Digital Commons Network^™

Building Resilience In A Major City Evacuation Plan Using Simulation Modeling, Adam Kirby, James Eric Dietz, Eric Matson, Joseph Pekny, Clifford Wojtalewicz

International Institute for Infrastructure Resilience and Reconstruction (I3R2) Conference

This study provides data on the optimal staff, materials, space, and time resources required to operate a regional hub reception center, a “short-term facility with the goal to process and transport displaced survivors (evacuees) to temporary or permanent shelters following a catastrophic incident,” (Regional Catastrophic Planning Team, 2012). The facility will process approximately 20,000 evacuees over its entire seven-day duration following a disaster to assist in community resilience. The study was performed using a model created using the computer simulation software, AnyLogic. The results of the study demonstrated that the goals set forth by the Illinois-Indiana-Wisconsin Regional Catastrophic Planning Team …

Resilient Cities: Plan Evaluation For Floods, Hwayoung Kim, Ryuji Kakimoto

International Institute for Infrastructure Resilience and Reconstruction (I3R2) Conference

A local hazard mitigation plan (LHMP) is the fundamental base to protect individual properties and citizens’ lives from the local chronic and unexpected, overwhelming natural disasters. Each community prepares their own LHMP based on their specific features and conditions since regions are different by geographical features, social norms, and cultural backgrounds. Of those differences, this study focuses on how the developed countries in hazard mitigation consist of LHMP and which part of the plan is strong or weak. This research presents comparisons for the LHMPs communities in three different countries: USA, Japan, and Korea. Indicators used in the research are …

Influence Of Decision Making During Disasters And How It Impacts A Community, Jayanrtha Withanaarachchi, Sujeeva Setunge

International Institute for Infrastructure Resilience and Reconstruction (I3R2) Conference

The frequency of natural disasters occurrences has increased and is becoming noticed by many due to the impact on economy, society, and the environment.

Decision making during disasters contributes towards community safety and resilience. Decisions taken to protect people from disasters have an impact on society, economy, environment, travel patterns, and reliability and performance of transport networks.

Decisions often affect the performance of transport networks and critical infrastructure systems during disasters and during demand times. Decision making and decision styles which were observed during disaster events will show the areas that the decisions have worked well or created more risks …

Estimating Gesture Accuracy In Motion-Based Health Games, Christian Barrett, Jacob Brown, Jay Hartford, Michael Hoerter, Andrew Kennedy, Ray Hassan, David M. Whittinghill

Computer Graphics Technology Faculty Publications

This manuscript details a technique for estimating gesture accuracy within the context of motion-based health video games using the MICROSOFT KINECT. We created a physical therapy game that requires players to imitate clinically significant reference gestures. Player performance is represented by the degree of similarity between the performed and reference gestures and is quantified by collecting the Euler angles of the player’s gestures, converting them to a threedimensional vector, and comparing the magnitude between the vectors. Lower difference values represent greater gestural correspondence and therefore greater player performance. A group of thirty-one subjects was tested. Subjects achieved gestural correspondence sufficient …

Designerly Ways Of Being, Josh Tenenberg, David Socha, Wolff-Michael Roth

Design Thinking Research Symposium

In this paper, we inquire into the stances that designers take in their design activities. The setting in which we investigate this question is that of design critiques, where participants make their stances publicly available to one another. During a critique, participants use their bodies as a framework for mutual orientation and reference. Design concepts are not so much told as they are staged and performed, using multiple semiotic modalities, including gesture, speech, gaze, orientation, inscription, and artifact. In performing their design, participants adopt and shift between several identified stances, which we call inscriptional, third-person, first-person and phenomenal. During the …

Study Of User Search Activities With Two Discovery Tools At An Academic Library, Xi Niu, Tao Zhang, Hsin-Liang Chen

Libraries Faculty and Staff Scholarship and Research

The goal of this study was to investigate and compare user search activities of two discovery tools at an academic library. The implementation of a new discovery tool (Primo by Ex Libris) to replace an existing system (VuFind) provided a unique opportunity to collect transaction logs of both systems and examine user search behavior in an empirical test. Results from a transaction log analysis and a user study of this study have contributed to the understanding of users’ search behavior and their preferences and perceptions of the two systems. We find both commonalities and differences between VuFind and Primo for …

Exploration Of A Rare Population Of Chinese Chestnut In North America: Stand Dynamics, Health And Genetic Relationships, Amy C. Miller, Keith E. Woeste, Sandra L. Anagnostakis, Douglass F. Jacobs

Department of Forestry & Natural Resources Faculty Publications

With the transport of plants around the globe, exotic species can readily spread disease to their native relatives; however, they can also provide genetic resistance to those relatives through hybrid breeding programmes. American chestnut (Castanea dentata) was an abundant tree species in North America until its decimation by introduced chestnut blight. To restore chestnut in North America, efforts are ongoing to test putative blight-resistant hybrids of Castanea dentata and Chinese chestnut (Castanea mollissima), but little is known about the ecology of C. mollissima. In a forest in northeastern USA in which C. mollissima has become …

Strain Modulations As A Mechanism To Reduce Stress Relaxation In Laryngeal Tissues, Eric J. Hunter, Thomas Siegmund, Roger W. Chan

School of Mechanical Engineering Faculty Publications

Vocal fold tissues in animal and human species undergo deformation processes at several types of loading rates: a slow strain involved in vocal fold posturing (on the order of 1 Hz or so), cyclic and faster posturing often found in speech tasks or vocal embellishment (1–10 Hz), and shear strain associated with vocal fold vibration during phonation (100 Hz and higher). Relevant to these deformation patterns are the viscous properties of laryngeal tissues, which exhibit non-linear stress relaxation and recovery. In the current study, a large strain time-dependent constitutive model of human vocal fold tissue is used to investigate effects …

Different Oral Sensitivities To And Sensations Of Short-, Medium-, And Long-Chain Fatty Acids In Humans, Cordelia Running, Richard D. Mattes

Department of Nutrition Science Faculty Publications

Fatty acids that vary in chain length and degree of unsaturation have different effects on metabolism and human health. As evidence for a “taste” of nonesterified fatty acids (NEFA) accumulates, it may be hypothesized that fatty acid structures will also influence oral sensations. The present study examined oral sensitivity to caproic (C6), lauric (C12), and oleic (C18:1) acids over repeated visits. Analyses were also conducted on textural properties of NEFA emulsions and blank solutions. Oral thresholds for caproic acid were lower compared with oleic acid. Lauric acid thresholds were intermediate but not significantly different from either, likely due to lingering …

Shots In The Dark: The Presence Of Absence In Imaginative Literature (Iw), Gene Washington

English Faculty Publications

Western metaphysics and IW can be described as a search for "first" presences, not absences. With the exception of philosophers like Martin Heidegger, Jean-Paul Sartre, and Aristotle, writers like Lord Rochester (John Wilmot), Jonathan Swift and Philip Larkin, no one, to my knowledge, has taken absence as a "first" and consequently as also a "last." This essay is a modest attempt to open the door, if only a crack, for investigations into the metaphysics and meaning of absence as a means of creating, and understanding an interesting IW—from the perspective of the presence of absence as "first" and as "last."

Blast-Induced Tinnitus: A Combined Behavioral, Memri, And Electrophysiology Study, Jessica Pengyun Ouyang

Wayne State University Dissertations

ABSTRACT

BLAST-INDUCED TINNITUS: A COMBINED BEHAVIORAL, MEMRE, AND ELECTROPHYSIOLOGY STUDY

by

JESSICA OUYANG

May 2014 Advisor: Drs. Steve Cala & Jinsheng Zhang

Major: Physiology

Degree: Doctor of Philosophy

Tinnitus and hearing loss are the frequent auditory-related co-morbidities of blast trauma. The etiology of blast-induced tinnitus is also muddled by brain mechanisms associated with emotional and cognitive problems such as anxiety, memory loss, and depression. We set out to develop a realistic and ecologically valid model to address changes of cognitive status and psychological state that are associated with blast- induced tinnitus. In this study, 19 adult rats were randomly divided …

Molecular Studies On The Anti-Tumor Effects Of Metal-Based Complexes: Involvement Of The Ubiquitin-Proteasome And Apoptotic Pathways, Sara M. Schmitt

Wayne State University Dissertations

The ubiquitin-proteasome pathway is crucial to normal cellular function, and as such, has been extensively investigated as a potential target for cancer therapeutics. Many compounds have been tested for their proteasome inhibitory ability, including various small peptide aldehydes, and, following the success of cisplatin, several metal-containing complexes. The efficacy of these compounds in preclinical studies ultimately resulted in the development and approval of the first-in-class proteasome inhibitor bortezomib, the use of which, unfortunately, has been hindered by toxicity and resistance. These limitations have led to a massive push toward designing and developing new, less toxic proteasome inhibitors for clinical use. …

Commedia: Rhetoric And Technology In The Media Commons, Conor James Shaw-Draves

Wayne State University Dissertations

This dissertation analyzes the organization of individuals through online social media applications and other community-building websites, such as Facebook, Wikipedia, Google Maps, and online classrooms, using the Aristotelian rhetorical concept of the commonplaces as well as political, critical, and legal theory. Based on these analyses, this dissertation also provides pedagogical recommendations for the teaching of writing with technology in both online and physical classrooms.

Pedestrian Head Protection During Car To Pedestrian Accidents: In The Event Of Primary Impact With Vehicle And Secondary Impact With Ground, Vishal Gupta

Wayne State University Dissertations

Current regulations for assessing pedestrian safety use a simplified test setup that ignores many real-world factors. In particular, the level of protection is assessed using a free-motion headform impacting the vehicle's hood at a fixed angle. As such, this test setup does not capture the effect due to the vehicle front-end profile, nor does it comprehend injury due to a possible secondary impact of the pedestrian's head with ground. This thesis aims to numerically simulate vehicle to pedestrian crashes to develop knowledge that may suggest ways to improve safety above and beyond the regulatory tests. Inputs to the simulations include …

Influence Of Target Population Misspecification On Employee Perceptions At A, Joe Lee Smith

Wayne State University Dissertations

Numerous researchers have conducted qualitative and quantitative studies examining employee perceptions related to changes in their work environment based upon management/top-down (deductive) communication of vision, mission, and envisioned organization goals Hofstede, Neuijen, Daval, Ohayv, & Sanders (1990), but research on the influence of subgroup/identity types on workforce perception is sparse Dutton, Dukerich, & Harquail (1994). Data on subgroup identification with the mission and strategic goals envisioned by management/administration is limited. Also limited is knowledge of the influence they have over their members, which places management at a disadvantage in planning strategic organization objectives Albert & Whetten, (1985). These subgroups have …

Cxcr2 Macromolecular Complex In Pancreatic Cancer: A Potential Therapeutic Target In Tumor Growth, Shuo Wang

Wayne State University Dissertations

The signaling mediated by the chemokine receptor CXC chemokine receptor 2 (CXCR2) plays an important role in promoting the progression of many cancers, including pancreatic cancer, one of the most lethal human malignancies. CXCR2 possesses a consensus PSD-95/DlgA/ZO-1 (PDZ) motif at its carboxyl termini, which might interact with potential PDZ scaffold/adaptor proteins. We have previously reported that CXCR2 PDZ motif-mediated protein interaction is an important regulator for neutrophil functions. Here, using a series of biochemical assays, we demonstrate that CXCR2 is physically coupled to its downstream effector phospholipase C-β3 (PLC-β3) that is mediated by PDZ scaffold protein Na(+)/H(+) exchange regulatory …

Matriptase Mediated C-Met Signaling In Breast Cancer, Gina Lynn Zoratti

Wayne State University Dissertations

MATRIPTASE MEDIATED c-MET SIGNALING IN CRITICAL FOR BREAST CANCER PROGRESSION

by

GINA ZORATTI

Historically proteases have been associated with tumor progression and metastasis through degradation of the basement membrane. However, in recent years these enzymes have also been shown to play key roles in the activation of growth factors and cytokines, thereby activating pro-oncogenic signaling pathways. Matriptase (MT-SP1, ST14) is an epithelia-specific pericellular protease which has received considerable attention in recent years spurred by the consistent dysregulation of the protease in human epithelial tumors including breast cancer. We have performed both functional and mechanistic studies of matriptase in breast cancer …

Altered Morphology And Composition Of Zymogen Granules In Acute Pancreatitis, Amanda Flack

Wayne State University Dissertations

In healthy physiology, pancreatic digestive enzymes secreted following a meal are stored as inactive zymogens within membrane bound secretory vesicles called Zymogen Granules (ZG), and activated extracellularly. In acute pancreatitis however, the digestive enzymes are prematurely activated within the cell, resulting in autodigestion of the tissue. Pancreatitis is a gastrointestinal disorder in which there are over 200,000 hospitalizations per year with a 5% mortality rate. It has been demonstrated that in acute pancreatitis the digestive enzymes are blocked from being secreted and are activated within the cell leading to acinar cell and surrounding pancreatic tissue death. Little is known about …

Provocation In The Political Theories Of Plato, Rousseau And Nietzsche, Aaron Martin

Wayne State University Dissertations

I devise a theoretical model that provides an interpretive framework to define and describe the concept of provocation as well as to analyze and explain the theoretical provocations in Plato, Jean-Jacques Rousseau and Friedrich Nietzsche's works. I assess their works as well as a wide-ranging body of scholarship both on the concept and the theorists, to show that--despite Plato, Rousseau and Nietzsche's many peculiarities both in terms of their lives and works--the three separate theoretical projects similarly use the conceptual language of provocation as an integral part of an overall rhetorical strategy to articulate their philosophical systems as ones of …

Proximate And Evolutionary Insights Into The Epigenetics Of Posttraumatic Stress Disorder, Levent Sipahi

Wayne State University Dissertations

Posttraumatic stress disorder (PTSD) is an important medical and social condition. Although the vast majority of individuals are exposed to traumatic events within their lifetime, a minority subsequently develop diagnosable PTSD. What underlies differential risk and resiliency in the face of trauma is an ongoing research and clinical question with implications for prevention and treatment. Recent work has revealed a putative role of epigenetic variation and modification - most notably DNA methylation - in the etiology of PTSD. That DNA methylation is stable, yet modifiable in response to lived experiences, makes it a strong candidate to mechanistically explain the ontogeny …

The Rise Of The Social And The Change In The Political: A Consideration Of Arendt, Habermas, And Foucault, George Tyler

Wayne State University Dissertations

I explore parallels within the work of Hannah Arendt, Jürgen Habermas, and Michel Foucault. I examine the unexamined connections and commonalities among the works of these three preeminent political theorists with the aim of understanding our common, contemporary construction of "the political." Specifically, I examine the way that each of these theorists describes a condition wherein the very concept of "the political" has undergone significant changes. I demonstrate how these thinkers converge around the notion that what was once understood as "the political," has come to include concerns, modes of thought, and forms of action that were previously considered unpolitical. …

Linking Molecular, Electrical And Anatomical Properties Of Human Epileptic Brain, Shruti Bagla

Wayne State University Dissertations

Epilepsy is a common neurological disorder of recurrent unprovoked seizures. It affects almost 1% of the world population. Although there is a wide range of anti-epileptic drugs (AEDs) available, they only treat the seizure symptoms and do not cure the disease itself. The poor role of AEDs can be attributed to the lack of knowledge of exact mechanisms and networks that produce epileptic activities in the neocortex. At present, the best cure for epilepsy is surgical removal of electrically localized epileptic brain tissue. Surgically removed brain tissue presents an excellent opportunity to discover the molecular and cellular basis of human …

Regulation Of Inositol Biosynthesis And Cellular Consequences Of Inositol Depletion: Implications For The Mechanism Of Action Of Valproate, Rania M. Deranieh

Wayne State University Dissertations

Inositol is a six-carbon cyclitol that is ubiquitous in biological systems. It is a precursor for the synthesis of numerous biologically important compounds, including inositol phosphates and phosphoinositides that are essential for cell function and viability. Inositol compounds play a role in membrane formation, gene regulation, signaling, regulation of ion channels, and membrane trafficking. Furthermore, inositol regulates hundreds of genes, including those involved in the biosynthesis of inositol and phospholipids. While transcriptional regulation of inositol biosynthesis has been extensively studied and well characterized, regulation of inositol biosynthesis at the enzymatic level has not been addressed. The current study shows that …

Absentee Soldier Voting In Civil War Law And Politics, David A. Collins

Wayne State University Dissertations

During the Civil War, twenty northern states changed their laws to permit absent soldiers to vote. Before enactment of these statutes, state laws had tethered balloting to the voter's community and required in-person participation by voters. Under the new laws, eligible voters - as long as they were soldiers - could cast ballots in distant military encampments, far from their neighbors and community leaders. This dissertation examines the legal conflicts that arose from this phenomenon and the political causes underlying it.

Legally, the laws represented an abrupt change, contrary to earlier scholarship viewing them as culminating a gradual process of …

Junctional Sarcoplasmic Reticulum Protein Processing And Trafficking In Cardiac Tissue And Primary Cultured Cardiomyocytes, Naama Sleiman

Wayne State University Dissertations

Junctional SR is an important and unique ER subdomain in the adult myocyte that releases Ca2+ through the actions of an exclusive set of resident proteins. Cardiac calsequestrin (CSQ2) undergoes two co-translational modifications: N-linked glycosylation on 316Asn, and phosphorylation by protein kinase CK2 on a cluster of 3 serines in its tail. In the heart, CSQ2 molecules undergo extensive mannose trimming by ER mannosidase(s), a posttranslational process that often regulates protein breakdown. To investigate CSQ2 protein processing in cardiomyopathy models, studies were performed to test whether CSQ2 glycan structures would be altered in heart tissue from mongrel dogs induced into …

Flexible Mems: A Novel Technology To Fabricate Flexible Sensors And Electronics, Hongen Tu

Wayne State University Dissertations

This dissertation presents the design and fabrication techniques used to fabricate flexible MEMS (Micro Electro Mechanical Systems) devices.

MEMS devices and CMOS(Complementary Metal-Oxide-Semiconductor) circuits are traditionally fabricated on rigid substrates with inorganic semiconductor materials such as Silicon. However, it is highly desirable that functional elements like sensors, actuators or micro fluidic components to be fabricated on flexible substrates for a wide variety of applications. Due to the fact that flexible substrate is temperature sensitive, typically only low temperature materials, such as polymers, metals, and organic semiconductor materials, can be directly fabricated on flexible substrates. A novel technology based on XeF2(xenon …

Ribonomic Control During Global Brain Ischemia And Reperfusion, Haihui Wang

Wayne State University Dissertations

Abstract

RIBONOMIC CONTROL DURING GLOBAL BRAIN ISCHEMIA AND REPERFUSION

by HAIHUI WANG

August 2014

Advisor: Donald J. DeGracia, Ph.D.

Major: Physiology

Degree: Doctor of Philosophy

The study presented here used "omic" technology to look at the mechanism behind the selective delayed death of hippocampus CA1 neurons after transient global brain ischemia. The main findings are summarized:

1. The main form of ELAV protein family member detected in CA1/CA3 in Hu protein immunoprecipitation and polysomes was HuB (Rel-N1). HuB is present in control CA3, 8 hr reperfused CA3, and 8 hr reperfused CA1, but absent from control CA1. AUF-1, hnRNP K, …

Adenosine A2b Receptor Effects On Post-Mi Remodeling And Cardiac Fibroblast Function, Enbo Zhan

Wayne State University Dissertations

Adenosine A_2B receptor (A_2BR) appear to contribute to chronic inflammation. This receptor is highly expressed in macrophages and cardiac fibroblasts, cells which play key roles in inflammation and healing following myocardial infarction (MI). A_2BR have been shown to induce collagen production and promote organ fibrosis, although the reports of A_2BR role on MI are limited and conflicting. The results of cardiac fibroblast (CF) studies however suggest that non-selective A_2BR stimulation inhibits collagen expression. The hypothesis of the present study was that deletion of A_2BR reduces adverse remodeling in post-MI, …

The Mechanism For Inhibition Of Vibrio Cholerae Virulence Gene Expression By Bile And Its Fatty Acid Components, Sarah Plecha

Wayne State University Dissertations

Vibrio cholerae is responsible for the diarrheal disease cholera by producing two major virulence factors: cholera toxin (CT) and toxin-coregulated pilus (TCP). During infection, V. cholerae downregulates its motility genes, which are actively expressed in the environment, and upregulates its virulence genes, which are inactive in the environment. Virulence gene transcription is regulated by the major transcriptional activator, ToxT. ToxT is regulated, in part, by host signals, which in turn, make ToxT active or inactive in respect to virulence gene expression. Host signals include temperature and pH as well as the chemical molecules bicarbonate and bile, which are positive and …

Cell Envelope Modifications By Lcp Family Proteins Of Group B Streptococcus And Virulence Singaling By Peptides Of The Salivaricin Locus Of Streptococcus Pyogenes, Hannah Morrison Rowe

Wayne State University Dissertations

ABSTRACT

CELL ENVELOPE MODIFICATIONS BY LCP FAMILY PROTEINS OF GROUP B STREPTOCOCCUS AND VIRULENCE SIGNALING BY PEPTIDES OF THE SALIVARICIN LOCUS OF STREPTOCOCCUS PYOGENES

by

HANNAH MORRISON ROWE

December 2014

Advisor: Dr. Melody Neely

Major: Immunology and Microbiology

Degree: Doctor of Philosophy

Streptococci are important human and animal pathogens. Group B Streptococcus (GBS) is a zoonotic pathogen that is the leading cause of human neonatal sepsis and meningitis. In order to cause systemic disease GBS must produce a polysaccharide capsule. Capsule expression is controlled in part by the protein CpsA. We demonstrate that deletion of the cpsA gene, or expression …