Digital Commons Network^™

High-Tech Services And Hospital Performance In The United States, Ferhat Devrim Zengul

All ETDs from UAB

This dissertation examined the relationship between high-technology medical services and hospital performance by focusing on financial and quality performance dimensions. An initial systematic review disclosed the paucity of research and mixed findings about the technology-performance relationship. The review indicated the need for further analyses by emphasizing some limitations of existing studies. The resource-based view (RBV) of a firm was used as a conceptual framework in examining the relationship between high-tech medical services and hospital financial performance. It was hypothesized that large breadth (number) of high-tech services and the use of rare high-tech services would be positively associated with hospitals' financial …

Regulation Of Stim1 By O-Glcnacylation In Cardiomyocytes, Xiaoyuan Zhu-Mauldin

All ETDs from UAB

In non-excitable cells, STIM1 and Orai1 are the primary mediators of store-operated Ca2+ entry (SOCE); however little is known about their roles in cardiomyocyte Ca2+ handling. We have previously shown that acute increases in the levels of O-GlcNAcylation (the attachment of O-linked N- acetylglucosamine (O-GlcNAc) to target proteins) are cardioprotective through attenuating Ca2+-mediated injury and increased O-GlcNAcylation blunts SOCE in cardiomyocytes. Therefore, the goals here were to determine the regulation of STIM1 and STIM1-mediated SOCE by O-GlcNAcylation in cardiomyocytes. Immunohistochemical analysis demonstrated the co-localization of STIM1 with SERCA and RyR in adult cardiomyocytes. NRVMs were transfected with the eYFP-tagged STIM1 …

The Role Of Nr4a3 And Its Agonists In Skeletal Muscle Glucose Transport And Insulin Sensitivity, Qinglan Liu

All ETDs from UAB

Insulin resistance plays a central role in the pathogenesis of Type 2 Diabetes (T2DM) and involves diminished stimulation of glucose transport in skeletal muscle. Improvements in insulin sensitivity are essential for both prevention and treatment of T2DM. However, the limitation of current medications highlights the need for alternative molecular regulators of insulin action and developing new insulin sensitizers. Our laboratory has initially identified roles for the orphan nuclear receptor NR4A3 in insulin-sensitization and stimulation of glucose transport. However, the cellular effect and downstream mechanisms of NR4A3 and its agonists (e.g. 6-mercaptopurine/6-MP) on insulin effector system in skeletal muscle remain unknown. …

Investigation Of Death Receptor-5 Mediated Apoptosis And Inhibition Of Wnt/Ss-Catenin Signaling In Basal-Like Breast Cancer Stem Cells, Angelina Ix-Ik' Londono-Joshi

All ETDs from UAB

Basal-like breast cancers (BLBC) display aggressive clinical behavior attributed to the presence of cancer stem cells (CSCs). TRA-8, a monoclonal antibody that binds specifically to TRAIL death receptor 5, preferentially induces apoptosis in BLBC subtype cells; however it is unknown if TRA-8 is also cytotoxic to the CSC population. Moreover, some BLBC cell lines are resistant to TRA-8, and overcoming resistance is critical for clinical translation of this therapy. One potential approach to overcome TRA- 8 resistance is to target the Wnt/ß-catenin pathway. LRP6 is a cell surface receptor that is an indispensable element of the Wnt/ß-catenin signaling pathway that …

Blood Pressure And Tobacco Exposure Among Rural Adolescents Ages 15-18, Luz Huntington-Moskos

All ETDs from UAB

High blood pressure is a prevalent precursor to cardiovascular disease. An estimated 3% of US adolescents have hypertension. In addition, prehypertension is predictive of hypertension in adolescents, with progression between these stages at approximately 7% per year. Tobacco use/exposure is strongly linked to cardiovascular risk and disease in adults. Further, rural communities have higher tobacco use prevalence and fewer community policies restricting tobacco use. Little is known about the effects of tobacco exposure on blood pressure and the mediating effects of inflammation (salivary C-reactive protein (CRP)) in rural adolescents. The purpose of this study is to determine the relationships between …

Spectrum Therapy Center, Lindsay Wilson

Honors Capstones

No abstract provided.

Intracellular Quantitation And Pharmacokinetic Modeling Of Nucleoside Analogs In The Female Genital Tract, Amanda Marie James

All ETDs from UAB

Human Immunodeficiency Virus (HIV) is one of the leading infectious diseases in the world. In spite of substantial progress in the advancement of antiretroviral therapy for HIV treatment, new infections outpace the number of infected persons initiating ART. Therefore, the prevention of HIV remains a crucial health issue. Pre-Exposure Prophylaxis, (PrEP), which involves using one or more antiretroviral agents to reduce the risk of HIV infection prior to potential exposure, has shown effectiveness at reducing HIV transmission in study volunteers with different sexual orientation around the world. The clinical pharmacology of antiretroviral drugs, specifically tenofovir (TFV) and emtricitabine (FTC), in …

Interracial Couple Status In Relation To Birth Outcomes Among Singleton Infants Born To U.S. Resident Mothers, 2004-2008., Su Jin Jeong

All ETDs from UAB

Due to the growing trend in interracial marriages in the United States, the issue of birth outcomes to infants born to such couples deserves more attention and examination. The purpose of this population-based, cross-sectional, observational study is to examine the association between interracial couple status and birth outcomes (i.e. low birth weight, very low birth weight, preterm birth, very preterm birth, small for gestational age) among singleton infants delivered in the United States. Interracial couples are defined as those in a relationship who are not of the same race or ethnic designation. Non-Hispanic white, non-Hispanic black, Hispanic, Asian, Chinese, Filipino, …

Interpretive Theorizing In The Seductive World Of Sexuality And Interpersonal Communication: Getting Guerilla With Studies Of Sexting And Purity Rings, Jimmie Manning

Faculty Articles, Papers, and Other Scholarship

The author explains how interpretive studies of sexuality will be of benefit to relationship studies in and out of the communication discipline.

Universal Reading Processes Are Modulated By Language And Writing System, Charles A. Perfetti, Lindsay N. Harris

Faculty Articles, Papers, and Other Scholarship

The connections among language, writing system, and reading are part of what confronts a child in learning to read. We examine these connections in addressing how reading processes adapt to the variety of written language and how writing adapts to language. The first adaptation (reading to writing), as evidenced in behavioral and neuroscience data, is achieved through a universal constraint that language places on writing and through the tuning of reading procedures imposed by specific features of writing systems. Children acquire skill in reading through increasing specialization of procedures tuned to their writing system, while also acquiring more general (universal) …

Domain 3: Situation Analysis, Yihui Tang

Faculty Articles, Papers, and Other Scholarship

No abstract provided.

Federal Constitutional Childcare Interests And Superior Parental Rights In Illinois, Jeffrey A. Parness

Faculty Articles, Papers, and Other Scholarship

Even without a majority rationale, the opinions in Troxel v. Granville, 530 U.S. 57 (2000), support the notion that there are federal constitutional “liberty interests of parents in the care, custody, and control of their children” which generally foreclose state – compelled nonparent childcare over parental objections. They also recognize there can be exceptions, including perhaps when parental wishes are accorded “at least some special weight;” when “harm or potential harm” to children may ensue; when there are already “substantial relationships” between children and nonparents; or when states legitimately seek to preserve “established familial or family-like bonds.” As well, the …

Parentage Law (R)Evolution: The Key Questions, Jeffrey A. Parness

Faculty Articles, Papers, and Other Scholarship

American state parentage laws have evolved significantly in the past half century in response to changes in both reproductive technologies and human conduct. Yet further evolution, if not a revolution, seems inevitable. In particular, American state laws increasingly recognize parenthood by consent for a nonbiological and nonadoptive parent-like figure in an intimate or familial relationship with a child’s biological or adoptive parent. Lawmakers, especially state legislators, will need to consider who may be granted standing as parents to seek court-ordered childcare, including former stepparents, former boyfriends and girlfriends, and present and former grandparents. As well, they must ponder whether standing …

Financial Literacy, Financial Education And Economic Outcomes, Justine S. Hastings, Brigitte C. Madrian, William L. Skimmyhorn

Faculty Publications

In this article we review the literature on financial literacy, financial education, and consumer financial outcomes. We consider how financial literacy is measured in the current literature, and examine how well the existing literature addresses whether financial education improves financial literacy or personal financial outcomes. We discuss the extent to which a competitive market provides incentives for firms to educate consumers or offer products that facilitate informed choice. We review the literature on alternative policies to improve financial outcomes, and compare the evidence to evidence on the efficacy and cost of financial education. Finally, we discuss directions for future research.

What Goes Up Must Come Down? Experimental Evidence On Intuitive Forecasting, John Beshears, James J. Choi, Andreas Fuster, David Laibson, Brigitte C. Madrian

Faculty Publications

Do laboratory subjects correctly perceive the dynamics of a mean-reverting time series? In our experiment, subjects receive historical data and make forecasts at different horizons. The time series process that we use features short-run momentum and long-run partial mean reversion. Half of the subjects see a version of this process in which the momentum and partial mean reversion unfold over 10 periods (‘fast’), while the other subjects see a version with dynamics that unfold over 50 periods (‘slow’). Typical subjects recognize most of the mean reversion of the fast process and none of the mean reversion of the slow process.

The Impact Of Parental Involvement On A Structured Youth Program Experience: A Qualitative Inquiry, Mat D. Duerden, Peter A. Witt, Christopher J. Harrist

Faculty Publications

Parental involvement is an often proposed, but rarely researched, key element of youth programs. Questions remain regarding the impact of parental involvement on program processes and outcomes. Qualitative data were collected over a one-year period with youth participants (n=46), parents (n=26), and teachers (n=5) associated with an international immersion/service learning program for adolescents. Three main research questions guided the data analysis: (1) what role does parental involvement play in the youths’ experience in the program; (2) how does parental involvement in the program influence the parent/child relationship; and (3) what role does parental involvement play in terms of the program’s …

Chapter 2 Exploring The Intersections Of Information Literacy And Scholarly Communication [Two Frames Of Reference For Undergraduate Instruction], Kim Duckett, Scott Warren

Librarian Publications

Common Ground at the Nexus of Information Literacy and Scholarly Communication presents concepts, experiments, collaborations, and strategies at the crossroads of the fields of scholarly communication and information literacy. The seventeen essays and interviews in this volume engage ideas and describe vital partnerships that enrich both information literacy and scholarly communication programs within institutions of higher education. Contributions address core scholarly communication topics such as open access, copyright, authors’ rights, the social and economic factors of publishing, and scholarly publishing through the lens of information literacy. This volume is appropriate for all university and college libraries and for library and …

Embedding Librarians Into The Stem Publication Process, Anne E. Rauh, Linda M. Galloway

Librarian Publications

STEM Librarians at Syracuse University actively participate throughout the scientific publication process. This chapter will outline points in the process where librarian involvement is applicable and beneficial. Librarians Anne Rauh and Linda Galloway will explain how and why it is important to teach tools that organize scientific literature to faculty and students before they begin the writing process. The use of assessment techniques to help inform targeted publication venues will be described. Post-publication, this chapter will describe how to help authors gauge the impact of their work, promote their publications and increase their visibility.

Characterization And Aerosol Dispersion Performance Of Spray-Dried Chemotherapeutic Pegylated Phospholipid Particles For Dry Powder Inhalation Delivery In Lung Cancer, Samantha A. Meenach, Kimberly W. Anderson, J. Zach Hilt, Ronald J. Mcgarry, Heidi M. Mansour

Chemical, Biomolecular, and Materials Engineering Faculty Publications

Pulmonary inhalation chemotherapeutic drug delivery offers many advantages for lung cancer patients in comparison to conventional systemic chemotherapy. Inhalable particles are advantageous in their ability to deliver drug deep in the lung by utilizing optimally sized particles and higher local drug dose delivery. In this work, spray-dried and co-spray dried inhalable lung surfactant-mimic PEGylated lipopolymers as microparticulate/nanoparticulate dry powders containing paclitaxel were rationally designed via organic solution advanced spray drying (no water) in closed-mode from dilute concentration feed solution. Dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine poly(ethylene glycol) (DPPE-PEG) with varying PEG chain length were mixed with varying amounts of paclitaxel in methanol …

Blast Response Of Curved Carbon/Epoxy Composite Panels: Experimental Study And Finite-Element Analysis, V. A. Phadnis, P. Kumar, A. Shukla, A. Roy, V. V. Silberschmidt

Mechanical, Industrial & Systems Engineering Faculty Publications

Experimental and numerical studies were conducted to understand the effect of plate curvature on blast response of carbon/epoxy composite panels. A shock-tube system was utilized to impart controlled shock loading to quasi-isotropic composite panels with differing range of radii of curvatures. A 3D Digital Image Correlation (DIC) technique coupled with high-speed photography was used to obtain out-of-plane deflection and velocity, as well as in-plane strain on the back face of the panels. Macroscopic post-mortem analysis was performed to compare yielding and deformation in these panels. A dynamic computational simulation that integrates fluid-structure interaction was conducted to evaluate the panel response …

Exploring Current And Projected Skills And Knowledge Areas To Meet U.S. Commercial Space Industry Needs, Sonya A. H. Mcmullen, Mac J. Mcmullen, Kenneth Witcher

Publications

In 2007, the Committee on Meeting the Workforce Needs for the National Vision for Space Exploration published findings related to age and skills of the current National Aeronautics and Space Administration (NASA) workforce and projected potential expertise shortages as a result of retirement in the 2014-2015 time frame. In addition, the expanding commercial space industry in both the United States and Europe will likely create further demand for space experts in engineering and a variety of related fields. Although NASA contributes $162 million in funding for education programs annually, those programs target kindergarten through grade 12, not collegiate-level programs. Further, …

Miranda And Its (More Rights-Protective) International Counterparts, Megan A. Fairlie

Faculty Publications

The goal of this article is to encourage the international legal community to revisit its unexamined acceptance of strategic communications. This can lead to a debate that, at a minimum, should prompt Court supporters — specifically civil society members — to think carefully before engaging in conduct that creates dangerous consequences for the ICC.

Connecting Classrooms: Russian Language Teaching Project At Ucf, Alla Kourova

Russian Language Journal

Change happens all the time and in all places. It is a characteristic of our modern world. A current trend in the world is globalization, which occurred by rapid developments in transportation and information technology. Today, people from diverse backgrounds come into more and more contact with each other with a regularity that is unique to this period of human history. As a result, intercultural communication has become increasingly important.

Individualized Project-Based Reading And Its Effect On Students’ Reading Habits And Beliefs, Filip Zachoval

Russian Language Journal

In recent years, a number of empirical and conceptual studies about Project-Based Learning (PBL) have presented consistent arguments rationalizing this approach to language learning and teaching. However, there are no known studies available on PBL in the Russian language classroom. This article presents the results of a qualitative research study that investigates incorporating an individualized reading project into a third-semester Russian classroom. Within the movement of studentcentered pedagogies, the overall purpose of this study was: (a) to implement a reading project into a third-semester university Russian language class and (b) to provide an analysis of some of the educational gains …

Key Indicators Of Language Impact On Identity Formation In Belarus, Tony Brown

Russian Language Journal

In 1986, a group of 28 intellectuals from Belarus wrote the following brief letter to then-General Secretary Mikhail Gorbachev: “Language is the soul of a nation, the supreme manifestation of its cultural identity, the foundation of its true spiritual life. A nation lives and flourishes in history while its language lives. With the decline of the language, culture withers and atrophies, the nation ceases to exist as a historical organism” (Letters to Gorbachev, 1987).

Review Essay: Popularizing Russian Language, Michael S. Gorham

Russian Language Journal

In an era rife with complaints over the degradation of language in the face of a host of commonly cited bugaboos (inferior schools, lazy pupils, declining morals, insidious new media technologies), one can only be heartened by the fact that language and language usage continue to be a source of popular discussion and debate. Even in American culture, where reverence for the national tongue has historically paled compared to the likes of France and Russia, one can find regular language-related rubrics in both print and broadcast media (e.g. “Word on the Street” and “Week in Words” [Wall St. Journal], “On …

Mapping The Literature Of Allied Health: Healthcare Chaplaincy, Emily Johnson, Diane Dodd Mccue, Alexander Tartaglia, Jennifer A. Mcdaniel

VCU Libraries Faculty and Staff Publications

OBJECTIVE: This study examined citation patterns and indexing coverage from 2008 to 2010 to determine (1) the core literature of health care chaplaincy and (2) the resources providing optimum coverage for the literature.

METHODS: Citations from three source journals (2008-2010 inclusive) were collected and analyzed according to the protocol created for the Mapping the Literature of Allied Health Professions Project. An analysis of indexing coverage by five databases was conducted. A secondary analysis of self-citations by source journals was also conducted.

RESULTS: The 3 source journals--Chaplaincy Today, the Journal of Health Care Chaplaincy, and the Journal of Pastoral Care and …

Social Network Development, Language Use, And Language Acquisition During Study Abroad: Arabic Language Learners’ Perspectives, Dan P. Dewey, R. Kirk Belnap, Rebecca Ann Hillstrom

Faculty Publications

Language learners and educators have subscribed to the belief that those who go abroad will have many opportunities to use the target language and will naturally become proficient. They also assume that language learners will develop relationships with native speakers allowing them to use the language and become more fluent, an assumption Pellegrino (Pellegrino, 1997, 1998) found to be held by study abroad participants. However, recent research has shown that students do not always use the language to the expected degree and that they often fall back on social relationships with native speakers of their own language (DeKeyser, 2007; Dewey, …

Applying A Mixed Methods Approach To Understanding And Evaluating The Effects Of Family Treatment Among Sexually Abusive Youth, Jamie R. Yoder

Electronic Theses and Dissertations

Families are frequently identified as a risk for supporting and perpetuating sexually abusive behavior among youth. Traditionally, the field has focused on deficits of families rather than considering them as a resource to promote change. Although emerging literature strongly argues the need to target families in the healing process, treatment initiatives rarely follow suite, and research has failed to comprehensively document the effectiveness of family-inclusive treatment. Knowing there are several gaps in literature, the current study was conducted to investigate the process of engagement in treatment, understand the nuances of family treatment, and to uncover positive outcomes associated with family …

Sustaining Juvenile Justice System Reform: A Report To The Louisiana Juvenile Justice Implementation Commission - Appendices, Institute For Public Health And Justice, Juvenile Justice System Reform

Policy & Position Papers

No abstract provided.