Digital Commons Network^™

Synthesis Of Sulfamoyl­‐Aminoacyl Adenylate Analogs For Use In Protein‐Rna Structure Determination, Emil Mikael Nilsson

University Honors Theses

Substrate analogs are small molecules that aid in the understanding of enzyme structure-­‐function relationships. By careful design they can be utilized to probe the nature of the transition state in catalysis, and to assist in the process of rational drug design. Aminoacyl-­‐sulfamoyl adenylate transition state analogs (aa-­‐ AMS) are analogs of the aminoacyl adenylate reaction intermediate in aminoacylation by aminoacyl-­‐tRNA synthetases (aaRS). To better understand the chemical mechanism of aaRS, aa-­‐AMS are used in crystallography experiments where x-­‐ray diffraction helps reveal interactions crucial to catalysis. Here we report the complete synthesis and purification of Ile-­‐AMS. The four-­‐step process proceeds via …

Interview With Maggie Michaels, Portland Public Schools, 2013 (Audio), Maggie Michaels

All Sustainability History Project Oral Histories

Interview of Maggie Michaels by Carmen Vigil in NE Portland, Oregon on May 23rd, 2013.

The interview index is available for download.

Hepatitis C Virus, Cholesterol And Lipoproteins — Impact For The Viral Life Cycle And Pathogenesis Of Liver Disease, Daniel J. Felmlee, Mohamed Lamine Hafirassou, Mathieu Lefevre, Thomas F. Baumert, Catherine Schuster

Peninsula Medical School

Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore, virus production is dependent on hepatic very-low-density lipoprotein (VLDL) assembly, and circulating virions are physically associated with lipoproteins in complexes termed lipoviral particles. Evidence has indicated several functional roles for the formation of these complexes, including co-opting of lipoprotein receptors for attachment and entry, concealing epitopes to facilitate immune escape, and hijacking host factors for HCV maturation and secretion. Here, we review …

Letting The Apes Run The Zoo: Using Tort Law To Provide Animals With A Legal Voice, Tania Rice

Pepperdine Law Review

Science is increasingly showing us that animals have many cognitive similarities with humans. In addition to calls for changes in our animal protection statutes, members of the legal community have begun debating over whether animals, or a certain category of animals, should be granted legal rights. This approach has the potential for drastic societal ramifications. David S. Favre has proposed a tort action for animals as a compromise to the animal rights debate. This Comment explores the different approaches to seeking improved conditions for animals, and proposes an adjusted tort cause of action in response to criticisms of Favre's tort.

Insurrectionary Heroines: The Possibilities And Limits Of Women’S Radical Action During The French Revolution, Sean M. Wright

Grand Valley Journal of History

The article titled, Insurrectionary Heroines: The Possibilities and Limits of Women’s Radical Action During the French Revolution, gathers research materials from multiple primary and secondary sources to generate an analysis of women’s participation in the French Revolution. The focus of this analysis draws on how these women confronted the Early Modern European female status quo through the use of radical action during the Revolution, which ultimately led to the creation of new possibilities for women's participation in society and revealed the limitations of this new found participation. Radical action is defined by four major events in the article: the female …

Students Experience Guatemala With Common Book Author Kelsey Timmerman, Winthrop University

Winthrop News 2013

• Students spent seven days in Guatemala, visiting fair trade cooperatives and coffee farmers and touring the area.
• Kelsey Timmerman wrote the 2012-13 Common Book, "Where Am I Wearing?"

Coevolution Of Nonlinear Trends In Vegetation, Soils, And Topography With Elevation And Slope Aspect: A Case Study In The Sky Islands Of Southern Arizona, Jon D. Pelletier, Greg A. Barron-Gafford, David D. Breshears, Paul D. Brooks, Jon Chorover, Matej Durcik, Ciaran J. Harman, Travis E. Huxman, Kathleen A. Lohse, Rebecca Lybrand, Tom Meixner, Jennifer C. Mcintosh, Shirley A. Papuga, Craig Rasmussen, Marcel Schaap, Tyson L. Swetnam, Peter A. Troch

Environmental Science and Geology Faculty Research Publications

Feedbacks among vegetation dynamics, pedogenesis, and topographic development affect the “critical zone”—the living filter for Earth’s hydrologic, biogeochemical, and rock/sediment cycles. Assessing the importance of such feedbacks, which may be particularly pronounced in water-limited systems, remains a fundamental interdisciplinary challenge. The sky islands of southern Arizona offer an unusually well-defined natural experiment involving such feedbacks because mean annual precipitation varies by a factor of five over distances of approximately 10 km in areas of similar rock type (granite) and tectonic history. Here we compile high-resolution, spatially distributed data for Effective Energy and Mass Transfer (EEMT: the energy available to drive …

Cal Poly Students Succeed At Statewide Csu Research Competition, Public Affairs Office

Press Releases

No abstract provided.

Ground-Penetrating Radar, Resistivity And Spontaneous Potential Investigations Of A Contaminated Aquifer Near Cancún, Mexico, Philip J. Carpenter, Ryan F. Adams, Melissa Lenczewski, Rosa M. Leal-Bautista

Sinkhole Conference 2013

pg(s) 231-237

Mapping Surface And Subsurface Karst Geohazards For Highway Projects: Sr 71 South Knoxville Boulevard Extension, Knox County, Tennessee, Harry L. Moore

Sinkhole Conference 2013

pg(s) 421-431

Towards A Karst Assessment Standard Practice, Robert K. Denton Jr

Sinkhole Conference 2013

pg(s) 1-12

Genome-Wide Identification Of Transcriptional Targets Of Rora Reveals Direct Regulation Of Multiple Genes Associated With Autism Spectrum Disorder, Tewarit Sarachana, Valerie Wailin Hu

Biochemistry and Molecular Medicine Faculty Publications

No abstract provided.

Geophysical Investigations Of The Edwards-Trinity Aquifer System At Multiple Scales: Interpreting Airborne And Direct-Current Resistivity In Karst, Marcus O. Gary, Dale F. Rucker, Bruce D. Smith, David V. Smith, Kevin Befus

Sinkhole Conference 2013

pg(s) 195-206

Government Canyon State Natural Area: An Emerging Model For Karst Management, George Veni

Sinkhole Conference 2013

pg(s) 433-440

Geophysical Investigations Of The Edwards-Trinity Aquifer System At Multiple Scales: Interpreting Airborne And Direct-Current Resistivity In Karst Nckri Symposium 2: Proceedings Of The Thirteenth Multidisciplinary Conference On Sinkholes And The Engineering And Environmental Impacts Of Karst, Marcus O. Gary, Dale F. Rucker, Bruce D. Smith

KIP Talks and Conferences

pg(s) 195-206 Electrical and electromagnetic geophysical characterization is a proven tool for delineating obscured subterranean karstic features, such as caves, sinkholes, and solution enlarged fissures. Geophysical characterizations allow a wide range of deployment scales; airborne methods can accommodate a regional view on the order of kilometers, and ground-based methods can follow up with focused data on the order of meters. A helicopter frequency domain electro-magnetic (HFDEM) survey and ground-based direct-current electrical resistivity imaging (DC-ERI) geophysical studies at the Camp Bullis Military Training Site (Camp Bullis) in central Texas have been used to characterize permeability properties of the Edwards and Trinity …

Delineating Source Areas To Cave Drips And Cave Streams In Austin Texas, Usa Nckri Symposium 2: Proceedings Of The Thirteenth Multidisciplinary Conference On Sinkholes And The Engineering And Environmental Impacts Of Karst, Nico Mark Hauwert, Brian Cowan

KIP Talks and Conferences

pg(s) 353-365 Delineating the source area of cave drips and streams (subsurface infiltration catchment area) is important for maintaining high-quality water sources critical for healthy cave ecosystems. In order to focus protection for cave ecosystems, particularly those containing federally listed species, it is necessary to accurately delineate the potential contributing infiltration area with high confidence. Various methods are used in conjunction to delineate subsurface infiltration catchment areas in four Balcones Escarpment sites (Buttercup Creek, Barker Ranch #1 Cave, McNeil Drive, and Davis Lane). The methods consists of 1) observation and flow measurement of drips, speleothems, pools, and streams under wet …

Restoring Land And Managing Karst To Protect Water Quality And Quantity At Barton Springs, Austin, Texas Nckri Symposium 2: Proceedings Of The Thirteenth Multidisciplinary Conference On Sinkholes And The Engineering And Environmental Impacts Of Karst, Kevin Thuesen

KIP Talks and Conferences

The Water Quality Protection Lands program was established in 1998 based on a bond proposal passed to protect Barton Springs in the heart of Austin, Texas. Barton Springs is a popular swimming area for citizens and is also home to at least one federally endangered species of salamander. The initial bond called for 6,070 hectares of land to be protected. Land acquisition has benefitted from additional bonds since then as well the use of grants to raise the total acreage to over 10,731 hectares at present. Additional cost saving measures such as the use of conservation easements have allowed these …

Mapping Surface And Subsurface Karst Geohazards For Highway Projects: Sr 71 South Knoxville Boulevard Extension, Knox County, Tennessee Nckri Symposium 2: Proceedings Of The Thirteenth Multidisciplinary Conference On Sinkholes And The Engineering And Environmental Impacts Of Karst, Harry L. Moore

KIP Talks and Conferences

pg(s) 421-431 The proposed extension of SR 71 (South Knoxville Boulevard) located in Knoxville, Tennessee necessitated a preliminary geologic evaluation of the corridor which was under consideration by the Tennessee Department of Transportation. A geohazards review disclosed the presence of extensive karst terrain located within the corridor being considered. A number of caves were also found during the investigation. The proposed routes within the study corridor were found to cross a series of very large multiple hectare (acre) sinkholes. In addition, a biological investigation of the route revealed the presence of a rare and endangered species of cave salamander called …

Government Canyon State Natural Area: An Emerging Model For Karst Management Nckri Symposium 2: Proceedings Of The Thirteenth Multidisciplinary Conference On Sinkholes And The Engineering And Environmental Impacts Of Karst, George Veni

KIP Talks and Conferences

pg(s) 433-440 Government Canyon State Natural Area (GCSNA) is located on the northwest edge of San Antonio, Texas, USA. Ninety percent of the 47.04 km2 property is located on the recharge zone of the karstic Edwards (Balcones Fault Zone) Aquifer. Urban development is encroaching onto the Edwards Aquifer karst and threatening groundwater quality and karst ecosystems. GCSNA has served as a model for karst management by: * defining existing resources; * restoring impacted resources; * monitoring and protecting groundwater quality and quantity by encompassing 62% of the 30.46-km2 Government Canyon watershed on the Edwards Aquifer recharge and contributing zones, and …

The Need For Presumptive Habitat Considerations In Working With Subterranean Aquatic Species Of Concern: Three Ozark Region Case Histories, Usa Nckri Symposium 2: Proceedings Of The Thirteenth Multidisciplinary Conference On Sinkholes And The Engineering And Environmental Impacts Of Karst, Shiloh L. Beeman, Thomas J. Aley, Michael Slay

KIP Talks and Conferences

pg(s) 377-381 Delineating habitats for aquatic species of concern present in groundwater systems, and especially those in karst groundwater systems, presents challenges. It is not reasonable to limit the delineated habitat to those portions of a groundwater system that can be directly observed. How then do we make reasonable delineations? Three case histories in the Ozarks region of the central USA illustrate differing approaches for identifying presumptive habitat in recharge area delineations for subterranean species of concern. The first case study of the Tumbling Creek Cavesnail explores the reasoning for designating presumptive habitat downgradient of observed habitat in a cave …

Towards A Karst Assessment Standard Practice Nckri Symposium 2: Proceedings Of The Thirteenth Multidisciplinary Conference On Sinkholes And The Engineering And Environmental Impacts Of Karst, Robert K. Denton Jr.

KIP Talks and Conferences

The assessment of karst conditions and putative karst geohazards prior to residential and commercial development is currently in its infancy, from a scientific aspect. Borrowing from the medical lexicon, most karst features at proposed building sites are dealt with using an approach wherein the "symptoms and conditions" are treated (e.g. sinkhole remediation), often only after site development activities have commenced. If karst hazards are suspected, roadways, foundations and specific at-risk areas may be investigated using various geophysical methods; however the results of these investigations require specialized knowledge to be interpreted and understood. Thus stakeholders without geological training may find the …

05-22-2013 Swosu Trio Wins Grant To Develop Software For Inventory Of City Trees, Southwestern Oklahoma State University

THE BARK ARCHIVE 2013

Two faculty and a student at Southwestern Oklahoma State University have received a $4,500 grant to develop portable computer software that will help to create an inventory of trees in the City of Weatherford.

Patterns Of Cave Biodiversity And Endemism In The Appalachians And Interior Plateau Of Tennessee, Usa, Matthew L. Niemiller, Kirk S. Zigler

KIP Articles

Using species distribution data, we developed a georeferenced database of troglobionts (cave-obligate species) in Tennessee to examine spatial patterns of species richness and endemism, including >2000 records for 200 described species. Forty aquatic troglobionts (stygobionts) and 160 terrestrial troglobionts are known from caves in Tennessee, the latter having the greatest diversity of any state in the United States. Endemism was high, with 25% of terrestrial troglobionts (40 species) and 20% of stygobionts (eight species) known from just a single cave and nearly two-thirds of all troglobionts (130 species) known from five or fewer caves. Species richness and endemism were greatest …

Ground-Penetrating Radar, Resistivity And Spontaneous Potential Investigations Of A Contaminated Aquifer Near Cancún, Mexico Nckri Symposium 2: Proceedings Of The Thirteenth Multidisciplinary Conference On Sinkholes And The Engineering And Environmental Impacts Of Karst, Philip J. Carpenter, Ryan F. Adams, Melissa Lenczewski

KIP Talks and Conferences

pg(s) 231-237 Geophysical surveys were made over portions of the Cancún municipal well field in the Yucatán Peninsula of Mexico, approximately 20 km southwest of the city of Cancún, in order to identify karst conduits that channel contaminated surface waters into the main aquifer. Specifically, ground-penetrating radar (GPR), vertical electrical soundings (VES) and spontaneous potential (SP) surveys were employed to identify these conduits and detect water movement through them. Cancún s municipal water supply has frequently been affected by fecal coliform bacteria and other contaminants. Water supplies are largely derived from highly permeable fractured karst limestone aquifers characterized by rapid …

Delineating Source Areas To Cave Drips And Cave Streams In Austin, Texas, Usa, Nico Hauwert, Brian Cowan

Sinkhole Conference 2013

pg(s) 353-365

Full Proceedings Of The Thirteenth Multidisciplinary Conference On Sinkholes And The Engineering And Environmental Impacts Of Karst, National Cave And Karst Research Institute

Sinkhole Conference 2013

Please note that the file size of this download is approximately 145MB. If you experience difficultly downloading please right click on the download button and select save as to directly download to your computer, instead of within your browser. Additionally, we have provided a lower resolution file below that is only 25MB.

Welcome to the Thirteenth Multidisciplinary Conference on Sinkholes and the Engineering and Environmental Impacts of Karst in sunny Carlsbad, New Mexico. This will be the farthest west the Sinkhole Conference, as it is informally known, has met since its inception in 1984. The setting will provide conference participants …

The Need For Presumptive Habitat Considerations In Working With Subterranean Aquatic Species Of Concern: Three Ozark Region Case Histories, Usa, Shiloh L. Beeman, Thomas J. Aley, Michael Slay

Sinkhole Conference 2013

pg(s) 377-381

Restoring Land And Managing Karst To Protect Water Quality And Quantity At Barton Springs, Austin, Texas, Kevin Thuesen

Sinkhole Conference 2013

pg(s) 403-409

Uab And School Of Dentistry Ranked First Nationally In Nidcr Funding, Reporter Staff

Browse All News

No abstract provided.

Seroprevalence Of Epstein-Barr Virus Infection In U.S. Children Ages 6-19, 2003-2010, Jennifer Beam Dowd, Tia Palermo, Jennifer Brite, Thomas W. Mcdade, Allison Aiello

Publications and Research

Background Epstein-Barr virus (EBV) is a common herpesvirus linked to infectious mononucleosis and multiple cancers. There are no national estimates of EBV seroprevalence in the United States. Our objective was to estimate the overall prevalence and sociodemographic predictors of EBV among U.S. children and adolescents aged 6–19. Methods We calculated prevalence estimates and prevalence ratios for EBV seroprevalence using data from the 2003–2010 U.S. National Health and Nutrition Examination Survey (NHANES) for children aged 6–19 (n = 8417). Poisson regression was used to calculate multivariable-adjusted prevalence ratios across subgroup categories (sex, race/ethnicity, parental education, household income, household size, foreign-born, BMI, …