Digital Commons Network^™

The Effects Of Hypergravity On Development Of The Heart And Behavior Of Xenopus Laevis, Stacey Howes

Honors Program Theses

Every living organism on earth has developed and evolved in a 1G environment. It is likely that any deviation from Earth’s standard gravity will influence development, particularly at early stages. Previous reports from this lab showed that body length is reduced and that ventricle size is increased during development at 7G. The objective of the present study was to investigate the effect of hypergravity on the development of the ventricular myocardial wall and neuromuscular responsiveness of Xenopus laevis. At early gastrulation, (Nieuwkoop and Faber Stage 10) embryos were placed in a centrifuge simulating 7G, 10G, 15G or 17G until they …

Bacterial Inactivation By High Voltage Atmospheric Cold Plasma: Influence Of Process Parameters And Effects On Cell Leakage And Dna, Lu Han, Sonal Patil, Kevin M. Keener, Patrick J. Cullen, Paula Bourke

Articles

Aims: This study investigated a range of atmospheric cold plasma (ACP) process parameters for bacterial inactivation with further investigation of selected parameters on cell membrane integrity and DNA damage. The effects of high voltage levels, mode of exposure, gas mixture and treatment time against Escherichia coli and Listeria monocytogenes were examined.

Methods and Results: 10⁸ CFU ml^-1 E. coli ATCC 25922, E. coli NCTC 12900 and L. monocytogenes NCTC11994 were ACP treated in 10ml phosphate buffered saline (PBS). Working gas mixtures used were; Air (gas mix 1), 90% N₂+10% O₂ (gas mix 2) and 65% …

Effects Of Phylogeny On Structural Correlations Of Vertebrate Eyes, Amanda Yl Jacobs

Scripps Senior Theses

Common ancestry prevents scientists from using traditional statistical tests in dimensional comparisons that span entire clades. Data in these cases are non-independent, so a variety of special statistical methods have been developed specifically for phylogenetic comparative analyses. A phylogenetic least squares method was used to re-examine four published datasets detailing structural correlates of eyes while factoring in the different ways the phylogeny was expected to affect the covariance in trait values. All analyses were carried out in a strict phylogenetic context, using published time-calibrated phylogenies and the statistical platform R. Specifically, Pagel’s lambda was used to determine how much of …

Exemplary Equines: Gazes And Gesture Of Bovine Animals In Trecento Fresco, Elsa L. Bruno

Scripps Senior Theses

Horses were high status animals in the middle ages. Strong, costly, and used in war, they symbolized power and wealth. Yet in some Trecento Italian frescos, horses take on another role. Particularly through their eyes, ears, and body positioning they seem to communicate with each other regarding the religious scenes at hand. Additionally, horses are often the only beings paying attention to Jesus or God, or are the sole beings who break the fourth wall of an image to engage with the viewer. While the revolutionary use of gesture and eye movement has been examined in humans in these frescoes, …

An Ethnographic Inquiry: Contemporary Language Ideologies Of American Sign Language, Anya A. Leyhe

Scripps Senior Theses

Historically, American Sign Language (an aspect of Deaf culture) has been rendered invisible in mainstream hearing society. Today, ASL’s popularity is evidenced in an ethnolinguistic renaissance; more second language learners pursue an interest in ASL than ever before. Nonetheless, Deaf and hearing people alike express concern about ASL’s place in hearing culture. This qualitative study engages ethnographic methods of participant observation and semi-structured interviewing as well as popular media analysis to understand language ideologies (ideas and objectives concerning roles of language in society) hearing and Deaf Signers hold about motivations and practices of other hearing Signers. Although most hearing ASLers …

Serotonin Receptor 2-Induced Mitochondrial Biogenesis As A Therapeutic Strategy For The Treatment Of Multiple Pathologies, Jennifer Linton Harmon

MUSC Theses and Dissertations

Mitochondrial dysfunction is a common pathophysiological feature in many acute and chronic organ injury states. Often, this mitochondrial dysfunction is sub-lethal and persistent and is a major contributor to loss of cellular function in the absence of cell death. Mitochondrial biogenesis (MB) is the process by which new mitochondria are created, and studies have demonstrated that pharmacological induction of MB can reverse loss of mitochondrial content, improve mitochondrial function and reduce measures of acute organ injury. Several classes of pharmacological agents that induce MB through divergent mechanisms have been identified. Previous studies demonstrated that 2,5-Dimethoxy-4-iodoamphetamine (DOI), a potent but non-specific …

A Review Of Common Drug-Drug And Food-Drug Interactions Associated With Cardiovascular Medications, Raymond Kho, Sarah Kim, Stacy Lee, Laura Tsu

Pharmacy Faculty Articles and Research

This home-study CPE activity has been developed to educate pharmacists on the common drug-drug and food-drug interactions associated with cardiovascular medications.

Nanoparticulate Drug Delivery Platforms For Advancing Bone Infection Therapies, Vuk Uskoković, Tejal A. Dasai

Pharmacy Faculty Articles and Research

Introduction—The ongoing surge of resistance of bacterial pathogens to antibiotic therapies and the consistently aging median member of the human race signal an impending increase in the incidence of chronic bone infection. Nanotechnological platforms for local and sustained delivery of therapeutics hold the greatest potential for providing minimally invasive and maximally regenerative therapies for this rare but persistent condition.

Areas covered—Shortcomings of the clinically available treatment options, including poly(methyl methacrylate) beads and calcium sulfate cements, are discussed and their transcending using calcium-phosphate/polymeric nanoparticulate composites is foreseen. Bone is a composite wherein the weakness of each component alone is …

Discovery Of Pharmacological Compounds That Stimulate Renal Mitochondrial Biogenesis And Restore Kidney Function, Sean Robert Jesinkey

MUSC Theses and Dissertations

Dysfunctional mitochondria are a primary pathological consequence of acute kidney injury (AKI). Mitochondrial homeostasis is disrupted up to 144 h after ischemia-reperfusion (I/R) induced-AKI in the renal cortical tissue of mice. Stimulation of mitochondrial biogenesis in renal cells after oxidant injury restores mitochondrial function. The primary goals of this project were to identify novel pharmacological compounds capable of inducing mitochondrial biogenesis in the renal proximal tubule and evaluate if this induction would promote the recovery of mitochondrial and/or renal function after in vivo AKI. The secondary goal was to employ our mitochondrial approach for drug discovery towards identifying a novel …

Phosphodiesterase Inhibition And Adenosine A2b Receptor Signaling In Mitochondrial Function: Pharmacology And Toxicology Of 3-Isobutyl 1-Methylxanthine (Ibmx) In The 661w Retina-Derived Cell Line, Anthony Presley Leonard

MUSC Theses and Dissertations

3-isobutyl 1-methylxanthine (IBMX) is a commonly used inhibitor of cyclic nucleotide phosphodiesterases (PDE) and G protein coupled adenosine receptors. Administration of IBMX to retina photoreceptor-derived 661w cell line results in decreased mitochondrial respiration followed by cell death, mimicking phenomena observed in inherited retina neurodegeneration in humans and animals and thus suggesting their use as a cell-based model of retina degeneration. In this dissertation, the temporal relationship between pathways altered by IBMX and how these pathways affect mitochondrial physiology are evaluated. These studies utilize a novel high content microscopic method for simultaneously measuring mitochondrial morphology and membrane potential in living cultured …

Aiming Attention Using Selective Stimulation Of Locus Coeruleus And Its Medial Prefrontal Efferents, Zackary A. Cope

MUSC Theses and Dissertations

Appropriate modification of behavior in response to dynamic environmental conditions is essential for the adaptation and survival of most biological organisms. This adaptability allows for organisms to maximize the benefit of behavior related energy expenditure (utility) while minimizing cost. Modern theories of locus coeruleus (LC) function implicate a pivotal role for the noradrenergic (NA) nucleus in mediating switches between focused behavior during periods of high utility (exploit) versus disengagement of behavior and exploration of other, more rewarding opportunities. Two modes of activity in LC neurons have been well characterized. During periods of accurate and focused behavior, LC neurons exhibit suppressed …

The Comprador Complex: Africa’S Iprs Elites, Neo-Colonialism And The Enduring Control Of African Ipr Agenda By External Interests, Ikechi Mgbeoji

Articles & Book Chapters

No abstract provided.

Objective Mens Rea And Attenuated Subjectivism: Guidance From Justice Charron In R. V. Beatty, Palma Paciocco

Articles & Book Chapters

Justin Ronald Beatty was driving on the Trans-Canada Highway on July 23, 2003 when, for no apparent reason, his truck suddenly crossed the solid centre line and collided with an oncoming car, killing three people. Beatty was charged with dangerous operation of a motor vehicle causing death. He was acquitted at trial on the grounds that his momentary lapse of attention was not enough to establish fault. The Crown appealed, and the Court of Appeal ordered a new trial after concluding that the trial judge had misapplied the fault standard. Beatty appealed to the Supreme Court of Canada, which undertook …

Professor Xavier Is A Gay Traitor! An Antiassimilationist Framework For Interpreting Ideology, Power And Statecraft, Michael Loadenthal

Journal of Feminist Scholarship

Ideology is an integral component in the reproduction of power. Integral to this central tenet of statecraft is the regulation of identity and proscribed methods of social engagement—positive portrayals of "good citizenry" and delegitimized representations of those challenging hegemony. Through an Althusserian and linguistic analysis, positioning the X-Men movie franchise as an Ideological State Apparatus (ISA), one can examine the lives of mutants portrayed in the text as indicative of preferred methods of state-legitimized sociopolitical interaction. This metaphorical and textual analysis is used to discuss the lived realities of queer persons resisting hegemony, and is located in the bodies and …

Advent Devotional Guide 2014, Belmont University

Advent Devotional Guides

No abstract provided.

Rare Books And Social Science, Donald J. Polzella

Psychology Faculty Publications

An essay on the impact of the works in the Imprints and Impressions: Milestones in Human Progress, an exhibition of rare books from the collection of Stuart Rose. Exhibition was held Sept. 29-Nov. 9, 2014, at the University of Dayton.

Oral History Project Handbook, Evergreen Education Foundation, Faith Chao, Lauren Kata, Nancy Mackay, Jo Whitlatch, Zhang Yu

Faculty Publications

This handbook was developed by the EEF Oral History Team to introduce conference participants to oral history best practices. The handbook is part of an ongoing documentation effort by EEF, which includes forms, assessment tools, training curricula, and outside resources. Documentation in English and Chinese is continually updated at the EEF wiki, http://evergreeneducation.org/wikipub/tiki-index.php

Relationships Between Equine Management Practices And Intestinal Parasite Infection, Abigail Pagel

Honors Projects

Parasitology is an important area of veterinary medicine, but the risk factors for high parasite loads are not well-understood. Equine intestinal parasites can cause extensive disease and death. In the current study, the relationship between equine intestinal parasite loads and adherence to veterinary guidelines for equine management practices was studied. Satisfactory adherence to guidelines regarding food, pasture, and flooding management was related to lower parasite loads. Adherence to guidelines regarding deworming, quarantine, bedding, and water did not appear to lower parasite loads. Still, adhering to these guidelines has been shown to improve equine welfare, even if they are not related …

Estimating Sustainable Harvests Of Eastern Oysters, Crassostrea Virginica, Thomas M. Soniat, Nathan Cooper, Eric N. Powell, John M. Klinck, Mahdi Abdelguerfi, Shengru Tu, Roger Mann, Patrick D. Banks

CCPO Publications

Sustainability of a fishery is traditionally and typically considered achieved if the exploited population does not decline in numbers or biomass over time as a result of fishing relative to biological reference point goals. Oysters, however, exhibit atypical population dynamics compared with many other commercial species. The population dynamics often display extreme natural interannual variation in numbers and biomass, and oysters create their own habitat--the reef itself. With the worldwide decline of oyster reef habitat and the oyster fisheries dependent thereon, the maintenance of shell has received renewed attention as essential to population sustainability. We apply a shell budget model …

Web Development For The Home Builders Associoation Serving Portage And Summit Counties, Gail Lewis White

Williams Honors College, Honors Research Projects

Gail Lewis White

Major: Business and Organizational Communication

Project Sponsor: Dr. Sylvia White

Number of Project Credits: 3

Abstract

This Honors project redesigned the website of the Home Builders Association serving greater Portage and Summit counties (HBA). The goal of the new website was to enhance the social media image and internet presence of the HBA. The project included a competitive analysis of competing websites throughout the construction industry and a thorough analysis of the HBA’s internal and external communications. Under the supervision of Vice President of Operations Carmine Torio, this project has met and surpassed the goals set by …

Becoming Reflective: Designing For Reflection On Physical Performances, Tom Moher, Cynthia Carter Ching, Sara Schaefer, Victor R. Lee, Noel Enyedy, Joshua Danish, Paulo Guerra, Alessandro Gnoli, Priscilla Jimenez, Brenda Lopez-Silva, Leilah Lyons, Anthony Perritano, Brian Slattery, Mike Tissenbaum, James Slotta, Rebecca Cober, Cresencia Fong

Instructional Technology and Learning Sciences Faculty Publications

Learners’ physical performances can serve as focal objects for reflection and insight across a variety of contexts and content areas. This session brings together a set of projects that leverage the physical performances of learners, construct concrete and abstract representations of those performances, and investigate how learners reflect on and understand the relationships between their performances and target content—physics, health and fitness, data literacy and navigation, animal foraging, and climate change. The session will share findings and design principles from each of the studies around constructing technological scaffolds for physical performance reflections. The symposium highlights the various ways performance can …

The Role Of Poly N Acetyl Glucosamine Nanofibers In Cutaneous Wound Healing, Amanda Haley Buff-Lindner

MUSC Theses and Dissertations

Treatment of cutaneous wounds with poly-N-acetyl-glucosamine nanofibers (pGlcNAc), a novel polysaccharide material derived from a marine diatom, results in increases in wound closure, antibacterial activities and innate immune responses. Treatment with nanofibers results in increased defensin, small antimicrobial peptides, expression both in vitro and in vivo. Induction of defensing expression results in bacterial clearance in a cutaneous wound model. We have also shown that Akt1 plays a central role in the regulation of these activities. We show that pGlcNAc treatment of cutaneous wounds in mice results in decreased scar sizes. Additionally, treatment of cutaneous wounds with pGlcNAc results in increased …

Examining How Students Make Sense Of Slow-Motion Video, Min Yuan, Nam Ju Kim, Joel Drake, Scott Smith, Victor R. Lee

Instructional Technology and Learning Sciences Faculty Publications

Slow-motion video is starting to appear in science classrooms as a source of data for students to examine. However, seeing important features in such video requires a particular kind of student engagement and supported acts of noticing. This poster reports on an exploratory study of what students noticed and talked about when viewing slow-motion video during a classroom design experiment focused on bodily activity as it relates to motion and animation.

The Nsf/Nih Effect: Surveying The Effect Of Data Management Requirements On Faculty, Sponsored Programs, And Institutional Repositories, Cheryl D. Walters, Anne R. Diekema, Andrew Wesolek

Library Faculty & Staff Publications

The scholarly communication landscape is rapidly changing and nowhere is this more evident than in the field of data management. Mandates by major funding agencies, further expanded by executive order and pending legislation in 2013, require many research grant applicants to provide data management plans for preserving and making their research data openly available. However, do faculty researchers have the requisite skill sets and are their institutions providing the necessary infrastructure to comply with these mandates? To answer these questions, three groups were surveyed in 2012: research and teaching faculty, sponsored programs office staff, and institutional repository librarians. Survey results …

Using Topology To Explore Mathematics Education Reform, Carling Sugarman

HMC Senior Theses

Mathematics education is a constant topic of conversation in the United States. Many attempts have been made historically to reform teaching methods and improve student results. Particularly, past ideas have emphasized problem-solving to make math feel more applicable and enjoyable. Many have additionally tackled the widespread problem of “math anxiety” by creating lessons that are more discussion-based than drill-based to shift focus from speed and accuracy. In my project, I explored past reform goals and some added goals concerning students' perceptions of mathematics. To do so, I created and tested a pilot workshop in topology, a creative and intuitive field, …

Diclazuril Protects Against Maternal Gastrointestinal Syndrome And Congenital Toxoplasmosis, Helieh S. Oz, Thomas Tobin

Internal Medicine Faculty Publications

BACKGROUND: Toxoplasmosis is a common cause of foodborne, gastrointestinal and congenital syndrome with particularly severe or unknown health consequences. There is no safe and effective preventive or therapeutic modality against congenital toxoplasmosis or to eliminate the persistent chronic infection.

HYPOTHESIS: Diclazuril to be safe in pregnancy and effective against gastrointestinal toxoplasmosis.

METHODS: CD1 programmed pregnant mice were divided into groups and administered a diet containing diclazuril, or sham control. Treatments were initiated on Day 5 of pregnancy and continued until Day 16 when dams were euthanatized. On Day 8 of pregnancy dams were infected intraperitoneally with escalating doses of tachyzoites …

Visuality And The Difficult Differences In Networked Knowledge Communities, Anita August

English Faculty Publications

This chapter argues that as Networked Knowledge Communities (NKCs) become increasingly the way knowledge is constructed, represented, and circulated, visuality in information-based societies is also being shaped, and shaped by, the interactive and collective ideologies of digital technology environments. Like the written text, which constructs and imposes hegemonic ideals of identity through discursive practices, visual representations of identities also serve as powerful discursive reservoirs of subordinating representations. By focusing on NKCs as an epistemic space that reflects, recirculates, and reacts to bodies of knowledge produced by the institutions of power in the larger social culture, this chapter examines the vulnerability …

Cross-Hauling And Regional Input-Output Tables: The Case Of The Province Of Hubei, China, Yongming Huang, Anthony T. Flegg, Timo Tohmo

Regional Research Institute Working Papers

Data for the Chinese province of Hubei are used to assess the performance of Kronenberg’s CHARM, a method that takes explicit account of cross-hauling when constructing regional input−output tables. A key determinant of cross-hauling is held to be the heterogeneity of the products of individual sectors, which is estimated using national data. However, contrary to the authors’ earlier findings for Finland, CHARM does not generate reliable estimates of Hubei’s sectoral exports, imports and volume of trade. It is crucial, therefore, especially in relatively small regions, to make adequate allowance for any known divergence between regional and national technology and heterogeneity.

A New Cold War? Cold Peace. Russia, Ukraine, And Nato, Dr. Eric A. Engle

Saint Louis University Law Journal

No abstract provided.

Theory Of Mind In Youth And Emerging Adults With Chromosome 22q11.2 Deletion Syndrome, With And Without Comorbid Mood Disorder, Amy K. Olszewski

Master's Theses and Doctoral Dissertations

Mood disorders are some of the most commonly diagnosed psychiatric disorders in childhood and adolescence. Major Depressive Disorder (MDD) and Bipolar Disorder (BPD) have become more widely recognized in children and adolescents in recent years and are especially common in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). Disruptions in social functioning are a common feature of mood disorders, including social withdrawal and loss of interest in activities that the individual typically experiences as pleasurable (anhedonia). Studies of individuals with 22q11.2DS also show they experience difficulty with social functioning, as well as social cognition, visuospatial, and executive functioning tasks. Studies of …