Digital Commons Network^™

Multimodal Literacy And Why It Matters: A Brief Overview, Samantha Hines

Against the Grain

No abstract provided.

Hunters And Gatherers: The Future Of Search, Andrea Fallas

Against the Grain

No abstract provided.

Queering Masturbation In Lorde's Life And Writing, Eric Sipyinyu Njeng

CLCWeb: Comparative Literature and Culture

In his article "Queering Masturbation in Lorde's Life and Writing" Eric Sipyinyu Njeng discusses masturbation in Audre Lorde's life and works to signal an important aspect of her oeuvre often neglected in scholarship. Lorde stands out among prominent queer queens by demonstrating theory corporeally thereby going beyond mere theory and positing her body as a space of complex sexual passions. When Judith Butler speaks of gender as performative rather than embodied, Lorde theorizes and foregrounds this in her works and self and celebrates a sexual matrix that ranges from heterosexuality to homosexuality to auto-sexuality. Lorde places masturbation between the binary …

Greenberg's Prose And Poetry About World War I, Chanita Goodblatt

CLCWeb: Comparative Literature and Culture

In her article "Greenberg's Prose and Poetry about World War I" Chanita Goodblatt analyzes the literary response of Uri Zvi Greenberg to the war. His volume of poetry Krieg oyf der Erd— largely untranslated to English — can be read as part of a multicultural literary response to World War I, particularly in juxtaposition with the poems of Wilfred Owen and Siegfried Sassoon. Goodblatt posits that a study of shared esthetic strategies and literary traditions underlines the way in which Greenberg created an "alienated wanderer" who witnesses and stands helpless in the face of the violence and destruction of …

Biophysical Mechanisms Of Early Heart Morphogenesis, Yunfei Shi

All Theses and Dissertations (ETDs)

The heart is the first functioning organ in the developing embryo. Initially, the heart is a relatively straight tube created by folding and fusion of the cardiogenic fields, which lie bilaterally within the blastoderm. Shortly after formation, the primitive heart tube (HT) undergoes the morphogenetic process of c-looping as it bends and twists into a c-shaped tube. All these transformations require physical forces, which remain poorly understood.

The aim of this dissertation is to elucidate some of the biophysical mechanisms that create and shape the early HT. Our work involves a combination of ex ovo experiments and computational modeling. Experiments …

Downhill Treadmill Running Does Not Induce Muscle Damage In Fvb Mice, Brenda Benson

Theses and Dissertations

Downhill treadmill running is a commonly used method to cause exercise-induced muscle damage, especially in rodents. Previous studies have evaluated which muscles in rats are more prone to damage. However research using downhill run mice (DHR) has shown some inconsistencies in which muscle is best analyzed for damage. Purpose: The purpose of this study was to quantify the damage in various muscles in a mouse after a single bout of DHR. Methods: Male FVB mice (5 months) were injected with Evans Blue dye (EBD) and then either used as control (CON) or run downhill (-16°) at 20 meters per minute …

Killing Time, Jim Easterhouse

A Midwestern Review: A Magazine of the Arts and Issues at DePauw University

No abstract provided.

Vaccination With A Genetically Modified Brugia Malayi Cysteine Protease Inhibitor-2 Reduces Adult Parasite Numbers And Affects The Fertility Of Female Worms Following A Subcutaneous Challenge Of Mongolian Gerbils (Meriones Unguiculatus) With B. Malayi Infective Larvae., Sridhar Arumugam, Junfei Wei, Danielle Ward, David Abraham, Sara Lustigman, Bin Zhan, Thomas R. Klei

Department of Microbiology and Immunology Faculty Papers

Vaccination of Mongolian gerbils with Brugia malayi cysteine protease inhibitor-2 in which the amino acid Asn66 was mutated to Lys66 (Bm-CPI-2M) resulted in reduced parasite numbers of 48.6% and 48.0% at 42 and 90 days p.i. with B. malayi L3s. Fertility of female worms was also affected at 90 days p.i. In vitro killing of L3s observed in the presence of gerbil peritoneal exudate cells and anti-Bm-CPI-2M sera suggests antibody-dependent cell-mediated cytotoxicity as a putative protective mechanism. These observations suggest that Bm-CPI-2M is a promising prophylactic and anti-fecundity vaccine candidate.

Gaming, September 1, 2014: Audit And Accounting Guide, American Institute Of Certified Public Accountants (Aicpa)

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.

Mir-103a-3p Targets The 5' Utr Of Gprc5a In Pancreatic Cells., Honglei Zhou, Isidore Rigoutsos

Computational Medicine Center Faculty Papers

MicroRNAs (miRNAs) are short noncoding RNAs that regulate the expression of their targets in a sequence-dependent manner. For protein-coding transcripts, miRNAs regulate expression levels through binding sites in either the 3' untranslated region (3' UTR) or the amino acid coding sequence (CDS) of the targeted messenger RNA (mRNA). Currently, for the 5' untranslated region (5' UTR) of mRNAs, very few naturally occurring examples exist whereby the targeting miRNA down-regulates the expression of the corresponding mRNA in a seed-dependent manner. Here we describe and characterize two miR-103a-3p target sites in the 5' UTR of GPRC5A, a gene that acts as a …

Snf1 Mediated Phosphorylation And Activation Of Pas Kinase, Bryan D. Badal

Theses and Dissertations

Nutrient sensing kinases sense available nutrients and regulate cell activity accordingly. Three of these enzymes are AMP regulated kinase (AMPK, or Snf1 in yeast), PAS kinase, and target of rapamycin (TOR), are conserved from yeast to man and have overlapping function. AMPK and Snf1 are important in sensing when nutrient status in the cell is low and down regulating energy consuming pathways. PAS kinase is required for glucose homeostasis in the cell, and responds to glucose levels. TOR senses nutrients such as amino acids and upregulates cell growth pathways primarily through protein synthesis. Due to the varying nature of these …

Guido Calabresi And The Construction Of Contemporary American Legal Theory , James R. Hackney Jr.

Law and Contemporary Problems

No abstract provided.

Consent, Choice, And Guido Calabresi’S Heterodox Economic Analysis Of Law , Alain Marciano, Giovanni B. Ramello

Law and Contemporary Problems

No abstract provided.

Vol 59 Conference Edition, Judy Kulp

MPLA Newsletter

No abstract provided.

“We Are Not Free”: The Meaning Of (Freedom) In American Indian Resistance To President Johnson’S War On Poverty, Casey Ryan Kelly

Department of Communication Studies: Faculty Publications

This essay examines how the ideograph was crafted through dialectical struggles between Euro-Americans and American Indians over federal Indian policy between 1964 and 1968. For policymakers, was historically sutured to the belief that assimilation was the only pathway to American Indian liberation. I explore the American Indian youth movement’s response to President Johnson’s War on Poverty to demonstrate how activists rhetorically realigned in Indian policy with the Great Society’s rhetoric of “community empowerment.” I illustrate how American Indians orchestrated counterhegemonic resistance by reframing the “Great Society” as an argument for a “Greater Indian American.” This analysis evinces the rhetorical significance …

Implementation And Validation Of Aortic Remodeling In Hypertensive Rats, Shijia Zhao, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

A computational framework was implemented and validated to better understand the hypertensive artery remodeling in both geometric dimensions and material properties. Integrating the stress-modulated remodeling equations into commercial finite element codes allows a better control and visualization of local mechanical parameters. Both arterial thickening and stiffening effects were captured and visualized. An adaptive material remodeling strategy combined with the element birth and death techniques for the geometrical growth were implemented. The numerically predicted remodeling results in terms of the wall thickness, inner diameter, and the ratio of elastin to collagen content of the artery were compared with and fine-tuned by …

The Trehalose Pathway In Maize: Conservation And Gene Regulation In Response To The Diurnal Cycle And Extended Darkness, Clémence Henry, Samuel W. Bledsoe, Allison Siekman, Alec Kollman, Brian M. Waters, Regina Feil, Mark Stitt, L. Mark Lagrimini

Department of Agronomy and Horticulture: Faculty Publications

Energy resources in plants are managed in continuously changing environments, such as changes occurring during the day/night cycle. Shading is an environmental disruption that decreases photosynthesis, compromises energy status, and impacts on crop productivity. The trehalose pathway plays a central but not well-defined role in maintaining energy balance. Here, we characterized the maize trehalose pathway genes and deciphered the impacts of the diurnal cycle and disruption of the day/night cycle on trehalose pathway gene expression and sugar metabolism. The maize genome encodes 14 trehalose-6-phosphate synthase (TPS) genes, 11 trehalose-6-phosphate phosphatase (TPP) genes, and one trehalase gene. Transcript abundance of most …

Use Of Cysteine-Reactive Crosslinkers To Probe Conformational Flexibility Of Human Dj-1 Demonstrates That Glu18 Mutations Are Dimers, Janani Prahlad, David N. Hauser, Nicole M. Milkovic, Mark R. Cookson, Mark A. Wilson

Department of Biochemistry: Faculty Publications

The oxidation of a key cysteine residue (Cys106) in the parkinsonism-associated protein DJ-1 regulates its ability to protect against oxidative stress and mitochondrial damage. Cys106 interacts with a neighboring protonated Glu18 residue, stabilizing the Cys106-SO₂ ⁻ (sulfinic acid) form of DJ-1. To study this important post-translational modification, we previously designed several Glu18 mutations (E18N, E18D, E18Q) that alter the oxidative propensity of Cys106. However, recent results suggest these Glu18 mutations cause loss of DJ-1 dimerization, which would severely compromise the protein’s function. The purpose of this study was to conclusively determine the oligomerization state of these mutants using X-ray …

Natural Infections Of Tetrathyridia Of Mesocestoides Species In Deer Mice, Peromyscus Maniculatus, From New Mexico, John E. Ubelaker, Nora Abdullah, Aya Mouhaffel, Rashmi Ananadampillair, Caitlyn Emigh, Scott Lyell Gardner

Papers in Parasitology

At Southern Methodist University campus about 6 miles south of Taos, New Mexico, we recovered tetrathyridia of Mesocestoides in five Peromyscus maniculatus in the summers of 2008 (3 of 129, 0.023%), 2009 (0 of 98, 0%), 2010 (1 of 112, 0.008%), 2011 (0 of 88, 0%), and 2012 (1 of 86, 0.011%). Tetrathyridia from the body cavity of one of the five infected mice were injected into the peritoneal cavity of laboratory white mice, Mus musculus. Our later examination of the laboratory mice revealed heavy infections of tetrathyridia continuing to reproduce asexually. Here we provide important new information on …

Natural Infections Of Tetrathyridia Of Mesocestoides Species In Deer Mice, Peromyscus Maniculatus, From New Mexico, John E. Ubelaker, Norah Abdullah, Aya Mouhaffel, Rashmi Ananadampillair, Caitlyn Emigh, Scott Lyell Gardner

Harold W. Manter Laboratory of Parasitology: Faculty Publications

At Southern Methodist University campus about 6 miles south of Taos, New Mexico, we recovered tetrathyridia of Mesocestoides in five Peromyscus maniculatus in the summers of 2008 (3 of 129, 0.023%), 2009 (0 of 98, 0%), 2010 (1 of 112, 0.008%), 2011 (0 of 88, 0%), and 2012 (1 of 86, 0.011%). Tetrathyridia from the body cavity of one of the five infected mice were injected into the peritoneal cavity of laboratory white mice, Mus musculus. Our later examination of the laboratory mice revealed heavy infections of tetrathyridia continuing to reproduce asexually. Here we provide important new information on the …

Radix Angelicae Sinensis And Radix Hedysari Enhance Radiosensitivity Of 12c6+ Radiation In Human Liver Cancer Cells By Modulating Apoptosis Protein, Wei Kou, Ying-Dong Li, Kai Liu, Shao-Bo Sun, Yu-Mei Dong, Zhen-Hua Wu

Saudi Medical Journal

OBJECTIVES: To investigate the radiosensitizing effects of Radix Angelicae Sinensis-Radix Hedysari (RAS-RH [an ultra-filtration extract]) and its underlying mechanisms in human liver cancer cells H22. METHODS: This study was conducted between September 2010 and August 2012 in the Gansu University of Traditional Chinese Medicine, Lanzhou, China. The groups were assigned as the control group, drug (RAS-RH) group, 12C6+ radiation group, and combination group. The cell counting kit-8 assay, colony formation assay, cell cycle changes, and apoptosis analysis were carried out, and survivin and casepase-9 were evaluated by reverse transcription polymerase chain reaction and Western blot analyses in the 4 groups. …

Effect Of Infliximab Against Cisplatin-Induced Nephrotoxicity, Erkan Cure, Aynur Kirbas, Levent Tumkaya, Medine C. Cure, Osman Z. Şahin, Yildiray Kalkan, Suleyman Yuce, Durdu Altuner

Saudi Medical Journal

OBJECTIVES: To investigate whether infliximab (Ib), an inhibitor of tumor necrosis factor alpha (TNF-±), prevents cisplatin (Cis)-induced nephrotoxicity. METHODS: The study was performed in the Department of Internal Medicine, Recep Tayyip Erdogan University, Rize, Turkey, between November 2012 and May 2013. Thirty male Wistar albino rats were divided into 3 groups, a control group, a Cis group, and a Cis+Ib group. The animals of the Cis group were injected with a single dose (7 mg/kg) of Cis intraperitoneally. The animals of the Cis+Ib group were injected with a single dose (7 mg/kg) of Ib 72 hours prior to Cis injection. …

Association Of Dietary Patterns With Body Mass Index, Waist Circumference, And Blood Pressure In An Adult Population In Ahvaz, Iran, Fatemeh Haidari, Esmat Shirbeigi, Makan Cheraghpour, Majid Mohammadshahi

Saudi Medical Journal

OBJECTIVES: To assess the association between dietary patterns, central obesity, and blood pressure (BP). METHODS: In this cross-sectional study, we evaluated anthropometric measurements, BP, and usual dietary intakes of 243 men, aged 30-50 years old, working at the Education and Culture Systems in Ahvaz, Iran, between October 2011 and March 2012 using the Food Frequency Questionnaire (FFQ). RESULTS: Using the factor analysis, we extracted 3 major dietary patterns: “prudent”, “high protein” and “high fat”. After controlling for confounders (energy and physical activity), “prudent” pattern scores were negatively associated with body mass index, waist circumference, waist-to-hip ratio, systolic and diastolic BP …

Protective Effect Of Seed Oil Of Herpetospermum Pedunculosum Against Carbon Tetrachloride-Induced Liver Injury In Rats, Gang Li, Xiao-Yan Wang, You-Rui Suo, Hong-Lun Wang

Saudi Medical Journal

OBJECTIVES: To investigate the protective effect of Herpetospermum pedunculosum (H. pedunculosum) seed oil against carbon tetrachloride (CCl4)-induced liver damage. METHODS: This experimental study was conducted at the Northwest Institute of Plateau Biology, Chinese Academy of Sciences, and Yantai University, China from November 2012 to May 2013. The H. pedunculosum seed oil was extracted using supercritical carbon dioxide. The antioxidant activities of H. pedunculosum seed oil were assayed in vitro by 2,2-diphenyl-1-picrylhydrazyl assay, lipid peroxidation assay, and antihemolytic assay. Adult Sprague Dawley rats were randomly divided into 6 groups (10 rats/group) including control, CCl4, CCl4+bifendate, and CCl4+H. pedunculosum seed oil (3 …

The Association Of Gallstone Disease And Diabetes Mellitus. A Meta-Analysis, Wen Wang, Niangfeng Li

Saudi Medical Journal

OBJECTIVES: To assess the association between diabetes mellitus and gallstone disease (GSD) by meta-analysis. METHODS: This study was carried out at Xiangya Hospital, Changsha, Hunan, China in September 2013. First, eligible studies were searched in PubMed and Cochrane Central databases from their inception to September 2013. Then, a random effect model was used to calculate the overall combined risk estimates. The meta-analysis included 403,001 cases and 411,877 controls from 6 case-control studies, 3 cohort studies, and 13 cross-sectional studies. Finally, statistical analyses were conducted according to the classification of study. RESULTS: Risk ratios for diabetes mellitus and GSD were 1.75 …

Is Systemic Infliximab Therapy Effective For Retinal Cavernous Hemangioma?, Sulaiman M. Alsulaiman, Marwan A. Abouammoh, Saad A. Al-Dahmash

Saudi Medical Journal

A 10-month-old infant with the diagnosis of retinal cavernous hemangioma involving the macula presented with an outward deviation of the right eye that has been noticed by her parents. Examination revealed a clearing vitreous hemorrhage, and grape-like clusters filled with blood in the posterior pole. After 4 cycles of intravenous infliximab over the period of 3 months, no evident change was noted on the size of the cavernous hemangioma.

Extreme Oral Myiasis, Benny Joseph, Suresh Vyloppilli, Auswaf Ahsan, Anroop Anirudhan

Saudi Medical Journal

Extreme oral myiasis is a rare condition, mostly affecting bedridden patients whose oral health care measures are neglected. Single stage manual removal of the maggots along with the necrotic tissue, debridement, and suturing under general anesthesia is the most effective way to treat the condition. Preventive measures are also equally important to eliminate the cause and recurrence.

Seroprevalence Of Toxoplasma Gondii In Women In Najran City, Saudi Arabia, Ismail S. El-Shahawy, Mokhtar I. Khalil, Mosa M. Bahnass

Saudi Medical Journal

OBJECTIVES: To evaluate the seroprevalence of Toxoplasma gondii among Saudi pregnant women in Najran City, as well as to measure the performance of the diagnostic tests used. METHODS: A total of 96 women attending prenatal special clinics (Oteafyn special clinic) in Najran Province, Saudi Arabia, over a one year period, from September 2012 to September 2013 were screened for the presence of Toxoplasma antibody in their blood serum using an indirect hemagglutination assay (IHA). Specific immunoglobulin (Ig) G and IgM antibodies were evaluated using an enzyme-linked immunosorbent assay (ELISA). RESULTS: Out of the 96 samples of sera tested using IHA, …

Retrospective Analysis Of Fetal Anterior Abdominal Wall Defects, Burcu A. Ulkumen, Halil G. Pala, Yesim Baytur, Faik M. Koyuncu

Saudi Medical Journal

OBJECTIVE: To analyze fetal abdominal defects diagnosed during the prenatal period in the perinatology department in a tertiary center in Turkey. METHODS: This retrospective study consisted of 27 cases diagnosed with fetal abdominal wall defects between January 2011 and February 2014 in the perinatology outpatient clinic of Celal Bayar University, Manisa, Turkey. RESULTS: Eighteen (66.7%) cases were diagnosed with omphalocele, 6 (22.2%) had gastroschisis, and 3 (11.1%) had limb body wall defects. Twenty-one (77.7%) patients diagnosed either as omphalocele or limb body wall defect were offered karyotype analysis; 11 (52.4%) of them accepted the intervention, and 2 of the 11 …

Virus-Host Mucosal Interactions During Early Siv Rectal Transmission, Wuxun Lu, Fangrui Ma, Alexander Churbanov, Yanmin Wan, Yue Li, Guobin Kang, Zhe Yuan, Dong Wang, Chi Zhang, Jianqing Xu, Mark Lewis, Qingsheng Li

Nebraska Center for Biotechnology: Faculty and Staff Publications

To deepen our understanding of early rectal transmission of HIV-1, we studied virus-host interactions in the rectal mucosa using simian immunodeficiency virus (SIV)-Indian rhesus macaque model and mRNA deep sequencing. We found that rectal mucosa actively responded to SIV as early as 3 days post-rectal inoculation (dpi) and mobilized more robust responses at 6 and 10 dpi. Our results suggests that the failure of the host to contain virus replication at the portal of entry is attributable to both a high-level expression of lymphocyte chemoattractant, proinflammatory and immune activation genes, which can recruit and activate viral susceptible target cells into …