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2013

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Accelerating Amyloid Formation By Islet Amyloid Polypeptide, Rehana Akter Dec 2013

Accelerating Amyloid Formation By Islet Amyloid Polypeptide, Rehana Akter

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Islet amyloid polypeptide (IAPP) is a 37 residues long polypeptide hormone. IAPP is co-secreted with insulin by the B-cells in the pancreas and is stored with insulin in secretory vesicles. IAPP helps to maintain glucose homeostasis in the body by regulating glucagon secretion. IAPP is one of the most amyloidogenic peptide known, and IAPP amyloid formation plays a role in type 2 diabetes. IAPP amyloid formation contributes to B-cells dysfunction and B-cells loss in islets. There is one known naturally found IAPP mutant; the serine 20 to glycine (S20G) mutant weakly increases the risk of early onset diabetes in Asian …

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The Design, Synthesis And Biological Evaluation Of Novel Taxoid Anticancer Agents And Their Tumor-Targeted Drug Conjugates, Joshua Seitz Dec 2013

The Design, Synthesis And Biological Evaluation Of Novel Taxoid Anticancer Agents And Their Tumor-Targeted Drug Conjugates, Joshua Seitz

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Cancer is the second leading cause of death in the United States and is responsible for one in eight deaths worldwide. Traditional chemotherapeutics target the processes involved in cell division and consequently produce dangerous and dose-limiting side effects. In an effort to identify the therapeutic windown of these drugs, tumor targeted drug conjugates (TTDCs) are currently under development. The Ojima lab has developed and extensive panel of next-generation taxoids that possess the requisite sub-nanomolar potency for incorporation into effective conjugates. A small library of 17 taxoids was synthesized and their cytotoxicity investigated. Selected taxoids were synthesized on the half-gram to …

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Integration Of Regenerative Shock Absorber Into Vehicle Electric System, Chongxiao Zhang Dec 2013

Integration Of Regenerative Shock Absorber Into Vehicle Electric System, Chongxiao Zhang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

For cars with combustion engine, fuel is wasted on powering electric devices and conquering resistant forces from the road while driving forward. Regenerative shock absorber can help to harvest kinetic energy from vehicle suspension and power on-car electric system. One innovative design of energy harvesting shock absorber with mechanical motion rectifier is used in this thesis to harvest power and to be integrated with existing vehicle electric system. Interfacing circuits are developed and tested to regulate unstable power and achieve input current control for damping adjustment purpose. The overall integration of car alternator, electric load and regenerative shock absorber is …

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Anger And Memory: Misleading People Is Easy When They Are Mad, Michael J. Greenstein Dec 2013

Anger And Memory: Misleading People Is Easy When They Are Mad, Michael J. Greenstein

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Previous work has shown that different discrete emotional states (e.g. anger) affect cognitive processing differently. Anger has been associated with simplifying cognition to promote rapid action-related processes. For example, anger promotes an increased tendency to rely on preexisting cognitive biases. Such a processing style may have been advantageous in evolutionary history, but it can also lead to increased memory errors. The present study examined the simplifying effects of anger on memorial processing, using three different misinformation paradigms. The first experiment, using a classic three-phase misinformation paradigm, showed that anger directly affects memory performance and that anger increases acceptance of misinformation …

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On The Optimization Of Grid Systems, Kai Wang Dec 2013

On The Optimization Of Grid Systems, Kai Wang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Grid systems are widely used to transfer power and information in various forms in many engineering and scientific areas such as grid computing systems, electrical grids, control grid and etc. A good handling of task partition, task allocation and load balancing can significantly increase a grid systems' efficiency. In this dissertation, balancing the loads in electrical grid systems and optimizing grid computing systems are analyzed. Unbalanced loads on feeders increase power system investment and operating costs. Three-phase lateral loads phase swapping is one of the popular methods to balance such systems. We employed a dynamic programming algorithm that makes optimal …

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A Stochastic Segmentation Model For Recurrent Copy Number Alterations In Grouped Array-Cgh Data, Ying Cai Dec 2013

A Stochastic Segmentation Model For Recurrent Copy Number Alterations In Grouped Array-Cgh Data, Ying Cai

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

With the recent advances in high resolution microarrays and next generation sequencing, DNA copy number can now be profiled in a high throughput global manner. This has enabled the systematic study of DNA copy number alterations in tumors, as well as the profiling of inherited population-wide copy number variants. Studies of DNA copy number usually involve many samples that fall into different groups, e.g. tumor subtype or ethnic group. It is often of interest to find recurrent alterations within each group. We develop a stochastic segmentation model for detecting recurrent DNA copy number alterations in grouped array-CGH data. In our …

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Characteristics Of Aerosolized Ice Forming Marine Biogenic Particles, Peter Aaron Alpert Dec 2013

Characteristics Of Aerosolized Ice Forming Marine Biogenic Particles, Peter Aaron Alpert

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Ice particles are ubiquitous in the atmosphere existing as the sole constituents of glaciated cirrus clouds or coexisting with supercooled liquid droplets in mixed-phase clouds. Aerosol particles serving as heterogeneous ice nuclei for ice crystal formation impact the global radiative balance by modification of cloud radiative properties, and thus climate. Atmospheric ice formation is not a well understood process and represents great uncertainty for climate prediction. The oceans which cover the majority of the earth's surface host nearly half the total global primary productivity and contribute to the greatest aerosol production by mass. However, the effect of biological activity on …

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Eagle Point School District Enrollment Forecasts 2014-15 To 2023-24, Portland State University. Population Research Center, Charles Rynerson, Vivian Siu, Kevin Christopher Rancik Dec 2013

Eagle Point School District Enrollment Forecasts 2014-15 To 2023-24, Portland State University. Population Research Center, Charles Rynerson, Vivian Siu, Kevin Christopher Rancik

School District Enrollment Forecast Reports

This report presents the results of a demographic study conducted by the Portland State University Population Research Center. The study includes analyses of population, housing and enrollment trends affecting the Eagle Point School District (EPSD) in recent years, forecasts of district‐wide enrollment by grade level and total enrollment of individual schools for the 2014‐ 15 to 2023‐24 school years.

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Tigard-Tualatin School District Enrollment Forecast Update 2014-15 To 2023-24, Portland State University. Population Research Center, Charles Rynerson, Ryan Dann Dec 2013

Tigard-Tualatin School District Enrollment Forecast Update 2014-15 To 2023-24, Portland State University. Population Research Center, Charles Rynerson, Ryan Dann

School District Enrollment Forecast Reports

This report presents the results of a demographic study conducted by the Portland State University Population Research Center (PRC) for the Tigard‐Tualatin School District (TTSD). The study includes analysis of population, housing and enrollment trends affecting the District in recent years, estimates of the impacts of housing development on TTSD enrollment, and forecasts of district‐wide and individual school enrollments for the 2014‐15 to 2023‐24 school years.

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Knox Street And The Complete Streets Initiative: A Comparative Analysis Of Complete Street Implementation In The City Of Dallas, Kelsey Berry Dec 2013

Knox Street And The Complete Streets Initiative: A Comparative Analysis Of Complete Street Implementation In The City Of Dallas, Kelsey Berry

Planning Masters Professional Reports - Archive

The Knox Street district, located just a few miles north of downtown Dallas, Texas, offers a variety of high-end retail, residential, and commercial use options. The increased popularity of downtown Dallas development and the Knox / Henderson neighborhood has drawn attention to the community situated on the edge of Highland Park and Dallas. This study examines Dallas' Complete Street best practices and their implementation on the Knox Street project. It asks: how effective has the implementation of this demonstration project been? It aims to answer this question by first comparing the City of Dallas' Complete Streets Manual draft with nationally …

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Wet Ponds As A Stormwater Management Tool And An Alternative Water Source For Irrigating Parks In Arlington, Texas, Cassandra Marie Harashe, Yekang Ko Dec 2013

Wet Ponds As A Stormwater Management Tool And An Alternative Water Source For Irrigating Parks In Arlington, Texas, Cassandra Marie Harashe, Yekang Ko

Planning Masters Professional Reports - Archive

A growing population in the Dallas - Fort Worth area will lead to water shortages if alternative water sources are not utilized. This reports looks into the aspects of utilizing wet ponds as a source of water for irrigating public playing fields in Arlington, Texas. It covers the benefits of reducing stormwater and utilizing this water for irrigation. It also covers different pond types, design aspects, the site selection process, potential cost savings, and the policy implications of utilizing this type of Low Impact Development. This study demonstrates that wet ponds are a viable option for treating stormwater to be …

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Human Services Subsector: The Effects Of Lancaster Outreach Center's Poverty Reduction Efforts In Rural Communities, Robert L. Sewell Dec 2013

Human Services Subsector: The Effects Of Lancaster Outreach Center's Poverty Reduction Efforts In Rural Communities, Robert L. Sewell

Planning Masters Professional Reports - Archive

Lancaster Outreach Center (LOC) has for almost 30 years provided high social welfare quality services with minimum setbacks. However, the faltering economy had a negative influence on the level of donor funding LOC expected. The decreased funding level has greatly affected LOC's operations, and the nonprofit organization no longer sees donor funding as a solid revenue source. This study aims to analyze the challenges that rural social workers encounter working for a small nonprofit. Data regarding the agency was collected directly from members of the LOC staff. The research findings for the literature review were obtained through the UTA online …

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Assessing Bus Rapid Transit (Brt) As An Alternate Mode Of Transportation For Dallas County., Francisco Estrada, Jianling Li Dec 2013

Assessing Bus Rapid Transit (Brt) As An Alternate Mode Of Transportation For Dallas County., Francisco Estrada, Jianling Li

Planning Masters Professional Reports - Archive

Traffic congestion in the Dallas County area continues to worsen while transportation funding continues to decline. Even if funding was available it is no longer possible to build our way out of congestion. The Dallas County area has reached a crucial stage in which new innovative methods are required to address congestion. This paper will propose the integration of an alternative mode of transportation known as Bus Rapid Transit (BRT). The analysis performed in this study will utilize the methodology developed by the Institute for Transportation and Development Policy to identify a potential BRT corridor in Dallas County. Existing transportation …

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Synthesis And Structures Of New Three-Dimensional Copper Metal-Organic Frameworks, Nitin Kumar Pally Dec 2013

Synthesis And Structures Of New Three-Dimensional Copper Metal-Organic Frameworks, Nitin Kumar Pally

Masters Theses & Specialist Projects

Metal-organic frameworks (MOFs) are crystalline materials with metal ions covalently bonded to organic ligands. The ligands act as spacers often creating a porous structure with very high pore volume and surface area. MOFs are known for their robust structures, high porosity, and different chemical functionalities and are considered for applications in adsorptions, separations, catalysis and gas storage. This work focuses on the synthesis of new MOFs using copper compounds. Different types of carboxylate ligands were used for the synthesis. Two new copper-organic frameworks, [Cu3(pyz)(btc)] (1), and [(Cu3(btc))•xH2O] (2) (btc= benzene-1,3,5-tricarboxylate, pyz= pyrazine) have been …

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Shared-Use Bus Priority Lanes On City Streets: Approaches To Access And Enforcement, Asha Weinstein Agrawal, Todd Goldman, Nancy Hannaford Dec 2013

Shared-Use Bus Priority Lanes On City Streets: Approaches To Access And Enforcement, Asha Weinstein Agrawal, Todd Goldman, Nancy Hannaford

Journal of Public Transportation

This paper examines policies and strategies governing the operations of bus lanes in major congested urban centers where the bus lanes do not completely exclude other uses. The two key questions addressed are: 1. What is the scope of the priority use granted to buses? When is bus priority in effect, and what other users may share the lanes during these times? 2. How are the lanes enforced? To answer these questions, the study developed detailed cases on management strategies in seven cities that currently have shared-use bus priority lanes: Los Angeles, London, New York City, Paris, San Francisco, Seoul, …

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The Modern Streetcar In The U.S.: An Examination Of Its Ridership, Performance, And Function As A Public Transportation Mode, Jeffrey Brown Dec 2013

The Modern Streetcar In The U.S.: An Examination Of Its Ridership, Performance, And Function As A Public Transportation Mode, Jeffrey Brown

Journal of Public Transportation

Seven U.S. cities reported operating streetcar service to the National Transit Database in 2012, and many other cities are building or planning streetcar investments. Yet despite the increased popularity of streetcar investments, there is a lack of information about how these investments function as transportation modes, as opposed to urban development tools. This paper examines the streetcar as a public transit mode by examining ridership, service, service productivity, cost effectiveness, and other indicators of the streetcar’s performance and function in the carriage of transit passengers. There is considerable variation in all of these measures, with the variability a function of …

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Bike-And-Ride: Build It And They Will Come, Robert Cervero, Benjamin Caldwell, Jesus Cuellar Dec 2013

Bike-And-Ride: Build It And They Will Come, Robert Cervero, Benjamin Caldwell, Jesus Cuellar

Journal of Public Transportation

Converting park-and-ride to bike-and-ride trips could yield important environmental, energy conservation, and public-health benefits. While cycling in general is becoming increasingly popular in the United States, it still makes up a miniscule portion of access trips to most rail transit stations. At several rail stations of the Bay Area Rapid Transit (BART) system, 10 percent or more of access trips are by bicycle, up considerably from a decade earlier. This paper adopts a case-study approach to probe factors that have had a hand in not only cycling grabbing a larger market share of access trips to rail stops, but also …

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Simulation-Based Regression Models To Estimate Bus Routes And Network Travel Times, Yaser E. Hawas Dec 2013

Simulation-Based Regression Models To Estimate Bus Routes And Network Travel Times, Yaser E. Hawas

Journal of Public Transportation

This paper presents an approach to estimate bus route and network travel times using micro-simulation. This can be used in predicting the effectiveness of bus route designs using some network traffic measures or indicators. The used indicators are average network traffic intensity, posted speeds, route length, frequency of bus operation, and average passenger loadings (boarding and alighting). Regression models are calibrated to predict both route and overall network travel times. The prediction errors of these models were investigated and analyzed, and regression models were validated. Results indicated the validity of the calibrated regression models. Conclusions are made on how the …

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Ridership And Revenue Implications Of Free Fares For Seniors In Northeastern Illinois, Paul Metaxatos Dec 2013

Ridership And Revenue Implications Of Free Fares For Seniors In Northeastern Illinois, Paul Metaxatos

Journal of Public Transportation

This paper reports on the ridership and revenue impacts for transit providers of a short-lived Seniors Free Ride Program in the Chicago metropolitan area. The discussion presents survey-free and survey-based approaches specifically developed to capture such effects during the program implementation. The analysis shows that instituting a free fare policy for seniors expectedly increased the demand for and associated costs of providing the service. In particular, the program had attracted approximately 75 percent additional senior rides at an associated cost of between $26.1 and $78.6 million. The Illinois legislature modified the program in 2011 to run as a means-tested program …

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Full Issue 16(4) Dec 2013

Full Issue 16(4)

Journal of Public Transportation

No abstract provided.

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The Effect Of Caffeine On Neurocognitive Testing, B. I. Esianor, C. M. Cullum, L. Khan, D. Blueitt, M. Schneider, R. Azmar, C. Shubet, J. Wilson, J. E. Resch Dec 2013

The Effect Of Caffeine On Neurocognitive Testing, B. I. Esianor, C. M. Cullum, L. Khan, D. Blueitt, M. Schneider, R. Azmar, C. Shubet, J. Wilson, J. E. Resch

Kinesiology Student Research - Archive

INTRODUCTION: Baseline assessments using computerized neurocognitive testing (CNT) has been advocated for the management of sport related concussion (SRC) The ImPACT is a commonly used CNT used in SRC management protocols. A potential extraneous variable, which may influence baseline ImPACT test performance, is caffeine. Caffeine ingestion is prevalent amongst children and adolescents due to the need to increase or boost energy levels. Sources of random error such as caffeine may limit the clinical utility of the baseline ImPACT assessment following a SRC. PURPOSE: The objective of this study was to examine the effect caffeine on computerized neurocognitive testing, using ImPACT, …

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The Effects Of Creatine Supplementation On Anaerobic Power Performance, Dominic Igbaji Ugar Dec 2013

The Effects Of Creatine Supplementation On Anaerobic Power Performance, Dominic Igbaji Ugar

Kinesiology Student Research - Archive

INTRODUCTION: Creatine is one of the most popular dietary supplements in the field of sport worldwide and is the most popular and widely researched natural supplements. Creatine is one of the few sport supplements that have not been banned and is used by athletes at various levels. Creatine is commercially available in different forms, but regardless of its form, supplementation with creatine has consistently shown to increase strength, fat free mass, muscle morphology and the synthesis of muscle contractile proteins. Scientific studies by: Stone et al.(2003), McGuine et al.(2002) and Zuniga JM et al.( 2012) have shown that creatine supplementation …

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The Effects Of Caffeine On Blood Lactate Levels During Submaximal Exercise, Sara Cleveland Dec 2013

The Effects Of Caffeine On Blood Lactate Levels During Submaximal Exercise, Sara Cleveland

Kinesiology Student Research - Archive

INTRODUCTION: Blood lactate concentration reflects the balance between lactate production and clearance. It is considered a marker of exercise intensity and muscle glycolysis. It is expressed in mmol/L of lactate found in the plasma of blood. Research shows that caffeine, a stimulant with ergogenic properties, increases blood lactate levels. It is also shown to improve aerobic performance and increase time to exhaustion during exercise. The physiological underpinnings of caffeine-provoked endurance performance gains are not yet fully understood but may be related to enhanced calcium availability, adenosine receptor antagonism and consequential reductions in pain and perceived exertion, and augmented lipolysis and …

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Physical Stress On The Body Using A Vo2 Max Test And Its Effects On Short-Term Memory In Male Students, Kimberly Alvarez Dec 2013

Physical Stress On The Body Using A Vo2 Max Test And Its Effects On Short-Term Memory In Male Students, Kimberly Alvarez

Kinesiology Student Research - Archive

Introduction. Research shows that rhythmic exercise changes in serotonin, epinephrine, norepinephrine and acetylcholine levels all affect cortical arousal and cognitive function (Potter & Keele, 2005). There are many reasons why the brain is affected during exercise. Some of these include: increased glucose, oxygen and nutrient levels to the brain. Exercise has been shown to enhance cognitive function in both short and long term memory. However, when the body is put under a large amount of physical stress, less oxygen is left in the brain due to the fact that the muscles require more of that oxygen and glucose. Does this …

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The Effects Of Caffeine Consumption On The Blood Lactate Levels In Recreationally Active College-Aged Males, James S. Hoerig Dec 2013

The Effects Of Caffeine Consumption On The Blood Lactate Levels In Recreationally Active College-Aged Males, James S. Hoerig

Kinesiology Student Research - Archive

INTRODUCTION: Caffeine has become the most widely used drug in the world. This xanthene derivative causes an increase in catecholamines circulating throughout the blood, and is commonly used by athletes looking for an increase in athletic performance. Besides having a stimulating effect on the cardiovascular and nervous system, many report a decrease in their levels of perceived exertion while performing exercise in conjunction with the drug. Blood lactate is a common way to quantify objectively the levels of exertion an athlete may be experiencing during exercise, as it is shown to increase linearly with perceived exertion and muscular fatigue. Additionally, …

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A Brief Study Of Cognition, Alfred Brown Dec 2013

A Brief Study Of Cognition, Alfred Brown

Kinesiology Student Research - Archive

BACKGROUND: The goal of this experiment was to determine the relation between cognition and fitness in the senior citizen population. METHODS: For the purpose of obtaining cognitive abilities, 41 participants completed a written exam called the Montreal Cognitive Assessment (MOCA) in a quiet location. No more than one participant was allowed to be in the testing area at a time. Before beginning the exam, participants were asked to complete a consent document. Participants were then asked to complete a series of questions pertaining to visual spatial awareness, memory, naming, attention, language, abstraction, delayed recall, and orientation. After completion, no participant …

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The Effects Of C4 During A Graded Exercise Treadmill Test To Max, Donna Khounvivongsy Dec 2013

The Effects Of C4 During A Graded Exercise Treadmill Test To Max, Donna Khounvivongsy

Kinesiology Student Research - Archive

INTRODUCTION: C4 is a pre-workout supplement which is a type of ergogenic aid. Ergogenic aids helps to enhance athletic performance, energy use, and recovery time. There are different types of pre-workout supplement ingredients such as caffeine, creatine, and nitric oxide precursors that all claim to work together to promote energy and improve performance. These supplements are used increasingly in the regimen of many athletes. PURPOSE: The purpose of this study was to determine the effects of C4 during a graded exercise treadmill to maximal exercise levels on college males. METHODS: Six men (age 21.17 + 1.79 yrs) of the UTA …

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Effects Of Caffeine On Anaerobic Power During Wingate, Javier Plascencia Dec 2013

Effects Of Caffeine On Anaerobic Power During Wingate, Javier Plascencia

Kinesiology Student Research - Archive

Introduction: The ergogenic effect of caffeine on short-term, high intensity exercise has been shown to be controversial throughout the literature. Some studies have shown little to no effect on anaerobic power with caffeine supplementation while a select few have shown significant gains. Anaerobic power is the energy that is stored in muscles that is readily available at any time and can be accessed without the use of oxygen. It may be expressed as an absolute value in Watts (S) or as a relative rate in Watts per Kilogram (/Kg). Anaerobic power has long been an integral part of sports that …

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The Association Between Muscle Contraction Ratings From Manual Muscle Testing Performed By Pre-Physical Therapy Students And Electromyography Readings Obtained From Isometric Contractions, Jason Ngu Dec 2013

The Association Between Muscle Contraction Ratings From Manual Muscle Testing Performed By Pre-Physical Therapy Students And Electromyography Readings Obtained From Isometric Contractions, Jason Ngu

Kinesiology Student Research - Archive

INTRODUCTION: Manual muscle testing (MMT) is utilized in different fields like physical therapy and other fields that require diagnosis of a person’s muscular strength and progression over time. MMT involves stabilization of a certain part of the body while external resistance is provided by the manual muscle tester. Muscular activity is graded on a 0 to 5 scale. Another way to measure muscle activation is by electromyography (EMG). EMG uses electrodes to record electrical activity produced by a muscle. PURPOSE: The purpose of the study was to determine the relationship between ratings of muscular activity by pre-physical therapy students and …

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The Effect Of Post Activation Potentiation On An Isometric Bicep Contraction, Nickesh Mistry Dec 2013

The Effect Of Post Activation Potentiation On An Isometric Bicep Contraction, Nickesh Mistry

Kinesiology Student Research - Archive

INTRODUCTION: Post activation Potentiation (PAP) is a new concept that has a need for further research. The performance of a muscle depends on the historic activity of that muscle. The concept of PAP is activating the muscle prior to maximal contraction. This concept works on the basis that the muscle has history of activating and, in turn, will be able to produce a greater force and torque. This idea was utilized with a biceps isometric contraction. An isometric contraction is a contraction where the joint angle as well as the muscle length is not going to change during the contraction. …

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