Digital Commons Network^™

Unlawful Religion? Modern Secular Power And The Legal Reasoning In The Jfs Case, Peter Danchin, Louis Blond

Maryland Journal of International Law

No abstract provided.

The Rising Expectations Of Free And Enslaved Blacks In The Greater Caribbean, Wim Klooster

History

As David Geggus has shown, scores of slave conspiracies and revolts occurred during the Age of Revolutions. In the Greater Caribbean, slave uprisings were especially frequent in the 1790s. One year stood out: 1795. While in a number of colonies revolts were planned in that year but failed to materialize, and in other colonies small numbers of slaves took up arms, large-scale rebellions involving slaves did occur in Coro and Curaçao. The seeds for such rebellious behaviour had been sown in 1789 with the destruction of the ancien régime in France, the adoption of the Declaration of the Rights of …

Modern Japanese Literature And Visual Culture: Constructions Of Religious And Historical Identity, Ronald S. Green

Philosophy and Religious Studies

This course is a survey of modern Japanese literature and visual culture since the Meiji Restoration (1868). It focuses on constructions of identities within historical contexts. Our objective is to analyze ways in which writers and artists have positioned their subjects and re-imagined culture to create particular portrayals. The class examines a selection of shōsetsu (the Japanese novel) of Natsume Soseki, Kawabata Yasunari, Mishima Yukio, Murakami Haruki, and Ogawa Yōko, films of Miyazaki Hayao, and important anime. The course promotes critical methodologies and interdisciplinary or comparative studies, combining, for example, literature with film, visual culture, gender studies, cultural history, Buddhist …

Treasuring What We Measure And Measuring What We Treasure: Post-2015 Monitoring For The Promotion Of Equality In The Water, Sanitation, And Hygiene Sector, Inga T. Winkler, Margaret L. Satterthwaite, Catarina De Albuquerque

Faculty Articles

The Millennium Development Goals (MDGs) harnessed the power of numbers to focus the world's attention on some of the most pressing development challenges. Numbers are perceived to be professional, rational, credible, and neutral. The MDGs embody both the promise and the peril of development approaches that view measurable outcomes as the most certain path to progress for all. They focus on quantifiable progress in access to basic social services and goods, using only well-known indicators, metrics, and established data sets for monitoring. Further, they focus on aggregate progress, failing-except in relation to a specific gender equality goal-to capture the dimension …

Auschwitz As A Site Of Memory, Emma Needham

OUR Journal: ODU Undergraduate Research Journal

Auschwitz is known as the most substantial site of the Holocaust namely because Auschwitz-Birkenau was the largest concentration camp in Europe, and it is estimated that about 960,000 Jews and 125,000 others were murdered there.¹ Not only was the process of creating the memorial at Auschwitz filled with controversies, but the site also remains questionable today with regards to dark tourism, or thanatourism, “the tourism of death.”² For some, the thought of traveling to a place subsumed in death and despair sounds troubling as the consumption of dark tourism involves a process of “confronting, understanding and accepting death.” …

University Of Dayton Magazine, Winter 2013-14, University Of Dayton Magazine

University of Dayton Alumni Publications

Up all night photo essay, law professor's research on social media, and history professor's research on KKK activities targeting Catholic schools.

“Something Has Gone Wrong”: The Jfs Case And Defining Jewish Identity In The Courtroom, Heather Miller Rubens

Maryland Journal of International Law

No abstract provided.

Customs Law, Gabriel Arriaga Callejas, Daniel Connors, Shane T. Devins, Brandi B. Frederick, Christine J. Sohar Henter, Jennifer Horvath, Andrew Hudson, Jamie Joiner, Sacha A. Kathuria, Daniel L. Kiselbach, Michael J. Lowell, Ann Mcgrath, Matt Nakachi, David Newton, Kathleen Porter, Rebecca A. Rodriguez, David Salkeld, Hena Schommer, Lauren Sigg, Zachary Silver, Christopher Skinner, Trice Stabler, Mark Swirt, Maureen E. Thorson, George Tuttle Iii, Sidney N. Weiss, Vicky Wu

The International Lawyer

No abstract provided.

International Trade, Stephen W. Brophy, Christine J. Sohar Henter, Johny Chaklader, Robert E. Defrancesco Iii, Geoffrey M. Goodale, Derick G. Holt, Bernd G. Janzen, Ron Kendler, Matthew T. Mcgrath, Diane Macdonald, Courtney O'Toole Morgan, David Newton, Laura El-Sabaawi, Sarah Sprinkle, Adam Teslik

The International Lawyer

No abstract provided.

International Courts, Mark E. Wojcik, Cindy Galway Buys

The International Lawyer

No abstract provided.

Memento Mori: Death And Wills, Karen J. Sneddon

Wyoming Law Review

No abstract provided.

Pharmacological Targeting Of The Mammalian Clock Regulates Sleep Architecture And Emotional Behaviour, Subhashis Banerjee, Yongjun Wang, Laura A. Solt, Kristine Griffett, Melissa Kazantzis, Ariadna Amador, Bahaa M. El-Gendy, Salvador Huitron-Resendiz, Amanda J. Roberts, Youseung Shin, Theodore M. Kamenecka, Thomas P. Burris

Department of Nutrition and Health Sciences: Faculty Publications

Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here we demonstrate that synthetic ligands targeting a key component of the mammalian clock, the nuclear receptors REV-ERBα and β, regulate sleep architecture and emotional behaviour in mice. REV-ERB agonists induce wakefulness and reduce REM and slow-wave sleep. Interestingly, REV-ERB agonists also reduce anxiety-like behaviour. These data are consistent with increased anxiety-like behaviour of REV-ERBβ-null mice, in which REV-ERB agonists have no effect. These results indicate that pharmacological targeting of REV-ERB …

The Current State Of Drug Discovery And A Potential Role For Nmr Metabolomics, Robert Powers

Robert Powers Publications

The pharmaceutical industry has significantly contributed to improving human health. Drugs have been attributed to both increasing life expectancy and decreasing health care costs. Unfortunately, there has been a recent decline in the creativity and productivity of the pharmaceutical industry. This is a complex issue with many contributing factors resulting from the numerous mergers, increase in out-sourcing, and the heavy dependency on highthroughput screening (HTS). While a simple solution to such a complex problem is unrealistic and highly unlikely, the inclusion of metabolomics as a routine component of the drug discovery process may provide some solutions to these problems. Specifically, …

Metabolomics Analysis Identifies D-Alanine-D-Alanine Ligase As The Primary Lethal Target Of D-Cycloserine In Mycobacteria, Steven M. Halouska, Robert J. Fenton, Denise K. Zinniel, Darrell D. Marshall, Raul G. Barletta, Robert Powers

Robert Powers Publications

D-cycloserine is an effective second line antibiotic used as a last resort to treat multi (MDR)- and extensively (XDR)- drug resistant strains of Mycobacterium tuberculosis. D-cycloserine interferes with the formation of peptidoglycan biosynthesis by competitive inhibition of Alanine racemase (Alr) and D-Alanine-D-alanine ligase (Ddl). Although, the two enzymes are known to be inhibited, the in vivo lethal target is still unknown. Our NMR metabolomics work has revealed that Ddl is the primary target of DCS, as cell growth is inhibited when the production of D-alanyl-Dalanine is halted. It is shown that inhibition of Alr may contribute indirectly by lowering …

Water Quantity And Quality In The Columbia Basin Trust Region, Janice Brahney

Watershed Sciences Faculty Publications

This report collects the documents generated as part of a two year effort to catalogue the variety of water quality and quantity data that has been collected in the Columbia Basin Trust region of British Columbia. Through the cataloguing effort, a number of important data and knowledge gaps were identified and specific recommendations developed. The available water quantity and climate data was then used in a number of analyses focused on understanding the relationship between changing climate conditions and stream discharges.

One overall finding is that there is a large variety of data collected and held by various different entities. …

The Belizean Environment, Lauren Marie Bach

Service-Learning

Lauren Bach's 2014 service-learning presentation on the environment in Belize.

Transitioning Cattle From Ramp® To A Finishing Diet On Feed Intake And Ruminal Ph, Cody J. Schneider, Adam L. Shreck, Terry J. Klopfenstein Klopfenstein, Galen E. Erickson

Nebraska Beef Cattle Reports

A metabolism trial was conducted where steers were adapted to high grain diets using a traditional approach or one of two RAMP^® adaptation programs. RAMP programs adapted cattle to a finishing diet either gradually over 28 days in four steps or switched to a finishing ration without steps. Feed intake and ruminal pH were monitored continuously throughout the trial. Cattle on the 4-STEP treatment spent more time eating compared to other treatments but total feed consumption was similar among treatments. Ruminal pH was greater for cattle on RAMP adaptation programs when compared to traditional grain adaptation. Cattle fed RAMP …

Corrigendum To Murine Langerin+ Dermal Dendritic Cells Prime Cd8+ T Cells While Langerhans Ells Induce Cross-Tolerance, Vincent Flacher, Christoph H. Trip, David G. Mairhofer

Publications

[No abstract available]

Classical Flt3l-Dependent Dendritic Cells Control Immunity To Protein Vaccine, Niroshana Anandasabapathy, Rachel E. Feder, Shamim A. Mollah

Publications

DCs are critical for initiating immunity. The current paradigm in vaccine biology is that DCs migrating from peripheral tissue and classical lymphoid-resident DCs (cDCs) cooperate in the draining LNs to initiate priming and proliferation of T cells. Here, we observe subcutaneous immunity is Fms-like tyrosine kinase 3 ligand (Flt3L) dependent. Flt3L is rapidly secreted after immunization; Flt3 deletion reduces T cell responses by 50%. Flt3L enhances global T cell and humoral immunity as well as both the numbers and antigen capture capacity of migratory DCs (migDCs) and LN-resident cDCs. Surprisingly, however, we find immunity is controlled by cDCs and actively …

Studies Of A Novel Phage Lytic Enzyme, Plyss2, Daniel B. Gilmer

Student Theses and Dissertations

Streptococcus suis infects pigs worldwide and may be zoonotically transmitted to humans with a mortality rate of up to 20%. Methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes (group A streptococci – GrAS) cause potentially fatal human diseases. These are just three of the many Gram-positive pathogens for which resistance to leading antibiotics has emerged. The goal of this work was to develop a novel antimicrobial treatment to combat these and other antibiotic-resistant pathogens. We identified a novel bacteriophage lysin, derived from an S. suis phage termed PlySs2 (phage lysin from S. suis 2). This thesis is divided into four main …

Abdominal-B Neurons Control Drosophila Virgin Female Receptivity, Jennifer J. Bussell

Student Theses and Dissertations

To choose their mates, male and female vinegar flies (Drosophila melanogaster) perform a duet of stereotyped, sexually dimorphic courtship behaviors, a suite of sensory back-and-forth that offers an excellent model for studying the neural circuitry of complex behavior (Dickson, 2008). However, the study of Drosophila courtship has focused overwhelmingly on the male, and little is known about how the female evaluates male courtship to decide whether to mate and how she executes that decision by slowing down and opening vaginal plates, a process known as receptivity. To expand the mechanistic understanding of Drosophila receptivity, we set out to identify neurons …

High Resolution Maps Of The Vasculature Of An Entire Organ, Oppenheim N. Jacob

Student Theses and Dissertations

The structure of vascular networks represents a great, unsolved problem in anatomy. Network geometry and topology differ dramatically from left to right and person to person as evidenced by the superficial venation of the hands and the vasculature of the retinae. Mathematically, we may state that there is no conserved topology in vascular networks. Efficiency demands that these networks be regular on a statistical level and perhaps optimal. We have taken the first steps towards elucidating the principles underlying vascular organization, creating the first map of the hierarchical vasculature (above the capillaries) of an entire organ. Using serial blockface microscopy …

Coordinating Stem Cell Behavior In The Hair Follicle, Chiung-Ying Chang

Student Theses and Dissertations

Tissue stem cells perform important functions throughout an organism's life. They generate new cells to replenish cells that are lost during normal wear and tear or in response to acute injury. Remarkably, hair follicles naturally undergo repetitive cycles of regeneration and degeneration, a process that is accomplished with the support of stem cells within the hair follicles. It is this feature that makes this miniorgan an attractive model system to study stem cell biology. Interestingly, hair follicle is home to two distinct stem cell populations: epithelial hair follicle stem cells (HFSCs), which contribute to the formation of hair shafts, and …

Exploration Of Cell Cycle-Specific Essential Gene Functions In The Microbial Plant Chlamydomonas Reinhardtii, Frej Tulin

Student Theses and Dissertations

The cell cycle encompasses all the steps required for cell proliferation, and is normally tightly coupled to growth and division in all organisms. Much research has resulted in a well-supported model of eukaryotic cell cycle control. However, since most of this research has been carried out in yeast and animals (opisthokonts), it could in principle apply poorly to early-diverging groups of organisms, such as the green plants. Plant cell cycle research has largely followed a candidate strategy based on reverse genetics. These studies have a provided insights into plant cell cycle control, but are generally dependent upon sequence conservation between …

The Neuropeptide Regulation Of Host-Seeking Behavior In Aedes Aegypti Mosquitoes, Jeff Liesch

Student Theses and Dissertations

Aedes aegypti mosquitoes are the principal vectors for several human diseases including Dengue Fever, which causes ~400 million cases and ~24,000 deaths per year (Bhatt et al., 2013; WHO, 2002). Novel strategies to combat mosquito-borne diseases are needed for A. aegypti and other mosquitoes such as the malaria vector Anopheles gambiae. Our goal was to discover new ways to interfere with the ability of a mosquito to locate a human host for a blood meal. Currently, the mechanistic basis of host-seeking and its regulation remain incompletely understood. Although it is known that mosquitoes require human odor cues to locate a …

Taming A Potent Mutator: Identification And Characterization Of Novel Mechanisms Of Regulating Antibody Diversification In B-Lymphocytes, Rebecca Kyle Delker

Student Theses and Dissertations

Often the needs of an organism exceed the number of genes in the genome. Thus, modification of the genes, themselves, or of the gene products is necessary. This becomes particularly important in cells of the immune system, which have to combat a virtually infinite array of foreign pathogens. Blymphocytes, the mediators of humoral immunity, have developed extensive mechanisms of gene diversification collectively known as antibody diversification. Antibody diversification, a set of processes necessary for an organism to mount a specific and robust immune response, relies on Activation Induced Cytidine Deaminase (AID) to initiate two of such processes: Somatic Hypermutation (SHM) …

The Origin Of Multiple Sclerosis Revisited: The Case For A Soluble Toxin, Kareem Rashid Rumah

Student Theses and Dissertations

After nearly two hundred years of scientific inquiry, the cause of Multiple Sclerosis (MS) remains unknown. Although generally considered an autoimmune disease, recent pathological findings have challenged the longstanding autoimmune view of MS. Indeed, lesions that are just hours past their initial onset display evidence of cellular degeneration in the absence of an inflammatory infiltrate. This seminal finding begs the fundamental question, if immune cells do not participate in early tissue damage in MS, what is the mysterious triggering agent? In the first half of this thesis, I will propose that a soluble bacterial toxin, Clostridium perfringens epsilon toxin (ETX), …

Mechanism And Evolutionary Origins Of Hiv-1 Virion Entrapment By Tetherin, Siddarth Venkatesh

Student Theses and Dissertations

The cellular restriction factor, tetherin, prevents HIV-1 and other enveloped virus particles from being disseminated into the extracellular milieu by infiltrating their envelopes and by physically crosslinking them to the cell surface. However, the mechanisms underlying virion retention have not yet been fully delineated. In this body of work, we employed biochemical assays and engineered tetherin proteins to demonstrate conclusively that virion tethers are composed of the tetherin protein itself, and to elucidate the configuration and topology that tetherin adopts during virion entrapment. We demonstrated that tetherin dimers adopt an "axial" configuration, in which pairs of transmembrane domains or pairs …

Hiv Specific B Cell Response In Patients With Broadly Neutralizing Serum Activity, Johannes F. Scheid

Student Theses and Dissertations

Antibodies to conserved epitopes on the HIV surface protein gp140 can protect against infection in non-human primates, suggesting that vaccines that elicit such antibodies would be protective. Some HIV infected individuals develop high titers of broadly neutralizing IgG antibodies in their serum, but until recently very little was known about the specificity and activity of these antibodies. To characterize the broadly neutralizing memory antibody responses to HIV we cloned 1078 antibodies from HIV envelope binding memory B cells from eight HIV infected patients with broadly neutralizing antibodies. We found that in these patients, the B cell memory response to gp140 …

The Structural And Biochemical Characterization Of Salmonella Host Specificity Determinant Gifsy-2 Gene E, Amanda C. Kohler

Student Theses and Dissertations

Salmonella enterica continues to be a significant public health concern, causing an estimated 93.8 million cases of non-typhoidal salmonellosis and 21 million cases of typhoid fever worldwide each year. There are thousands of Salmonella enterica serovars, some with a very specific host set, and others that cause disease in rodents, birds, livestock, domestic fowl, and humans alike. In recent years, there has been much progress in the delineation of Salmonella infection, with the goal of understanding Salmonella pathogenesis at the molecular level. Salmonella produces many different effector proteins capable of interacting with and altering numerous biological pathways in the host …