Digital Commons Network^™

Farmer To Pharmacist: Curcumin As An Anti-Invasive And Antimetastatic Agent For The Treatment Of Cancer, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

A huge number of compounds are widely distributed in nature and many of these possess medicinal/biological/pharmacological activity. Curcumin, a polyphenol derived from the rhizomes (underground stems) of Curcuma longa Linn (a member of the ginger family, commonly known as turmeric) is a culinary spice and therapeutic used in India for thousands of years to induce color and flavor in food as well as to treat a wide array of diseases. The origin of turmeric as spice and folklore medicine is so old that it is lost in legend. Curcumin has many beneficial pharmacological effects which includes, but are not limited …

An Empirical Analysis Of Student Perceptions Of Website Components For Class Web-Sites, Jay M. Lightfoot

Communications of the IIMA

Technology has improved to the point where web-sites for every course taught by an instructor are possible. This has produced many instructional benefits; however, it has also created a new set of problems. The problem addressed by this paper is the question of which web-site components to include in the class web-site. This is important because different web components support different student learning styles. Because it is not feasible to include all known webcomponents, the instructor must select those components that are most useful and support the broadest group of students. To address this question, a survey instrument was developed …

An Exploratory Investigation Of The Learning Styles Of Students In An On-Line Degree Program, Nicholas A. Beadless Ii, Christopher M. Lowery

Communications of the IIMA

This study is an exploratory investigation into whether different leaning styles predict performance in an online course. Students enrolled in several cohorts of an accredited MBA program were surveyed with regard to their learning styles and those styles were correlated with the grades earned in the course. The program is unique in that the entire program could be completed online.

A New Cecal Slurry Preparation Protocol With Improved Long-Term Reproducibility For Animal Models Of Sepsis, Marlene E. Starr, Allison M. Steele, Mizuki Saito, Bill J. Hacker, B. Mark Evers, Hiroshi Saito

Surgery Faculty Publications

Sepsis, a life-threatening systemic inflammatory response syndrome induced by infection, is widely studied using laboratory animal models. While cecal-ligation and puncture (CLP) is considered the gold standard model for sepsis research, it may not be preferable for experiments comparing animals of different size or under different dietary regimens. By comparing cecum size, shape, and cecal content characteristics in mice under different experimental conditions (aging, diabetes, pancreatitis), we show that cecum variability could be problematic for some CLP experiments. The cecal slurry (CS) injection model, in which the cecal contents of a laboratory animal are injected intraperitoneally to other animals, is …

Epigenetic Regulation Of Nuclear Hormone Receptor Dax-1, Michael B. Heskett

Master's Theses

DAX-1 (NR0B1) is an orphan nuclear receptor that plays a key role in the development and maintenance of steroidogenic tissue in mammals. Dax-1 is also expressed in mouse embryonic stem (ES) cells and is required to maintain pluripotency. Duplication of the X-chromosome in the region containing the NR0B1 gene results in sex reversal, and mutations in NR0B1 cause adrenal hypoplasia congenita. DAX-1 has been observed to act as a corepressor of other nuclear receptors including androgen receptor (AR), estrogen receptor (ER), and steroidogenic factor 1 (SF-1). In addition to pluripotent ES cells, DAX-1 is primarily expressed in select tissues of …

Mtorc2 Is Required For Rit-Mediated Oxidative Stress Resistance, Weikang Cai, Douglas A. Andres

Molecular and Cellular Biochemistry Faculty Publications

Rit, a member of the Ras family of GTPases, has been shown to promote cell survival in response to oxidative stress, in part by directing an evolutionarily conserved p38 MAPK-Akt survival cascade. Aberrant Rit signaling has recently been implicated as a driver mutation in human cancer, adding importance to the characterization of critical Rit effector pathways. However, the mechanism by which Rit-p38 signaling regulated Akt activity was unknown. Here, we identify mTORC2 as a critical downstream mediator of Rit-dependent survival signaling in response to reactive oxygen species (ROS) stress. Rit interacts with Sin1 (MAPKAP1), and Rit loss compromises ROS-dependent mTORC2 …

Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, And Inflammation, Chang Kim, Jeongho Park, Myunghoo Kim

Department of Comparative Pathobiology Faculty Publications

T cells are central players in the regulation of adaptive immunity and immune tolerance. In the periphery, T cell differentiation for maturation and effector function is regulated by a number of factors. Various factors such as antigens, co-stimulation signals, and cytokines regulate T cell differentiation into functionally specialized effector and regulatory T cells. Other factors such as nutrients, micronutrients, nuclear hormones and microbial products provide important environmental cues for T cell differentiation. A mounting body of evidence indicates that the microbial metabolites short-chain fatty acids (SCFAs) have profound effects on T cells and directly and indirectly regulate their differentiation. We …

Exploring The Efficacy Of Speech-Act Theory In Biblical Literature, Emory David Dively

Communication & Leadership Dissertations and Theses

No abstract provided.

Analyzing Flying Chameleons: Using Autoethnography To Explore Change In The Female Educator, Leslie Pourreau

The Qualitative Report

What is a chameleon in the world of education? What defines her professionally, personally, and why? In this autoethnography, I explore the chameleon metaphor for meanings and implications in my personal and professional identity as a female educator by seeking answers to questions stemming from Mitchell and Weber (2005): Just who do I think I am? Just who do I think I am? Just who do I think I am? Just who do I think I am? I analyzed my own autobiographical journals using the four-part Listening Guide (Gilligan, Spencer, Weinberg, & Bertsch, 2003) coupled with theme-based family coding to …

Analyzing Flying Chameleons: Using Autoethnography To Explore Change In The Female Educator, Leslie Pourreau

Faculty Articles

What is a chameleon in the world of education? What defines her professionally, personally, and why? In this autoethnography, I explore the chameleon metaphor for meanings and implications in my personal and professional identity as a female educator by seeking answers to questions stemming from Mitchell and Weber (2005): Just who do I think I am? Just who do I think I am? Just who do I think I am? Just who do I think I am? I analyzed my own autobiographical journals using the four-part Listening Guide (Gilligan, Spencer, Weinberg, & Bertsch, 2003) coupled with theme-based family coding to …

Celebrities In Popular Culture: How Their Use Of Social Media Contributes To Their Success, Caleb Lamont

Communication & Leadership Dissertations and Theses

It is amazing to see the potential impacts social media can have on an individual. If used effectively, social media can transform the way ordinary people live into instant celebrity status. If individuals with talent are not media literate and do not have the knowledge to use the Internet and use social media platforms to showcase their abilities for the world to see, their talent could be going to waste. Social media allows media literate individuals to connect with the world and satisfy any needs or desires that they may have.

December 20, 2014 (Pages 7809-8000), Pennsylvania Legislative Reference Bureau

Volume 44 (2014)

No abstract provided.

High Intralocus Variability And Interlocus Recombination Promote Immunological Diversity In A Minimal Major Histocompatibility System, Anthony B. Wilson, Camilla M. Whittington, Angela Bahr

Publications and Research

Background: The genes of the major histocompatibility complex (MHC/MH) have attracted considerable scientific interest due to their exceptional levels of variability and important function as part of the adaptive immune system. Despite a large number of studies on MH class II diversity of both model and non-model organisms, most research has focused on patterns of genetic variability at individual loci, failing to capture the functional diversity of the biologically active dimeric molecule. Here, we take a systematic approach to the study of MH variation, analyzing patterns of genetic variation at MH class IIα and IIβ loci of the seahorse, which …

In The Social Amoeba, Dictyostelium Discoideum , Density, Not Farming Status, Determines Predatory Success On Unpalatable Escherichia Coli, Susanne Disalvo, Debra A. Brock, Jeff Smith, David C. Queller, Joan E. Strassmann

Biology Faculty Research

Background
The social amoeba Dictyostelium discoideum interacts with bacteria in a variety of ways. It is a predator of bacteria, can be infected or harmed by bacteria, and can form symbiotic associations with bacteria. Some clones of D. discoideum function as primitive farmers because they carry bacteria through the normally sterile D. discoideum social stage, then release them after dispersal so the bacteria can proliferate and be harvested. Some farmer-associated bacteria produce small molecules that promote host farmer growth but inhibit the growth of non-farmer competitors. To test whether the farmers’ tolerance is specific or extends to other growth inhibitory …

Book Reviews Volume 2(Ii)

International Journal of Religious Tourism and Pilgrimage

No abstract provided.

Interleukin-17 Inhibits Adult Hippocampal Neurogenesis, Qiang Liu, Wei Xin, Ping He, Dharshaun Turner, Junxiang Yin, Yan Gan, Fu Dong Shi, Jie Wu

Translational Neuroscience

Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability, and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of …

Registration Of ‘Newell’ Smooth Bromegrass, K P. Vogel, R B. Mitchell, B L. Waldron, M R. Haferkamp, J D. Berdahl, D D. Baltensperger, Galen Erickson, T J. Klopfenstein

Green Canyon Environmental Research Area, Logan Utah

No abstract provided.

Guarding Against Abuse: The Costs Of Excessively Long Copyright Terms, Derek Khanna

CommLaw Conspectus: Journal of Communications Law and Technology Policy (1993-2015)

No abstract provided.

Why We Built A Teleportation Machine And Why It Was A Bad Idea: Marcus Landers’ Oral History About The Invention Of The World’S First Matter Transference Device, James Brubaker

Booth

Stevie and I were sick of this town. That’s why we built our teleportation machine. Or rather, we decided to build our teleportation machine in part because we were sick of this town, but also because this town’s public transportation isn’t very good, and both of us got busted for Operating a Vehicle after Underage Consumption and lost our licenses for two years—though neither of us even owned a car to begin with—and because my mom is dead and my dad is a drunk, and because Stevie’s parents, while both alive and not drunks, are too busy to drive him …

Unilateral Heat Accelerates Bone Elongation And Lengthens Extremities Of Growing Mice, Maria A. Serrat, Thomas J. Schlierf, Morgan L. Efaw, Franklin D. Shuler, Justin Godby, Laura M. Stanko

Orthopaedics

Linear growth failure results from a broad spectrum of systemic and local disorders that can generate chronic musculoskeletal disability. Current bone lengthening protocols involve invasive surgeries or drug regimens, which are only partially effective. Exposure to warm ambient temperature during growth increases limb length, suggesting that targeted heat could noninvasively enhance bone elongation. We tested the hypothesis that daily heat exposure on one side of the body unilaterally increases femoral and tibial lengths. Mice (N = 20) were treated with 40 °C unilateral heat for 40 min/day for 14 days post-weaning. Non-treated mice (N = 6) served as controls. Unilateral …

The Coveted Souls Of Oppressed Persons, Connie L. Gibb

Department of Teaching, Learning, and Teacher Education: Theses and Other Student Research

Marcus Aurelius (167 A.C.E. III. 16) stated that: “[b]ody, soul, intelligence: to the body belong sensations, to the soul appetites, to the intelligence principles.” In my philosophical inquiry (my play) I argue it isn’t that simple and that the concept of soul is much like what Aristotle (1994, II, 1, 412 a 28) wrote, "The soul, therefore, is the primary act of a physical body potentially possessing life." Or, like Fincher (2007, p. 32) who wrote, “My soul is me, and I own all of my soul’s abilities and experiences…” I also discuss that the intelligence of human beings could …

December 19, 2014 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Tracfone Wireless, Inc. V. State Appellant's Reply Brief 1 Dckt. 41868

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Managing Threats To The Urban Forest: From Dutch Elm Disease To Emerald Ash Borer - Learning From Experience, Christopher J. Borman

Doctor of Plant Health Program: Dissertations and Student Research

The urban forest provides important essential services to all municipalities; however, its value is often overlooked. The urban forest contributes to energy savings, environmental benefits, psychological well-being, and social benefits. Managing the urban forest in a sustainable manner is important if we wish to benefit from these services well into the future. Reliable management techniques have been created through previous experiences with pests, and these should be utilized and improved for use on urban forests.

American elm (Ulmus americana L.) was once a major component of the urban forests of North America. In 1927, Dutch elm disease (DED) was …

Tidy Guide – A Beginner’S Guide To An Organized Home, Katie Hollenbeck

Theses

Search for "how to organize" on the web, and you will be inundated with endless resources. Organizing information is everywhere, making the task seem intimidating. For my thesis project, I sought out to create an interactive, instructional, web-based application that would coach users on how to organize objects within a specific space. My goal was to create a unique, visual, creative solution - one that did not already exist on the web, and one that would become an important tool for users who were seeking organizing assistance and advice. Not only did I intend the application to be unique, visual, …

Sustainable Packaging Design Visually Explained Guidebook Prototype, Sara Almudhaf

Theses

As the fields of graphic and packaging design continue to evolve, it is important to keep their applications sustainable and green. Unaware graphic and packaging designers need to have an easy-to-comprehend source of information about sustainability. Developing an educational information graphics guidebook prototype has potential to serve as a unique tool for understanding the need for sustainable packaging design. The purpose of it is to eases the understanding of a complex system and enables users to discover relationships and connections among design, economy, environment, and society.

This prototype project involved designing a comprehensive sustainability symbol set where no satisfactory symbol …

Parks, Historic Areas, Memorials, And Recreation Hb 715, Georgia State University Law Review

Georgia State University Law Review

The Act establishes a set number of acres that may be developed on Jekyll Island. It states that no more than 1,675 acres of the Island’s total land area may be developed. Currently, 1,597 of those acres have been developed, and the Act delineates how the remaining seventyeight acres may be used.

Trade In Telecommunications Services, Jonathan D. Aronson

Georgia Journal of International & Comparative Law

No abstract provided.

Pesticides: Problems Facing The Industry In Submitting Proprietary Scientific Data To An International Organization, Alexander R. Nemajovsky

Georgia Journal of International & Comparative Law

No abstract provided.

Panel On Negotiating Acquisitions Of Public Companies, Moderator Richard E. Climan, Counsel For The Acquiring Company Joel I. Greenberg, Counsel For The Target Company Lou R. Kling, Honorable E. Norman Veasey, Harvey A. Goldman, Dennis S. Hersch, Samuel C. Thompson

University of Miami Business Law Review

No abstract provided.