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Theoretical And Experimental Studies Of Noncovalent Metal Cation Binding And Base Pairing Interactions Of Cytosine And Modified Cytosines, Bo Yang

Wayne State University Dissertations

ABSTRACT

THEORETICAL AND EXPERIMENTAL STUDIES OF NONCOVALENT METAL CATION BINDING AND BASE PARING INTERACTIONS OF CYTOSINE AND MODIFIED CYTOSINES

by

BO YANG

December 2014

Advisor: Professor Mary T. Rodgers

Major: Analytical Chemistry

Degree: Doctor of Philosophy

Binding of metal cations to the nucleobases can lead to formation of rare tautomers of the nucleobases. The infrared multiple photon dissociation (IRMPD) action spectroscopy of five alkali metal cation-cytosine complexes, M⁺(cytosine), where M⁺ = Li⁺, Na⁺, K⁺, Rb⁺, and Cs⁺, are examined using a Fourier transform ion cyclotron resonance mass …

The Reliability And Validity Of The Thin Slice Technique: Observational Research On Video Recorded Medical Interactions, Tanina Suzanne Foster

Wayne State University Dissertations

The Reliability and Validity of the Thin Slice Technique: Observational Research on Video Recorded Medical Interactions

Introduction: Observational research using the thin slice technique has been routinely incorporated in observational research methods, however there is limited evidence supporting use of this technique compared to full interaction coding. The purpose of this study was to determine if this technique could be reliability coded, if ratings are consistent between the first, second and third slice, and if they are indeed representative of full interactions.

Methods: Three 30-second thin slices were sampled from the beginning, middle and end of a full-length video-recorded …

Technologically-Mediated Writing In The First Year Writing Classroom: Twitter And Immediate Writing, Jason Kahler

Wayne State University Dissertations

A series of assignments in First Year Writing classes at Saginaw Valley State University utilizes social media to address issues of kairos in student writing experiences. The term "immediate writing" is applied to these writing activities which require students to produce polished writing in a specific moment, a different objective than commonly-used impromptu or freewriting. Included are considerations of technologically-mediated writing and the artifacts used to generate it.

Analysis Of A Dual Scissored-Pair,Variable-Speed, Control Moment Gyroscope Driven Spherical Robot, Richard Chase

Wayne State University Dissertations

The objective of this research is to compare barycenter offset based designs of spherical robots to control moment gyroscope (CMG) based designs in order to determine which approach is most effective. The first objective was to develop a list of current state of the art designs in order to gain an overall understanding of what the obstacles in this area of research were. The investigation showed that barycenter offset designs can produce a low, continuous output torque, whereas CMG based designs can usually only produce a high, momentary output torque. The second objective was to develop a CMG based design …

Inclusive Education For Students With Emotional Impairments: Factors For Success, Jessica Cohen

Wayne State University Dissertations

Special education policy and practice are ever evolving to best meet the needs of all students in an inclusive environment. Since the implementation the Individuals with Disabilities Education Act (IDEA) thirty years ago, students with special needs have moved from restrictive, exclusionary placements to being educated alongside their same aged non-disabled peers. As we have moved towards viewing special education as a service, not a place, including more students with disabilities in the general education setting and curriculum has become the expected practice in the majority of public schools in the United States. Despite this progress, students with emotional impairments …

Interaction Of Positrons And Electrons With Atoms, Robert D. Dubois

Physics Faculty Research & Creative Works

Progress in differential studies of ionization resulting from positron and electron impact being performed at the Missouri University of Science and Technology is described. Examples of doubly and triply (fully) differential single ionization data for the ejected electron and the scattered projectile channels are presented. Energy loss data for double ionization, plus estimates for the first-order interaction, shake off, SO, and TS1, are also presented.

Information Systems User Competency: A Conceptual Foundation, Brenda Eschenbrenner, Fiona Fui-Hoon Nah

Business and Information Technology Faculty Research & Creative Works

Research has identified a variety of factors that influence people's intentions to use IS and their degree of IS use. However, what has not been well understood are the characteristics of competent IS users who are proficient in using IS and are able to achieve quality IS usage. Considering that improving IS users' abilities to more efficiently and effectively use IS has always been and remains a challenge, research that provides a comprehensive view of the characteristics associated with competent IS users is warranted. This paper addresses this research question by proposing a conceptual foundation for IS user competency. Based …

Measuring And Modelling The Thermal Performance Of The Tamar Suspension Bridge Using A Wireless Sensor Network, Nicholas De Battista, James M. W. Brownjohn, Hwee-Pink Tan, Ki Young Koo

Research Collection School Of Computing and Information Systems

A study on the thermal performance of the Tamar Suspension Bridge deck in Plymouth, UK, is presented in this paper. Ambient air, suspension cable, deck and truss temperatures were acquired using a wired sensor system. Deck extension data were acquired using a two-hop wireless sensor network. Empirical models relating the deck extension to various combinations of temperatures were derived and compared. The most accurate model, which used all the four temperature variables, predicted the deck extension with an accuracy of 99.4%. Time delays ranging from 10 to 66 min were identified between the daily cycles of the air temperature and …

School Violence Perpetrators Speak: An Examination Of Perpetrators Views On School Violence Incidents, Gordon A. Crews

Criminal Justice Faculty Publications

In the last few decades researchers have attempted to determine correlates for school violence. While the number of extreme incidents of school violence remains relatively small, extreme incidents cause the most concern for parents, teachers, law enforcement, and educational administrators. In addition to the fear these types of events cause, they also bring about a great deal of debate regarding proper responses. Some feel that stringent zero tolerance policies are the answer, while others argue for more gun control in society. Some feel that increased counseling and service to young people is the answer, while others argue for the increased …

Tickling The Palate: Gastronomy In Irish Literature And Culture, Máirtín Mac Con Iomaire, Eamon Maher

Books

This volume of essays, which originated in the inaugural Dublin Gastronomy Symposium held in the Dublin Institute of Technology in June 2012, offers fascinating insights into the significant role played by gastronomy in Irish literature and culture. The book opens with an exploration of food in literature, covering figures as varied as Maria Edgeworth, James Joyce, Charles Dickens, Enid Blyton, John McGahern and Sebastian Barry. Other chapters examine culinary practices among the Dublin working classes in the 1950s, offering a stark contrast to the haute cuisine served in the iconic Jammet's Restaurant; new trends among Ireland's 'foodie' generation; and the …

The Alignment Of Law And Norms: Of Mirrors, Bulwarks, And Pressure Valves, Mark A. Edwards

FIU Law Review

No abstract provided.

Snakes And Ladders: Suo Moto Intervention And The Indian Judiciary, Marc Galanter

FIU Law Review

No abstract provided.

Layering Law Upon Custom: The British In Colonial West India, James A. Jaffe

FIU Law Review

No abstract provided.

A Fundamentally Different Regulatory Calculus: The Advent Of Regulation D, Rule 506(C), Ashley J. Hersutamto

FIU Law Review

No abstract provided.

Trunk Coordination In Dancers And Non-Dancers, Danielle N. Jarvis, Jo Armour Smith, Kornelia Kulig

Physical Therapy Faculty Articles and Research

Variability, or how a task changes across trials, may reveal differences between athletes of differing skill levels. The purpose of this study was to examine trunk and lower extremity (LE) single joint kinematic variability and inter-segmental coordination variability in dancers and non-dancers during bipedal vertical dance jumps (sautés). Twenty healthy females, ten with no formal dance training and ten professional dancers, performed 20 consecutive sautés. Single joint kinematic variability was assessed using mean standard deviation of angular displacement, and inter-segmental coordination variability was assessed using angular deviation of the coupling angle between segments. Within the context of the standard error …

Research Thesis Essay Of Findings From Campus Language Capacity Survey 2012-2014 Done In Collaboration With The Heritage Language Initiative, Laura Van Doren

University Honors Theses

This paper presents the findings of the Campus Language Capacity Survey 2013, a study conducted as an online survey to investigate heritage language usage at Portland State University. Heritage language is defined as “an indigenous or immigrant language other than English.” The survey was sent to 15,000 randomly selected participants from the PSU student, staff, and faculty body; over 1,000 responses were collected. There was a 10% response rate with 119 participants self-identified as heritage language speakers and/or learners. These participants are individuals in the PSU community who have ties to their heritage community. The top five heritage languages named …

Energy Versus Property, Michael Pappas

Faculty Scholarship

This article is the first to detail the balance legislatures and courts have struck between private property rights and the compelling public interest in energy production. By examining how property rights have consistently yielded to energy development from colonial times to the most recent decisions involving hydraulic fracturing (“fracking”), it identifies a coherent energy/property balance that has shaped property expectations to accommodate energy needs. The article then applies this insight to current disputes pitting aggressive renewable energy policies— such as nuisance immunity or mandatory installations on private property— against fundamental property expectations— the right to exclude and the right to …

Risk, Uncertainty And Precaution: Lessons From The History Of Us Environmental Law, Robert V. Percival

Faculty Scholarship

Globalization and expanding world trade are creating new pressures to harmonize environmental standards. Countries increasingly are borrowing legal and regulatory policy innovations from one another, moving toward greater harmonization of regulatory policies. Regulatory policy generally seeks to prevent harm before it occurs, but the reality is that it usually has been more reactive than precautionary, responding only after harm has become manifest. As regulators seek to improve their responses to new and emerging environmental risks, it is useful to consider what lessons can be learned from past experience with regulatory policy. This chapter reviews controversies over regulatory policy through the …

Wisdom In The Counseling Relationship, Linda C. Osterlund

Jesuit Higher Education: A Journal

The counselor’s wisdom, expressed through the self-of- the-counselor, will potentially transform the counseling relationship. The purpose of this phenomenological pilot study was to define wisdom from the counselor’s perspective and describe the lived experience of wisdom in the therapeutic working alliance. Several descriptive themes emerged as distinct aspects of the wisdom of the counselor; a reflective attitude, the ability to gain insight from experience, emotional intelligence, cognitive ability, real-world skills, and concern for others. The holistic description of wisdom which materialized has important implications for counselor education and supervision, since it can be intentionally incorporated into counselor training programs from …

Using The Myers-Briggs Type Indicator® And Ignatian Pedagogy Model For Improved Learning In Master’S Level Finance Classes For Nurses, Rick Muller, Karen Pennington Pennington

Jesuit Higher Education: A Journal

Faculty of Jesuit universities remain challenged on seamlessly incorporating the Ignatian Pedagogy (IP) Model into the fabric of everyday educational life in a way that is practical, understandable, and relevant to an increasingly demanding learner population. An ongoing longitudinal evaluation of nurse content retention and learner satisfaction1 in the nonclinical courses of economics, finance, and accounting revealed an unacceptable level of learner dissatisfaction.2 The generalized reflective process of the IP model was used to assess the specific gaps in expectations and knowledge between learners and faculty as identified by the Myers-Briggs Type Indicator® (MBTI). The gap between contextual understanding and …

Reflective Writing: From Pedagogy To Practice In A Jesuit University, Janet Preis, Erin Stauder

Jesuit Higher Education: A Journal

The purpose of this pilot study was to examine the effects of reflective writing when it was integrated into graduate students’ early clinical experience in speech-language pathology. Journaling was introduced to teach, support, and foster Jesuit ideals, particularly that of reflection. Statistical analysis comparing students’ pre and post semester understanding of how to apply journaling to themselves, their clients, their clinical education, and Ignatian Pedagogy showed a significant increase over time for each of these areas. In addition, effect size analysis indicated that the “learning curve” was great, as all areas of understanding (self, others, education, and Ignatian Pedagogy) showed …

Deal Deconstructions, Case Studies, And Case Simulations: Toward Practice Readiness With New Pedagogies In Teaching Business And Transactional Law, Michelle M. Harner, Robert J. Rhee

Faculty Scholarship

In this short commentary, we explore the use of two interrelated pedagogical methods for teaching transactional and business law. The first method is deal deconstruction, which analyzes the set of final deal documents and outcomes. This method is backward-looking, conducting a post-mortem on business transactions and analyzing the parties’ choices memorialized in the agreement against the legal and financial alternatives. The second method involves case studies and simulations, which are commonly seen in business schools. This method is forward-looking, exposing students to the uncertainties and situational contexts of doing deals and deal-related litigation. Together, these complementary methods help students understand …

Anti-Waste, Michael Pappas

Faculty Scholarship

It may be a bad idea to waste resources, but is it illegal? Legally speaking, what does “waste” even mean? Though the concept may appear completely subjective, this Article builds a framework for understanding how the law identifies and addresses waste.

Drawing upon property and natural resource doctrines, the Article finds that the law selects from a menu of five specific, and sometimes competing, societal values to define waste. The values are: 1) economic efficiency, 2) human flourishing, 3) concern for future generations, 4) stability and consistency, and 5) ecological concerns. The law recognizes waste in terms of one or …

Influence Of Social Class Perceptions On Attributions Among Mental Health Practitioners, Mindi Thompson, Jacob Diestelmann, Odessa Cole, Abiola O. Keller, Takuya Minami

Physician Assistant Studies Faculty Research and Publications

Objective: A vignette-based study assessed the influence of social class attributions toward a hypothetical client's difficulty. Method: 188 licensed mental health professionals who were recruited through professional listservs completed an online survey after reviewing one of two versions of a vignette describing a hypothetical client that varied based on social class cues. Results: As expected, this sample of licensed mental health practitioners detected social class differences based on the descriptors of the hypothetical client across the two vignettes. These perceived social class differences, however, did not impact participants' attributions toward the client for causing or solving her problems, level of …

Inventing Identities: The Case Of Frederick May, Mark Fitzgerald

Books/Book Chapters

This chapter examines how Frederick May has been depicted in previous musicological literature and the ways in which both biographical facts and May’s music have been misrepresented in an attempt to create the impression that he was part of the main stream of central European modernism. The article uncovers new material regarding the early stages of May’s career and demonstrates that May’s educational trajectory was similar to other pupils of Vaughan Williams. The article counters the narrative of failure created by musicologists who judge May for failing to achieve aesthetic aims that he never set out to attain and reflects …

The Potential For Energy Reduction In Uk Commercial Offices Through Effective Management And Behaviour Change, Mark Mulville, Keith Jones, Gesche Huebner

Articles

eneral office equipment can be responsible for a significant proportion of overall electrical energy consumption in UK offices and this is predicted to rise significantly over the coming years [Webber, C. A., Roberson, J. A., Brown, R. E., Payne, C. T., Nordman, B., & Koomey, J. G. (2001). Field surveys of office equipment operating patterns. Berkley: CA: Lawrence Berkley National Laboratory]. As a significant contributor to overall energy use, this equipment has a corresponding cost and carbon impact. The legally binding requirements of the climate change act [Department of Energy and Climate Change. (2008 Department of Energy and …

William Boyce White, Jr. Papers - Accession 1488, William Boyce White Jr., White Family

Manuscript Collection

The William Boyce White, Jr. Papers consist of his genealogical research as well as his research concerning the history of York County and the city of Rock Hill, South Carolina. The papers also include records and manuscripts relating to several of his published works. His local history interests include the families and businesses on Main Street, Rock Hill; Colonel William Hill; the Catawba River; the Catawba Indian Nation; Rock Hill and York County schools; historic homes (including photographs, many of which were used by Elizabeth Reed in her long running series on historic homes in the Rock Hill Evening Herald …

Concern-Driven Integrated Toxicity Testing Strategies For Nanomaterials - Report Of The Nanosafety Cluster Working Group 10, Hugh Byrne, Agnes G. Oomen, Peter M.J. Bos, Teresa F. Fernandes, Kerstin Hund-Rinke, Diana Boraschi, Karin Aschberger, Stefania Gottardo, Frank Von Der Kammer, Dana Kühnel, Danail Hristozov, Antonio Marcomini, Lucia Migliore

Articles

Bringing together topic-related European Union-(EU)-funded projects, the so-called “NanoSafety Cluster” aims at identifying key areas for further research on risk assessment procedures for nanomaterials (NM). The outcome of NanoSafety Cluster Working Group 10, this commentary presents a vision for concern-driven integrated approaches for the (eco-)toxicological testing and assessment (IATA) of NM. Such approaches should start out by determining concerns, i.e. specific information needs for a given NM based on realistic exposure scenarios. Recognized concerns can be addressed in a set of tiers using standardized protocols for NM preparation and testing. Tier 1 includes determining physico-chemical properties, non-testing (e.g. structure …

Effect Of Substrate Choice And Tissue Type On Tissue Preparation For Spectral Histopathology By Raman Microspectroscopy, Hugh Byrne, Leanne M. Fullwood, Dave Griffiths, Katherine Ashton, Timothy Dawson, Robert W. Lea, Charles Davis, Franck Bonnier, Matthew J. Baker

Articles

Raman spectroscopy is a non-destructive, non-invasive, rapid and economical technique which has the potential to be an excellent method for the diagnosis of cancer and understanding disease progression through retrospective studies of archived tissue samples. Historically, biobanks are generally comprised of formalin fixed paraffin preserved tissue and as a result these specimens are often used in spectroscopic research. Tissue in this state has to be dewaxed prior to Raman analysis to reduce paraffin contributions in the spectra. However, although the procedures are derived from histopathological clinical practice, the efficacy of the dewaxing procedures that are currently employed is questionable. Ineffective …

Vibrational Spectroscopy: Disease Diagnostics And Beyond, Hugh Byrne, Kamila Ostrowska, Haq Nawaz, Jennifer Dorney, Aidan Meade, Franck Bonnier, Fiona Lyng

Books/Book Chapters

Summary

This chapter outlines some developments in the applications of vibrational spectroscopy for disease diagnostics and demonstrates how the applications of the spectroscopic techniques can be extended to the analysis and evaluation of disease aetiology and the mechanisms of interaction and the cellular and subcellular responses to, for example chemotherapeutic agents and nanoparticles. The primary emphasis is on Raman spectroscopy, although some examples are based on infrared absorption spectroscopy. The studies presented are chosen to illustrate how a range of multivariate analytical techniques can be employed to maximize the potential benefits of the complex spectral information obtained from tissue or …