Digital Commons Network^™

Synthesis And Preliminary Biological Screening Of Bis-Aroyl Methanes And Chemically-Modified Curcumins As Matrix Metalloproteinse Inhibitors, Yijun Chen

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Matrix Metalloproteinases (MMPs) are a family of more than 25 structurally-related enzymes that can degrade a variety of substances including collagen. Basal levels of these enzymes play an important role in tissue turnover under normal physiological conditions, while excessive levels of these enzymes may cause or exacerbate many diseases related to tissue loss, including arthritis, cancer, cardiovascular disease, coma, periodontal disease, stroke etc. For decades, research teams from both industrial companies and academic institutions have been trying to develop an effective matrix metalloproteinase inhibitor as a drug to treat MMP-involved diseases. Our group have been working on MMP inhibitor development …

Part I. Stereospecific Synthesis Of Vinyl Iodides: Iododesilylation Of Homoallylic Alcohol Derivatives Part Ii. Model Studies, A Formal Synthesis Of (-)-Englerin A, And The Total Synthesis And Biological Evaluation Of New Englerin Analogs, Daniel Craig Elliott

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Part I. Vinyl iodides with defined geometry are important chemical building blocks. Their preparation by iododesilylation of the corresponding vinyl silane is an attractive method. Kishi et al. have shown that if iododesilylation is carried out with N-iodosuccinimide (NIS) in an acetonitrile/chloroacetonitrile mixture, one obtains vinyl iodides in which the geometry of the olefin is highly retained. By carrying out iododesilylation with NIS in hexafluoroisopropanol, Zakarian et al. have shown that the olefin geometry is also retained, but to a larger degree. Previously, the Parker group has applied this methodology to a synthetic study of trisubstituted vinyl iodides. Therein, they …

Untangling The Interactions: Structural Basis Of Nitric Oxide Regulated Cyclic-Di-Gmp Metabolism In Bacteria, Tanaya Lahiri

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Bacteria use numerous small molecules for cellular signaling. These primary and secondary messengers act within the cell to relay signal transduction and regulate distinct pathways. Among these the diatomic gas molecule nitric oxide (NO) and the nucleotide cyclic-di-GMP play central role in virulence, quorum sensing, and biofilm formation. In this dissertation, we have focused on H-NOX, a heme-nitric oxide/oxygen binding protein in the biofilm-dwelling bacterium Shewanella woodyi (Sw), which mediates NO-induced biofilm dispersal by modulating the activity of a dual-functioning diguanylate cyclase/phosphodiesterase enzyme that we have named HaCE, (H-NOX-associated cyclic-di-GMP enzyme). These enzymes tightly regulate the intracellular spatio-temporal concentrations of …

Macrocyclic Host-Guest Framework For Polymerization Of Diiodobutadiyne, Xianzhi Liu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Conjugated organic polymers have optical and electronic properties that make them candidates for applications in organic field effect transistors (OFETs) and light emitting materials. Polydiacetylenes (PDAs) are an important branch of conjugated polymers with alternating poly(ene-yne) structure. The all-carbon polymer without any side groups is carbyne, which has only alternating single and triple carbon-carbon bonds. Carbyne provides a good opportunity to investigate the inherent properties of conjugated polymers. Polydiiododiacetylene (PIDA), a simple PDA with only iodine atom substituents, can be successfully obtained by the topochemical polymerization of the monomer diiodobutadiyne. This polymerization is achieved through the use of bis(nitrile) or …

Poly(Diiododiacetylene): A Potential Precursor For New All-Carbon Materials, Daniel Joseph Resch

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Poly(diiododiacetylene) (PIDA) is a polymer consisting entirely of carbon and iodine. The polymer is prepared by cocrystallizing a bis(nitrile) oxalamide host with the monomer diiodobutadiyne. These compounds are held together by a halogen bond and an ordered 1,4-topochemical polymerization occurs in the solid state. The formation of the monomer cocrystals was found to be highly solvent dependent. Acetonitrile was found to greatly improve the yield of cocrystals over solvents used in the past. Cocrystals could not be obtained from other solvents such as dimethoxyethane and acetone. THF did give some cocrystal but the yield was poor. The use of acetonitrile …

The Structural And Relative Stability Of Temperament In Young Children Based On A Laboratory-Observational Measure, Margaret Wegner Dyson

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Despite the continued debate regarding the structure of temperament in young children, it is often assumed that temperament traits demonstrate temporal stability over time. This research has relied predominately on parent-report measures. The present study used an alternative approach, a laboratory-observational measure (Laboratory Temperament Assessment Battery [Lab-TAB]), to examine the structural and relative stability of temperament traits in a community sample of young children (N = 440). Using structural equation modeling (SEM), we derived a similar five-factor structure consisting of the dimensions of Positive Affect/Interest, Sociability, Dysphoria, Fear/Inhibition, and Impulsivity vs. Constraint at both age 3 and 6 years, suggesting …

Investigation Of The Mouse Sperm Acrosome Reaction With Synthetic Glycopolymers, Linghui Wu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The sperm acrosome reaction (AR), an essential step in mammalian fertilization, is mediated by a highly species-specific interaction of sperm surface molecules with glycan moieties on the egg. Many previous studies indicate that a subset of terminal carbohydrate residues on the mouse egg zona pellucida (ZP) trigger the AR by cross-linking or aggregating receptors on the sperm membrane. However, the exact role of those carbohydrates in AR has not been identified and the mechanism underlying the induction of the AR still needs further investigation. To study this process, a series of synthetic glycopolymers were synthesized. The glycopolymer is composed of …

Extinction Risk Assessment As A Tool For Biological Conservation, Jessica Carol Stanton

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Effective conservation of biological diversity requires accurate assessments of species extinction risks. Both under- and over-estimating extinction risks can have serious consequences. Overlooking species that are in need of conservation management can result in extinction or expensive recovery efforts. Misidentifying species which have stable populations as threatened can misdirect limited conservation resources or unnecessarily halt economic activity and development. I used a retrospective multi-modeling framework to explore the extinction of a once abundant and wide-spread North American species, the Passenger Pigeon (Ectopistes migratorius). I simulated three different types of anthropogenic impacts: harvest, habitat loss, and nest disturbance. I …

Systematic Modeling And Characterization Of Analog Circuits Using Symbolic And Data Mining Techniques, Cristian Ferent

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Analog circuit design activities mainly depend on designers' expertise and their ability to produce new designs by combining basic devices, sub-circuits, and ideas from similar solutions as the source for innovation. There are very few systematic methods that can characterize similarities and differences between analog circuits while maintaining the correlation between design variables, performance, and trade-offs. Moreover, many computer-aided design tools are focused only on routine tasks, like transistor sizing and layout design. This dissertation presents novel techniques to automatically characterize the analog design space based on feature uniqueness and variety and to perform systematic circuit comparisons using symbolic models. …

Protecting The " House Beautiful" : Eco-Consciousness In The Victorian Novel, Margaret Kennedy

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation discusses how literary writers of the Victorian age render toxicity and toxic behaviors visible in order to encourage reform, as well as offering models of healthy environmental engagement. This literary trend reveals what I call a rising eco-consciousness, the awareness of our relationship to the environment and the exchanges between human and nonhuman. This project emphasizes the novel, which offers a rich ground of inquiry by looking at a set of characters interacting with a space over time; in other words, it focuses on how authors mapped a complete ecology into their fiction, participating in a genre that …

Language, Science, Society, And The Line Between Human And Animal In Swift's Gulliver's Travels And Wells's The Island Of Doctor Moreau, Adam Schultheiss

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This thesis examines line between human and non-human animals in Jonathan Swift's Gulliver's Travels and H.G. Wells's The Island of Doctor Moreau. Both Gulliver's Travels and The Island of Doctor Moreau examine this separation through the prism of language, societal views of animality, and biology. Looking back at the history surrounding the idea that man is separate from, and superior to, animals, one finds that it can be traced back in western tradition to the Bible, and is so ingrained in our language that it is difficult for narrators such as Lemuel Gulliver and Edward Prendick to recount their experiences …

New Development On Market Microstructure And Macrostructure: Patterns Of U.S. High Frequency Data And A Unified Factor Model Framework, Xu Dong

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In this thesis we study the problem of modeling cross-sectional volatility structure of U.S. stock market. The thesis contains two parts. In the first part we identify a particular volatility spike phenomenon, that the cross-sectional volatility is significantly stronger at every 5 minute. An empirical spike study is conducted on individual stock level by applying Lee-Mykland jump detector. By constructing spike ratio statistics, the evolving paths of this spike phenomenon is studied during the 1993 to 2009 time period. In the second part, we model the volatility structure using factor structures. Particular, we propose two approaches to build a better …

Francisella Tularensis: Interactions With Hepatocytes And Pathways For The Acquisition Of Iron, Cindy Arisa Thomas-Charles

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

ABSTRACT OF THE DISSERTATION Francisella tularensis: Interactions with Hepatocytes and Pathways for the Acquisition of Iron by Cindy A. Thomas-Charles Doctor of Philosophy in Genetics Stony Brook University 2013 Francisella tularensis is a Gram-negative, facultative intracellular bacterium and the causative agent of tularemia. Due to its high virulence, this organism has been classified as a Tier 1 select agent of bioterrorism. Regardless of the route of inoculation, the lungs, spleen, and liver are major targets of infection. Furthermore, this organism replicates to high numbers in hepatocytes, the predominant cells in the liver. Factors that mediate the uptake by and replication …

" Don't Mask It, Fix It" : Distinguishing Characteristics Of Complementary And Alternative Medicine Patients With Chronic Pain And Their Pathways Toward Pain Resolution, Misty Amadona Curreli

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The sociological literature on pain and the body largely emphasizes the social and cultural dynamics of suffering. Within this realm, the medical institution is often paramount in regulating how pain is understood and the responses that are appropriate in managing pain. Less is known about other forms of healthcare that treat pain, namely Complementary and Alternative Medicine (CAM). While most research explains the overall " who" of the population of CAM users, few studies address the " why" and the overall effects of using a nonconventional system of medicine. This research is aimed at discerning health beliefs and behaviors that …

Species Composition And Reproductive Strategies Of Commensal Synalpheus Shrimp (Decapoda:Alpheidae) Occupying The Sponges Spheciospongia Vesparium And Spongia Sp. Of The Florida Reef Tract, Brittnee Nicole Barris

HCNSO Student Theses and Dissertations

Synalpheus shrimp species of the gambarelloides group are the only marine organisms displaying the highest level of social functioning, eusociality. Their social hierarchies are equally complex compared to the reproductive abnormalities that have been recently discovered. For instance, snapping shrimp of the genus Synalpheus were thought to be gonochoric, i.e. developing as independent sexes, until scanning electron microscopy studies revealed intersexed gonopores in several species. This project analyzed both the species composition, and accompanying reproductive structures, of Synalpheus spp. (Caridea: Alpheidae) comprised of densely aggregating communal and pair-living colonies in the Florida Keys, Florida.

Colonies of pair-living and communal Synalpheus …

The Battle Over The Embryo: How West Virginia Should Legally Define The Embryo And Regulate Embryo Adoption, Alyssa Lechmanik

West Virginia Law Review

No abstract provided.

Racial Differences In Human Platelet Par4 Reactivity Reflect Expression Of Pctp And Mir-376c., Leonard Edelstein, Lukas M Simon, Raúl Teruel Montoya, Michael Holinstat, Edward S Chen, Angela Bergeron, Xianguo Kong, Srikanth Nagalla, Narla Mohandas, David E Cohen, Jing-Fei Dong, Chad Shaw, Paul Bray

Cardeza Foundation for Hematologic Research

Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black (n = 70) and white (n = 84) subjects. Platelet aggregation and calcium mobilization induced by the PAR4 thrombin receptor were significantly greater in black subjects. Numerous differentially expressed RNAs were associated with both race and PAR4 reactivity, including PCTP (encoding phosphatidylcholine transfer protein), and platelets from black subjects expressed higher levels of PC-TP protein. PC-TP inhibition or depletion blocked PAR4- but not PAR1-mediated activation of platelets and megakaryocytic cell lines. miR-376c levels were differentially expressed by race and …

Effect The Natural Lighting In The Visual Comfort & Workers Satisfaction In Industrial Companies, Atheer Abdullah Mohammed

Journal of Economics and Administrative Sciences

Energy crisis and the requirements of health and feel good, all this renewed attention to the importance of natural lighting in all kinds of factories. Research problem was how to achieve the plant's own natural outlets visual comfort and satisfaction of workers in Companies, the industries of cotton and general al-fedaa. The research compuns address the impact of daylight to provide visual comfort in the factory. Indeed, the light must be treated very carefully, and natural lighting should be thinking from the perspective of the occupants of the plant and not wishing to view from the outside, but enjoy the …

Using High-Throughput Illumina Sequencing To Infer Evolutionary Dynamics Of Simple Sequence Repeats Across Squamate Genomes, Laura Drzich

McNair Scholars Research Journal

No abstract provided.

Temperature-Sensitive Nanoparticles For Lung Cancer Treatment, Khanh Vu

McNair Scholars Research Journal

No abstract provided.

Granite State College, University System Of New Hampshire 2013-2014 Undergraduate Catalog, Granite State College

Granite State College Catalogs

No abstract provided.

Perception And Decision At The Threshold Of Tort Law: Explaining The Infrequency Of Claims, David M. Engel

DePaul Law Review

No abstract provided.

When Institutions Fail: The Case Of Underage Marriage In India, Michele Goodwin

DePaul Law Review

No abstract provided.

Compensation For Terrorism: What We Are Learning, Marshall S. Shapo

DePaul Law Review

No abstract provided.

Scitech Book News Reviews, Susan Fingerman

Sci-Tech News

No abstract provided.

Full Issue, Vol. 67, Issue 4

Sci-Tech News

No abstract provided.

Development And Verification Of A Test System To Quantify Strain Of An Optical Displacement Indicator And The Design Of A Strain Indicating Prototype, Josh Lake

All Theses

The organic-rich Middle Devonian Marcellus Shale of the Appalachian basin is a rapidly developing natural gas play. Stratigraphic boundaries of the Marcellus Shale in Westmoreland County, Pennsylvania were identified using geophysical logs from 10 vertical gas-producing wells in a 23 sq. km area. Gamma-ray, bulk density, and resistivity well logs were examined to assess hydrocarbon potential. Values of porosity, total organic carbon (TOC), and water saturation (SW) were derived and mapped by incorporating well-log data into Marcellus-specific formulas. Gamma-ray, penetration (minutes per foot drilled), and mud-logging gas (total gas) from 12 horizontal wells from within the study area were also …

Charles R. Garoian: Exploring The In-Between, Leda Cempellin

School of Design Faculty Publications

No abstract provided.

Cost And Embodied Energy Optimization Of Rectangular Reinforced Concrete Beams, Alexander Kosloski

All Theses

Concrete has a large environmental footprint so it is desirable to find ways to efficiently design structural members. Engineers can exercise their abilities early on in the design phase of construction projects to reduce the environmental footprint by minimizing the amount of materials required. One way to achieve these results is to optimize the design of structural concrete. In this study, simple-span rectangular reinforced concrete (RC) beams with a range of different bending moments were analyzed. The primary goal was to combine life cycle analysis (LCA), numerical optimization, and reinforced concrete mechanics to create a framework for designing efficient RC …

Aqueous Geochemistry Of Rhenium And Chromium In Saltstone: Implications For Understanding Technetium Mobility In Saltstone, Amanda Hatfield

All Theses

Incorporation of low level radioactive waste in cementitious materials is an important waste disposal technology in practice at a U.S. DOE facility, the Savannah River Site (SRS), Aiken, SC. One of the major risk drivers, technetium (99Tc)