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2013

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Honduras’ Presidential Election Demands An Investigation, Lauren Carasik, Azadeh Shahshahani Nov 2013

Honduras’ Presidential Election Demands An Investigation, Lauren Carasik, Azadeh Shahshahani

Media Presence

No abstract provided.

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Serine/Threonine Kinase 17a Is A Novel Candidate For Therapeutic Targeting In Glioblastoma, Pingping Mao, Mary P. Hever-Jardine, Gilbert J. Rahme, Eric Yang, Janice Tam, Anita Kodali, Bijesh Biswal, Camilo E. Fadul, Arti Gaur, Mark A. Israel, Michael J. Spinella Nov 2013

Serine/Threonine Kinase 17a Is A Novel Candidate For Therapeutic Targeting In Glioblastoma, Pingping Mao, Mary P. Hever-Jardine, Gilbert J. Rahme, Eric Yang, Janice Tam, Anita Kodali, Bijesh Biswal, Camilo E. Fadul, Arti Gaur, Mark A. Israel, Michael J. Spinella

Dartmouth Scholarship

STK17A is a relatively uncharacterized member of the death-associated protein family of serine/threonine kinases which have previously been associated with cell death and apoptosis. Our prior work established that STK17A is a novel p53 target gene that is induced by a variety of DNA damaging agents in a p53-dependent manner. In this study we have uncovered an additional, unanticipated role for STK17A as a candidate promoter of cell proliferation and survival in glioblastoma (GBM). Unexpectedly, it was found that STK17A is highly overexpressed in a grade-dependent manner in gliomas compared to normal brain and other cancer cell types with the …

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Bending Stresses Of Steel Web Tapered Tee Section Cantilevers, Boksun Kim, Andrew Oliver, Joshua Vyse Nov 2013

Bending Stresses Of Steel Web Tapered Tee Section Cantilevers, Boksun Kim, Andrew Oliver, Joshua Vyse

School of Engineering, Computing and Mathematics

No abstract provided.

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Revealing The Ubiquitous Effects Of Quantum Entanglement-Toward A Notion Of God Logic, Wen-Ran Zhang, Karl E. Peace Nov 2013

Revealing The Ubiquitous Effects Of Quantum Entanglement-Toward A Notion Of God Logic, Wen-Ran Zhang, Karl E. Peace

Biostatistics: Faculty Publications

Following Spinoza-Einstein’s interpretation of God or nature, the notion “God Logic” is proposed. This notion is to serve as an elicitation for a consistent set of necessary criteria for: 1) developing the logical foundation of quantum gravity as envisaged by Einstein, 2) revealing the ubiquitous effects of quantum entanglement as suggested by Roger Penrose, and 3) programming the universe as proposed by Seth Lloyd. An evolving set of eleven criteria is proposed for the notion. The possibility of inventing such a logical system is analyzed. A supersymmetrical candidate logic of negative-positive energy dynamic equilibrium is introduced and assessed against the …

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Why The Madness On Black Friday?, Donelson R. Forsyth Nov 2013

Why The Madness On Black Friday?, Donelson R. Forsyth

Jepson School of Leadership Studies articles, book chapters and other publications

Black Friday's climb from marketing ploy to popular craze resists easy explanation. A day of sleeping late, leftover turkey and trimmings and football seems to easily outgun one spent battling strangers to save a few bucks on this year's cool new toy or gizmo, but last year nearly a quarter of a billion Americans chose the check-out line and not the couch. Why?

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Concluding Remarks: What's In A Name? "Negritos" In The Context Of The Human Prehistory Of Southeast Asia, Stanley J. Ulijaszek Nov 2013

Concluding Remarks: What's In A Name? "Negritos" In The Context Of The Human Prehistory Of Southeast Asia, Stanley J. Ulijaszek

Human Biology

The "negrito" hypothesis posits that various indigenous groups throughout Island and Mainland Southeast Asia have a shared phenotype due to common descent from a putative ancestral population, representing a preagricultural substrate of humanity in the region. This has been examined and tested many times in the past, with no clear resolution. With many new resources to hand, the articles in this volume reexamine this hypothesis in a range of different ways. The evidence presented in this double issue of Human Biology speaks more against the category of "negrito" than for it. While populations with the negrito phenotype form a small …

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The Australian Barrineans And Their Relationship To Southeast Asian Negritos: An Investigation Using Mitochondrial Genomics, Peter Mcallister, Nano Nagle, Robert John Mitchell Nov 2013

The Australian Barrineans And Their Relationship To Southeast Asian Negritos: An Investigation Using Mitochondrial Genomics, Peter Mcallister, Nano Nagle, Robert John Mitchell

Human Biology

The existence of a short-statured Aboriginal population in the Far North Queensland (FNQ) rainforest zone of Australia’s northeast coast and Tasmania has long been an enigma in Australian anthropology. Based on their reduced stature and associated morphological traits such as tightly curled hair, Birdsell and Tindale proposed that these "Barrinean" peoples were closely related to "negrito" peoples of Southeast Asia and that their ancestors had been the original Pleistocene settlers of Sahul, eventually displaced by taller invaders. Subsequent craniometric and blood protein studies, however, have suggested an overall homogeneity of indigenous Australians, including Barrineans. To confirm this finding and determine …

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Making Friends In The Rainforest: "Negrito" Adaptation To Risk And Uncertainty, Lye Tuck-Po Nov 2013

Making Friends In The Rainforest: "Negrito" Adaptation To Risk And Uncertainty, Lye Tuck-Po

Human Biology

The so-called negritos adapt not just to a tropical forest environment but also to an environment characterized by perturbations and fluctuations. As with other hunter-gatherers in the region and, indeed, throughout the world, they use both social and ecological methods to enhance their chances of survival in this changing environment: socially, they have developed networks of trading and marriage partners; ecologically, they maintain patches of key resources that are available for future harvesting. As evidenced in the case of the Batek (Orang Asli), patterns of forest structure and composition are sometimes direct outcomes of intentional resource concentration and enrichment strategies. …

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Why Have The Peninsular "Negritos" Remained Distinct?, Geoffrey Benjamin Nov 2013

Why Have The Peninsular "Negritos" Remained Distinct?, Geoffrey Benjamin

Human Biology

The primary focus of this article is on the so-called negritos of Peninsular Malaysia and southern Thailand, but attention is also paid to other parts of Southeast Asia. I present a survey of current views on the "negrito" phenotype—is it single or many? If the phenotype is many (as now seems likely), it must have resulted from parallel evolution in the several different regions where it has been claimed to exist. This would suggest (contrary to certain views that have been expressed on the basis of very partial genetic data) that the phenotype originated recently and by biologically well-authenticated processes …

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Terror From The Sky: Unconventional Linguistic Clues To The Negrito Past, Robert Blust Nov 2013

Terror From The Sky: Unconventional Linguistic Clues To The Negrito Past, Robert Blust

Human Biology

Within recorded history. most Southeast Asian peoples have been of "southern Mongoloid" physical type, whether they speak Austroasiatic, Tibeto-Burman, Austronesian, Tai-Kadai, or Hmong-Mien languages. However, population distributions suggest that this is a post-Pleistocene phenomenon and that for tens of millennia before the last glaciation ended Greater Mainland Southeast Asia, which included the currently insular world that rests on the Sunda Shelf, was peopled by short, dark-skinned, frizzy-haired foragers whose descendants in the Philippines came to be labeled by the sixteenth-century Spanish colonizers as "negritos," a term that has since been extended to similar groups throughout the region. There are three …

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Time And Place In The Prehistory Of The Aslian Languages, Michael Dunn, Nicole Kruspe, Niclas Burenhult Nov 2013

Time And Place In The Prehistory Of The Aslian Languages, Michael Dunn, Nicole Kruspe, Niclas Burenhult

Human Biology

The Aslian language family, located in the Malay Peninsula and southern Thai Isthmus, consists of four distinct branches comprising some 18 languages. These languages predate the now dominant Malay and Thai. The speakers of Aslian languages exhibit some of the highest degree of phylogenetic and societal diversity present in Mainland Southeast Asia today, among them a foraging tradition particularly associated with locally ancient, Pleistocene genetic lineages. Little advance has been made in our understanding of the linguistic prehistory of this region or how such complexity arose. In this article we present a Bayesian phylogeographic analysis of a large sample of …

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Kinship Matters: Structures Of Alliance, Indigenous Foragers, And The Austronesian Diaspora, James West Turner Nov 2013

Kinship Matters: Structures Of Alliance, Indigenous Foragers, And The Austronesian Diaspora, James West Turner

Human Biology

The study of kinship systems has direct relevance for the field of human genetics and the study of microevolution in human populations. Some types of postmarital residence rules—rules requiring a married couple to live with or near relatives of the husband or wife—will have consequences for the distribution of mitochondrial DNA and Y chromosome lineages. Rules that proscribe or encourage marriage with close kin will also have consequences for allele frequency. A preference for marrying at a distance, both socially and geographically, creates alliances that can have survival value for individuals and groups in an environment of periodic or unpredictable …

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Who Are The Philippine Negritos? Evidence From Language, Lawrence A. Reid Nov 2013

Who Are The Philippine Negritos? Evidence From Language, Lawrence A. Reid

Human Biology

This article addresses the linguistic evidence from which details about Philippine "negritos" can be inferred. This evidence comes from the naming practices of both negrito and non-negrito peoples, from which it can be inferred that many negrito groups have maintained a unique identity distinct from other groups since the dispersal of Malayo-Polynesian languages. Other names, such as Dupaningan and Dumagat, reference locations, from which it is assumed the negritos left after contact with Malayo-Polynesian people. Evidence also comes from the relative positions of negrito groups vis-à-vis other groups within the subfamily with which their current language can be grouped. Many …

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Phenotypic Plasticity Of Climbing-Related Traits In The Ankle Joint Of Great Apes And Rainforest Hunter-Gatherers, Vivek V. Venkataraman, Thomas S. Kraft, Jeremy M. Desilva, Nathaniel J. Dominy Nov 2013

Phenotypic Plasticity Of Climbing-Related Traits In The Ankle Joint Of Great Apes And Rainforest Hunter-Gatherers, Vivek V. Venkataraman, Thomas S. Kraft, Jeremy M. Desilva, Nathaniel J. Dominy

Human Biology

The "negrito" and African "pygmy" phenotypes are predominately exhibited by hunter-gatherers living in rainforest habitats. Foraging within such habitats is associated with a unique set of locomotor behaviors, most notably habitual vertical climbing during the pursuit of honey, fruit, and game. When performed frequently, this behavior is expected to correlate with developmentally plastic skeletal morphologies that respond to mechanical loading. Using six measurements in the distal tibia and talus that discriminate nonhuman primates by vertical climbing frequency, we tested the prediction that intraspecific variation in this behavior is reflected in the morphology of the ankle joint of habitually climbing human …

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Mountain Pygmies Of Western New Guinea: A Morphological And Molecular Approach, M Tommaseo-Ponzetta, S Mona, F M. Calabrese, G Konrad, E Vacca, M Attimonelli Nov 2013

Mountain Pygmies Of Western New Guinea: A Morphological And Molecular Approach, M Tommaseo-Ponzetta, S Mona, F M. Calabrese, G Konrad, E Vacca, M Attimonelli

Human Biology

The presence of "pygmy" or pygmoid groups among New Guinea populations has been the object of scientific interest since the end of the nineteenth century. Morphological and molecular data are used here to study western New Guinea population variability, focusing in particular on two pygmoid groups living in the eastern fringe highlands of Papua: the Una and the Ketengban. Various kinds of anthropometric data are examined, as well as height, weight, and body mass index, to carry out comparisons with nearby ethnic groups living in the highland and lowland regions. The Ketengban data were also compared with other data recorded …

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Evolution Of The Pygmy Phenotype: Evidence Of Positive Selection From Genome-Wide Scans In African, Asian, And Melanesian Pygmies, Andrea Bamberg Migliano, Irene Gallego Romero, Mait Metspalu, Matthew Leavesley, Luca Pagani, Tiago Antao, Da-Wei Huang, Brad T. Sherman, Katharine Siddle, Clarissa Scholes, Georgi Hudjashov, Elton Kaitokai, Avis Babalu, Maggie Belatti, Alex Cagan, Bryony Hopkinshaw, Colin Shaw, Mari Nelis, Ene Metspalu, Reedik Mägi, Richard A. Lempicki, Richard Villems, Marta Mirazon Lahr, Toomis Kivisild Nov 2013

Evolution Of The Pygmy Phenotype: Evidence Of Positive Selection From Genome-Wide Scans In African, Asian, And Melanesian Pygmies, Andrea Bamberg Migliano, Irene Gallego Romero, Mait Metspalu, Matthew Leavesley, Luca Pagani, Tiago Antao, Da-Wei Huang, Brad T. Sherman, Katharine Siddle, Clarissa Scholes, Georgi Hudjashov, Elton Kaitokai, Avis Babalu, Maggie Belatti, Alex Cagan, Bryony Hopkinshaw, Colin Shaw, Mari Nelis, Ene Metspalu, Reedik Mägi, Richard A. Lempicki, Richard Villems, Marta Mirazon Lahr, Toomis Kivisild

Human Biology

Human pygmy populations inhabit different regions of the world, from Africa to Melanesia. In Asia, short-statured populations are often referred to as "negritos." Their short stature has been interpreted as a consequence of thermoregulatory, nutritional, and/or locomotory adaptations to life in tropical forests. A more recent hypothesis proposes that their stature is the outcome of a life history trade-off in high-mortality environments, where early reproduction is favored and, consequently, early sexual maturation and early growth cessation have coevolved. Some serological evidence of deficiencies in the growth hormone/insulin-like growth factor axis have been previously associated with pygmies’ short stature. Using genome-wide …

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Mount Pinatubo, Inflammatory Cytokines, And The Immunological Ecology Of Aeta Hunter-Gatherers, Robin M. Bernstein, Nathaniel J. Dominy Nov 2013

Mount Pinatubo, Inflammatory Cytokines, And The Immunological Ecology Of Aeta Hunter-Gatherers, Robin M. Bernstein, Nathaniel J. Dominy

Human Biology

Early growth cessation and reproduction are predicted to maximize fitness under conditions of high adult mortality, factors that could explain the pygmy phenotype of many rainforest hunter-gatherers. This life-history hypothesis is elegant but contentious in part because it lacks a clear biological mechanism. One mechanism stems from the field of human immunological ecology and the concept of inflammation "memory" across the life cycle and into subsequent generations. Maternal exposures to disease can infl uence immunological cues present in breast milk; because maternal provisioning via lactation occurs during critical periods of development, it is plausible that these cues can also mediate …

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Anthropology And Gis: Temporal And Spatial Distribution Of The Philippine Negrito Groups, Sabino G. Padilla Jr Nov 2013

Anthropology And Gis: Temporal And Spatial Distribution Of The Philippine Negrito Groups, Sabino G. Padilla Jr

Human Biology

The Philippine "negrito" groups comprise a diverse group of populations speaking over 30 different languages, who are spread all over the archipelago, mostly in marginal areas of Luzon Island in the north, the central Visayas islands, and Mindanao in the south. They exhibit physical characteristics that are different from more than 100 Philippine ethnolinguistic groups that are categorized as non-negritos. Given their numbers, it is not surprising that Philippine negritos make up a major category in a number of general ethnographic maps produced since the nineteenth century. Reports from various ethnological surveys during this period, however, have further enriched our …

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Genetic Diversity Of Four Filipino Negrito Populations From Luzon: Comparison Of Male And Female Effective Population Sizes And Differential Integration Of Immigrants Into Aeta And Agta Communities, E Heyer, M Georges, M Pachner, P Endicott Nov 2013

Genetic Diversity Of Four Filipino Negrito Populations From Luzon: Comparison Of Male And Female Effective Population Sizes And Differential Integration Of Immigrants Into Aeta And Agta Communities, E Heyer, M Georges, M Pachner, P Endicott

Human Biology

Genetic data corresponding to four negrito populations (two Aeta and two Agta; n = 120) from the Luzon region of the Philippines have been analyzed. These data comprise mitochondrial DNA (mtDNA) hypervariable segment 1 haplotypes and haplogroups, Y-chromosome haplogroups and short tandem repeats (STRs), autosomal STRs, and X-chromosome STRs. The genetic diversity and structure of the populations were investigated at a local, regional, and interregional level. We found a high level of autosomal differentiation, combined with no significant reduction in diversity, consistent with long-term settlement of the Luzon region by the ancestors of the Agta and Aeta followed by reduced …

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Admixture Patterns And Genetic Differentiation In Negrito Groups From West Malaysia Estimated From Genome-Wide Snp Data, Timothy A. Jinam, Maude E. Phipps, Naruya Saitou, The Hugo Pan-Asian Snp Consortium Nov 2013

Admixture Patterns And Genetic Differentiation In Negrito Groups From West Malaysia Estimated From Genome-Wide Snp Data, Timothy A. Jinam, Maude E. Phipps, Naruya Saitou, The Hugo Pan-Asian Snp Consortium

Human Biology

Southeast Asia houses various culturally and linguistically diverse ethnic groups. In Malaysia, where the Malay, Chinese, and Indian ethnic groups form the majority, there exist minority groups such as the "negritos" who are believed to be descendants of the earliest settlers of Southeast Asia. Here we report patterns of genetic substructure and admixture in two Malaysian negrito populations (Jehai and Kensiu), using ~50,000 genome-wide single-nucleotide polymorphism (SNP) data. We found traces of recent admixture in both the negrito populations, particularly in the Jehai, with the Malay through principal component analysis and STRUCTURE analysis software, which suggested that the admixture was …

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The Andaman Islanders In A Regional Genetic Context: Reexamining The Evidence For An Early Peopling Of The Archipelago From South Asia, Gyaneshwer Chaubey, Phillip Endicott Nov 2013

The Andaman Islanders In A Regional Genetic Context: Reexamining The Evidence For An Early Peopling Of The Archipelago From South Asia, Gyaneshwer Chaubey, Phillip Endicott

Human Biology

The indigenous inhabitants of the Andaman Islands were considered by many early anthropologists to be pristine examples of a "negrito" substrate of humanity that existed throughout Southeast Asia. Despite over 150 years of research and study, questions over the extent of shared ancestry between Andaman Islanders and other small-bodied, gracile, dark-skinned populations throughout the region are still unresolved. This shared phenotype could be a product of shared history, evolutionary convergence, or a mixture of both. Recent population genetic studies have tended to emphasize long-term physical isolation of the Andaman Islanders and an affinity to ancestral populations of South Asia. We …

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Climate Change Influenced Female Population Sizes Through Time Across The Indonesian Archipelago, Elsa G. Guillot, Meryanne K. Tumonggor, Stephen J. Lansing, Herawati Sudoyo, Murray P. Cox Nov 2013

Climate Change Influenced Female Population Sizes Through Time Across The Indonesian Archipelago, Elsa G. Guillot, Meryanne K. Tumonggor, Stephen J. Lansing, Herawati Sudoyo, Murray P. Cox

Human Biology

Lying at the crossroads of Asia and the Pacific world, the Indonesian archipelago hosts one of the world’s richest accumulations of cultural, linguistic, and genetic variation. While the role of human migration into and around the archipelago is now known in some detail, other aspects of Indonesia’s complex history are less understood. Here, we focus on population size changes from the first settlement of Indonesia nearly 50 kya up to the historic era. We reconstructed the past effective population sizes of Indonesian women using mitochondrial DNA sequences from 2,104 individuals in 55 village communities on four islands spanning the Indonesian …

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Craniodental Affinities Of Southeast Asia's "Negritos" And The Concordance With Their Genetic Affinities, David Bulbeck Nov 2013

Craniodental Affinities Of Southeast Asia's "Negritos" And The Concordance With Their Genetic Affinities, David Bulbeck

Human Biology

Genetic research into Southeast Asia's "negritos" has revealed their deep-rooted ancestry, with time depth comparable to that of Southwest Pacific populations. This finding is often interpreted as evidence that negritos, in contrast to other Southeast Asians, can trace much of their ancestry directly back to the early dispersal of Homo sapiens in the order of 70 kya from Africa to Pleistocene New Guinea and Australia. One view on negritos is to lump them and Southwest Pacific peoples into an "Australoid" race whose geographic distribution had included Southeast Asia prior to the Neolithic incursion of "Mongoloid" farmers. Studies into Semang osteology …

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The Skeletal Phenotype Of "Negritos" From The Andaman Islands And Philippines Relative To Global Variation Among Hunter-Gatherers, Jay T. Stock Nov 2013

The Skeletal Phenotype Of "Negritos" From The Andaman Islands And Philippines Relative To Global Variation Among Hunter-Gatherers, Jay T. Stock

Human Biology

The "negrito hypothesis" suggests that populations of small-bodied foragers in South and Southeast Asia who share common phenotypic characteristics may also share a common, ancient origin. The key defining characteristics of the "negrito" phenotype, small body size, dark skin, and tightly curled hair, have been interpreted as linking these populations to sub-Saharan Africans. The underlying assumption of this interpretation is that the observed phenotypic similarities likely reflect shared ancestry rather than phenotypic convergence. Current genetic evidence is inconclusive, as it both demonstrates that negrito populations have genetic affinities with neighboring populations but also rare and ancient variation that suggests considerable …

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"Small Size" In The Philippine Human Fossil Record: Is It Meaningful For A Better Understanding Of The Evolutionary History Of The Negritos?, Florent Détroit, Julien Corny, Eusebio Z. Dizon, Armand S. Mijares Nov 2013

"Small Size" In The Philippine Human Fossil Record: Is It Meaningful For A Better Understanding Of The Evolutionary History Of The Negritos?, Florent Détroit, Julien Corny, Eusebio Z. Dizon, Armand S. Mijares

Human Biology

"Pygmy populations" are recognized in several places over the world, especially in Western Africa and in Southeast Asia (Philippine "negritos," for instance). Broadly defined as "small-bodied Homo sapiens" (compared with neighboring populations), their origins and the nature of the processes involved in the maintenance of their phenotype over time are highly debated. Major results have been recently obtained from population genetics on present-day negrito populations, but their evolutionary history remains largely unresolved. We present and discuss the Upper Pleistocene human remains recovered from Tabon Cave and Callao Cave in the Philippines, which are potentially highly relevant to these research …

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Hunter-Gatherers In Southeast Asia: From Prehistory To The Present, Charles Higham Nov 2013

Hunter-Gatherers In Southeast Asia: From Prehistory To The Present, Charles Higham

Human Biology

Anatomically modern hunter-gatherers expanded from Africa into Southeast Asia at least 50,000 years ago, where they probably encountered and interacted with populations of Homo erectus and Homo floresiensis and the recently discovered Denisovans. Simulation studies suggest that these hunter-gatherers may well have followed a coastal route that ultimately led to the settlement of Sahul, while archaeology confirms that they also crossed significant seas and explored well into the interior. They also adapted to marked environmental changes that alternated between relatively cool and dry conditions and warmer, wetter interludes. During the former, the sea fell by up to 120 m below …

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Introduction: Revisiting The "Negrito" Hypothesis: A Transdisciplinary Approach To Human Prehistory In Southeast Asia, Phillip Endicott Nov 2013

Introduction: Revisiting The "Negrito" Hypothesis: A Transdisciplinary Approach To Human Prehistory In Southeast Asia, Phillip Endicott

Human Biology

The "negrito" hypothesis predicts that a shared phenotype among various contemporary groups of hunter-gatherers in Southeast Asia - dark skin, short stature, tight curly hair - is due to common descent from a region-wide, pre-Neolithic substrate of humanity. The alternative is that their distinctive phenotype results from convergent evolution. The core issues of the negrito hypothesis are today more relevant than ever to studies of human evolution, including the out-of-Africa migration, admixture with Denisovans, and the effects of environment and ecology on life-history traits. Understanding the current distribution of the negrito phenotype dictates a wide-ranging remit for study, including the …

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In The News, Sathyan Mathai, Vashti Mercado, Eduardo Pezo, Dawn Sequiera Nov 2013

In The News, Sathyan Mathai, Vashti Mercado, Eduardo Pezo, Dawn Sequiera

Health Law and Policy Brief

No abstract provided.

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Washington Update: News From Our Nation's Capital, Sherine B. Abdul-Khaliq, Jit Chatterjee, Chandana Kolavala, Rebecca Wolf Nov 2013

Washington Update: News From Our Nation's Capital, Sherine B. Abdul-Khaliq, Jit Chatterjee, Chandana Kolavala, Rebecca Wolf

Health Law and Policy Brief

No abstract provided.

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The Benghazi Six And International Medical Neutrality In Times Of War And Peace, Johanna Michaels Kreisel Nov 2013

The Benghazi Six And International Medical Neutrality In Times Of War And Peace, Johanna Michaels Kreisel

Health Law and Policy Brief

No abstract provided.

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