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2013

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A Prospective Study Of Bone Augmentation With Growth Factors In Extraction Sockets, Athanasios Ntounis Jan 2013

A Prospective Study Of Bone Augmentation With Growth Factors In Extraction Sockets, Athanasios Ntounis

All ETDs from UAB

Ridge preservation protocols reduce crestal remodeling after tooth extraction. Limited evidence supports the potential of different grafting materials to preserve the alveolar ridge. There is limited evidence to indicate advantage of bone replacement grafting in combination with platelet rich plasma (PRP), compared to grafting alone. A combination of recombinant human platelet derived growth factor (rhPDGF-BB) with beta tricalcium phosphate (ß-TCP) has recently been approved to aid wound healing. Aim: To evaluate early healing of grafted and non-grafted extraction sockets in the es-thetic zone, with or without PRP and rhPDGF-BB. Materials and Methods: Population consisted of 41 healthy adult patients whose …


Uptake Of Antenatal Care Services And Pregnancy Outcome In Kumasi, Ghana, Asundep Ntui Jan 2013

Uptake Of Antenatal Care Services And Pregnancy Outcome In Kumasi, Ghana, Asundep Ntui

All ETDs from UAB

A prior study reported a 44.6% prevalence of adverse pregnancy outcomes in Kumasi, Ghana. This study investigated factors that may influence antenatal care (ANC) utilization and their association with adverse pregnancy outcomes; defined as low birth weight, stillbirth, preterm delivery or small for gestational age among pregnant women in Kumasi. A quantitative cross sectional study of 643 women, age 19-48 years who presented for delivery at select public hospitals and private traditional birth attendants from July through November 2011 was conducted. Information on socio-demographic characteristics and other factors associated with ANC attendance was collected using a structured questionnaire. Medical and …


Epigenetic Regulation Of Kir4.1 In Normal And Pathological States: A Focus On Spinal Cord Injury, Sinifunanya Elvee Nwaobi Jan 2013

Epigenetic Regulation Of Kir4.1 In Normal And Pathological States: A Focus On Spinal Cord Injury, Sinifunanya Elvee Nwaobi

All ETDs from UAB

Astrocytes are the most numerous cells in the brain and play a critical role in maintaining homeostatic extracellular potassium ([K+]e). This process is mediated, in part, by a glial-specific, inwardly rectifying potassium channel, Kir4.1. Pharmacological inhibition, knock down, or complete knock out of this channel results in astrocytes with increased membrane resistance, depolarized resting membrane potential, and altered extracellular potassium dynamics. Subsequent to the dysregulation of [K+]e, Kir4.1 knockout (KO) animals suffer from ataxia, seizures, and early postnatal death. Interestingly, Kir4.1 has long been characterized as a seizure susceptibility gene. The importance of Kir4.1 is further underscored by recent studies …


New Mouse Models To Aid Studies Of The Role Of Primary Cilia In Limb Patterning And Bone Development, Amber Kathleen O'Connor Jan 2013

New Mouse Models To Aid Studies Of The Role Of Primary Cilia In Limb Patterning And Bone Development, Amber Kathleen O'Connor

All ETDs from UAB

Hedgehog (Hh) signaling is required for many developmental processes, and causes several diseases and cancers. Described in chapter one below, vertebrate Hh sig-naling is dependent on the primary cilium (PC), a small organelle that extends from the surface of most mammalian cell types. A better understanding of how the PC modulates Hh signaling is important, as defects in the structure or function of PC result in severe human disorders termed the ciliopathies. For example, patients with Meckel-Gruber Syndrome have extra digits and neural tube defects, which are Hh both related pheno-types. In chapter two we sought to further understand the …


Obesity, Prediabetes, And Perceived Stress In Municipal Workers, Louise Camilleri O'Keefe Jan 2013

Obesity, Prediabetes, And Perceived Stress In Municipal Workers, Louise Camilleri O'Keefe

All ETDs from UAB

Obesity and diabetes are major contributors to morbidity and mortality in the United States. According to the American Public Health Association and Partnership for Prevention, obesity is growing faster than any other public health problem in the United States. The prevalence of diabetes has also increased significantly with an estimated 79 million Americans aged 20 years or older suffering from prediabetes. Few studies have examined the influence of perceived stress on obesity and prediabetes among working adults. Investigations are needed to examine factors that can contribute to higher health care costs for both employees and employers. The aims of this …


The Comparison Of Dental Arch Forms Obtained From Teeth, Alveolar Bone, And The Overlying Soft Tissue, Patrick O'Neil Jan 2013

The Comparison Of Dental Arch Forms Obtained From Teeth, Alveolar Bone, And The Overlying Soft Tissue, Patrick O'Neil

All ETDs from UAB

THE COMPARISON OF DENTAL ARCH FORMS OBTAINED FROM TEETH, ALVEOLAR BONE, AND THE OVERLYING SOFT TISSUE Patrick D. O'Neil, DMD UAB DEPARTMENT OF ORTHODONTICS: DENTISTRY ABSTRACT Objective: The objective of this study was to determine if a difference existed between arch forms created from tooth surfaces, alveolar bone, and overlying soft tissue. Materials and Methods: The sampling population for this study was 18 individuals with a Class I malocclusion, mild crowding, and a CBCT image of good diagnostic quality. The Facial-axis point was chosen to create the arch form from teeth, the Bowman-Kau point was used to establish the arch …


Environmental Specific Effects On Life History And Energy Metabolism Traits In A Permethrin Resistant Strain Of Anopheles Gambiae, Dennis Otali Jan 2013

Environmental Specific Effects On Life History And Energy Metabolism Traits In A Permethrin Resistant Strain Of Anopheles Gambiae, Dennis Otali

All ETDs from UAB

Widespread use of pyrethroids for control of malaria vectors together with use in agriculture for pest control has led to an increase in emergence of populations of pyrethroid resistant phenotypes. Insecticide resistance can likely alter vector development time, reproduction, behavior, and longevity, all of which can affect the potential for disease transmission. In this study we assessed whether the genetic modifications (kdr mutation, cytochrome P450 and esterase detoxification) in a permethrin resistant strain of An. gambiae influence traits related to fitness. The performances of these traits were compared between two strains of An. gambiae, one permethrin susceptible (ASEMBO1) and the …


Computational Studies On Metal Bound Amyloid-Ss Peptide Complexes: Implications For Oligomerization, Lurong Pan Jan 2013

Computational Studies On Metal Bound Amyloid-Ss Peptide Complexes: Implications For Oligomerization, Lurong Pan

All ETDs from UAB

Amyloid-beta (Abeta) peptide is the primary component of the senile plaques that char-acterize Alzheimer's disease (AD). Numerous studies have shown that small soluble oligomers of Aß have higher neurotoxicity than large, insoluble aggregates and fibrils. Brain tissue analysis has shown that excessive metal ions including zinc, copper and iron are co-localized with the plaques. In addition, in vitro studies suggest that these ions play an important role in the aggregation and toxicity of Abeta. Nevertheless, due to the large number of variables that must be controlled it is difficult to characterize the detailed mechanisms by which metal ions modulate Abeta …


Urban Kindergarten Teachers' Perceptions Of Former Head Start Students And Their Readiness For School, Stephanie Hardy Parker Jan 2013

Urban Kindergarten Teachers' Perceptions Of Former Head Start Students And Their Readiness For School, Stephanie Hardy Parker

All ETDs from UAB

The purpose of this qualitative multiple case study was to explore the experiences and instruction of kindergarten teachers in an urban school district who are teaching students who were previously enrolled in a Head Start program. Eleven kindergarten teachers who taught in an urban school district in the southeastern United States participated in this study. Data sources collected for this multiple case study included: (a) semi-structured interviews, (b) observations, and (c) curriculum documents. Results from the study revealed mixed experiences teaching former Head Start students. While some teachers expressed positive experiences teaching former Head Start students, others indicated teaching former …


Phospho-Erk And Amyloid Beta: Targets Of Estrogen In The Brain, Thomas Reed Peavy Jan 2013

Phospho-Erk And Amyloid Beta: Targets Of Estrogen In The Brain, Thomas Reed Peavy

All ETDs from UAB

Estrogen replacement therapy (ERT) has been shown to improve memory function in menopausal women, but increases hormone sensitive cancers, prompting a more targeted investigation of estrogen's action in learning and memory to develop more targeted therapeutics. Estrogen improves performance on the novel object recognition task by increasing phosphorylation of extracellular signal-regulated kinase (pERK) within minutes in the hippocampus. Dr. Lori McMahon's lab showed that the improvement in novel object recognition can be seen 24 hours after subcutaneous injection of proestrous levels of estrogen (referred to as E24). Whether a corresponding increase in pERK occurs at the E24 time point had …


Engaging First Graders In Transformational Early Childhood Emergent Learning Themes, Amanda Daniel Pendergrass Jan 2013

Engaging First Graders In Transformational Early Childhood Emergent Learning Themes, Amanda Daniel Pendergrass

All ETDs from UAB

The purpose of this qualitative case study was to encourage learners to care for others and make a difference in the world through Reggio Emilia-inspired teaching and learning practice that promoted transformational education. Students were anticipated to take an active role in helping to develop the transformational educational curriculum. Students recommended ways of making a difference in their school, neighborhood, and community while investigating a learning theme of their interest and choice. A total of 15 first grade students and nine parents participated in this study. Limited literature exists on the topic of Reggio Emilia-inspired early childhood classrooms and recycling …


Characterization Of The Retina In The Alpha 7 Nicotinic Acetylcholine Receptor Knockout Mouse, Marci Lynn Smith Jan 2013

Characterization Of The Retina In The Alpha 7 Nicotinic Acetylcholine Receptor Knockout Mouse, Marci Lynn Smith

All ETDs from UAB

Acetylcholine receptors (AChRs) are involved in visual processing and are expressed by inner retinal neurons in all species studied to date (Keyser et al., 2000; Dmitrieva et al., 2007; Liu et al., 2009), but their distribution in the mouse retina remains unknown. Reductions in alpha 7 nicotinic AChRs (nAChRs) are thought to contribute to memory and visual deficits observed in Alzheimer's and schizophrenia (Coyle et al., 1983; Nordberg et al., 1999; Leonard et al., 2006). However, the alpha 7 nAChR knockout (KO) mouse has a mild phenotype (Paylor et al., 1998; Fernandes et al., 2006; Young et al., 2007; Origlia …


Oral Language Development In Title I Preschools In Central Alabama: A Multi-Case Study, Suzanne O'Rear Snow Jan 2013

Oral Language Development In Title I Preschools In Central Alabama: A Multi-Case Study, Suzanne O'Rear Snow

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Among risk factors associated with reading difficulties, underdeveloped oral language skills can be detrimental to students' reading success. Many educators are teaching early reading skills without prior knowledge of scaffolding methods and developmentally appropriate developmentally appropriate factors from research (Kirkland & Patterson, 2005). This multi-case study examined aspects of how five preschool personnel developed oral language development in two Titles I preschool by answering the following questions: How do preschool teachers and paraprofessionals describe the ways in which oral language development is developed in a preschool setting? The research sub-questions included were: Two Title I schools were purposefully chosen for …


Host Genetic Factors Associated With Cervical Human Papillomavirus Clearance, Staci Lynn Sudenga Jan 2013

Host Genetic Factors Associated With Cervical Human Papillomavirus Clearance, Staci Lynn Sudenga

All ETDs from UAB

This dissertation research focuses on how variants in various host genes are associated with clearance of HPV in three longitudinal cohorts from the United States. I first examined the definition of the intermediate phenotype to cervical cancer, HPV persistence and then I incorporated this phenotype in all my three aims by examining variations in xenobiotic metabolism genes in HIV-1 negative and immune-related genes in HIV-1 positive females and how these contribute to HPV infection outcomes. Several significant variants were associated with HPV clearance for the three aims. For the first aim, in ALTS assessing functional variants within xenobiotic metabolism genes …


A Phenomenological Study Of Principals' Self-Efficacy Beliefs In Alabama Torchbearer Schools, Mark Anthony Sullivan Jan 2013

A Phenomenological Study Of Principals' Self-Efficacy Beliefs In Alabama Torchbearer Schools, Mark Anthony Sullivan

All ETDs from UAB

A PHENOMENOLOGICAL STUDY OF PRINCIPALS' SELF-EFFICACY BELIEFS IN ALABAMA TORCHBEARER SCHOOLS MARK A. SULLIVAN EDUCATIONAL LEADERSHIP ABSTRACT The purpose of this phenomenological study was to gain an in-depth understanding of the self-efficacy beliefs of 10 principals of Torchbearer schools in Alabama. Principals who serve in schools that have high concentrations of students who are living in poverty face challenges in improving student achievement. Principals of these schools are required to promote school environments that are conducive to learning for all students. In February 2005, the Alabama State Department of Education began recognizing high-poverty public schools and their principals for overcoming …


Biocomposite Material Evaluation And Processing For Automotive Interior Components, Theresa Lee Sullins Jan 2013

Biocomposite Material Evaluation And Processing For Automotive Interior Components, Theresa Lee Sullins

All ETDs from UAB

There is growing demand for materials that are environmentally friendly and sustainable. One of the areas of focus right now is the transportation/automotive field where more energy efficient vehicles are needed to meet growing government regulations and to reduce the negative impacts on global air quality, human health and global climate. Several researchers are focusing on bio-based composites with natural fibers being the prime choice for fiber reinforced composites. The processing and characterization of 30 wt. % industrial hemp fiber reinforced PP composites for automotive interior components are discussed. The material was compounded by a twin screw and then processed …


The Effect Of Incentive Strategy On Health Behaviors And Outcomes In The Workplace, Lindsay M. Sutton Jan 2013

The Effect Of Incentive Strategy On Health Behaviors And Outcomes In The Workplace, Lindsay M. Sutton

All ETDs from UAB

This study examined participation, engagement, and achievement of health-related targets under two sequentially administered wellness programs for approximately 2,000 full-time city personnel of a Southern municipal government. Program A utilized paper fliers and community posters as the primary communication strategy and incented employees for achieving 3 health outcomes only by a lump-sum, one-time monetary reward distributed at the end of the year. Program B subsequently utilized a web-based site where employees logged into individualized accounts and received points that accrued for both completing behaviors and achieving health outcomes. Both electronic and paper communication strategies were utilized to as primary mediums …


Three-Dimensional Photography Of Facial Morphology Of Adult African-Americans Compared To Various Population Sets, Leslie Talbert Jan 2013

Three-Dimensional Photography Of Facial Morphology Of Adult African-Americans Compared To Various Population Sets, Leslie Talbert

All ETDs from UAB

The purpose of this study is to compare the facial morphologies of an adult African-American population to an adult Caucasian-American population using three-dimensional surface imaging. Materials and Methods: Three-dimensional facial images were captured via a stereo-photogrammetric camera system (3dMDfaceTM system). One hundred images of each population (African-American and Caucasian-American) were taken. Subjects were between 19-30 years of age, normal BMI, and no gross craniofacial anomalies. All facial images were aligned and combined using Rapidform 2006 Plus Pack 2 software to produce a male and female facial average for each population. The facial averages were then superimposed for comparison and the …


Effects Of Light Spectra And Uv Radiation In Relation To Dietary Carotenoids On The Sea Urchin Lytechinus Variegatus, James Christopher Taylor Jan 2013

Effects Of Light Spectra And Uv Radiation In Relation To Dietary Carotenoids On The Sea Urchin Lytechinus Variegatus, James Christopher Taylor

All ETDs from UAB

An important factor in the marketability of sea urchin gonad is color. A marketable color is suggested to be dependent upon the in vivo accumulation of red and yellow carotenoid pigments within the gonad. Carotenoids obtained through the diet can be modified in sea urchins, but the function of these carotenoids is unknown. We hypothesize that differential light exposure can affect carotenoid deposition and, as a consequence, gonad color in sea urchins. We performed two experiments to determine if light spectra affect gonad color of Lytechinus variegatus. In the first experiment, urchins were fed a formulated feed supplemented with or …


Patient-Centered Medical Homes: An Analysis Of The Effects Of Practice Capabilities On Costs, Mary Temm Jan 2013

Patient-Centered Medical Homes: An Analysis Of The Effects Of Practice Capabilities On Costs, Mary Temm

All ETDs from UAB

The purpose of this research was to examine the relationship between Patient-Centered Medical Homes (PCMH) practice capabilities and costs. Complexity science theory was used to develop a theoretical framework to address three primary and twelve secondary hypotheses. Secondary data from a consortium of physician organizations participating in Blue Cross Blue Shield of Michigan's Physician Group Incentive Program and Blue Cross Blue Shield of Michigan's administrative claims data were used to test hypothesized relationships using fixed effects panel regression models. It was found that higher levels of aggregated PCMH practice capabilities were negatively associated with certain costs, specifically average readmission costs. …


Plga Nanospheres For Sustained Release Of Rifampicin, Alyssa Brianna Terry Jan 2013

Plga Nanospheres For Sustained Release Of Rifampicin, Alyssa Brianna Terry

All ETDs from UAB

Although Tuberculosis (TB) is often regarded as a disease of the past, it is still one of the leading killers of people worldwide. TB is caused by Mycobacterium tuberculosis, a bacterium that mostly infects the lungs but can also infect other organs throughout the body. One goal for TB treatment is to create a biocompatible, biodegradable drug delivery system that employs the use of multiple drugs while simultaneously relieving the patient from the burden of self-medicating. For this study, we optimized a procedure for making poly(lactic acid-co-glycolic acid) (PLGA) nanospheres and loading Rifampicin, one of the most potent and least …


Carbon Dioxide Enhanced Oil Recovery From The Citronelle Oil Field And Carbon Sequestration In The Donovan Sand, Southwest Alabama, Konstantinos A. Theodorou Jan 2013

Carbon Dioxide Enhanced Oil Recovery From The Citronelle Oil Field And Carbon Sequestration In The Donovan Sand, Southwest Alabama, Konstantinos A. Theodorou

All ETDs from UAB

Capturing carbon dioxide (CO2) from stationary sources and injecting it into deep underground geologic formations has been identified as a viable method for reducing carbon emissions to the atmosphere. Sedimentary rocks, such as sandstones overlain by shales or evaporites, are the preferred formations because their morphology and structure provide pore space, and containment for the long term storage of CO2. Sandstone formations have also served as repositories to migrating hydrocarbons, and are the sites of many oil recovery operations. For many depleted oil reservoirs, secondary waterflooding recovery methods are no longer efficient or economically viable, hence the application of tertiary …


The Origin, Regulation, And Function Of Tbet In Effector Cd4 T Cells During Chronic Autoimmune Disease, Wen-I Yeh Jan 2013

The Origin, Regulation, And Function Of Tbet In Effector Cd4 T Cells During Chronic Autoimmune Disease, Wen-I Yeh

All ETDs from UAB

Multiple Sclerosis (MS) is an autoimmune disease resulting from aberrant immune cells causing demyelination. We utilize the well-studied mouse model, experimental autoimmune encephalomyelitis (EAE), to decipher the underlying pathogenesis of MS. Effector CD4 T-cells play a critical role during EAE because the disease is induced by adoptively transferring myelin-specific CD4 T-cells into naïve mice. Classically, effector CD4 T-cells have been divided into distinct subsets based on their functional properties: Th1 cells produce IFNγ, Th2 cells secrete IL-4, IL-5, and IL-13, Th17 cells make IL-17A, IL-17F, IL-21, and IL-22, and regulatory T cells produce IL-10. Th1 cells were originally identified as …


A Generalized Noisy Communication Channel Approach For Quantum Computing, Fan Xiong Jan 2013

A Generalized Noisy Communication Channel Approach For Quantum Computing, Fan Xiong

All ETDs from UAB

Quantum computing is considered to be a promising technology for some specific types of computing purposes. Modeling of quantum computing could help study and research of this field. In this dissertation, we approach quantum computing from a communication perspective that is to model quantum computing with a generalized noisy communication channel approach. We proposed a generalized noisy communication channel approach (GNCom) for quantum computing. The proposed GNCom approach is applied to quantum computing as a universal quantum register. GNCom further extended the noisy communication channel framework by associating it with Quantum Electrodynamics (QED). Based on GNCom and QED, we proposed …


High-Tech Services And Hospital Performance In The United States, Ferhat Devrim Zengul Jan 2013

High-Tech Services And Hospital Performance In The United States, Ferhat Devrim Zengul

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This dissertation examined the relationship between high-technology medical services and hospital performance by focusing on financial and quality performance dimensions. An initial systematic review disclosed the paucity of research and mixed findings about the technology-performance relationship. The review indicated the need for further analyses by emphasizing some limitations of existing studies. The resource-based view (RBV) of a firm was used as a conceptual framework in examining the relationship between high-tech medical services and hospital financial performance. It was hypothesized that large breadth (number) of high-tech services and the use of rare high-tech services would be positively associated with hospitals' financial …


Regulation Of Stim1 By O-Glcnacylation In Cardiomyocytes, Xiaoyuan Zhu-Mauldin Jan 2013

Regulation Of Stim1 By O-Glcnacylation In Cardiomyocytes, Xiaoyuan Zhu-Mauldin

All ETDs from UAB

In non-excitable cells, STIM1 and Orai1 are the primary mediators of store-operated Ca2+ entry (SOCE); however little is known about their roles in cardiomyocyte Ca2+ handling. We have previously shown that acute increases in the levels of O-GlcNAcylation (the attachment of O-linked N- acetylglucosamine (O-GlcNAc) to target proteins) are cardioprotective through attenuating Ca2+-mediated injury and increased O-GlcNAcylation blunts SOCE in cardiomyocytes. Therefore, the goals here were to determine the regulation of STIM1 and STIM1-mediated SOCE by O-GlcNAcylation in cardiomyocytes. Immunohistochemical analysis demonstrated the co-localization of STIM1 with SERCA and RyR in adult cardiomyocytes. NRVMs were transfected with the eYFP-tagged STIM1 …


The Role Of Nr4a3 And Its Agonists In Skeletal Muscle Glucose Transport And Insulin Sensitivity, Qinglan Liu Jan 2013

The Role Of Nr4a3 And Its Agonists In Skeletal Muscle Glucose Transport And Insulin Sensitivity, Qinglan Liu

All ETDs from UAB

Insulin resistance plays a central role in the pathogenesis of Type 2 Diabetes (T2DM) and involves diminished stimulation of glucose transport in skeletal muscle. Improvements in insulin sensitivity are essential for both prevention and treatment of T2DM. However, the limitation of current medications highlights the need for alternative molecular regulators of insulin action and developing new insulin sensitizers. Our laboratory has initially identified roles for the orphan nuclear receptor NR4A3 in insulin-sensitization and stimulation of glucose transport. However, the cellular effect and downstream mechanisms of NR4A3 and its agonists (e.g. 6-mercaptopurine/6-MP) on insulin effector system in skeletal muscle remain unknown. …


Investigation Of Death Receptor-5 Mediated Apoptosis And Inhibition Of Wnt/Ss-Catenin Signaling In Basal-Like Breast Cancer Stem Cells, Angelina Ix-Ik' Londono-Joshi Jan 2013

Investigation Of Death Receptor-5 Mediated Apoptosis And Inhibition Of Wnt/Ss-Catenin Signaling In Basal-Like Breast Cancer Stem Cells, Angelina Ix-Ik' Londono-Joshi

All ETDs from UAB

Basal-like breast cancers (BLBC) display aggressive clinical behavior attributed to the presence of cancer stem cells (CSCs). TRA-8, a monoclonal antibody that binds specifically to TRAIL death receptor 5, preferentially induces apoptosis in BLBC subtype cells; however it is unknown if TRA-8 is also cytotoxic to the CSC population. Moreover, some BLBC cell lines are resistant to TRA-8, and overcoming resistance is critical for clinical translation of this therapy. One potential approach to overcome TRA- 8 resistance is to target the Wnt/ß-catenin pathway. LRP6 is a cell surface receptor that is an indispensable element of the Wnt/ß-catenin signaling pathway that …


Blood Pressure And Tobacco Exposure Among Rural Adolescents Ages 15-18, Luz Huntington-Moskos Jan 2013

Blood Pressure And Tobacco Exposure Among Rural Adolescents Ages 15-18, Luz Huntington-Moskos

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High blood pressure is a prevalent precursor to cardiovascular disease. An estimated 3% of US adolescents have hypertension. In addition, prehypertension is predictive of hypertension in adolescents, with progression between these stages at approximately 7% per year. Tobacco use/exposure is strongly linked to cardiovascular risk and disease in adults. Further, rural communities have higher tobacco use prevalence and fewer community policies restricting tobacco use. Little is known about the effects of tobacco exposure on blood pressure and the mediating effects of inflammation (salivary C-reactive protein (CRP)) in rural adolescents. The purpose of this study is to determine the relationships between …


Spectrum Therapy Center, Lindsay Wilson Jan 2013

Spectrum Therapy Center, Lindsay Wilson

Honors Capstones

No abstract provided.