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Microencapsulation Of A Connexin-43 Mimetic Peptide As A Novel Wound Healing Agent In An Ocular Injury Model, Keith Brian Moore

Theses and Dissertations

Corneal transplantation and related surgical procedures are areas of tissue replacement which have seen promising advances. Currently, cornea transplants are one of the most common surgical procedures, with approximately 40,000 occurring each year in the United States. Still, problems exist with a 20% rejection rate, post surgical infections, and the need for a constant supply of donors. The ability to safely and quickly heal and regenerate corneal epithelia fills an area of advancement in regenerative medicine, with implications reaching beyond the scope of vision therapies toward healing of a wide range of tissues and wounds. In vivo corneal wounds were …

Gold Nanoparticles And Peptoids As Novel Inhibitors Of Amyloid Beta Aggregation In Alzheimer's Disease, Kelly Ann Moore

Theses and Dissertations

In 2012 it was estimated that one in every nine Americans over the age of 65 has Alzheimer's disease (AD) (1). These patients experience gradual loss of memory, cognition, and behavioral stability eventually leading to death (2). These symptoms were first described in 1906 by Alois Alzheimer and now are the classic signs of the number one neurodegenerative disease today. Current AD therapies delay or mitigate the symptoms associated with AD to improve the quality of life for the patient; however, there is currently no cure for those that have been diagnosed. In order to develop a possible treatment for …

A New Method For The Comparison Of Survival Distributions, Jaymie Shanahan

Theses and Dissertations

The assessment of overall homogeneity of time-to-event curves is a key element in survival analysis in biomedical research. The currently commonly used testing methods, e.g. log-rank test, Wilcoxon test, and Kolmogorov-Smirnov test, may have a significant loss of statistical testing power under certain circumstances. In this thesis we replicate a testing method (Lin & Xu, 2009) that is robust for the comparison of the overall homogeneity of survival curves based on the absolute difference of the area under the survival curves using normal approximation by Greenwood's formula, and propose a new weight component to their test statistic. The weight component …

Theoretical Investigation Of The Water-Gas Shift Reaction At The Three Phase Boundary Of Ceria Supported Platinum Metal Clusters, Sara Aranifard

Theses and Dissertations

The Water-Gas Shift (WGS: CO+H2O→CO2+H2) reaction is a key step in hydrogen fuel processing for mobile fuel cell applications. Since the reaction is equilibrium-limited and exothermic, high conversions are favored by low temperatures. However, conventional low-temperature shift catalysts are not active enough. Reducible oxide supported small noble metal clusters have shown excellent activity as low temperature WGS catalysts and it is generally believed that these catalysts are bifunctional. In other words, the reaction occurs at the three-phase boundary (TPB) of the noble metal, the reducible oxide, and the gas phase. The small noble metal cluster adsorbs/activates the CO molecules and …

Understanding The Effect Of Balance Of Plant Contaminants On Pemfcs Performance: Models, Mechanisms, Functional Group, Hyun-Seok Cho

Theses and Dissertations

This dissertation considers contamination of a proton exchange membrane fuel cell (PEMC) that may result from chemicals that leach from balance of plant (BOP) materials. Both model predictions and experimental data are presented. The model is used to predict the cathode contamination impact on the Pt/C electrode and the membrane assuming no transport of contaminant from cathode to anode. The model prediction accounts for the contamination mechanisms such as adsorption, ion-exchange, absorption and three sources of voltage (i.e., performance) loss. The simple 2-D time-dependent model is developed by considering well known chemical engineering concepts of Langmuir adsorption, partition coefficients, plug …

Rational Design Of Perovskite Based Anode Materials For Solid Oxide Fuel Cells: A Computational Approach, Suwit Suthirakun

Theses and Dissertations

A key challenge in the development of solid oxide fuel cell (SOFC) technology is related to finding a suitable replacement for Ni-based cermet anodes. Although conventional Ni-based electrodes exhibit excellent catalytic activity and current collection, they suffer from several limitations such as instability upon redox cycling, nickel sintering, and sulfur and carbon poisoning when exposed to practical hydrocarbon fuels. Therefore, alternative anode materials need to be developed for SOFCs. Among the novel anode electrodes, perovskite based materials are of great interest because they have been shown to satisfy most intrinsic SOFC anode requirements such as high thermodynamic stability in anodic …

Gender And Programming: A Comparison Of Program Availability And Participation In U.S. Prisons For Men And Women, Courtney A. Crittenden

Theses and Dissertations

The current study examines the state of prison programming across the U.S. and whether availability of and participation in prison programs varies by gender and other key factors such as the interaction effects of race and gender, self-identified needs, and facility-level characteristics. Using Morash, Rucker, and Haarr's (1994) study, the last major study comparing prison programming for men and women in U.S. prisons, as a guide, I explore the current state of prison programming using national-level survey data. The results indicate that gender does indeed matter for both prison programming availability and participation with women having more programs available to …

Experimental Investigation Of Steady Flows At A Breached Levee, Cyrus K. Riahi-Nezhad

Theses and Dissertations

Steady flow at a breached levee is studied in this dissertation through a generalized model and a case study. The generalized experimental set-up consists of a main channel with an opening in its side wall and an adjustable sluice gate at its downstream end. Water surface elevation and the three-dimensional velocity field are measured by a point gauge and an Acoustic Doppler Velocimeter (ADV), respectively. Time-averaged measured values of velocity field and free surface elevation are presented. In addition, Froude Number, turbulent kinetic energy (TKE) and bed shear stress are computed from the measured results. Results show that the flow …

Novel T(5;19) Translocation In A Patient With Pdgfrb Associated Chronic Leukemia: Implications For Treatment Strategy., Joel D Provenzano, J Phillip Kuebler

Oncology Articles

Myeloproliferative disorders are variable disorders, based on the genetic abnormality present and the cell line progenitors that are affected. In this case, we discuss a novel gene translocation in the subset of PDGFRB mutations, first seen with prominent hyperbasophilia. This case demonstrates the possibility for lower therapeutic doses of imatinib mesylate than previously reported, in order to control leukocyte counts and reverse the genetic mutation.

Rewriting The Human: Death Anxiety And Posthuman Vision In Literature Since 1945, John Allen Brooks

Theses and Dissertations

ISS_para>The technology-driven years following the close of World War II provided a new lens through which the human subject could be rethought and, theoretically, improved: no longer did physical and mental shortcomings have to limit the capacity of the individual. The atomic bomb and Colossus computer, though destructive forces, pushed scientists and philosophers to consider new models of the human, including flesh/machine amalgamation and reinscription as downloadable, digital information. While these posthuman constructions promised to distance the human from its material shortcomings, especially its vulnerability to bodily decay and death, they encountered significant resistance in the twentieth century.

By …

Selling The Country’S Secrets: Willa Cather’S Eco(Self)Criticism In My Antonia And The Professor’S House, Elizabeth Nicole Morgan

Theses and Dissertations

This study considers Willa Cather's ecological consciousness as a writer of place, particularly in My Antonia and The Professor's House. In these two works, Cather's narrative distance provides her with the room to investigate the relationship between humans and their environments. Jim Burden, Godfrey St. Peter, and Tom Outland all exploit their environments to greater or lesser extents based on their way of seeing the world, which Cather draws attention to through her careful characterization and narrative distance. In each narrative, Cather forces readers to recognize the environmental consequences of egocentric vision, and the way such vision can be sustained …

Optimal Cooperation In Joint Action Tasks, Scott Michael Blanchette

Theses and Dissertations

Joint action can be succinctly defined as an action in which two or more individuals work together for a common outcome. There have been numerous studies on the mechanisms behind joint action, but none have focused on the existence of optimal cooperators. The present study investigated if optimal cooperators, individuals who are better partners in joint action tasks, exist in the population. Individuals completed a virtual bar balancing task in dyads in which four hands were used to control the bar. Based on success rate, significant differences in performance variables were found. This study provides empirical evidence that some individuals …

Measuring Organizational Member Involvement In Physical Activity Coalitions Across The United States, Daniel Benjamin Bornstein

Theses and Dissertations

Physical inactivity has been labeled a global pandemic with enormous economic, social, environmental, and public health consequences. The vast majority of American adults and youth are insufficiently physically active. Increasing population-levels of physical activity (PA) requires broad social and environmental change. PA coalitions provide the structure through which such broad change can be achieved. An extensive literature on health-based coalitions suggests that coalition success is impacted by coalition members. Coalitions are generally comprised of member organizations. Little is known about the characteristics of PA coalitions and less is known about organizational member involvement in PA coalitions. The purpose of this …

Exploring The Role Of Culture And Race In Stroke Rehabilitation Disparities, Jennifaye Verdina Greene

Theses and Dissertations

A study found that racial differences exist in stroke rehabilitation care and outcomes between African Americans (AAs) and Caucasian Americans (CAs). In addition to health status, the rehabilitation care of AAs with stroke (AAwS) may be influenced by cultural and or racial similarities or differences that exist between themselves and their physical therapists (PTs). Distorted perceptions of culture and race in the patient-PT relationship may contribute to disparities in stroke rehabilitation care and outcomes for AAwS. Current stroke rehabilitation literature lacks qualitative research that examines racialized differences in treatment. The purpose of this qualitative exploratory research study was to investigate …

"Makin' It": A Study Of First Generation College Graduates Lives Out Of Poverty, Sharla Benson-Brown

Theses and Dissertations

Scholars across various disciplines concur that poverty , especially when experienced generationally, is difficult to escape (MacLeod, 2009; Bowles & Gintis, 2002; Nieto, 2005; Corak, 2006; Sawhill & Haskins, 2008). Yet, while much is known about the existence and persistence of poverty, we know less about how and why those individuals who successfully escape poverty are able to do so (Hardaway & McLoyd, 2009).

Guided by critical social and institutional theory this qualitative study, examined the experiences of individuals who grew up in generational poverty (with parents who had no high school diploma), yet became first-generation college graduates, and entered …

A Qualitative Study On How Prenatal Genetic Counselors Prioritize Cultural Issues When Counseling Patients, Darcy Katherine Berry

Theses and Dissertations

The genetic counseling community has long recognized that the successful outcome of a session with a patient whose cultural background differs from the genetic counselor's is best achieved through recognition of the cultural differences and implementation of specific skills to overcome cultural barriers. Although research has examined the need and effects of cultural competency in genetic counseling, no prior study has evaluated how genetic counselors perceive the importance of addressing cultural issues in a genetic counseling session. Prenatal genetic counselors were recruited by emailing all NSGC members. For this study, sixteen prenatal genetic counselors were interviewed and asked to prioritize …

Use Of Social Media As A Support Network In Families With A Child Diagnosed With Trisomy 13, 18, Or 21, Ginger Elizabeth Edwardsen

Theses and Dissertations

Social media is a web based technology that allows individuals to communicate with other individuals, organizations, and communities about common interests and experiences. Recently, social media use has expanded into the healthcare field and many individuals are using social media to connect with others in similar situations and find support. Family members of children or pregnancies with trisomy 13, 18, or 21 were invited to participate in an online survey that explored the use of social media as a support network including their purposes for using social media as a support network, how often the use social media, and what …

Complexity And Salience: Evaluating The Inter-Scene Variability Of Animated Choropleth Maps, Michael Dubois

Theses and Dissertations

Animated choropleth maps allow for the compilation of potentially massive time-series datasets which can portray space-time change in a congruent manner. They are also becoming increasingly common for data visualization. When users view and interact with these maps, however, there is the likelihood that the human cognitive-perceptual system may be overwhelmed by a large number of simultaneous changes in each scene: this so-called `change blindness' is a common malady when viewing successive scenes, unless scene-to-scene graphical changes are salient enough to attract the fixation of the user. Even then, there may be a limit to the number of simultaneous changes …

An Assessment Of Technology Adoptability In Sugarcane Burning Smoke Plume Mitigation, Sara Flecher

Theses and Dissertations

The adverse health effects of sugarcane burning emissions on surrounding communities are well documented. Sugarcane farmers in Louisiana, a major sugarcane producing state with 385,000 acres dedicated to sugarcane farming throughout, attempt to mitigate the effects of burn emissions by estimating the characteristics of the resultant smoke plume using meteorological variables as parameters. The current mitigation method designed by the LSU AgCenter, the American Sugar Cane League, and the Louisiana Department of Agriculture and Forestry is a manual process requiring the tedious look-up of atmospheric variables from multiple sources and physically drawing a predicted smoke plume on a paper map, …

A Geographic Modeling Framework For Assessing Critical Infrastructure Vulnerability: Energy Infrastructure Case Study, Leanne Sulewski

Theses and Dissertations

Vulnerability of critical infrastructure systems is of the utmost importance to a nation's national security interests, especially the electric grid. Despite the importance of these systems, disruptions continue to occur at an alarming rate, thus indicating that there is a fundamental flaw in the way critical infrastructure systems are analyzed for vulnerability.

Critical infrastructure systems are typically analyzed using mathematical approaches such as graph theory, which strip systems of their important geographic information, and only look at their connections to each other. While these relationships and metrics provide useful information, they cannot provide the entire picture. As such, this research …

Subsurface Imaging And Petrophysical Analysis Of The South Georgia Rift Basin, South Carolina, Olusoga Martins Akintunde

Theses and Dissertations

The Triassic-Jurassic South Georgia Rift (SGR) basin, buried beneath Coastal Plain sediments of southern South Carolina, southeastern Georgia, western Florida, and southern Alabama, consists of an assemblage of continental rift deposits (popularly called red beds), and mafic igneous rocks (basalt flows and diabase sills). The red beds are capped by basalts and/or diabase sills, and constitute the target for supercritical CO2 storage as part of a Department of Energy funded project to study feasibility for safe and long-term sequestration. This study addresses key stratigraphic, structural and petrophysical issues critical to determine subsurface suitability for CO2 storage as well as improved …

Understanding Online And Offline Sex Seeking Behavior Among Young Men Who Have Sex With Men: Implications For Hiv/Aids Interventions, Winston Eromosele Abara

Theses and Dissertations

Men who have sex with men (MSM), especially in the southeastern US are disproportionately impacted by the HIV/AIDS epidemic. Young MSM and African American MSM are particularly burdened accounting for a greater proportion of HIV/AIDS diagnoses. Factors such as risky sexual behavior, perception of sexual risk, ignorance about HIV sero-status, internalized homonegativity/homophobia (IH), stigma, and alcohol and illegal drug use have been advanced as reasons for this disproportionate burden. HIV/AIDS prevention efforts aimed at stemming the epidemic among MSM have focused on locations where MSM meet other men for sex such as parks, beaches, bathhouses, adult book stores, clubs, and …

Exploring African American And White 18-19 Year Old Males' Communication Experiences With Their Parents And Partners About Sex And Contraception, Charlotte Toole Galloway

Theses and Dissertations

Background: Increasing parent-child and partner communication about sex and contraception have been identified as protective factors that are amenable to change by teen pregnancy prevention programs.

Purpose and Methods: From June through July 2012, a total of six focus groups (N=30) were conducted with African American and White 18-19 year old males to retrospectively explore their communication experiences with parents and partners about sex and contraception, and their attitudes and beliefs about sex, pregnancy, and contraception.

Results: Most participants felt that parent-child sexual risk communication would be more effective when parents had a history of open communication and a good …

Investigating Developmental Patterns Of Symptom And Impairment Change Among Youth With Adhd, Subthreshold Adhdand Youth Without Adhd, Lorie Love Geryk

Theses and Dissertations

Introduction. Despite a substantial prevalence of subthreshold Attention-Deficit/Hyperactivity Disorder (ADHD) and research indicating that many youth with this disorder have impaired functioning and negative outcomes, few studies have considered patterns of symptom and functioning change for youth with probable ADHD, subthreshold ADHD and youth without ADHD transitioning from childhood to adolescence. Additionally, we are not aware of any studies examining predictors of impairment severity among youth with subthreshold ADHD, and few studies have examined predictors of treatment utilization and patterns of symptom and functioning change based on medication status for youth with subthreshold ADHD compared to youth with ADHD. Methods. …

Generational Differences In Motivation To Attend College, John Michael Cote

Theses and Dissertations

The National Center for Education Statistics recently released a report indicating that the amount of full-time students attending college has increased by 45 percent over the past ten years. While many reasons assist in explaining this increase in college attendance, this study explored the differences in motivations for attending college amongst generations. This quantitative study used secondary data collected by the Cooperative Institutional Research Program (CIRP) Freshman survey to explore the differences in reasons for attending college amongst the Baby Boomer, Generation X, and Millennial generations and predict reasons that may be important to future generations of college students. These …

Congeries In The Backcountry, James Andrew Stewart

Theses and Dissertations

The early 18th century Public Monopoly employed a unique form of labor organization to facilitate an administered deerskin trade. This study examines ethnohistoric and archaeological data as a means to evaluate subaltern laborers' participation in a commercializing colonial economy. It utilizes a practice based political-economic framework to situate their activities within the deerskin commodity chain. Activities identified through ethnohistoric research are evaluated through material and spatial analysis of the Fort Congaree, 38LX30/319, site. This trading factory and garrison played a central part in the articulation of the government deerskin trade. Material correlates of hide production, procurement, and transportation activities contextualize …

Modeling Ultrasonic Field Emanating From Scanning Acoustic Microscope For Reliable Characterization Of Pathogens (Biological Materials), Rowshan Ara Rima

Theses and Dissertations

Acoustic microscopy provides extraordinary advantages over state-of-the-art invasive imaging techniques to determine the mechanical properties of living colonies of pathogens and micro-organisms. It is possible to obtain the morphomechanical parameters of the pathogenic colonies e.g. variation of thickness, stiffness and the coefficients of attenuation, using scanning acoustic microscope (SAM). However, the process requires an expert with extensive understanding of SAM and ultrasonic signals which is very time consuming and expensive for complex form of analysis. Due to lack of a suitable computational tool, presently the ultrasonic wave scattering, reflection and transmission through the biological specimens cannot be properly visualized. Without …

Doc Dynamics In Eddies Of The Sargasso Sea, Eric Matthew Lachenmyer

Theses and Dissertations

Bacterial productivity and size-fractioned rates of dissolved organic carbon (DOC) excretion from primary and secondary producers were measured in two eddy types, one anti-cyclonic (February 2012) and one cyclonic eddy (July 2012), in the Sargasso Sea. Bacterial productivity (BP) rates in the cyclonic eddy were highest in the center (9.2 mg C m-2d-1) and edge (10.4 mg C m-2d-1) of the eddy compared to the anti-cyclone center (2.2 mg C m-2d-1) and edge (5.1 mg C m-2d-1). Rates of DOC excretion from14C-tracer experiments were not significantly higher than background; lack of accumulation of labeled material indicated very fast uptake of …

Biomechanics Of Porcine Renal Artery And The Development Of A Replacment Vessel, Mohamed Gabr

Theses and Dissertations

Mechanical characterization of biological soft tissues is essential in the field of biomedical engineering. In this study several loading experiments have been performed to efficiently characterize the passive mechanical response of both native porcine renal arteries and newly developed tissue constructs. The first aim of these studies is to determine whether there is a difference in mechanical response between the main renal artery and its first branch. After fitting the bi-axial data to a Holzapfel-type constitutive model, the results show that there is no statistical difference between the model parameters for renal artery and the first branch. The only significant …

The South Carolina Sanatorium: The Landscape Of Public Healthcare In The Segregated South, Amanda Noll

Theses and Dissertations

This site-specific study examines the development of the South Carolina Sanatorium, which operated as a state-funded tuberculosis treatment center between 1915 and 1953. Using the South Carolina Sanatorium as a case study, this thesis draws upon the history of the Progressive Era, medicine, and architecture to analyze the influence of segregation on public healthcare in the South. By looking at the development of individual buildings and the site as whole, the built environment of the South Carolina Sanatorium is used as a framework to assess the effects of segregation on tuberculosis treatment in South Carolina.