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2014

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Designing Multi-Layered Nanoparticles For Combination Gene And Drug Cancer Therapy., Asiri Saumya Ediriwickrema Jan 2014

Designing Multi-Layered Nanoparticles For Combination Gene And Drug Cancer Therapy., Asiri Saumya Ediriwickrema

Yale Medicine Thesis Digital Library

Cancer continues to be a highly prevalent and lethal disease, despite significant advances in understanding tumor biology and developing new chemotherapies. Major obstacles in cancer chemotherapy are drug resistance and systemic toxicities. Potential strategies for addressing these problems include delivering combination therapies to overcome drug resistance, and utilizing synergistic agents to minimize dosing and subsequently drug toxicity. In turn, delivery can also be optimized to target the tumor site and consequently minimize systemic side effects. Polymer nanocarriers are gaining interest as vehicles for cancer therapeutics for their abilities to not only deliver multiple agents, but also target the tumor itself. …

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Strict Liability In The Shadow Of Juries, Darryl K. Brown Jan 2014

Strict Liability In The Shadow Of Juries, Darryl K. Brown

SMU Law Review

No abstract provided.

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Genome-Wide Sequencing Of Small Rnas Reveals A Tissue-Specific Loss Of Conserved Microrna Families In Echinococcus Granulosus, Yun Bai, Zhuangzhi Zhang, Lei Jin, Hui Kang, Yongquiang Zhu, Lu Zhang, Xia Li, Fengshou Ma, Li Zhao, Et Al. Jan 2014

Genome-Wide Sequencing Of Small Rnas Reveals A Tissue-Specific Loss Of Conserved Microrna Families In Echinococcus Granulosus, Yun Bai, Zhuangzhi Zhang, Lei Jin, Hui Kang, Yongquiang Zhu, Lu Zhang, Xia Li, Fengshou Ma, Li Zhao, Et Al.

PCOM Scholarly Works

Background: MicroRNAs (miRNAs) are important post-transcriptional regulators which control growth and development in eukaryotes. The cestode Echinococcus granulosus has a complex life-cycle involving different development stages but the mechanisms underpinning this development, including the involvement of miRNAs, remain unknown. Results: Using Illumina next generation sequencing technology, we sequenced at the genome-wide level three small RNA populations from the adult, protoscolex and cyst membrane of E. granulosus. A total of 94 pre-miRNA candidates (coding 91 mature miRNAs and 39 miRNA stars) were in silico predicted. Through comparison of expression profiles, we found 42 mature miRNAs and 23 miRNA stars expressed with …

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Milestones For Animal Welfare: Public Prosecutor V. Ling Chung Yee Roy, Alvin W. L. See Jan 2014

Milestones For Animal Welfare: Public Prosecutor V. Ling Chung Yee Roy, Alvin W. L. See

Research Collection Yong Pung How School Of Law

Animal law is a little-known subject in Singapore. However, the increase in public awareness and concern about animal welfare issues demand that more attention is directed at the legal aspects of such issues. An opportunity to examine this area of the law arose in the case of Ling Chung Yee Roy. The District Court, presided by District Judge Ng Peng Hong, had to decide whether the accused was guilty of an animal cruelty offence under s. 42(1)(e) of the Animals and Birds Act. The majority of animal cruelty complaints were against pet owners, of which a significant number concerned the …

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In Territorio Veritas? Bringing Geographical Coherence Into The Ambiguous Definition Of Geographical Indications Of Origin, Irene Calboli Jan 2014

In Territorio Veritas? Bringing Geographical Coherence Into The Ambiguous Definition Of Geographical Indications Of Origin, Irene Calboli

Research Collection Yong Pung How School Of Law

In this article, I criticize what I call “ambiguous geographical origin” in the concept of geographical indications of origin (GIs) and note that the current definition of GIs in Art. 22(1) of TRIPS essentially misuses, or at least misinterprets, of the terms “geographical origin.” More specifically, I expose the partial inconsistency between the legal definition under TRIPs and the dictionary definition of the terms “geographical” and “origin”. In this respect, I point out that, from a strictly linguistic standpoint, the term “geographical”, in its variation as “geographic”, is defined as “of or relating to geography” and as “belonging to or …

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Failed Agricultural Impoundments: An Interdisciplinary Assessment Of Community Structure And Social Resilience, Stacy Nicole Peterson Jan 2014

Failed Agricultural Impoundments: An Interdisciplinary Assessment Of Community Structure And Social Resilience, Stacy Nicole Peterson

LSU Master's Theses

The remnants of the wetland reclamation era of the early 1900s are visible in the leveed, drained, and failed impoundments across the United States, and especially in coastal regions. The common themes of their history are flooding, restoration, and – sometimes - community resilience. The physical changes occurring during and after impoundment, and after failure includes subsidence, erosion, and flooding are well-documented. Here I construct an environmental history that integrates data on these physical changes with archival records, historical documents, site visits and personal interviews. The primary region of focus is ‘Delta Farms’ - a failed agricultural impoundment in Lafourche …

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Brief For Amici Curiae Professors Of Law In Support Of Petitioner, Neil Vidmar, Lisa Kern Griffin Jan 2014

Brief For Amici Curiae Professors Of Law In Support Of Petitioner, Neil Vidmar, Lisa Kern Griffin

Faculty Scholarship

No abstract provided.

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After Recess: Historical Practice, Textual Ambiguity, And Constitutional Adverse Possession, Curtis A. Bradley, Neil S. Siegel Jan 2014

After Recess: Historical Practice, Textual Ambiguity, And Constitutional Adverse Possession, Curtis A. Bradley, Neil S. Siegel

Faculty Scholarship

The Supreme Court’s interpretation of the Recess Appointments Clause in NLRB v. Noel Canning stands as one of the Supreme Court’s most significant endorsements of the relevance of “historical gloss” to the interpretation of the separation of powers. This Article uses the decision as a vehicle for examining the relationship between interpretive methodology and historical practice, and between historical practice and textual ambiguity. As the Article explains, Noel Canning exemplifies how the constitutional text, perceptions about clarity or ambiguity, and “extra-textual” considerations such as historical practice operate interactively rather than as separate elements of interpretation. The decision also provides a …

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Evidence Of Methane Cycling Beneath The Western Margin Of The Greenland Ice Sheet, Erik L. J. E. Broemsen Jan 2014

Evidence Of Methane Cycling Beneath The Western Margin Of The Greenland Ice Sheet, Erik L. J. E. Broemsen

LSU Master's Theses

The greenhouse gas methane mainly regulated by microbial processes. Methanogenic archaea, a major biological source of methane, are a diverse group of organisms that produce methane as a metabolic byproduct. The generation of methane takes place in diverse anoxic environments using CO2 and other reduced substrates. The release of methane into oxic environments often is regulated by methanotrophic Proteobacteria and Archaea, specialized groups of bacteria that use methane as sole sources of carbon and energy. These organisms can play major roles in the regulation of methane transport into the atmosphere and make up one part of the methane cycle. Pools …

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Dissolved Oxygen Dynamics And Modeling - A Case Study In A Subtropical Shallow Lake, Zhen Xu Jan 2014

Dissolved Oxygen Dynamics And Modeling - A Case Study In A Subtropical Shallow Lake, Zhen Xu

LSU Master's Theses

As one of the most valued and treasured natural resources, today many lakes in the world face degradation of their water quality due to nutrient enrichment, toxic contamination, and hydrological modification from their drainage areas. Among various water quality impairments, dissolved oxygen (DO) depletion is often a leading stressor in lake systems. Despite numerous studies on DO in deep water lakes in temperate regions, the knowledge of DO dynamics in eutrophic shallow lakes in subtropical regions is still limited. This thesis research conducted intensive DO monitoring in an eutrophic shallow lake in south Louisiana to characterize diel cycles of DO …

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History, Nesting Population, Migration, Home Range And Habitats Used By Louisiana Bald Eagles, Nickolas Ryan Smith Jan 2014

History, Nesting Population, Migration, Home Range And Habitats Used By Louisiana Bald Eagles, Nickolas Ryan Smith

LSU Master's Theses

The population of Bald Eagles (Haliaeetus leucocephalus) nesting in Louisiana reached precariously low numbers in the early 1970’s, and although the population has since increased markedly, resident eagles remain a species of conservation concern in Louisiana. Using statewide aerial nest survey data from 1975–2008, I documented the history and quantified the recovery of the nesting population in Louisiana. Known active nests increased exponentially from 7 to 387 during this period, exhibiting a mean annual rate of increase of 11.1 ± 0.3% per year with no indications of slowing. By 1990, the nesting population in Louisiana had exceeded all goals of …

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The Environmental Impact Of Urbanization Within Abu Dhabi On The Microbial Profile Of Man-Made Beaches, Fatima Al Marzooqi, Fatme Al Anouti Jan 2014

The Environmental Impact Of Urbanization Within Abu Dhabi On The Microbial Profile Of Man-Made Beaches, Fatima Al Marzooqi, Fatme Al Anouti

All Works

The United Arab Emirates (UAE) is witnessing a significant development in several areas. Many new construction projects are currently underway. One of the main project aims at establishing new beaches around the coastal areas of the UAE. Particularly, in Abu Dhabi the capital of UAE, a new man-made beach has been recently developed in the north coast of the city. The urbanization of this newly developed beach might have a significant impact on the environment. This study aims to investigate the effects of urban development of beaches within Abu Dhabi on the microbial profile of the soil. It is hypothesized …

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To Outsource Web Development Or Not: A Small Automotive Company Considers Search Engine Marketing, Martine Robinson Beachboard, John C. Beachboard Jan 2014

To Outsource Web Development Or Not: A Small Automotive Company Considers Search Engine Marketing, Martine Robinson Beachboard, John C. Beachboard

All Works

No abstract provided.

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Exploring The Utilization Of Non-Invasive Methods For Assessing Health Statusof Patients With Chronic Respiratory Inflammation Within The United Arabemirates, Fatme Al Anouti Jan 2014

Exploring The Utilization Of Non-Invasive Methods For Assessing Health Statusof Patients With Chronic Respiratory Inflammation Within The United Arabemirates, Fatme Al Anouti

All Works

Asthma is defined as the chronic inflammation of the large airways that is characterized by reversible airflow obstruction and airway hyper-responsiveness. On the other hand, Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammation that is marked by progressive and irreversible airflow obstruction. Both conditions are manifested by symptoms of wheezing, coughing, and shortness of breath. Similarity in symptoms between these two conditions could lead to misdiagnosis and mistreatment. Although inflammation is present in both conditions, there are some marked differences. The main difference is that inflammation in asthma is an IgE mediated and involves the release of histamine while …

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Boldness And Asymmetric Contests: Role- And Outcome-Dependent Effects Of Fighting In Hermit Crabs, Winnie Courtene-Jones, Mark Briffa Jan 2014

Boldness And Asymmetric Contests: Role- And Outcome-Dependent Effects Of Fighting In Hermit Crabs, Winnie Courtene-Jones, Mark Briffa

School of Biological and Marine Sciences

No abstract provided.

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Toxicity Of Cerium Oxide Nanoparticles To The Earthworm Eisenia Fetida: Subtle Effects, E Lahive, K Jurkschat, Bj Shaw, Rd Handy, Dj Spurgeon, C Svendsen Jan 2014

Toxicity Of Cerium Oxide Nanoparticles To The Earthworm Eisenia Fetida: Subtle Effects, E Lahive, K Jurkschat, Bj Shaw, Rd Handy, Dj Spurgeon, C Svendsen

School of Biological and Marine Sciences

No abstract provided.

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Seasonality Affects Macroalgal Community Response To Increases In Pco2., Cecilia Baggini, Maria Salomidi, Emanuela Voutsinas, Laura Bray, Eva Krasakopoulou, Jason M. Hall-Spencer Jan 2014

Seasonality Affects Macroalgal Community Response To Increases In Pco2., Cecilia Baggini, Maria Salomidi, Emanuela Voutsinas, Laura Bray, Eva Krasakopoulou, Jason M. Hall-Spencer

School of Biological and Marine Sciences

Ocean acidification is expected to alter marine systems, but there is uncertainty about its effects due to the logistical difficulties of testing its large-scale and long-term effects. Responses of biological communities to increases in carbon dioxide can be assessed at CO2 seeps that cause chronic exposure to lower seawater pH over localised areas of seabed. Shifts in macroalgal communities have been described at temperate and tropical pCO2 seeps, but temporal and spatial replication of these observations is needed to strengthen confidence our predictions, especially because very few studies have been replicated between seasons. Here we describe the seawater chemistry and …

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What's In A Name? What Have Taxonomy And Systematics Ever Done For Us?, David T. Bilton Jan 2014

What's In A Name? What Have Taxonomy And Systematics Ever Done For Us?, David T. Bilton

School of Biological and Marine Sciences

There is increasingly little doubt that we are in the midst of an anthropogenically driven extinction event which may end up rivalling the mass extinctions of the geological past (Barnosky et al., 2011). Increasingly the world’s natural and seminatural habitats are being irreversibly transformed by human populations, meaning that much of global biodiversity is under threat (see Caro et al., 2011 on remaining intact ecosystems). Given this “biodiversity crisis” and the fact that biodiversity is ultimately essential to human survival on this planet (e.g. Juniper, 2013) one might expect that the basic science underpinning the study of biodiversity would be …

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Biological Invasions: Insights Into Ecology And Evolution, Jennifer Naomi Smith Jan 2014

Biological Invasions: Insights Into Ecology And Evolution, Jennifer Naomi Smith

Graduate Student Theses, Dissertations, & Professional Papers

Introductions of exotic species commonly restructure native communities, but the mechanisms driving native species responses are poorly understood. Invasion biology has focused its research on the negative impacts of invaders, yet invaders can also have positive interactions. A holistic understanding of how biological invasions can have a full range of potential responses from negative to neutral to positive. Understanding the mechanics that underlie native species responses to invasions can help elucidate those factors structuring the native communities we see today. I used a combination of experimental and observational studies in the field and laboratory to determine the effects of spotted …

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Shape Shifting: Local Landmarks Interfere With Navigation By, And Recognition Of, Global Shape., Matthew G. Buckley, Alastair D. Smith, Mark Haselgrove Jan 2014

Shape Shifting: Local Landmarks Interfere With Navigation By, And Recognition Of, Global Shape., Matthew G. Buckley, Alastair D. Smith, Mark Haselgrove

School of Psychology

No abstract provided.

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Implicit Meaning In 18-Month-Old Toddlers., Luche C Delle, Samantha Durrant, Caroline Floccia, Kim Plunkett Jan 2014

Implicit Meaning In 18-Month-Old Toddlers., Luche C Delle, Samantha Durrant, Caroline Floccia, Kim Plunkett

School of Psychology

A substantial body of evidence demonstrates that infants understand the meaning of spoken words from as early as 6 months. Yet little is known about their ability to do so in the absence of any visual referent, which would offer diagnostic evidence for an adult-like, symbolic interpretation of words and their use in language mediated thought. We used the head-turn preference procedure to examine whether infants can generate implicit meanings from word forms alone as early as 18 months of age, and whether they are sensitive to meaningful relationships between words. In one condition, toddlers were presented with lists of …

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Frozen, Old, Or New? : Comparing Biochemical Markers And Tissue Oxygenation In Transfused Blood, Connor Wiles Jan 2014

Frozen, Old, Or New? : Comparing Biochemical Markers And Tissue Oxygenation In Transfused Blood, Connor Wiles

University Honors Theses

The transfusion of red blood cells is a necessary therapy used to treat anemia that often results from traumatic hemorrhage. The traditional method of storing red blood cells prior to transfusion in the United States has been as a liquid in a refrigerated fashion at a temperature between two and eight degrees Celsius. Throughout the storage duration, the red cells undergo a series of structural, functional, and biochemical changes commonly known as the storage lesion. Increased length of storage has been associated with increased rates of infection, as well as higher incidents of mortality. We hypothesized that this prospective, randomized, …

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Platonic Forms And Unicorns: Plato's Philosophy In Peter S. Beagle's The Last Unicorn, Jade Donigan Jan 2014

Platonic Forms And Unicorns: Plato's Philosophy In Peter S. Beagle's The Last Unicorn, Jade Donigan

University Honors Theses

Since its publication in 1968, Peter S. Beagle’s enduring fantasy novel The Last Unicorn has captured both the popular and critical imagination. While several critics have noted that Beagle seems to incorporate various aspects of Plato’s philosophy, none have dedicated a focused analysis to this specific textual feature. This thesis explores the way in which The Last Unicorn both invokes and subverts Plato’s dualistic conception of "reality" and "truth", and concludes that it does so in order to construct a vision of reality that recognizes transient, human experiences and knowledge are just as "true" as transcendent, timeless experiences and knowledge. …

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Network Analysis-Based Psychoeducation For Gad, Corinna Scott Jan 2014

Network Analysis-Based Psychoeducation For Gad, Corinna Scott

University Honors Theses

Psychoeducation, providing essential information for a client about psychological and physiological processes, is typically the first step in cognitive-behavioral therapy (CBT) but its content and implementation is currently underdeveloped. Generalized anxiety disorder (GAD) is a prevalent mental disorder in the United States. Often, persons with GAD and their primary care providers and family do not recognize or understand the meaning of their symptoms because of the diffuse and imprecise nature of the diagnosis. This thesis aims to investigate a systems network analysis of generalized anxiety disorder to explore suggestions for enhancing psychoeducation as an initial intervention for GAD clients. A …

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Sense Of Place And Stakeholder Involvement In Rural Environmental Management, Jessica Lynn Beutler Jan 2014

Sense Of Place And Stakeholder Involvement In Rural Environmental Management, Jessica Lynn Beutler

University Honors Theses

There is a growing need for involvement of local communities in environmental management in order to develop dynamic and holistic management strategies. Communities have direct impact on the ecosystems they live in; therefore, it is vital to understand the environmental values and knowledge of environmental threats held by those communities. Integrating the community’s knowledge into local environmental management can help engage instead of alienate them. The relationship between rural communities and their local environment in Puget Island, WA was investigated by conducting interviews with residents, examining at their values and understanding of environmental issues. Additionally, this research investigates how sense …

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If It Wasn't This: Collected Short Stories, Kevin Dorn Jan 2014

If It Wasn't This: Collected Short Stories, Kevin Dorn

University Honors Theses

Collected short stories dealing with limitations in various forms.

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Comics And The Complicit Reader: Closure As A Transgressive Technique In Transmetropolitan, Kyle Knox Jan 2014

Comics And The Complicit Reader: Closure As A Transgressive Technique In Transmetropolitan, Kyle Knox

University Honors Theses

In recent years, the critical analysis of comic books has come to be a respected field in popular culture studies. Transmetropolitan, a 60 issue comic book created by writer Warren Ellis and artist Darick Robertson, became a one of the most popular nonsuperhero series throughout its publication by DC Comics in the late 1990's and early 2000's. Since the beginning of the present decade, scholars have paid increased attention to the thematic content of the series, identifying the text as a brutal transgressive satire of Western consumerist culture. This paper examines the formal structure of the work, primarily through …

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Communication Tools Towards A Bioregional Consciousness, Elona Trogub Jan 2014

Communication Tools Towards A Bioregional Consciousness, Elona Trogub

University Honors Theses

Recognizing that ecological collapse is within reach, I draw upon the observations that poorly distributed power dynamics supported through the reinforcement of individualism, hierarchism, reductionism, linear thinking, etc. are some of the basic principles that pose a challenge when it comes to embracing new and very ancient ways of interacting with the rest of living systems. There exist “original instructions,” reinforced by recent scientific acknowledgements, that contain guidelines for needed action and interaction to prevent anthropogenic ecological collapse. I utilize storytelling as well as several of the leverage points for systems change suggested by Donella Meadows (1999) in deconstructing the …

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Katharsis & Tragic Pathos, Jared L. Wait-Molyneux Jan 2014

Katharsis & Tragic Pathos, Jared L. Wait-Molyneux

University Honors Theses

This project is bound up with the old question of what gives tragedy its lasting appeal. The majority of contemporary criticism on tragedy focuses on aspects having to do with the democratic polis. Many of these studies take this musical genre as primarily a means for exposing Athenian civic ideology and norms in social behavior. But this does not account for continued interest in Greek drama. To answer the question at hand, more attention needs to be paid [to] pathos and katharsis, by students and critics of Greek tragedy, as these are vital aspects of the tragic experience, both within …

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Américo Castro, Saint James, And Spain: The History Of A Belief, Daniel Blanchard Jan 2014

Américo Castro, Saint James, And Spain: The History Of A Belief, Daniel Blanchard

University Honors Theses

The present essay is broadly interested in the problem of writing history, and the way different manners of confronting this problem are received and represented in the modern day as our historiographical compass increases in depth, scope, and capacity. Within the breadth of this theme, my case study is centered on the Spanish historian Américo Castro (1885–1972), an author whose work embodies not only the Spanish intellectual trends of his day, but also a substantial swath of Western philosophy and academic scholarship. I demonstrate the influence of existential philosophy on Castro, as well as the myopic filter of nationalism through …

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