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Articles 1951 - 1980 of 46354
Full-Text Articles in Entire DC Network
Integrating The Credit-Bearing Information Literacy Course Into The Curriculum: Goals, Benefits And Challenges, Dominique Daniel, Elizabeth W. Kraemer
Integrating The Credit-Bearing Information Literacy Course Into The Curriculum: Goals, Benefits And Challenges, Dominique Daniel, Elizabeth W. Kraemer
LOEX Conference Proceedings 2012
This presentation provides a model for the design and implementation of a successful credit-bearing information literacy course that addresses the most common objections against stand-alone library instruction. It emphasizes two key principles, making it relevant to students and university administrators alike: integration into the university general education program, and the contextualization of information-seeking mechanics by introducing students to the economic, political and social context in which information is produced, managed and used. These principles lay the foundation for the development of critical information literacy skills that students can transfer to other courses and beyond. Offering stand-alone instruction while integrating it …
Blending, Mixing, And Processing: Strategies Used To Engage Students In The Classroom, Mark Aaron Polger, Karen Okamoto
Blending, Mixing, And Processing: Strategies Used To Engage Students In The Classroom, Mark Aaron Polger, Karen Okamoto
LOEX Conference Proceedings 2012
Two of the biggest challenges in the provision of library instruction are memory retention and student engagement. How can students retain all of the information they receive in a “one shot” library instruction class and how do librarians engage them in a memorable way?
A Library instruction class provides a unique opportunity to not only educate students (and even teaching faculty) but promote valuable services and resources. Librarians must be creative and must use a variety of teaching strategies that will help promote critical thinking, memory retention, and student engagement. Our presentation will provide numerous teaching examples from our library …
College Student’S Perceptions Of Living And Learning With Attention Deficit Hyperactivity Disorder (Adhd), Michael P. Gallo, Patricia Mahar, Lynne Chalmers
College Student’S Perceptions Of Living And Learning With Attention Deficit Hyperactivity Disorder (Adhd), Michael P. Gallo, Patricia Mahar, Lynne Chalmers
The Journal of Special Education Apprenticeship
How does the K-12 special education system prepare children with ADHD for the rigors and independent learning of higher education? This article examines the K-12 experiences, including special education, of three college students diagnosed with ADHD during their early elementary years. In their own words, they provide insight into what benefited them and what educators can do to prepare children with ADHD to have a successful post secondary experience.
A Synthesis Of Literature Examining The Structured Teaching Components Of The Teacch Model Employing The Use Of A Visual Conceptual Model, Karin Kliemann
A Synthesis Of Literature Examining The Structured Teaching Components Of The Teacch Model Employing The Use Of A Visual Conceptual Model, Karin Kliemann
The Journal of Special Education Apprenticeship
A synthesis of research on the TEACCH Model was conducted to determine which components of Structured Teaching under the TEACCH model meet criteria as evidenced based practices using the Reichow, Volkmar, and Cicchetti criteria (2007) along with reporting on the findings of the National Autism Center report (2009). The critical components of the Structured Teaching approach under the TEACCH model as defined by Schopler et al. (1995) are: physical structure; visual schedules; work systems; and task organization. Our analysis found visual schedules met the Reichow et al. (2008) criteria and a case can be made for task organization. A secondary …
Interpretations Of Patterns And Actors In The Lapp Fund Documents, Geir Grenersen
Interpretations Of Patterns And Actors In The Lapp Fund Documents, Geir Grenersen
Proceedings from the Document Academy
The Lapp Fund (“Finnefondet” in Norwegian) was an important instrument in the norwegianization policy toward the Sámi and Finnish minorities between 1852 – 1921. Two studies, one from the midst 1950s (Dahl 1957) and one from the early 1980s (Eriksen & Niemi 1981), have been the standard works on this period. Recent archival studies (Grenersen N.d. & Maliniemi 2009, 2010) prove the need for a new look at the Lapp Fund documents. Through a detailed archival study Maliniemi has shown that the Sámi and the Finnish languages was much used in a local political administration. But the documents written in …
Front Tracking Method With High-Order Enhancement And Its Application In Two-Phase Micromixing Of Incompressible Viscous Fluids, Yijie Zhou
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
We develop a front tracking method based on the hydrodynamic library FronTier for the solution of the governing equations of motion for two-phase micromixing of incompressible, viscous, liquid-liquid solvent extraction processes. The method is used for accurate simulation of the turbulent micromixing dynamics of an aqueous and an organic phase exposed to intense centrifugal force and shearing stress. The onset of mixing is the result of the combination of the classical Rayleigh-Taylor and Kelvin-Helmholtz instabilities. We demonstrate verification and convergence results for one-phase and unmixed, two-phase flows. For mixed, two-phase flow a mixing environment that emulates a sector of the …
Event-Based Modeling And Control Of An Advanced Manufacturing System, Yang Li
Event-Based Modeling And Control Of An Advanced Manufacturing System, Yang Li
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Although the widely application of advanced IT technology has enabled production information to become increasingly transparent, detailed and real-time, the utilization of the information for system modeling and control remains largely unexplored. In fact, instantaneously transforming information gathered from a vast array of sources into useful knowledge for effective decision making has been identified as one of the six grand challenges in the vision for manufacturing 2020 and beyond. It is necessary to have a real-time integrated system modeling and control method, which utilizes the production information to quickly respond to unpredictable disturbance to manufacturing system and ensure smooth production …
Maintaining Stable Wireless Communication Connections Among Multiple Collaborative Mobile Robots By Intelligent Robot Motion Control, Xu Zhong
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
This dissertation addresses the critical issue of establishing and maintaining desired wireless communication connectivity in a team of collaborative mobile robots, which is highly demanded for reliable functioning of multi-robot systems but challenging in realistic environments. The signal propagation of wireless communications among mobile robots is affected by many issues, including the transmission power, distance, obstacles, robot movement, and other environmental conditions, which result in signal loss, attenuation, multi-path fading and shadowing. Consequently, the communication condition among mobile robots in a physical environment is usually unstable, and it is difficult to accurately predict the actual communication ranges of robots. We …
Representations Of Gender In Young Adult (Ya) Literature, 1960-2010, Maria I. Cipriani
Representations Of Gender In Young Adult (Ya) Literature, 1960-2010, Maria I. Cipriani
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
This dissertation focuses the lens of queer studies and trauma studies on YA literature published in the United States between 1960 and 2010 to demonstrate that authors embed cultural messages in YA texts. Those messages for YA readers intend to model behavior considered appropriate and teach about normative sex and gender roles. Individuals between the ages of 10 and 20 comprise YA readership, and the means of teaching these readers cultural norms include imagery and cautionary tales. The content of the literature inculcates views of acceptable behaviors with respect to sexuality and gender roles and generally conflates sex and gender. …
Exploring The Erp And Facial Response To Cocaine And Emotional Cues, Hojin Choi
Exploring The Erp And Facial Response To Cocaine And Emotional Cues, Hojin Choi
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
With the advancement of affective computing technologies, spontaneous and complex emotions that were difficult or even impossible to recognize in the past are rapidly becoming the focus of many research. One intriguing example of these non-basic emotions is drug craving, a sophisticated concept which neuroscientists have studied for a long time. Nevertheless, it is not yet known whether craving is accompanied by a characteristic expressive behavior when it occurs, and only little work has been done on exploring the relationship between craving and facial expressions. In this thesis, we assume that drug-related stimuli can induce craving-related emotional states in drug …
Achieving Regulatory Compliance In Data Management, Sumeet Vijay Bajaj
Achieving Regulatory Compliance In Data Management, Sumeet Vijay Bajaj
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Regulations mandate consistent procedures for information access, processing, and storage. In the United States alone, over 10,000 data management regulations exist in the financial, life sciences, health care and government sectors. A recurrent theme in data management regulations is the need for regulatory compliant storage to ensure data confidentiality, data integrity, audit trails maintenance, data retention, and guaranteed deletion. This thesis describes the design and implementation of several regulatory compliant relational databases and file systems. The systems increase efficiency and lower costs of regulatory compliance through the use of novel cryptographic and system security constructs. The first system described in …
Greendm: A Versatile Tiering Hybrid Drive For The Trade-Off Evaluation Of Performance, Energy, And Endurance, Zhichao Li
Greendm: A Versatile Tiering Hybrid Drive For The Trade-Off Evaluation Of Performance, Energy, And Endurance, Zhichao Li
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
There are trade-offs among performance, energy, and device endurance for storage systems. These trade-offs become more complex in storage system comprising different storage technologies. Designs optimized for one dimension or workload often suffer in another. Therefore, it is important to study the trade-offs so as to be able to adapt the system to workloads. As different types of drives have different traits, tiering hybrid drives are studied more closely. However, previous tiering hybrids are often designed for high throughput, efficient energy consumption, or improving endurance--leaving empirical study on the trade-offs being unexplored. Past endurance studies also lack a concrete model …
Hollywood On The Tiber And Italian Cinema: Practices Of Transatlantic Stardom 1949-1965, Maria Elena D'Amelio
Hollywood On The Tiber And Italian Cinema: Practices Of Transatlantic Stardom 1949-1965, Maria Elena D'Amelio
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
My dissertation aims to contribute to the emergent scholarly conversation on transnational stardom by examining the transatlantic career of the three male stars Amedeo Nazzari, Vittorio Gassman, and Steve Reeves, as case studies to define specific transnational practices of film production, aesthetics, and reception between Italy and the United States. | 205 pages
Collective Memory And Performative Reconquista: Action And Inaction In The Performance Art Of Regina Jose Galindo, Jasnira Lizbeth Zuniga
Collective Memory And Performative Reconquista: Action And Inaction In The Performance Art Of Regina Jose Galindo, Jasnira Lizbeth Zuniga
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Using Coco Fusco's notion of the Reconquista to read ¿Quién puede borrar las huellas? of 2003 and Reconocimiento de un cuerpo of 2008, this paper investigates performance artist Regina José Galindo's conceptual approaches of action and inaction. Grappling with very specific histories of violence and repression in attempts to deal with the unresolved, Regina José Galindo's performances here concern themselves with permanence and impermance, confronting and reactivating the bodies of her viewers by restaging collective memory and trauma. Focusing on pieces conceived and staged in the Latin American context, this paper contextualizes Galindo's performance in Guatemala and Argentina as attempts …
The Ritualistic And Theatrical Elements Of Ashura, Nooran Abdulkareem Fattah Al-Salihi
The Ritualistic And Theatrical Elements Of Ashura, Nooran Abdulkareem Fattah Al-Salihi
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Ashura (also spelled Ashoura) takes place on the tenth day of Muharram when Shia Muslims commemorate the martyrdom of Imam Husayn that took place in 61 AH/ 680 AD. It is a socio-religious phenomenon that combines ritualistic and theatrical behavior. My objective is to shed light on the interaction between ritual and theatrical behavior and how these work together to form the overall event. The first section introduces the historical background of Ashura, the second section explores the ritualistic and theatrical characteristics of Ashura, and the last, concluding section talks about the relation between the two aspects and how they …
Art And Cognition: A Methodological Critique Of The Pre-Atonal Arnold Schoenberg, Antonio Pellegrino
Art And Cognition: A Methodological Critique Of The Pre-Atonal Arnold Schoenberg, Antonio Pellegrino
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
What I will attempt in this essay is to bring the critique to Schoenberg's artistic legacy first on the grounds of the philosophical debate that was going on in those years in the German-speaking world, more specifically between Idealism and Materialism. The second step will be that of bringing the understanding of Schoenberg methods on a cognitive level; and in doing so, I will establish theoretical ties between those philosophical systems and cognitive systems; namely the Cognitivist and the Connectionist approaches. The third step will be that of mirroring the association between the philosophical plane and the cognitive one in …
Os Gemeos And The Giant Of Boston, Phuong-Lan Rebekah Tonthat
Os Gemeos And The Giant Of Boston, Phuong-Lan Rebekah Tonthat
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
On August 1st 2012, the Institute of Contemporary Art introduced the work of the twins Otavio and Gusavo Pandolfo, otherwise known as Os Gêmeos. This was the first solo US museum exhibition of the artists, who are possibly the best-known street artists of Brazil, and who have shown their work at Miami Art Basel, the Armory Show, P.S. 1, and the Tate Modern. The display consisted of two murals within the city of Boston, the most notable of the two commonly referred to as The Giant of Boston. The 70 foot by 70 foot crouched figure with a hidden face …
An Examination Of Candida Albicans Mannosylation Mutants And Their Cw Structures, Frank August Mindlin
An Examination Of Candida Albicans Mannosylation Mutants And Their Cw Structures, Frank August Mindlin
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Candida albicans is the most important human pathogenic fungus. Due to rising rates of infection and limited treatment options, it has become increasingly vital to identify the structures of the cell wall (CW) that can serve as ligands for anti-fungal drug recognition. Recently, a number of studies have focused their attention to the outer portion of the CW, which is comprised of glycoproteins modified with asparagine (N)-linked or serine or threonine (O)-linked mannan. Current models have shown N-linked mannan to be one of the key structures responsible for immune-cell recognition. Mutations in construction of the N-linked mannan outer chain, which …
Low Intensity Vibrations Mitigate Cancer-Induced Bone Loss With Indications Of Reduced Tumor Progression, Gabriel M. Pagnotti
Low Intensity Vibrations Mitigate Cancer-Induced Bone Loss With Indications Of Reduced Tumor Progression, Gabriel M. Pagnotti
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Osteopenia is a comorbidity frequently observed in patients being treated for and recovering from cancer treatment, elevating their risk of fracture. These skeletal losses are compounded by chemotherapy and irradiation, damaging both bone and contents of the marrow, thereby undermining recovery efforts. Exercise is commonly prescribed as a non-pharmacological means of maintaining bone mass. However, in those with compromised bone strength, the loads imposed by rigorous exercises may facilitate a fracture it was intended to prevent. Low intensity vibrations (LIV), a mechanical signal demonstrated as anabolic to bone by biasing mesenchymal stem cells (MSCs) towards an osteogenic endpoint, may represent …
Synthesis Of Thermally-Responsive Amphiphilic Tri-Arm Star Copolymers, Menglan Jiang
Synthesis Of Thermally-Responsive Amphiphilic Tri-Arm Star Copolymers, Menglan Jiang
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Amphiphilic block copolymers have attracted much research interest due to their potential applications in various areas, such as drug delivery and gene therapy and. Those polymers usually contain hydrophobic and hydrophilic blocks, which allow them to undergo self-assemby in aqueous solution. Thermally-responsive amphiphilic copolymers have been investigated by our group. Thermally-responsive blocks which have a lower critical solution temperature (LCST) will become insoluble in aqueous solution upon heating and induce the morphological changes in copolymer assembly. In this project, amphiphilic tri-arm star copolymer which contains one hydrophilic polyethylene glycol (PEG) block, one hydrophobic polylactide (PLA) block and one thermally-responsive Poly(N,N-diethylacrylamide) …
Computational Modeling And Analysis Of Cardiac Excitation, Abhishek Murthy
Computational Modeling And Analysis Of Cardiac Excitation, Abhishek Murthy
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Modeling, analysis, and control of cardiac excitation, the biological process cardiac cells undergo on a periodic basis, is indispensable for understanding and countering life-threatening electrical disturbances of the heart, such as atrial and ventricular fibrillation. Modeling involves the derivation of a mathematical/computational representation of the dynamics of cardiac cells and their diffusivity. The key to effective modeling lies in striking a balance between i) precision, the ability of the model to replicate the underlying biological phenomena, and ii) performance, in terms of amenability to automated analysis techniques, such as simulation and formal verification. The techniques of abstraction and compositionality have …
Parallel And Flexible Hardware Implementation Of Fletcher Checksum, Maria Isabel Mera Collantes
Parallel And Flexible Hardware Implementation Of Fletcher Checksum, Maria Isabel Mera Collantes
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Checksums are utilized in many contexts such as communications, storage and reliable processing. The balance between checksum strength, implementation cost and obtained throughput often pose a challenge for present day system designers. In this research we propose two new methods for implementing the Fletcher Checksum (FC) in a parallelized context. We determined an extended parallel definition from the original FC and applied it to two different hardware implementation approaches. We then created a generator that would automatically output parameterized designs. We controlled the input word length, number of parallel inputs and architecture of the designs, and we then synthesized these …
Evaluation Of Wrf Planetary Boundary Layer Schemes Over The Coastal Waters Of Southern New England, Matthew Joseph Sienkiewicz
Evaluation Of Wrf Planetary Boundary Layer Schemes Over The Coastal Waters Of Southern New England, Matthew Joseph Sienkiewicz
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Winds, temperatures and moisture in the planetary boundary layer (PBL) are often difficult for operational models to predict given the relatively sparse observations and that most model PBL parameterizations were developed over inland locations. Coastal marine layer forecasts are important for the forecasting of severe storms and wind energy resources in the highly populated coastal marine environment of the Northeast U.S. (NEUS). Mesoscale models are known to have large biases in wind speeds and temperatures at these lower levels over coastal waters. The goal of this project is to evaluate the performance of six PBL schemes in the Weather Research …
Evaluation Of Wrf Planetary Boundary Layer Schemes Over The Coastal Waters Of Southern New England, Matthew Joseph Sienkiewicz
Evaluation Of Wrf Planetary Boundary Layer Schemes Over The Coastal Waters Of Southern New England, Matthew Joseph Sienkiewicz
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Winds, temperatures and moisture in the planetary boundary layer (PBL) are often difficult for operational models to predict given the relatively sparse observations and that most model PBL parameterizations were developed over inland locations. Coastal marine layer forecasts are important for the forecasting of severe storms and wind energy resources in the highly populated coastal marine environment of the Northeast U.S. (NEUS). Mesoscale models are known to have large biases in wind speeds and temperatures at these lower levels over coastal waters. The goal of this project is to evaluate the performance of six PBL schemes in the Weather Research …
The Effect Of Patch Dynamics And Nutrient Availability On The Production Of Zostera Marina Seeds Within Shinnecock Bay, Ny, Lisa Jackson
The Effect Of Patch Dynamics And Nutrient Availability On The Production Of Zostera Marina Seeds Within Shinnecock Bay, Ny, Lisa Jackson
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Exposing Zostera marina to fertilized porewater has been shown to increase vegetative shoot density and leaf growth rates, as well as affect morphological shoot characteristics including increasing leaf length, leaf area and the number of leaves per shoot. However, aside from changes in shoot density, records of morphological changes in reproductive shoots subjected to increased nutrient availability are lacking. To address this, five replicate ambient and nutrient enriched patches, each between 0.5 and 2.0 m2, were selected within a developing Z. marina meadow in Shinnecock Bay, NY. Fertilizer stakes, with a N:P:K of 15:3:3, were used to amend enriched patches …
Evaluation Of Wrf Planetary Boundary Layer Schemes Over The Coastal Waters Of Southern New England, Matthew Joseph Sienkiewicz
Evaluation Of Wrf Planetary Boundary Layer Schemes Over The Coastal Waters Of Southern New England, Matthew Joseph Sienkiewicz
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Winds, temperatures and moisture in the planetary boundary layer (PBL) are often difficult for operational models to predict given the relatively sparse observations and that most model PBL parameterizations were developed over inland locations. Coastal marine layer forecasts are important for the forecasting of severe storms and wind energy resources in the highly populated coastal marine environment of the Northeast U.S. (NEUS). Mesoscale models are known to have large biases in wind speeds and temperatures at these lower levels over coastal waters. The goal of this project is to evaluate the performance of six PBL schemes in the Weather Research …
Ready, Set, Change: An Exploratory Case Study Of Readiness For Change Within Five New York State Voluntary Child Welfare Agencies, Jennette Allen-Mccombs
Ready, Set, Change: An Exploratory Case Study Of Readiness For Change Within Five New York State Voluntary Child Welfare Agencies, Jennette Allen-Mccombs
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Each year, significant financial resources are expended to implement new policies and programs in an attempt to facilitate organizational change (Fleming, Culler, McCorkle, Becker, & Ballard, 2011). In 2007, the New York State Office of Children and Family Services (OCFS) collaborated with Andrus Center for Learning and Innovation (ACLI) to implement the Sanctuary Model of organizational change within selected voluntary residential child welfare programs that serve youth with behavioral, emotional and social challenges. Since these organizations typically have bureaucratic structures in which culture is maintained through a set of rules and regulations, change may be particularly difficult (Dickinson & Perry, …
Refining Mid-Infrared Emission Spectroscopy As A Tool For Understanding Planetary Surface Mineralogy Through Laboratory Studies, Computational Models, And Lunar Remote Sensing Data, Jessica Anne Arnold
Refining Mid-Infrared Emission Spectroscopy As A Tool For Understanding Planetary Surface Mineralogy Through Laboratory Studies, Computational Models, And Lunar Remote Sensing Data, Jessica Anne Arnold
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Mid-infrared emissivity spectra, while useful for quantifying mineral abundance, are dependent on a variety of other factors, including grain size. At present, scattering models are not fully able reproduce this dependence, especially for very fine-grained powders (d~<60μ m) typical of planetary regolith. Previous studies have modeled emissivity spectra of mineral powders by using Mie single scattering theory coupled with a radiative transfer model, such as Hapke [1993]. Chapter 2 of this work uses multiple scattering T-matrix code (from Mackowski and Mishchenko, 2011) to calculate the scattering coefficients for a cluster of spheres, rather than a single sphere as in Mie theory. I acquired emissivity spectra of highly uniform silica glass spheres, normally used for sieve calibration, for comparison to modeled spectra. Then, I calculated optical constants of the glass from micro-FTIR reflectance spectra of polished grains mounted on a petrographic slide. Modeled emissivity spectra computed with this T-matrix/radiative transfer hybrid method show a marked improvement over Mie-radiative transfer hybrid models, especially for smaller grain sizes. The complex index of refraction (ñ =n+ik) as a function of wavelength, where n and k are often referred to as optical constants, is an essential input into radiative transfer models. Hence, quantitative estimates of mineral abundance from remote sensing data require that optical constants are known for a comprehensive set of relevant minerals. While many geologically abundant materials are monoclinic or triclinic, due to both the additional complexity of the models needed and the increased effort required to orient these samples, very few sets of optical constants have been measured for lower-symmetry minerals. Chapter 3 describes how optical constants were calculated from polarized mid-infrared reflectance spectra of oriented single-crystals of five natural samples in the monoclinic crystal system, which include four pyroxene samples and one orthoclase sample. Lastly, in Chapter 4, remote sensing emissivity data from the Diviner Lunar Radiometer Experiment, along with lunar environment laboratory measurements of mineral mixtures, are used to establish constraints on the absolute abundance of olivine at sites where it has been detected by the visible/near-infrared instruments Moon Mineralogy Mapper and Kaguya Spectral Profiler. The two main results of this section are: 1) spectra do not mix linearly at these wavelengths for particles sizes typical of lunar regolith and 2) Diviner data are consistent with a wide range in olivine abundances at these sites. | 170 pages
Software Tools For Stochastic Simulations Of Turbulence, Ryan Kaufman
Software Tools For Stochastic Simulations Of Turbulence, Ryan Kaufman
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
We present two software tools useful for the analysis of mesh based physics application data, and specifically for turbulent mixing simulations. Each has a broader, but separate scope, as we describe. Both features play a key role as we push computational science to its limits and thus the present work contributes to the frontier of research. The first tool is Wstar, a weak* comparison tool, which addresses the stochastic nature of turbulent flow. The goal is to compare underresolved turbulent data in convergence, parameter dependence, or validation studies. This is achieved by separating space-time data from state data (e.g. density, …
Mathematical Modeling Of G-Protein-Coupled Receptor Signaling Pathways, Tao Jiang
Mathematical Modeling Of G-Protein-Coupled Receptor Signaling Pathways, Tao Jiang
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
G-protein-coupled receptor (GPCR) signaling plays an important role in converting extracellular stimuli into cellular responses. Many biological functions are regulated by GPCR signaling, and nearly 40\% of current pharmaceuticals target GPCRs. In this work, mathematical modeling is used to investigate the initial steps of GPCR signaling with two major aims: 1) to understand the causes for non-canonical signaling behaviors; 2) to understand how signaling specificity is reacted to in the individual reactions of the pathway. The classic ternary complex model describing the interaction between a single ligand, receptor and G-protein served as our basic model for the initial investigation. Dose …