Digital Commons Network^™

Correlation Between Expression Of Mir-155 In Colon Cancer And Serum Carcinoembryonic Antigen Level And Its Contribution To Recurrence And Metastasis Forecast, Cao Hongliang, Huang Shaojun, Liu Aihua, Jiang Hua

Saudi Medical Journal

OBJECTIVE: To analyze the correlation between expression of miR-155 in colon cancer tissue and serum carcinoembryonic antigen (CEA) levels, and then explore its contribution to forecasting recurrence and metastasis. METHODS: Eighty-four pairs of colon cancer specimens and their corresponding non-tumor adjacent tissues were collected and analyzed between March 2009 and December 2011 in Xiangyang Central Hospital, Xiangyang, Hubei, China. The expression of miR-155 in both tissues was tested using reverse transcription-polymerase chain reaction (RT-PCR), the preoperative serum CEA level was assessed, and the postoperative serum CEA level was also assessed bimonthly during the follow-up period of 2 years. RESULTS: The …

Ipads For Stem Teachers: A Case Study On Perceived Usefulness, Perceived Proficiency, Intention To Adopt,And Integration In K-12 Instruction, Haihong Hu, Uma Garimella

Journal of Educational Technology Development and Exchange (JETDE)

With the rapidly growing popularity of mobile learning and the trend for Bring Your Own Device (BYOD) in the United States, there is an emergent need for up-to-date training on the use of mobile technologies for K-12 STEM teachers. This article will discuss the implementation of and results from an exploratory case study conducted within a summer professional development focused on cultivating teacher readiness for mobile learning on iPads in the STEM fields.

Oncolytic Tanapoxvirus Expressing Flic Causes Regression Of Human Colorectal Cancer Xenografts In Nude Mice, Steven J. Conrad

Dissertations

Cancers of the colon and rectum are a significant cause of morbidity and mortality worldwide and existing therapies often perform poorly for individuals afflicted with advanced stage disease. Oncolytic virotherapy is an emerging therapeutic modality which shows great promise for addressing this serious medical need. Herein we describe the in vivo testing of recombinant variants of the tanapoxvirus (TPV), a virus endemic to equatorial Africa which causes a mild and self-limiting disease in humans. Recombinant tanapoxviruses were made deleted for the 66R gene, the 2L gene, or both. Some of the recombinants were armed with mouse chemotactic protein 1 (m …

Correlational Studies Of Organophosphate Levels And Endocrine Disruption, Immunomodulation, And Altered Glucose Homeostasis In A Human Population Study, Carrie Mckean

Dissertations

Organophosphate (OP) pesticides have become the most widely used insecticides since the removal of organochlorine pesticides (“Ch4 Organophosphate Insecticides.pdf,” n.d.) and are generally the most toxic of all pesticides to vertebrates (Soltaninejad & Abdollahi, 2009). As a result, ongoing research has been aimed at further understanding potential health effects from exposure.

The aim of this dissertation research project is to investigate and characterize correlations of OP body burden with human health effects. This research involves an investigation into three pertinent areas concerning OP exposure: thyroid disruption, altered hematology biomarkers, and alterations of glucose homeostasis. Data under investigation come exclusively from …

Drugged Out: How Cognitive Bias Hurts Drug Innovation, Cynthia M. Ho

San Diego Law Review

This Article hopes to provide a balanced picture of how current patent law and policy promotes mostly modest, yet high priced new drugs, as well as how cognitive biases have perpetuated this situation. This Article highlights the important interplay of cognitive biases not only by the frequently maligned industry but also previously presumed neutral parties, such as academics and policymakers. Most scholars would likely agree that considering how to optimize or at least not distort innovation is an important part of legal scholarship. However, to date, there has been little recognition, let alone robust discussion, of how patent and related …

J Am Coll Dent 2014 81 3

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

Privatization And Property In Biology, Joan E. Strassmann, David C. Queller

Biology Faculty Research

Organisms evolve to control, preserve, protect and invest in their own bodies. When they do likewise with external resources they privatize those resources and convert them into their own property. Property is a neglected topic in biology, although examples include territories, domiciles and nest structures, food caching, mate guarding, and the resources and partners in mutualisms. Property is important because it represents a solution to the tragedy of the commons; to the extent that an individual exerts long-term control of its property, it can use it prudently, and even invest in it. Resources most worth privatizing are often high in …

Genetic Explanations: Sense And Nonsense, Garland E. Allen

Biology Faculty Research

Book review of Sheldon Krimsky; Jeremy Gruber (Editors). Genetic Explanations: Sense and Nonsense. xi + 368 pp., index. Cambridge, Mass.: Harvard University Press, 2013. $45 (cloth).

The Agreement On Trade Facilitation And Its Implications: An Interpretative Perspective, Heng Wang

Research Collection Yong Pung How School Of Law

As a highly compromising and flexible agreement, the Agreement on Trade Facilitation (hereinafter “TFA” or “the agreement”) may shed light on the future direction of the world trade regime. Going beyond the tariffs and border, the agreement is featured with good governance requirements. Its delicate relationship with free trade agreements (hereinafter “FTAs”), the domestic law, and existing World Trade Organization (hereinafter “WTO”) agreements deserves attention and carries important implications. What is the relationship between of the TFA and non-WTO rules? How do existing WTO agreements apply to the TFA explicitly or implicitly? What is the interpretative challenge? In addressing these …

Brave: A Feminist Perspective On The Disney Princess Movie, Danielle Morrison

Communication Studies

No abstract provided.

Review Of Just Queer Folks: Gender And Sexuality In Rural America By Colin R. Johnson, Emily Kazyak

Department of Sociology: Faculty Publications

Colin Johnson’s book Just Queer Folks provides a powerful corrective to the faulty assumption that gender and sexual nonnormativity and rurality are incompatible. As a historian, Johnson focuses on both the discourses about sexuality emerging and the wide array of sexual practices occurring in the first half of the twentieth century in rural America. He analyzes a wide range of sources to make two central points: first, that heterosexuality and heteronormativity are not “indigenous to rural areas,” but were constructed there (p. 18); second, that same-sex sexual behavior and gender nonconformity were commonplace in rural America in early twentieth century. …

The New Hampshire, Vol. 103 [104], No. 49 (Summer 2014), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 103, but it is the 104th volume in the series. This was corrected in pencil.

Installation Plan For An Automatic Fresh Water Ball Valve For The Dairy Unit Flush Tank At California Polytechnic State University, Garret James Rowley

Agricultural Education and Communication

The purpose of this senior project was to plan for the installation of an automatic fresh water valve at the Dairy Unit at California Polytechnic State University. This new valve will replace the existing manual gate valve that repeatedly overfills the tank. The data and research was completed in order to assess the projects feasibility and installation needs. This project outlines the steps needed to be taken in order to install the valve, as well provides a detailed explanation on why this installation is pertinent.

Project Proposal And Development Plan For A New Security Gate At Swanton Pacific Ranch, K. Morgan Perry

Agricultural Education and Communication

The purpose of this project was to develop a prototype gate for Cal Poly’s Swanton Pacific Ranch in Santa Cruz, CA. Swanton Pacific Ranch requested that the author design and build a 21’x5’ single-retractable gate for Swanton Pacific Ranch to help decrease the security issues that have recently arisen at the facility. The design and format of this project are focused towards the desires and goals set forth by Swanton Pacific Ranch and the Operations Manager, Steve Auten in order to obtain a certain outcome. This project provides an outline of what needs to be done in order to produce …

Aged 539 Graduate Project, Clint C. Cowden

Agricultural Education: Graduate Internship Reports

This internship report contains documented evidence required in meeting the quality criteria used to evaluate Community College Programs. These criteria were established by the Agriculture/Natural Resources Advisory Committee and are used to evaluate Community Colleges throughout California. In addition to documented evidence, the internship report also includes a special project on Program Effectiveness. The project created a degree qualification profile for the Agriculture Science and Technology degree at West Hills College, Coalinga which was approved by the DQPP committee at West Hills College, Coalinga. The DQP describes five basic areas of learning: Broad, Integrative Knowledge; Specialized Knowledge; Intellectual Skills; Applied …

Agricultural Education Graduate Internship Reports, Mark H. Powell

Agricultural Education: Graduate Internship Reports

This internship/project report includes validation documents required in meeting the quality criteria for secondary-level programs of instruction in agriculture. The documents are concurrently used for the Agriculture Incentive Grant review process at Santa Maria High School conducted by representatives of the California Department of Education. The internship included the development and implementation of a constitution and by-laws to govern the Agriculture Advisory committee for Santa Maria High School. The internship project includes information to receive state/local funding, outline the goals and objectives of the program, along with an overview of Santa Maria High School, the agriculture program and community.

Characterization Of Corynebacterium Pseudotuberculosis Biovar Equi Isolates Obtained From Cal Poly Horses And Review Of Application Of Transposons To Better Prevent Pigeon Fever In Horses, Irene Hasen

Animal Science

No abstract provided.

Beef Cattle Lesson Plans: For Use In The Education Of School-Age Children In The Beef Cattle Industry, Katherine M. Halloran, Cheyenne H. Love

Animal Science

This project was initially created for use at Fort Hope in Arroyo Grande, California. It designs lesson plans created to teach children about the beef cattle industry. The project consists of lesson plans for three age groups: 7-9, 10-12, and 13-15. Each age group will learn various aspects about beef cattle, and lessons will increase in complexity as the children advance age groups. The groups will spend six days in lecture completing worksheets and activities, and on the seventh day, after completion of a review game, the children receive certificates. While the project was created specifically for the Fort Hope …

The Effects Of Different Cryopreservation Techniques On The Survival Rate Of In Vitro Produced (Ivp) And Biopsied Bovine Blastocysts, Diana J. Gumber

Animal Science

This study’s objectives were to determine if the biopsy of expanded blastocysts prior to cryopreservation affected the survival rates and determine if there is a difference between slow-freezing in 10% glycerol, slow freezing in ethylene glycol, and vitrification in terms of survival rate of the embryos. Blastocoeles were reduced prior to cryopreservation by means of biopsy. Embryos for slow freezing were exposed to ethylene glycol (SynGRO Ethylene Glycol with Sucrose, BIONICHE, Pullman, WA, USA) or 10% glycerol (SynGRO 10% Glycerol, BIONICHE, Pullman, WA, USA) as cryoprotectants. Vitrified embryos were exposed to 10% and 40% ethylene glycol. Survival rate of biopsied …

Development And Implementation Of Assessment Methods For Tissue-Engineered Blood Vessel Mimics, Tanner Stevenson

Biomedical Engineering

Coronary Artery Disease (CAD), the most prevalent form of heart disease, is the result of clogged or damaged coronary arteries and claims around 380,000 Americans annually. A common treatment for CAD involves placing a stent into the artery in order to open the lumen and support the native tissue—a procedure that drastically reduces patient recovery times in comparison to heart bypass surgery. However, stents do not always interact well with the body and require additions such as surface coatings or drug elution in order for additional biocompatibility. These additions necessitate extensive in vitro and in vivo testing which are expensive …

Endothelial And Smooth Muscle-Dependent Vascular Reactivity In Immature Arterialized Collateral Capillaries, Caitlin Koeroghlian

Biomedical Engineering

Peripheral arterial occlusive disease (PAOD) occurs due to the build up of atherosclerotic plaque and reduces blood flow to cause chronic ischemia. Patients with PAOD may experience intermittent claudication, or the pain in limb skeletal muscles due to a decease in blood flow. Collateral arteries can act as a natural bypass and improve blood flow to hypoxic tissue by creating an alternate route for blood to flow, but not all patients with PAOD have pre-existing collateral networks. Animal studies indicate that tissues without pre-existing collateral networks can form de novo collaterals from capillaries following occlusion of a feed artery. Unfortunately, …

Play From The Heart: On Crafting A Community Of Empathy In The Theatre, Kevin Kingston

The Theatre School MFA in Directing Theses

The power of story goes beyond mere escapist entertainment. Yes it should entertain, but that is not the ultimate goal. It may even offer a bit of escape, but again this is not the holy grail. When we experience a well-crafted narrative, we are called to cross a threshold. We pass through the door of our own life and enter into the experience of another. This is what we mean when we say we "got lost" in the story. We take on the experience of another as our own. When a group of people experience a narrative they cross this …

The Truth Of Christianity? Michel Henry's Words Of Christ, Christina M. Gschwandtner

Journal of Scriptural Reasoning

No abstract provided.

Learning From And Thoughts On The Handbook Of Research On Educational Communications And Technology (3rd Edition): Part 2 — Insights In Complexity Theory, Situational Theory, And Several Other Hot Topics, Kekang He

Journal of Educational Technology Development and Exchange (JETDE)

This paper elaborates on what the author has learned from the Handbook of Research on Educational Communications and Technology (3rd edition) in four respects: complexity theory and the complex learning supported by technology, situational theory and the scenariobased teaching model and strategy, the first principles of instruction and the four-component instructional design model (4C/ID), and the debate regarding the future of educational technology as a result of the changes in the direction of technical research.

Cytokine Changes In Colonic Mucosa Associated With Blastocystis Spp. Subtypes 1 And 3 In Diarrhoea-Predominant Irritable Bowel Syndrome, Javed Yakoob, Zaigham Abbas, Muhammad Waqas Usman, Aisha Sultana, Muhammad Islam, Safia Awan, Zubair Ahmad, Saeed Hamid, Wasim Jafri

Section of Gastroenterology

We determined cytokines (e.g. interleukin-8, 10, 12 and TNF-α) expression by peripheral blood mononuclear cells (PBMCs) and in rectal mucosa in diarrhoea-predominant irritable bowel syndrome (D-IBS) with Blastocystis spp. Eighty patients with D-IBS and Blastocystis spp. infection were classified as 'cases' and 80 with D-IBS without Blastocystis spp. infection were classified as 'control'. Cases were subdivided into D-IBS and Blastocystis sp. defined type 1 (subtype-specific primer SB83) and type 3 (SB227). Stool microscopy and culture were performed. Rectal biopsies were obtained for histology and cytokines by real-time PCR for mRNA expression of cytokines. PBMCs IL-8 was similar in different groups …

Functional Vasodilation Is Impaired In Arterialized Capillaries In The Spinotrapezius, Joshua P. Cutts

Biomedical Engineering

Ischemic diseases are the result of atherosclerotic plaques, which occlude conduit arteries. Ischemic disease in different tissues leads to different conditions, such as coronary artery disease (CHD), cerebrovascular disease (CVD), and peripheral arterial occlusive disease (PAOD). Patient vasculature architecture is variable; some patients having many collateral vessels, which are connect one arterial branch to another, and readily serve as natural bypass routes to atherosclerotic occlusions, to enlarge and provide blood flow to tissue distal to the occlusion. Patients with many natural collateral vessels are ischemia protected. Unfortunately, not all patients have collateral arterioles to remodel into conduit vessels and provide …

Lamb Bacon: How The Method Of Brine Distribution And Addition Of A Dry Rub Influences Yields, Morgan Metheny

Animal Science

This study was conducted to test the whether lamb breasts can substitute as the raw material in producing a bacon product. Due to the difference in fat saturation between pork and lamb, this research was used to test how successful lamb absorbs the brine in order to make bacon. The yield results of two different processing techniques, injection and tumbling, were compared along with comparing the affect of adding a dry rub of seasonings to the lamb surface. The 120 lambs breasts were split into four groups of 30. Each group received a different treatment: plain tumbled, plain injected, seasoned …

Water In The 21st Century, Grayson Michael Shor

Social Sciences

The aim of this research project is to provide a comprehensive and global analysis of water use in order to provide the reader with a comprehensive grasp of current and impending issues. The included five (5) chapters discuss water distribution, conservation, purification, law, international development, economic debates, ethical consideration, as well as educated estimations of the effects water related issues may cause in the next one-hundred years.

Queer(Y)Ing Permanent Partnership, Alix L. Olson

Wagadu: A Journal of Transnational Women's & Gender Studies

Analyzing discourses surrounding a recent LGBT immigration reform proposal, this paper argues that the current trajectory of homonational forms of citizenship is ultimately an “alienating production.” It is by critically assessing the casualties wrought by these kinds of assimilationist strategies, the author suggests, that we might look instead toward alternative conceptions of citizenship altogether.

Questions And Answers: Copyright Column, Laura Gasaway

Against the Grain

No abstract provided.