affect the peripheral nervous system. The genetic disorder is characterized by muscular wasting, weakness, and sensory loss, and is most severe in the distal lower extremities. Common symptoms include foot drop, high-stepped gait with frequent tripping or falls, foot deformities such as high arches and hammer toes, and loss of muscle bulk in the distal lower extremities. …

Outpatient Interventions For Femoral Acetabular Impingement Complicated By Hip Osteoarthritis, Labral Tear And L5 Sacralization: A Case Report, Brianna Palmer

Case Report Posters

Background: Femoral Acetabular Impingement (FAI) is a known cause of hip pain in adolescents and young adults produced by altered hip joint mechanics. Types of FAI include Cam deformity, Pincer deformity or a combination. Abnormal abutment of the femoral head on the acetabular rim, especially during hip flexion and internal rotation (IR) causes a sharp, pinching pain in the groin and lateral hip. Chronic FAI can lead to hip osteoarthritis (OA) and labral and/or chondral defects. It is unknown if there is a correlation between FAI and sacralization.

Outpatient Physical Therapy Following Surgical Debridement Of Osteochondritis Dissecans Of The Talar Dome: A Case Report, Angela Serrani

Case Report Papers

Background: Osteochondritis Dissecans (OCD) is an alteration of subchondral bone with possible disruption of the surrounding articular cartilage. Hypothesized causes of the chondral defect include repeated trauma or vascular disruption within the joint. Surgical treatment may be used to relieve symptoms of OCD and improve function. Purpose: The purpose of this paper is to describe physical therapy treatment and outcomes for a patient following surgical debridement of OCD of the talar dome. Case Description: The patient was a 27 year old female with a history of frequent ankle sprains. She reported a specific incident earlier this year that led to …

Volume 50 - Issue 09 - Friday, December 5, 2014, Rose Thorn Staff

The Rose Thorn Archive

The Rose Thorn, Rose-Hulman's independent student newspaper.

Addressing Medicaid/Marketplace Churn Through Multimarket Plans: Assessing The Current State Of Play, Sara Rosenbaum

Health Policy and Management Faculty Publications

No abstract provided.

Public Act 098-0295 Or The "Open Access To Research Articles Act" Findings And Recommendations, Open Access Task Force

Open Access Task Force

Final report containing the findings and recommendations of Governors State University's Open Access Task Force in compliance with Public Act 098-0295.

Primary Care In Geriatrics: Context, Opportunities, And Resources For Occupational Therapy, Catherine V. Piersol, Phd, Otr/L

Department of Occupational Therapy Posters and Presentations

Learning Objectives:

1. Discuss health care delivery trends and system changes that offer opportunities for occupational therapy in primary care for older adults in the community.

2. Describe the contributions of occupational therapy on the interprofessional primary care team.

3. Utilize current resources and evidence that support the role of occupational therapy in geriatric primary care.

Agenda:

1. Overview of primary care.

2. Health trends and reform initiatives that open doors for occupational therapy.

3. Opportunities (and barriers) for occupational therapy in primary care

4. Current NIH funded study testing a primary care occupational therapy intervention.

5. Resources and Discussion. …

How Much Dna Is Lost? Measuring Dna Loss Of Str Length Fragments Targeted By The Powerplex 16® System Using The Qiagen Minelute Purification Kit, Brian M. Kemp, Misa Winters, Cara Monroe, Jodi Lynn Barta

Human Biology Open Access Pre-Prints

The success in recovering genetic profiles from aged and degraded biological samples is diminished by fundamental aspects of DNA extraction, as well as its long-term preservation that are not well understood. While numerous studies have been conducted to determine whether one extraction method performed superior to others, nearly all of them were initiated with no knowledge of the actual starting DNA quantity in the samples prior to extraction, so they ultimately compared the outcome of all methods relative to the best. Using quantitative PCR (qPCR) to estimate the copy count of synthetic standards before (i.e., “copies in”) and after (i.e., …

Board Of Trustees Meeting Minutes 2014-12-05, Bowling Green State University

Board of Trustees Meeting Minutes

The official meeting minutes of Bowling Green State University's Board of Trustees.

Alum Speak About Law Nonprofit Advocacy Government Relations, Dec. 5, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

December 5-6, 2014, Vs. Lake Superior State, University Of North Dakota

UND Athletics Publications: Men's Hockey

Program for the December 5-6, 2014, weekend series against the Lake Superior State Lakers.

Collection Development Policy, Psychology, Hal Mendelsohn

Libraries' Documents

No abstract provided.