Digital Commons Network^™

Developmental Dysplasia Of The Hip: Linkage Mapping And Whole Exome Sequencing Identify A Shared Variant In Cx3cr1 In All Affected Members Of A Large Multi-Generation Family., George J Feldman, Javad Parvizi, Mark Levenstien, Kathryn Scott, Jill A Erickson, Paolo Fortina, Marcella Devoto, Christopher L Peters

Department of Orthopaedic Surgery Faculty Papers

Developmental Dysplasia of the Hip (DDH) is a debilitating condition characterized by incomplete formation of the acetabulum leading to dislocation of the femur, suboptimal joint function, and accelerated wear of the articular cartilage resulting in arthritis. DDH affects 1 in 1000 newborns in the United States with well defined "pockets" of high prevalence in Japan, Italy and other Mediterranean countries. Although reasonably accurate for detecting gross forms of hip dysplasia, existing techniques fail to find milder forms of dysplasia. Undetected hip dysplasia is the leading cause of osteoarthritis of the hip in young individuals causing over 40% of cases in …

Probiotics, Prebiotics And Immunomodulation Of Gut Mucosal Defences: Homeostasis And Immunopathology., Holly Hardy, Jennifer Harris, Eleanor Lyon, Jane Beal, Andrew D. Foey

School of Biomedical Sciences

Probiotics are beneficial microbes that confer a realistic health benefit on the host, which in combination with prebiotics, (indigestible dietary fibre/carbohydrate), also confer a health benefit on the host via products resulting from anaerobic fermentation. There is a growing body of evidence documenting the immune-modulatory ability of probiotic bacteria, it is therefore reasonable to suggest that this is potentiated via a combination of prebiotics and probiotics as a symbiotic mix. The need for probiotic formulations has been appreciated for the health benefits in "topping up your good bacteria" or indeed in an attempt to normalise the dysbiotic microbiota associated with …

Climate Change Impacts On Precipitation Extremes Over The Columbia River Basin Based On Downscaled Cmip5 Climate Scenarios, Ghulam Hussain Dars

Dissertations and Theses

Hydro-climate extreme analysis helps understanding the process of spatio-temporal variation of extreme events due to climate change, and it is an important aspect in designing hydrological structures, forecasting floods and an effective decision making in the field of water resources design and management. The study evaluates extreme precipitation events over the Columbia River Basin (CRB), the fourth largest basin in the U.S., by simulating four CMIP5 global climate models (GCMs) for the historical period (1970-1999) and future period (2041-2070) under RCP85 GHG scenario.

We estimated the intensity of extreme and average precipitation for both winter (DJF) and summer (JJA) seasons …

The Effect Of Temperature On Phenotypes Of The Invasive European Green Crab: Physiologic Mechanisms That Facilitate Invasion Success, Amanda Kelley

Dissertations and Theses

Invasion physiology is an emerging field that endeavors to understand the influence of physiological traits on the establishment of non-native species in novel environments. The invasive European green crab,Carcinus maenas, is one of the world's most successful aquatic invaders, and is currently distributed across temperate marine ecosystems globally. The work presented here explored the thermal physiology of this species, and has highlighted several physiological traits that have likely influenced establishment success.

Intraspecific comparisons of crabs sampled from the northern and southern edges of their recipient, or invaded range on the west coast of North America have identified both organismal and …

Session 1-3-F: The Alberta Cohorts Of Gambling Behaviors An Update, Nady El-Guebaly, David Casey, David Hodgins, Garry Smith, Don Schopflocher, Shawn Currie, Rob Williams

International Conference on Gambling & Risk Taking

Objectives

1.Experience with recruitment & retention of five cohorts

2.Patterns of continuity & discontinuity in gambling behaviors as well as patterns of recovery from problems?

3. Biopsychosocial variables (risks & resilience) predicting the spectrum of gambling behaviors from responsible to problematic?

Genetic And Environmental Predictors Of Empathy In Children At Risk For An Autism Spectrum Disorder, Nicole Marie Mcdonald

Open Access Dissertations

Individuals with autism spectrum disorders (ASD) have difficulty empathizing with others. These empathy deficits are apparent from as early as 12 months of age and predict later ASD diagnosis and symptom severity; however, the factors that influence empathy development in children at risk for an ASD are not clear. In typically developing samples, genetic factors, such as the oxytocin receptor gene (OXTR), and environmental factors, such as early parent-child interactions, contribute to individual differences in empathy. In this study, I investigated the influence of OXTR variants and characteristics of early parent-child interactions on later empathic behavior in toddlers at high- …

Mismatch In Higher Education: Neoliberal Shortcomings In Intrinsic Value In The University, Jake A. Grahn

Student Research Initiative

This research focuses on uncovering how the neoliberal atmosphere in which we find ourselves has influenced and socialized students to view college as a transaction between a buyer and a seller. Neoliberalism promotes free trade, open markets, and consumerism. How does neoliberal ideology affect student choices (i.e. schools, classes, teachers, etc.) that support and undermine neoliberalism itself? How does the internalization of the student-as-customer model contradict or reinforce neoliberal higher education? Higher education has become a complex institution, and free-market trade may benefit or hinder students. Approximately 31 open-ended interviews were conducted with students at BSU, and I conducted a …

05-28-2013 Garage Sale Planned Saturday To Benefit Tech Trek, Southwestern Oklahoma State University

THE BARK ARCHIVE 2013

The Weatherford branch of the American Association of University Women (AAUW) is hosting a multi-family garage sale this Saturday, June 1, at 1329 N. Terrace Drive in Weatherford to raise funds for Tech Trek, an upcoming summer camp for eighth grade girls.

Expression Of Three Gnrh Receptors In Specific Tissues In Male And Female Sea Lampreys Petromyzon Marinus At Three Distinct Life Stages, Jeffrey A. Hall, Wayne A. Decatur, Dana M. Daukss, Mary K. Hayes

New Hampshire Agricultural Experiment Station Publications

Two recently cloned gonadotropin-releasing hormone (GnRH) receptors (lamprey GnRH-R-2 and lamprey GnRH-R-3) along with lamprey (l) GnRH-R-1 were shown to share similar structural features and amino acid motifs common to other vertebrate receptors. Here we report on our findings of RNA expression of these three GnRH receptors in the three major life stages (larval, parasitic, and adult phases) of the sea lamprey, Petromyzon marinus, a basal vertebrate. For each stage, we examined the expression of messenger RNA encoding the receptors in the brain, pituitary, gonad, heart, muscle, liver, eye, intestine, kidney, skin, thyroid, gill, and endostyle by RT-PCR. In adult …

Computational Analysis Of Bacterial Rna-Seq Data, Ryan Mcclure, Divya Balasubramanian, Yan Sun, Maksym Bobrovskyy, Paul Sumby, Caroline Genco, Carin K. Vanderpool, Brian Tjaden

Faculty Research and Scholarship

Recent advances in high-throughput RNA sequencing (RNA-seq) have enabled tremendous leaps forward in our understanding of bacterial transcriptomes. However, computational methods for analysis of bacterial transcriptome data have not kept pace with the large and growing data sets generated by RNA-seq technology. Here, we present new algorithms, specific to bacterial gene structures and transcriptomes, for analysis of RNAseq data. The algorithms are implemented in an open source software system called Rockhopper that supports various stages of bacterial RNA-seq data analysis, including aligning sequencing reads to a genome, constructing transcriptome maps, quantifying transcript abundance, testing for differential gene expression, determining operon …

Spectro-Astrometry Of Water In Dr Tauri, Logan Brown, Matthew Troutman, Erika Gibb

Physics Faculty Works

We present high-resolution, near-infrared spectro-astrometric (SA) data for the T Tauri star DR Tau using NIRSPEC at the Keck II telescope. Spectro-astrometry obtains sub-seeing spatial information from emission lines originating in a non-point source object, such as a circumstellar disk. We report the first detection of water SA signatures in a protoplanetary disk. Three water features near 3 μm were averaged together to produce the total signal analyzed. Using a disk model, we constrained the position angle of the disk (~140°), the inclination of the disk (~13°), and the emitting region of the emission lines (~0.056-0.38 AU).

From The Lab To The Classroom

News Releases

No abstract provided.

Two Uab Students Win National Dentistry Research Awards, Jim Bakken

Browse All News

No abstract provided.

Vitamin D And The Athlete: Risks, Recommendations, And Benefits, Dana Ogan, Kelly Pritchett

All Faculty Scholarship for the College of the Sciences

Vitamin D is well known for its role in calcium regulation and bone health, but emerging literature tells of vitamin D’s central role in other vital body processes, such as: signaling gene response, protein synthesis, hormone synthesis, immune response, plus, cell turnover and regeneration. The discovery of the vitamin D receptor within the muscle suggested a significant role for vitamin D in muscle tissue function. This discovery led researchers to question the impact that vitamin D deficiency could have on athletic performance and injury. With over 77% of the general population considered vitamin D insufficient, it’s likely that many athletes …

05-28-2013 Dr. Faruk Khan Named H.F. Timmons Endowed Professor At Swosu, Southwestern Oklahoma State University

THE BARK ARCHIVE 2013

The late Homer F. Timmons established the Timmons Endowed Professorship at Southwestern Oklahoma State University, and SWOSU Associate Professor Dr. Faruk Khan has been named the first recipient on the Weatherford campus.

Dental Resident Receives Prestigious Research Award, Jim Bakken

Browse All News

No abstract provided.

Dissemination Of Bloodmeal Acquired Rickettsia Felis In Cat Fleas, Ctenocephalides Felis, Chutima Thepparit, Supanee Hirunkanokpun, Vsevolod L. Popov, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

Background: Cat fleas, Ctenocephalides felis, are known biological vectors for Rickettsia felis. Rickettsial transmission can be vertical via transovarial transmission within a flea population, as well as horizontal between fleas through a bloodmeal. The previously undescribed infection kinetics of bloodmeal-acquired R. felis in cat fleas provides insight into the R. felis-flea interaction. Findings. In the present study, dissemination of R. felis in previously uninfected cat fleas fed an R. felis-infected bloodmeal was investigated. At weekly intervals for 28 days, rickettsial propagation, accumulation, and dissemination in gut epithelial cells, specifically in the hindgut and the specialized cells in the neck region …

Multiscale Modeling Of The Causal Functional Roles Of Nssnps In A Genome-Wide Association Study: Application To Hypoxia, Li Xie, Clara Ng, Thahmina Ali, Raoul Valencia, Barbara L. Ferreira, Vincent Xue, Maliha Tanweer, Dan Zhou, Gabriel G. Haddad, Philip E. Bourne, Lei Xie

Publications and Research

Background It is a great challenge of modern biology to determine the functional roles of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on complex phenotypes. Statistical and machine learning techniques establish correlations between genotype and phenotype, but may fail to infer the biologically relevant mechanisms. The emerging paradigm of Network-based Association Studies aims to address this problem of statistical analysis. However, a mechanistic understanding of how individual molecular components work together in a system requires knowledge of molecular structures, and their interactions. Results To address the challenge of understanding the genetic, molecular, and cellular basis of complex phenotypes, we have, for the …

Promotion Of Brain Self-Repair Mechanisms By Stereotaxic Micro-Stimulation, Shijie Song, Juan Sanchez-Ramos

USF Patents

A method of treating neurological deficit in which the brain area affected is focally and precisely stimulated by the transient insertion and subsequent removal of a micro-needle. This insertion and subsequent removal of the micro-needle induces endogenous stem cells to proliferate, migrate and promote the brain's self-repair mechanisms. The micro-needle stimulation causes the birth of new neural cells within the brain as well as mobilizes bone marrow derived cells with a neuronal phenotype to migrate to the site of stimulation to repair and replace damaged neural cells. By repairing and/or replacing injured or dead cells, this approach will slow down …

Dynamic Dual-Tracer Mri-Guided Fluorescence Tomography To Quantify Receptor Density In Vivo, Scott C. Davis, Kimberley S. Samkoe, Kenneth M. Tichauer, Kristian J. Sexton, Jason R. Gunn, Sophie J. Deharvengt, Tayyaba Hasan, Brian W. Pogue

Dartmouth Scholarship

The up-regulation of cell surface receptors has become a central focus in personalized cancer treatment; however, because of the complex nature of contrast agent pharmacokinetics in tumor tissue, methods to quantify receptor binding in vivo remain elusive. Here, we present a dual-tracer optical technique for noninvasive estimation of specific receptor binding in cancer. A multispectral MRI-coupled fluorescence molecular tomography system was used to image the uptake kinetics of two fluorescent tracers injected simultaneously, one tracer targeted to the receptor of interest and the other tracer a nontargeted reference. These dynamic tracer data were then fit to a dual-tracer compartmental model …

Lim Protein Ajuba Participates In The Repression Of The Atr-Mediated Dna Damage Response, Sampada Kalan, Anastasiya Matveyenko, Diego Loayza

Publications and Research

LIM proteins constitute a superfamily characterized by the presence of a LIM domain, known to be involved in protein–protein interactions. Our previous work has implicated members of the Zyxin family of LIM proteins, namely TRIP6 and LPP, in the repression of the DNA damage response (DDR) at telomeres. Here, we describe a role for Ajuba, a closely related LIM molecule, in repressing the ATR-mediated DDR. We found that depletion of Ajuba led to apparent delays in the cell cycle, accompanied with increased Rb phosphorylation, Chk1 phosphorylation, induction of p53, and cell death. Ajuba could be found in a complex with …

Amyloid-Β Probes: Review Of Structure-Activity And Brain-Kinetics Relationships, Todd J. Eckroat, Abdelrahman S. Mayhoub, Sylvie Garneau-Tsodikova

Pharmaceutical Sciences Faculty Publications

The number of people suffering from Alzheimer's disease (AD) is expected to increase dramatically in the coming years, placing a huge burden on society. Current treatments for AD leave much to be desired, and numerous research efforts around the globe are focused on developing improved therapeutics. In addition, current diagnostic tools for AD rely largely on subjective cognitive assessment rather than on identification of pathophysiological changes associated with disease onset and progression. These facts have led to numerous efforts to develop chemical probes to detect pathophysiological hallmarks of AD, such as amyloid-β plaques, for diagnosis and monitoring of therapeutic efficacy. …

Finite Element Analysis Of Left Ventricle Motion And Mechanical Properties In Three Dimensions / Abdallah Ibrahim Mohammed Hasaballa, Mohammed Hasaballa Abdallah Ibrahim

Student Works (2010-2019)

Despite the wide variety of research in medicine and bioengineering treatment strategies developed over the last half century, heart disease remains among the most serious diseases threatening human longevity. Modeling the mechanics of the human myocardium, particularly the left ventricle, which is the main pumping chamber and most common site for heart disease, plays a significant role in better understanding the performance of the heart in healthy and diseased states. The core part of this work constitutes the implementation of a more realistic three-dimensional finite element model of the human left ventricle to provide a reliable description of both myofiber …

Peripheral T-Cell Lymphomas: A Review Of Current Approaches And Hopes For The Future., Alan P Skarbnik, Meher Burki, Barbara Pro

Kimmel Cancer Center Faculty Papers

Peripheral T-cell lymphomas (PTCL) are a diverse group of lymphoproliferative disorders, which share a common denominator of overall poor prognosis, with few exceptions. In this article, the authors review current standard of care approaches for the treatment of PTCLs, the role of stem-cell/bone marrow transplantation, and current developments in novel targeted therapies.

Adaptive Selection On Bracovirus Genomes Drives The Specialization Of Cotesia Parasitoid Wasps, Séverine Jancek, Annie Bézier, Philippe Gayral, Corentin Paillusson, Laure Kaiser, Stéphane Dupas, Bruno Pierre Le Ru, Valérie Barbe, Georges Periquet, Jean Michel Drezen, Elisabeth A. Herniou

All Peer-Reviewed Publications

The geographic mosaic of coevolution predicts parasite virulence should be locally adapted to the host community. Cotesia parasitoid wasps adapt to local lepidopteran species possibly through their symbiotic bracovirus. The virus, essential for the parasitism success, is at the heart of the complex coevolutionary relationship linking the wasps and their hosts. The large segmented genome contained in the virus particles encodes virulence genes involved in host immune and developmental suppression. Coevolutionary arms race should result in the positive selection of particular beneficial alleles. To understand the global role of bracoviruses in the local adaptation or specialization of parasitoid wasps to …

Ecology Of White-Cheeked Crested Gibbons In Laos, Julia Cleverly Ruppell

Dissertations and Theses

The endangered white-cheeked crested gibbon (Nomascus leucogenys), native to Laos, Vietnam, and perhaps China, remains little known and highly threatened. I studied seasonal variation in the diet, activity budget, and ranging behavior of three groups of white-cheeked crested gibbons in Nam Kading National Protected Area, Bolikhamxay Province, Laos, over 12 months in wet seasonal evergreen forest. Crested gibbons (Nomascus spp.) are speculated to be more folivorous than other gibbons, but this has never been confirmed because of the paucity of fieldwork on the genus. I studied diet in relation to forest seasonality to determine the contribution …

Development Of Techniques For The Fabrication Of Micro- And Nano-Batteries For Biomedical Applications, Hayley Osman, V. S.Sandeep Akkanapragada, Jacob Conner, Saibal Mitra

College of Natural and Applied Sciences

Future bio-medical devices with dimensions in the nanoscale region will need independent energy sources to power them. Lithium-ion micro- and nano-batteries are excellent candidates for these power sources. Our proposed nanobattery design ensures that these batteries remain lightweight and safe with fast rechargeable times. We have used femtosecond laser for precision machining. Intense electric fields produced by the laser beam induces electrical breakdown due to avalanche ionization. For femtosecond pulses, this breakdown threshold remains fairly deterministic thereby allowing the use of femtosecond lasers for micro- and nano-machining. The nanobattery consisted of an anode, cathode and separator. The anode was made …

Synergistic Inhibition Of Survival, Proliferation, And Migration Of U87 Cells With A Combination Of Ly341495 And Iressa, Zarina Yelskaya, Vangie Carrillo, Ewa Dubisz, Hira Gulzar, Devon Morgan, Shahana S. Mahajan

Publications and Research

Glioblastomas exploit various molecular pathways to promote glutamate-dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal growth factor receptor, EGFR. We hypothesized that targeting more than one of these pathways would be more effective in inhibiting glutamate-dependent growth. Using a model of U87 cell line, we show that blocking glutamate release by Riluzole inhibits cell proliferation. Glutamate-dependent growth is effectively inhibited by a combination of Iressa, an inhibitor of EGFR activation and LY341495, a group II mGluR inhibitor. Treatment of U87 cells with a combination of Iressa and LY341495 …

Gender Transformation At The Grassroots: A Gender And Development Program From The Practitioners' Perspective, Tyler Curtis

Master's Theses - Sociology and Anthropology

This study investigates the “gender transformative” Men as Partners (MAP) program as implemented in the West African nation of Togo. Using a qualitative research design, the project examines the successes and barriers of implementation, with an emphasis on the relationship of foreign (the American international development agency, the Peace Corps) and native practitioners (Togolese individuals implementing the program at the grassroots level). The study provides an ethnographic perspective of the researcher’s work as a MAP practitioner in Togo whose experiences are juxtaposed with seven different interviews from American and native practitioners administering the program on the national, regional, and community …

The Principles And Practices Of Bar And Beverage Management - The Drinks Handbook, James Peter Murphy

Books/Book Chapters

The bar and drinks business is hugely competitive. The key to success or failure between the many beverages and services offered in any bar is the employees who make, market, sell and serve them. Customer expectation and demand is constantly increasing and so it’s crucial for all staff to have comprehensive product knowledge and superior specialized service skills.

The Principles and Practices of Bar and Beverage Management - The Drinks Handbook is an authoritative resource and comprehensive training guide, essential for all students, bartenders, sommeliers, mixologists, waiters and food and beverage practitioners the world over. Written and configured in an …