Digital Commons Network^™

Increasing Label-Free Stem Cell Sorting Capacity To Reach Transplantation-Scale Throughput, Melinda Simon, Ying Li, Janahan Arulmoli, Lisa Mcdonnell, Adnan Akil, Jamison Nourse, Abraham Lee, Lisa Flanagan

Faculty Publications

Dielectrophoresis (DEP) has proven an invaluable tool for the enrichment of populations of stem and progenitor cells owing to its ability to sort cells in a label-free manner and its biological safety. However, DEP separation devices have suffered from a low throughput preventing researchers from undertaking studies requiring large numbers of cells, such as needed for cell transplantation. We developed a microfluidic device designed for the enrichment of stem and progenitor cell populations that sorts cells at a rate of 150,000 cells/h, corresponding to an improvement in the throughput achieved with our previous device designs by over an order of …

The Effects Of Hmtba (2-Hydroxy-4-Methylthio-Butanoic Acid) Supplementation On Ruminal Microbial Crude Protein Synthesis And Community Structure In Dairy Cattle, Chad James Robert Jenkins

Department of Animal Science: Dissertations, Theses, and Student Research

Metabolizable protein (MP) is protein that reaches the small intestine and is available for absorption and utilization by the cow. Dairy rations may be limited in the supply of MP essential to meeting the demands of milk synthesis, however as much as half of the MP flowing to the small intestine may be attributed to microbial origins and is referred to as microbial CP (MCP). Experiment 1 utilized a technique in which DNA was used as a microbial marker to estimate the concentration of bacterial CP (BCP) in the solid and liquid portions of rumen digesta. Rumen digesta was sampled …

Metformin And Erlotinib Synergize To Inhibit Basal Breast Cancer, Ying-Ka Ingar Lau, Xing Du, Vinayak Rayannavar, Benjamin Hopkins, Jacquelyn Shaw, Eliana Bessler, Tiffany Thomas, Maira M. Pires, Megan Keniry

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Basal-like breast cancers (BBCs) are enriched for increased EGFR expression and decreased expression of PTEN. We found that treatment with metformin and erlotinib synergistically induced apoptosis in a subset of BBC cell lines. The drug combination led to enhanced reduction of EGFR, AKT, S6 and 4EBP1 phosphorylation, as well as prevented colony formation and inhibited mammosphere outgrowth. Our data with other compounds suggested that biguanides combined with EGFR inhibitors have the potential to outperform other targeted drug combinations and could be employed in other breast cancer subtypes, as well as other tumor types, with activated EGFR and PI3K signaling. Analysis …

The Fat Of The Matter: How Dietary Fatty Acids Can Affect Exercise Performance, Barbara J. Pierce, Scott R. Mcwilliams

Biology Faculty Publications

Fatty-acid composition of fat stores affects exercise performance in a variety of vertebrates although few such studies focus on flying vertebrates such as migratory birds, which are exceptional exercisers. We first discuss the natural variation in quality of fat available in natural foods eaten by migratory birds and their behavioral preferences for specific fatty acids in these foods. We then outline three proposed hypotheses for how dietary fatty acids can affect exercise performance, and some of the evidence to date that pertains to these hypotheses with special emphasis on the exercise performance of migratory birds. In theory, selectively feeding on …

Nutrient Runoff Following Swine Manure Application, Seth J. Lamb

Department of Environmental Engineering: Theses and Other Student Research

A field study was completed to compare the effects of land application methods, swine growth stage, and varying flow rates following the application of varying amounts of swine manure to 0.75-m by 2.00-m long plots. Three different manure sources were used to represent key different growth stages including growers, finishers, and sows and gilts. The different swine manures were applied in May and Jun 2011 to meet a 1 year nitrogen (N) requirement for corn. Three different land application methods were used to apply the swine manure, broadcast, incorporation, and injection. Runoff water quality was measured during three 30 minute …

Occurrence Of Rift Valley Fever In Cattle In Ijara District, Kenya, Nelson O. Owange, William O. Ogara, Hippolyte Affognon, Gathura B. Peter, Jacqueline Kasiiti, Sam Okuthe, W. Onyango-Ouma, Tobias Landmann, Rosemary Sang, Murithi Mbabu

All Peer-Reviewed Publications

Ijara district in Kenya was one of the hotspots of rift valley fever (RVF) during the 2006/2007 outbreak which led to human and animal deaths causing huge economic and public health losses. The main constraint in the control and prevention of RVF is inadequate knowledge on its occurrence during the interepidemic period. This study was aimed at understanding the occurrence of RVF in cattle in Ijara to enable the development of improved community-based disease surveillance, prediction, control and prevention.Six herds each 700-1000 cattle were identified with participatory involvement of locals and project technical team of the project. One animal per …

Adolescent Bisphenol-A Exposure Decreases Dendritic Spine Density: Role Of Sex And Age, Rachel E. Bowman, Victoria N. Luine, Hameda Khandaker, Joseph J. Villafane, Maya Frankfurt

Psychology Faculty Publications

Bisphenol-A (BPA), a common environmental endocrine disruptor, modulates estrogenic, androgenic, and anti-androgenic effects throughout the lifespan. We recently showed that low dose BPA exposure during adolescence increases anxiety and impairs spatial memory independent of sex. In the current study, six week old Sprague Dawley rats (n=24 males, n=24 females) received daily subcutaneous injections (40 µg/kg bodyweight) of BPA or vehicle for one week. Serum corticosterone levels in response to a 1 h restraint stress and spine density were examined at age 7 (cohort 1) and 11 (cohort 2) weeks. Adolescent BPA exposure did not alter stress dependent corticosterone responses but …

Physical, Chemical And Biological Assessment Of Yoncalla Log Ponds, Rich Miller, Mark D. Sytsma, Angela L. Strecker

Center for Lakes and Reservoirs Publications and Presentations

The Yoncalla Log Ponds are a series of four ponds located in within the city limits of the town in Yoncalla in northern Douglas County, Oregon. The ponds were created in stages between the late 1930s and the 1950s and used for log storage through the 1970s (North Douglas Betterment 2014). North Douglas Betterment purchased the land surrounding the ponds and contracted with the Center for Lakes and Reservoirs at Portland State University to assess the current morphometry, vegetation and water quality status of the ponds and provide recommendations for management of the aquatic vegetation. The scope of this document …

Spatiotemporal Variation In Flow-Dependent Recruitment Of Long-Lived Riverine Fish: Model Development And Evaluation, Daisuke Goto, Martin J. Hamel, Jeremy J. Hammen, Mathew L. Rugg, Mark A. Pegg, Valery E. Forbes

School of Biological Sciences: Faculty Publications

Abstract Natural flow regimes can play a major role as an overarching ecosystem driver in reproduction and recruitment of riverine fishes. Human needs for freshwater however have altered hydrology of many riverine systems worldwide, threatening fish population sustainability. To understand and predict how spatiotemporal dynamics of flow regimes influence reproductive and recruitment variability, and ultimately population sustainability of shovelnose sturgeon (Scaphirhynchus platorynchus), we develop a spatially explicit (1D) individual-based population model that mechanistically (via energetics-based processes) simulates daily activities (dispersal, spawning, foraging, growth, and survival). With field observations of sturgeon and habitat conditions in a major tributary of …

5th Asian Preventive Cardiology And Cardiac Rehabilitation Conference Cum 9th Certificate Course In Cardiac Rehabilitation

Journal of the Hong Kong College of Cardiology

No abstract provided.

Federalization Of The Law Of Charity, Mark L. Ascher

Vanderbilt Law Review

To this day, the law of charity is often thought of as a matter for the states. In fact, the crucial law relating to charity is now almost always federal. For certain purposes, state law still determines whether a given entity is "charitable." It also determines the propriety of a charitable fiduciary's conduct when someone who has standing sues. But federal law determines whether an entity qualifies for various tax incentives, such as exemption from the federal income tax and eligibility to receive tax-deductible gifts, and qualification for these incentives generally determines whether the entity comes into existence and, if …

Planning For Adaptation To Climate Change: Lessons From The Us National Wildlife Refuge System, Robert L. Fischman, Vicky J. Meretsky, Alexei Babko, Michael Kennedy, Lei Liu, Michelle Robinson

Articles by Maurer Faculty

US national wildlife refuges have recent, detailed management plans illustrating the state of planning for climate-change adaptation in protected areas. Discussion of and prescriptions for addressing climate change increased in refuge plans between 2005 and 2010 but decreased in 2011. The plans respond to some climate-change impacts on biodiversity and call for monitoring but with little clarity regarding how to act on monitoring results and scant attention to future changes in phenology and community composition. The threats posed by sea-level rise generated the best-developed plan prescriptions. Examples of excellent prescriptions provide models for future planning. Some decision-support tools, such as …

The Hepatoprotective Effect Of Nitric Oxide On Murine Schistosomiasis Mansoni, Samar Alhusseiny, Samar El-Beshbishi, Hosam E. El-Nemr, Abeer El-Henawy, Aya Handoussa, Maha Abu Hashim

Mansoura Medical Journal

Background: Schistosomiasis is amajor public health problem in developingcountries. Currently, praziquantel(PZQ) is the drug of choiceforhuman schistosomiasis. Isosorbide-5-mononitrate(IS-5-MN) is a nitrocompound that is used as an antianginalremedy. It must beenzymaticallymetabolized to releasenitricoxide (NO) to exert its pharmacologicactivities. This study evaluatesthe vasodilator effect of theNOdonor IS-5-MN on hepatic bilharziallesions caused by Schistosomamansoni,and determines whetherthecombined use of IS-5-MN andPZQis synergistic or antagonistic. Methods: Swiss albino femalemice (CD I strain) were divided intofive groups: (i) non-infected; (ii) infectednon-treated; (iii) infected andtreatedwith PZQ, 6 weeks post infection(WPI) in a dose of 500 mg/kg/dayfor two successive days; (iv)infectedand treated with IS-5-MNfromthe fourth to the tength …

Water Resources And The Historic Wells Of Barbuda: Tradition, Heritage And Hope For A Sustainable Future, Rebecca Boger, Sophia Perdikaris, Amy E. Potter, John Mussington

Earth, Environment & Sustainability: Faculty Publications

The island of Barbuda has a relatively unique history, land tenure and geography. Unlike its Caribbean counterparts, the island is not suited to large-scale agriculture due to its arid climate and relatively thin soils. Instead, the enslaved and eventually free people of Barbuda developed a complex herding ecology centered on common land ownership. As a result, carefully designed historic wells are strategically located around the island. With the challenges brought about by climate change, an interdisciplinary, international team led by the Barbuda Research Complex is investigating the state of existing water and food resources and examining how the availability and …

Click-Through-Based Subspace Learning For Image Search, Yingwei Pan, Ting Yao, Xinmei Tian, Houqiang Li, Chong-Wah Ngo

Research Collection School Of Computing and Information Systems

One of the fundamental problems in image search is to rank image documents according to a given textual query. We address two limitations of the existing image search engines in this paper. First, there is no straightforward way of comparing textual keywords with visual image content. Image search engines therefore highly depend on the surrounding texts, which are often noisy or too few to accurately describe the image content. Second, ranking functions are trained on query-image pairs labeled by human labelers, making the annotation intellectually expensive and thus cannot be scaled up. We demonstrate that the above two fundamental challenges …

Toward A Posthuman Education, Nathan Snaza, Peter Appelbaum, Siân Bayne, Dennis Carlson, Marla Morris, Nikki Rotas, Jennifer Sandlin, Jason Wallin, John A. Weaver

Curriculum, Foundations & Reading: Faculty Publications

The text of our manifesto will introduce posthumanism to a curriculum studies audience and propose new directions for curriculum theory and educational research more broadly. Following a description of what is variously called the “posthuman condition” or the “posthuman era,” our manifesto outlines the main theoretical features of posthumanism with particular attention to how it challenges or problematizes the nearly ubiquitous assumptions of humanism. In particular, we focus on how posthumanism responds to the history of Western humanism’s justification and encouragement of colonialism, slavery, the objectification of women, the thoughtless slaughter of non-human animals, and ecological devastation. We dwell on …

Citizen Ai: Warrior, Jester And Middleman, William A. Callahan

Research Collection School of Social Sciences

Ai Weiwei is famous for crossing boundaries, especially the boundary between art and politics. To appreciate the often contradictory nature ofAis work, this essay employs multiple narratives: " Ai the Heroic Warrior" who cńticizes the Chinese government; " Ai the Court Jester " who plays with the Chinese state and Western media; and "Ai the Middleman " who acts as a broker between China and the West, between young and old people, and between civil society and the state in the PRC. The essay concludes that afourth narrative can bńng together these three stones in a multicoded understanding ofAis work: …

Multi-Region Hemispheric Specialization Differentiates Human From Nonhuman Primate Brain Function, H-Y. Wey, Kimberley A. Phillips, D. R. Mckay, A. R. Laird, P. Kochunov, M. D. Davis, D. C. Glahn, T. Q. Duong, P. T. Fox

Psychology Faculty Research

The human behavioral repertoire greatly exceeds that of nonhuman primates. Anatomical specializations of the human brain include an enlarged neocortex and prefrontal cortex (Semendeferi et al. in Am J Phys Anthropol 114:224–241, 2001), but regional enlargements alone cannot account for these vast functional differences. Hemispheric specialization has long believed to be a major contributing factor to such distinctive human characteristics as motor dominance, attentional control and language. Yet structural cerebral asymmetries, documented in both humans and some nonhuman primate species, are relatively minor compared to behavioral lateralization. Identifying the mechanisms that underlie these functional differences remains a goal of considerable …

Effects Of Sodium/Glucose Co-Transporter Inhibitors On Contractility And Ca2+ Signalling In Ventricular Myocytes From Streptozotocin-Induced Diabetic Rats., Norin Nabil Fathalla Hamouda

Theses

The prevalence of diabetes mellitus is increasing at an alarming rate worldwide. Cardiovascular (CV) disease is the major cause of morbidity and mortality in diabetic patients. The search for new treatments has led to developing alternative insulin-independent treatment strategies such as sodium/glucose co-transporter (SGLT) inhibitors. Inhibition of intestinal SGLT1 impairs dietary glucose absorption, while inhibition of renal SGLT2 promotes glucose excretion leading to calorie loss and improved glycemic control. In this study, we hypothesized that inhibiting cardiac SGLTs may alter Ca²⁺ mobilization in myocytes. The effects of Phlorizin (PHLOR) (non-selective SGLT1 and 2 inhibitor), Quercetin-3-O-glucoside (QUER-3-G) (selective SGLT1 inhibitor), …

Study The Quality Of Groundwater Of Al-Zoroup Area In Mahdah State, The Sultanate Of Oman, Fahad Khalifa Rashid Al-Shidi

Theses

The groundwater is the most important source of water in the Sultanate of Oman. Accordingly, the Oman Government has paid great attention commensurate with the importance of water resource in terms of their sources, quality, and ways to rationalize consumption to remain under the term of sustainability and validity of present and future generations. This study was conducted in Al Buraymi at Mahdah State in Al-Zoroub area targete a groundwater quality for 20 wells in private farms. The water samples were taken from these wells and subjected to analysis for microbial and geochemical aspects. For this analysis, the assorted devices …

K-Sketch: Digital Storytelling With Animation Sketches, Richard Christopher Davis, Nur Camellia Binte Zakaria

Research Collection School Of Computing and Information Systems

K-Sketch gives novice animators an easy way to tell stories with animation sketches. It relies on users’ intuitive sense of space and time, and makes animation easy through the use of sketching and demonstration. Our studies have shown that people take naturally to telling stories with K-Sketch, and it is particularly helpful for exploring the timing of events. We also found that K-Sketch is a good collaborative medium for telling stories. In this demonstration we will show how K-Sketch works and explain how these advantages are realized in practice.

Determination Of Dissolved Iron In Seawater: A Historical Review, Paul J. Worsfold, Maeve C. Lohan, Simon J. Ussher, Andrew R. Bowie

School of Geography, Earth and Environmental Sciences

This paper overviews the evolution of suitable analytical approaches for the determination of dissolved iron in seawater. The focus is on sampling and sample treatment, detection methods and quality assurance of the data. Iron is a vital trace element for the growth of marine organisms and is the limiting micronutrient for primary production in many parts of the world's oceans. The concentration of dissolved iron in seawater therefore influences the past and present day global carbon cycle and consequently Earth's climate. Hence it is important to understand the marine biogeochemistry of iron and quantify the spatial and temporal distribution of …

Extending The Sensing Of Online Social Networks – A Healthcare Perspective, Asma’ Wasfi Fayez Mustafa

Theses

Obesity is a rising health concern in the United Arab Emirates. Obesity leads to health risks such as diabetes, heart disease, and other conditions. It may also lead to eating disorders, depression, and low self-esteem. Regular exercising helps to protect from obesity, diabetes, heart disease, high blood pressure and better manage stress. Despite all the benefits of exercising, people are doing less of it. In this research, an effort is made to encourage people to exercise by extending the prevalent sensing abilities of Online Social Networks (OSNs). Sensors are used to collect and generate data to be processed, clustered and …

Grumon: Fast And Accurate Group Monitoring For Heterogeneous Urban Spaces, Rijurekha Sen, Youngki Lee, Kasthuri Jayarajah, Rajesh Krishna Balan, Archan Misra

Research Collection School Of Computing and Information Systems

Real-time monitoring of groups and their rich contexts will be a key building block for futuristic, group-aware mobile services. In this paper, we propose GruMon, a fast and accurate group monitoring system for dense and complex urban spaces. GruMon meets the performance criteria of precise group detection at low latencies by overcoming two critical challenges of practical urban spaces, namely (a) the high density of crowds, and (b) the imprecise location information available indoors. Using a host of novel features extracted from commodity smartphone sensors, GruMon can detect over 80% of the groups, with 97% precision, using 10 minutes latency …

The Effects Of Whole-Food Plant Based Diets On Ldl-C Levels In Adults, Jason Bryan

Graduate Research Projects

No abstract provided.

Auburn Sun, Tiffany Scales

Sketches: the Online Creative Arts Journal of Tennessee State University

No abstract provided.

She Slapped Me, Fawaz Alotaibi

Sketches: the Online Creative Arts Journal of Tennessee State University

No abstract provided.

When You Grow Up To Be A Child, Viviauna Brown

Sketches: the Online Creative Arts Journal of Tennessee State University

No abstract provided.

Elias Hicks And Thomas Shilltoe: Two Paths Diverge, Cynthia E. Kerman

Quaker Studies

Two prominent Quaker ministers, English Thomas Shillitoe and American Elias Hicks, at the end of their long lives of exhortation devoted to the mission of persuading others to follow the will of God, came together on the American continent in 1826-29. They turned out to be key players on opposite sides in the struggle which ended with the splitting of American Friends into two antagonistic groups, the Orthodox and the Hicksite.

Through a close reading of the journals of these two men, supplemented by biographies and other relevant materials, this paper analyzes similarities and differences in their views on humanity …

A Rude Awakening: Sleeping Beauty As A Metaphor For The Slumber Of Post-Feminism, Kendra Reynolds

Journal of International Women's Studies

Ann Beattie asserts that “As a culture, we are fairly preoccupied with sleep” (Beattie 2002: 38), yet, this essay contests that, instead of being ‘preoccupied with sleep’, we as a culture are asleep. When Beattie states that “there is a period in one’s life when fortunate children, who do not yet understand the extent of their good fortune, really do sleep in this way” (Beattie 2002: 38), she unconsciously forms the basis of this essay’s contention that women of today certainly do not ‘understand the extent of their good fortune’ (good fortune being the feminist successes hitherto achieved). Thus, I …