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"Characterization Of Red Diamondback Rattlesnake Venom Proteins On Cell Death And Function", Venus Ebrahimian

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Snake venom is composed of many different toxins and protein components such as metalloproteases and phospholipase A2. Together, these proteins cause an up regulation in cell death pathways and disrupt the overall homeostasis of a living cell. The Red Diamondback Rattlesnake is abundantly available and well-known specie and has been used as a source for development of new drugs. It has been mainly used for the purposes of making anti-venom but it has also been therapeutically used for surgical purposes to act as an anti-aggregate. Integrins derived from RDB venom has been used for cancer cell treatment as well. Specifically …

Locating Chelerythrine, An Alkaloid, Within A Cytosolic Environment By Maldi-Tof Mass Spectrometry, Bradley Allen Williams

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The quaternary benzo-phenanthridine alkaloid (QBA) chelerythrine (CET) is a well-known inhibitor of PKC and cancer growth (Herbert et al., 1990). In human lens epithelial cells (HLECs), CET almost completely inhibits the Na+/K+ pump ATPase (NKA) without changes in phosphorylation (Lauf et al. 2013). Protein alignment studies revealed B-lymphocyte type 2 protein (Bcl-2) BH1- like motifs within the a1 subunit of the NKA to which CET, a drug mimicking Bcl-2 protein BH3-like motifs, might bind thus disrupting NKA function (Lauf et al, 2013). It is unknown by which mechanism CET crosses the plasma membrane to reach its intracellular targets, especially the …

Al Qaeda's Propaganda War: A War For Hearts And Minds, Jill Hannah Pohl

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Literature on terrorist efforts to win over hearts and minds discusses several influential factors: the politics of the organization, the relationship of the organization to the public, levels of violence, provocation of counterterror responses, and the use of various forms of propaganda. It is my contention that mass media propaganda, which reaches the widest audience, is most influential in the battle for hearts and minds. Al Qaeda has exploited this tool to sustain support.

In spite of this, Arab Public Opinion Surveys show a decline in support for Al Qaeda's anti-Western goals, and fluctuations in support for its methods. They …

N-Glycosylation, Localization And Trafficking Of Endogenous Nkcc1 In Cos7 Cells, Richa Singh

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The Na+K+2Cl^- co-transporter-1 (NKCC1) effects the electroneutral movement of Na+, K+ and 2Cl^- ions across plasma membranes. NKCC1 is considered a widely distributed, highly N-glycosylated ion transporter involved in the regulation of the intracellular chloride concentration ([Cl^-]i), cell volume and salt secretion. NKCC1 locates in the plasma membrane of all cells studied so far, particularly on the basolateral side of most polarized cells. However, the majority of immunoreactive NKCC1 distributes in intracellular compartments of unknown nature whereas a small proportion of the transporter appears to be located in the plasma membrane. Here, we identified and characterized …

The Normative Ethics Of Gandhian Nonviolence, Jacob N. Bauer

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This thesis examines Mahatma Gandhi's ethical views on nonviolence from the perspective of contemporary philosophical ethics. Gandhian nonviolence is situated in the field of contemporary ethics by using the concepts and terminology from Shelly Kagan's work, Normative Ethics. Three questions are asked that classify and clarify Gandhian nonviolence. First, is nonviolence primarily instrumentally or intrinsically significant? This question is closely tied to the second, does Gandhian nonviolence belong to which type of ethical theory, consequentialism or deontology? And third, is nonviolence an absolutist constraint or a high threshold that allows for exceptions? Gandhi views nonviolence as both instrumentally and …

Distributed Sensor Fault Diagnosis For Automated Highway Systems, Hui Chen

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Fault diagnosis problems for large-scale nonlinear systems have attracted significant attentions from researchers in recent years. Most fault detection and isolation (FDI) methods have been proposed based on a centralized architecture. However, due to the complexity of the system, most of these centralized fault detection and diagnosis schemes are not able to delivery effective fault detection and isolation performance for a large-scale nonlinear system, which contains subsystems interacting with neighboring subsystems.

In this thesis, a distributed fault detection and isolation method is developed for the automated highway systems (AHS). For each subsystem of AHS, a distributed fault detection and isolation …

Rwanda: (Limited) Effects Of The First Female Parliamentary Majority In The World, Charlene Anita Raman-Preston

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The case of Rwanda provides a laboratory to explore a unique set of circumstances. This thesis builds upon feminist theory, the literature on post-conflict situations and failed states. It finds that although Rwanda's post-conflict situation provided unexpected and historic opportunities for women to enter politics (a record 64 percent of the members of parliament are female), more women in parliament does not mean the end of patriarchy. Since 1994, Rwanda has experienced significant yet limited progress toward gender equality in employment and education. However, much remains to be done and gender dynamics have not changed substantively. Rather, increasing the numbers …

Computational Analysis Of Vortex Structures In Flapping Flight, Zongxian Liang

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Vortex structures and vortical formation in flapping flight are directly related to the force production. To analyze the connection between vortex structures and aerodynamic performance of flapping flight, we have developed highly efficient algorithms for large-scale flow simulations with moving and deforming bodies. To further understand the underlying mechanisms of force generation caused by the coherent structures of the vortex formation, a new analysis method has been developed to measure the influence of Proper Orthogonal Decomposition (POD) modes on aerodynamic forces.

It is challenging to finish three-dimensional Direct Numerical Simulations (DNS) of insect flight in a limited amount of time. …

Accurate Splicing Of Hdac6 Requires Son, Vishnu Priya Chowdary Battini

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Pre-mRNA splicing requires proper splice site selection mediated by many factors including snRNPs and serine-arginine rich (SR) splicing factors. Son is the largest known SR splicing factor, and it has several putative functional domains including an RS domain, a glycine rich patch (G-patch) and double stranded RNA binding domain (DSRBD). One-third of Son's amino acid sequence consists of novel repetitive sequence motifs of unknown function (Sharma et al., 2010). Son is essential for organization of pre-mRNA processing factors in nuclear speckles and for cell cycle progression (Sharma et al., 2010; Sharma et al., 2011; Ahn et al 2011). Exon array …

A Methodology For Extracting Human Bodies From Still Images, Athanasios Tsitsoulis

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Monitoring and surveillance of humans is one of the most prominent applications of today and it is expected to be part of many future aspects of our life, for safety reasons, assisted living and many others. Many efforts have been made towards automatic and robust solutions, but the general problem is very challenging and remains still open. In this PhD dissertation we examine the problem from many perspectives. First, we study the performance of a hardware architecture designed for large-scale surveillance systems. Then, we focus on the general problem of human activity recognition, present an extensive survey of methodologies that …

Effects Of Red Diamondback Rattlesnake Venom On Keloid Dermal Fibroblasts In Vitro, Mackenzie Shelby Newman

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Keloid scarring is an inflammatory healing response to physical injury such as incision or piercing in the dermis. It is characterized by aberrant extracellular matrix production, the overaccumulation of mature collagen, and excessive fibroblast proliferation and migration beyond the borders of the original wound site. This results in swelling, depigmentation, itchiness, and pain akin to a benign tumor. Although there are myriad treatments for the condition, most are invasive and exhibit a high recurrence rate. Previous studies have shown that rattlesnake venom stimulates apoptosis in the skin via multiple specific mechanisms, largely composed of extracellular matrix and its receptors' interactions. …

The Grand Tour Gala, Exhibit Brochure, Kelly Robinson, Tim Bottorff

Rosen Library Exhibits

No abstract provided.

Being Ethically Minded: Practising The Scholarship Of Teaching And Learning In An Ethical Manner, Ruth L. Healey, Tina Bass, Johnette (Jay) Caulfield, Adam Hoffman, Michelle K. Mcginn, Janice Miller-Young, Martin Haigh

Management Faculty Research and Publications

The authors propose a working definition of ethical Scholarship of Teaching and Learning (SoTL), advance an ethical framework for SoTL inquiry, and present a case study that illustrates the complexity of ethical issues in SoTL. The Ethical SoTL Matrix is a flexible framework designed to support SoTL practitioners, particularly in the formative stages of their inquiries. Three dominant ethical traditions form the basis of the matrix: teleological or pragmatic, external, and deontological. The key message of the paper is that SoTL practitioners should reflect on different perspectives in their efforts to do what is right in any given situation. The …

Arkansas Animal Science Department Report 2012, David L. Kreider

Arkansas Agricultural Experiment Station Research Series

No abstract provided.

How Ideas Grow: Critical Mass In The Linear Threshold Model, Hossein Alidaee

Mathematics, Statistics, and Computer Science Honors Projects

We study how ideas spread through a social network using the Linear Threshold Model. Each node i on the complete graph K_n is given a threshold Ɵ_i chosen uniformly at random from (0, 1]. This threshold indicates the fraction of the social network that must be active (or believe the idea) prior to node i becoming active. We start with an activated group of early adopters, called the seed set. Considering various scenarios, we use the probabilistic method to find lower bounds on size of a seed set which guarantees that all nodes become active with high …

The Phylogenetics Of Tachinidae (Insecta: Diptera) With An Emphasis On Subfamily Structure, Daniel J. Davis

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The parasitoid flies of the Tachinidae family are an important and diverse (>10,000 species) lineage of insects. However, tachinids are not well studied partially due to their confusing classification and taxonomy. DNA sequences were obtained from twenty tribal representatives of Tachinidae, along with eight outgroups in order to phylogenetically reconstruct the superfamilial, subfamilial and tribal relationships of Tachinidae. Seven gene regions of six genes (18S, 28S, COI, CAD, Ef1a, and TPI) were sequenced for each taxon (6214 bp total). Both maximum likelihood and Bayesian methods were used to infer phylogenies. The Sarcophagidae and Oestridae were usually reconstructed as monophyletic. …

Rice, Tobacco, And Agricultural Globalization: Exploring The Narrative Of The Chinese Agricultural Colony In Sub-Saharan Africa, Hunter Bradley

Geography Honors Projects

According to media outlets, China's involvement in the Sub-Saharan African agricultural sector is part of a colonial land grab to meet the needs of a modernizing China. This paper challenges this narrative by examining the two constituent narrative elements: 1) China actively purchases land or land rights to meet the food needs at home and 2) that this process has led to decreased food security for African states. Using Zimbabwe and Mozambique as cases, this paper demonstrates China's participation is not part of a long-term food security strategy and is better understood in light of the "Go Out Policy." However, …

Design And Fabrication Of An Eddy Current Brake Dynamometer For Efficiency Determination Of Electric Wheelchair Motors, Wesley Brin

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Electric wheelchairs have a considerable impact on improving the quality of life for the millions of disabled persons around the world. These modern pieces of technology offer freedom and mobility for disabled persons to interact with the world outside of their homes. The goal of this project is to assist in advancements of conventional electric wheelchairs. This includes replacing the heavy, bulky, and inefficient lead acid batteries and worm gear drive systems with lithium-ion batteries and wheel hub motors in order to decrease weight and size, and increase efficiency. This master thesis research is focused on designing, fabricating, and testing …

Anomalies In Sensor Network Deployments: Analysis, Modeling, And Detection, Giovani Rimon Abuaitah

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A sensor network serves as a vital source for collecting raw sensory data. Sensor data are later processed, analyzed, visualized, and reasoned over with the help of several decision making tools. A decision making process can be disastrously misled by a small portion of anomalous sensor readings. Therefore, there has been a vast demand for mechanisms that identify and then eliminate such anomalies in order to ensure the quality, integrity, and/or trustworthiness of the raw sensory data before they can even be interpreted.

Prior to identifying anomalies, it is essential to understand the various anomalous behaviors prevalent in a sensor …

Heuristics: Bias Vs. Smart Instrument. An Exploration Of The Hot Hand, Jehangir Cooper

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Classical perspectives on judgment and rationality view heuristics as erroneous, leading to suboptimal judgments. Conversely, ecological perspectives view heuristics as smart mechanisms that result in good judgments in the face of uncertainty. Our research focused on the hot hand heuristic and examined it using non-linear analysis methods. This research attempted to answer two questions. The first question concerned the applicability of frequency analysis methods for detecting constraints (such as the hot hand) or structure in a time series of binary data, which we attempted to investigate through Monte Carlo simulations. We found that this method was sensitive enough to detect …

The Synthesis Of Haplomyrtin Utilizing The Triisopropylsilyl Protecting Group, William S. Barrow

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The synthesis of the arylnaphthalene lignan haplomyrtin using vanillin as a starting material is synthesized via: 1) a bromination of vanillin, 4-hydroxy-5-methoxybenzaldehyde, to produce 6-bromovanillin 2) a hydroxyl protection step of 6-bromovanillin with triisopropylsilylchloride to produce 2-bromo-4-triisopropylsilyoxy-5-methoxybenzaldehyde 3) an aldehyde protection step through a cyclic acetal formation using ethylene glycol to produce 2-(2-bromo-4-triisopropylsilyloxy-5-methoxyphenyl)-1,3-dioxolane 4) a lithium for halogen exchange of the doubly protected 6-bromovanillin leads to neucleophilic coupling with piperonal producing 1,3-benzodioxol-5-yl-[5-triisopropylsilyloxy-2-(1,3-dioxolane-2-yl)-4-methoxyphenyl]methanol and 5) an acid catalyzed intramolecular cycloaddition /Diels Alder adduct with dimethyl acetylenedicarboxylate producing dimethyl 1-(1,3-benzodioxol-5-yl)-4-hydroxy-6-methoxy-7-triisopropylsilyloxynaphthalene-2,3-dicarboxylate.

Modeling And Minimization Of Integrated Circuit Packaging Parasitics At Radio Frequencies, Christopher Benedik

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Many integrated circuits are connected to their packaging pins through bondwires. Due to the low cost of bondwires, there is interest in extending operating frequencies or negating their effects in order to keep the price of packaged integrated circuits as low as possible. Bondwires function as lumped circuits consisting of inductors, capacitors, and resistors which can be modeled based on wire geometry. Knowing this, models can be created which approximate the effects of bondwires. With the knowledge of these models, compensation techniques can be implemented which will match the bondwire impedance to the signal line impedance. The effects of these …

Can Antibiotics From Recently Discovered Marine Actinobacteria Slow The Tide Of Antibiotic Resistance?, Lorraine Susan Tangeman

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Actinobacteria, one phylum of gram positive bacteria, are found throughout all the environments on earth. Actinobacteria have long been studied for the benefits they provide, both to their environment and to humans, and have a great capacity for adaptation and evolution. They decompose organic matter, replenishing nutrients into the soil, and as such are important members of the food chain. Humans benefit from the exploitation of Actinobacterial metabolites as antimicrobial drugs. These antimicrobials have been effectively utilized for decades in the fight against infectious disease. Despite the success of this drug arsenal we are now in the midst of an …

Fabrication Of Responsive Polymer Brushes For Patterned Cell Growth And Detachment, Ashley B. Sutherland

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Patterned polymer brushes are used in biological applications to enhance cell function and to achieve selective cell growth. These patterned surfaces have a variety of applications, including cell sheet harvesting and tissue engineering. This work describes creation of chemical, topological, and responsive patterns on glass by sequential surface-initiated polymerization of poly(N-isopropylacrylamide)-co-(2-hydroxyethyl methacrylate) (pNIPAM-co-HEMA) and subsequent use of UV lithography to pattern the surface with pNIPAM. The cell adhesion peptide, RGD, is then immobilized on the surface of the copolymer pHEMA via DSC-coupling to spatially enhance cell adhesion properties. By culturing cells at 37 degrees celsius, cells selectively grow on DSC-activated …

Flash Lag Effect Model Discrimination, Stephen R. Gabbard

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The purpose of this study was to test the various models describing the Flash Lag Effect (FLE). Beginning with the initial work of Nijhawan (1994), several models have emerged endeavoring to explain the FLE (e.g., Eagleman & Sejnowski, 2000; Whitney, 2000; Baldo & Caticha, 2005). Two series of studies comprising 11 separate experiments were undertaken to differentiate these models, with a particular focus on the neural network model of Baldo and Caticha (2005). The experiments included the three primary FLE experimental paradigms: continuous motion (CM), flash-initiated (FIC) and flash-terminated (FTC). Ninety-three participants made observations in these three paradigms using a …

Effects Of Ang 1-7 And Endothelial Microvesicles On Ang Ii-Induced Dysfunction And Apoptosis In Cerebral Endothelial Cells, Xiang Xiao

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Angiotensin II (Ang II) induces endothelial dysfunction and is implicated in the pathogenesis of vascular diseases. Angiotensin 1-7 (Ang 1-7) has been reported to counteract many deleterious effects of Ang II. Endothelial microvesicles (EMVs) are small membrane vesicles released from endothelial cells (ECs) undergoing stress and apoptosis. But their functions are largely unknown. In this study, we investigated the effects of Ang 1-7 and EMVs on apoptosis and dysfunction of human brain microvascular endothelial cells (HbmECs). Reactive oxygen species (ROS) and nitric oxide (NO) production, and Nox2, p-Akt/Akt, p-eNOS/eNOS expression were analyzed. We found that Ang II dose-dependently induced HbmEC …

Likely Successors Of Ash Species In Response To The Emerald Ash Borer In Ohio Forests, Brian Michael Good

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Invasive species have the capability to alter landscapes and change the composition of a forest in a very short time. The recent invasive pest, Agrilus planipennis, emerald ash borer, was unintentionally introduced to the United States via ship route to Michigan. The pest attacks and kills all five native ash species in Ohio. This study focused on an area in west central Ohio not yet affected by the borer. Ash centered plots were used to record all species and sizes (diameter at breast height) within a 5m radius of a central ash tree. Plots ranged in topography and all five …

Visualizing Confusion Matrices For Multidimensional Signal Detection Correlational Methods And Semantic Cluster Based Visualization In Virtual Environments, Yue Zhou

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General Recognition Theory (GRT) is a multidimensional signal detection theory framework for capturing sources of perceptual and decisional dependence. The primary type of data for GRT models is an identification-confusion matrix derived in a complete factorial identification task. This confusion matrix plots the responses of study participant for a given signal. The responses may reveal that participants were unable to recognize the signal properly. Such violations of any type of independence in the GRT framework result in response patterns that reflect some form of correlation in the GRT space. While an individual confusion matrix is rather small and relatively easy …

Batterer's Intervention Program: The Partner's Perspective, Megan Denae Nichols

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The following study attempted to determine the effectiveness of the Preventing Abuse in the Home (PATH) batterer's intervention program from the perspective of the partners of men enrolled in the program. The partner's perspective was obtained through the collection of qualitative data from interviews conducted with women who were currently or recently involved with men who had been participating in the PATH program for a minimum of 16 weeks. Interview questions were created based upon several variables including review of empirical literature and specific questions that researchers were interested in addressing in regards to PATH. Results highlighted the various types …

Novel Approaches For The Eradication Of Hiv Latently Infected Cells, Sally Al Ali

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The development of a suitable experimental cell model to study HIV latency in primary cells could have a massive effect on the current approaches to eradicate virus in latently infected cells. The main proposal of this paper is to develop an in vitro HIV cell model that represents HIV latency in vivo, then to create a more effective viral vector in order to target HIV reservoirs. For this goal, a directed evolution method is suggested to be used in order to mutate the AAV cap gene to generate a recombinant AAV vector that is capable of infecting primary resting CD4+ …