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Ua3/9 Opening Faculty And Staff Convocation Speech 2013, President Gary Ransdell

Presidential Speeches

No abstract provided.

Genome-Wide Analyses Of Shavenbaby Target Genes Reveals Distinct Features Of Enhancer Organization, Delphine Menoret, Marc Santolini, Isabelle Fernandes, Rebecca Spokony, Jennifer Zanet, Ignacio Gonzalez, Yvan Latapie, Pierre Ferrer, Hervé Rouault, Kevin P. White, Philippe Besse, Vincent Hakim, Stein Aerts, Francois Payre, Serge Plaza

Publications and Research

Background: Developmental programs are implemented by regulatory interactions between Transcription Factors (TFs) and their target genes, which remain poorly understood. While recent studies have focused on regulatory cascades of TFs that govern early development, little is known about how the ultimate effectors of cell differentiation are selected and controlled. We addressed this question during late Drosophila embryogenesis, when the finely tuned expression of the TF Ovo/Shavenbaby (Svb) triggers the morphological differentiation of epidermal trichomes.

Results: We defined a sizeable set of genes downstream of Svb and used in vivo assays to delineate 14 enhancers driving their specific expression in trichome …

Individual Interactions Of The B Subunits Within The Stator Of The Escherichia Coli Atp Synthase., Karsten Brandt, Sarah Maiwald, Brigitte Herkenhoff-Hesselmann, Kerstin Gnirss, Joerg-Christian Greie, Stanley D Dunn, Gabriele Deckers-Hebestreit

Biochemistry Publications

FOF1 ATP synthases are rotary nanomotors that couple proton translocation across biological membranes to the synthesis/hydrolysis of ATP. During catalysis, the peripheral stalk, composed of two b subunits and subunit δ in Escherichia coli, counteracts the torque generated by the rotation of the central stalk. Here we characterize individual interactions of the b subunits within the stator by use of monoclonal antibodies and nearest neighbor analyses via intersubunit disulfide bond formation. Antibody binding studies revealed that the C-terminal region of one of the two b subunits is principally involved in binding of subunit δ, while the other one is accessible …

The Tiger Orientation Issue 2013-08-23, Clemson University

Tiger Newspapers

No abstract provided.

New Faculty And Staff Join Iwu, Sherry Wallace

News and Events (Discontinued Series)

No abstract provided.

Mccarthy Named As Associate Dean For Faculty Graduate Studies And Research, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Study Explains How The Brain Remembers Pleasure And Its Implications For Addiction, Jim Bakken

Browse All News

No abstract provided.

Multicultural Counseling Issues: Ethnic Groups’ Attitudes Towards Mental Illness, Rose Hirt, Dr. Timothy B. Smith

Journal of Undergraduate Research

In the world of counseling, there are many issues that arise due to differences between cultures. These differences are particularly apparent in how different cultural groups view mental illness. There have been studies done on this topic, but the literature must be compiled and compared in order for any overall effect to be measured. My research set out to begin compiling this literature.

The Metastatic Role Of Macrophages, Ryley Enz, Dr. K. L. O'Neill

Journal of Undergraduate Research

Macrophages perform a variety of functions from phagocytosis and the release of pro-inflammatory cytokines to the repair and remodeling of damaged tissues. Two phenotypically different types of macrophages have been proposed to identify their diverse roles: types M1 and M2. (Mantovani et al., 2002) The M1 macrophage refers to the cell which aggressively destroys foreign invaders and tumor cells, and releases pro-inflammatory cytokines. Antigen presentation by the M1 links innate immunity to adaptive immunity. The M2 macrophage acts as a support cell by promoting the healing of damaged cells by angiogenesis and tissue remodeling. Macrophages have been observed to have …

Trpv1 Modulation Of Synaptic Plasticity In The Hippocampus: The Hot Pepper Receptor Effect, Douglas Bennion, Dr. Jeffrey Edwards

Journal of Undergraduate Research

As a new and untried undergraduate researcher, I aspired to do something to impact the lives of others through a modest research contribution of my own. While I have not lost that aspiration, I have been \ surprised to discover that, in fact, others have been the ones making the greater impact in my life. I offer my deepest thanks to Dr. Edwards for his endless patience in explaining time after time things that I should have already known. His impromptu diagrams will always be the first pictures my mind calls up in moments of explanatory need. I also express …

The Effects Of Cholesterol On Snare Induced Liposome Fusion, Brandon Forbes, Dr. Dixon Woodbury

Journal of Undergraduate Research

Throughout our lives we often take our wonderful nervous system for granted. We simply accept that it will do its job and help us to organize our thoughts into plans for the day, or research reports such as this. At a cellular level, the SNARE proteins mediate fusion of neurotransmitter containing vesicles to the plasma membrane of a neuron to release neurotransmitter. This exocytotic process is part of the orchestra of events that enable us to think. There are three main proteins of the SNARE protein complex with many other proteins playing a role as well. VAMP is associated with …

The New Hampshire, Vol. 103 [104], No. 01 (Aug. 23, 2013), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 103, but it is the 104th volume in the series. This was corrected in pencil.

New Faculty And Staff Join Iwu, Sherry Wallace

News and Events (Discontinued Series)

No abstract provided.

Identity Development Of Adolescent Gay Black Males, Miles James Allen Crumley

Dissertations and Theses

During adolescence, self-identified gay black males may develop their identities differently than their gay white male counterparts. This may be attributed to the reconciliation of stressors when developing gay, black, and male identities within certain environmental contexts. To investigate this, twelve qualitative interviews were conducted of gay black males from which developmental themes were extracted. While many of the developmental processes are similar to their white homosexual counterparts, some differences were noted regarding racism, objectification by the white gay community, and use of the internet to develop particular identities. A new theory using dynamic systems theory that includes many complexities …

The Daily Gamecock, Friday, August 23, 2013, University Of South Carolina, Office Of Student Media

August

No abstract provided.

Soundings 2013-08-23, N/A N/A

Soundings

No abstract provided.

Synthesis And Evaluation Of Unnatural Hpaa, Norcoclaurine, And Tyramine Analogues, Sean Crowe

College of Science and Health Theses and Dissertations

There are several approaches to obtaining unnatural analogues of natural products. One of these approaches is precursor-directed biosynthesis (PDB), which is the process of using natural biosynthetic machinery to transform unnatural analogues of precursor compounds to produce an unnatural analogue of a target natural product. Berberine and galanthamine are chosen as model systems for the evaluation of PDB for the production of aromatic alkaloids in plants. Several approaches to the synthesis of unnatural 4 hydroxyphenylacetaldehyde (HPAA), norcoclaurine, and tyramine analogues are explored. 3-chloro-, 3-bromo-, and 3-iodoHPAA are all synthesized in good yields via and oxidative decarboxylation of tyrosine. These analogues …

Positron Emission Tomography For Pre-Clinical Sub-Volume Dose Escalation, Christopher Bass

Theses and Dissertations

Purpose: This dissertation focuses on establishment of pre-clinical methods facilitating the use of PET imaging for selective sub-volume dose escalation. Specifically the problems addressed are 1.) The difficulties associated with comparing multiple PET images, 2.) The need for further validation of novel PET tracers before their implementation in dose escalation schema and 3.) The lack of concrete pre-clinical data supporting the use of PET images for guidance of selective sub-volume dose escalations. Methods and materials: In order to compare multiple PET images the confounding effects of mispositioning and anatomical change between imaging sessions needed to be alleviated. To mitigate the …

Exploring The Solution Behavior Of The Translational Gtpase Bipa Using Molecular Dynamics, Gilman L. Dionne

Master's Theses

BipA is a conserved prokaryotic GTPase necessary for securing bacterial survival and successful invasion of the host. Structural and biochemical studies indicate that GTP and ppGpp compete for binding to BipA to promote differential association of BipA to either the 70S or 30S ribosomal species. Exactly how guanine nucleotide binding to BipA prompts a change in the association of this protein with the ribosome is not understood. Crystallographic models show local structural rearrangements occur near the nucleotide-binding pocket but unexpectedly the overall domain arrangement, and therefore intramolecular contacts are similar in the various guanine nucleotide bound states. One explanation is …

Navarro V. State Respondent's Brief Dckt. 40469

Not Reported

No abstract provided.

2013-August-23-Faculty Awards, University Marketing And Communication, East Tennessee State University

ETSU News

No abstract provided.

The Bg News August 23, 2013, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. August 23, 2013. Volume 93-Issue 1.

Cardiac Myocyte Diversity And A Fibroblast Network In The Junctional Region Of The Zebrafish Heart Revealed By Transmission And Serial Block-Face Scanning Electron Microscopy, Pascal J. Lafontant

Biology Faculty publications

The zebrafish has emerged as an important model of heart development and regeneration. While the structural characteristics of the developing and adult zebrafish ventricle have been previously studied, little attention has been paid to the nature of the interface between the compact and spongy myocardium. Here we describe how these two distinct layers are structurally and functionally integrated. We demonstrate by transmission electron microscopy that this interface is complex and composed primarily of a junctional region occupied by collagen, as well as a population of fibroblasts that form a highly complex network. We also describe a continuum of uniquely flattened …

Conservation And Diversification Of Appendage Identity Specification Mechanisms Along The Anteroposterior And Proximodistal Axes In Panarthropoda, Frank W. Smith Iii

Doctoral Dissertations

In Chapter 1, the roles of genes that specify antennal identity in Drosophila melanogaster were investigated in the flour beetle Tribolium castaneum. Antenna-to-leg transformations occurred in response to RNA interference (RNAi) against homothorax, extradenticle, spineless and Distal-less. However, for homothorax/extradenticle RNAi, the extent of transformation along the proximodistal axis differed between embryogenesis and metamorphosis. In chapter 2, the metamorphic roles of the Hox genes, extradenticle, and homothorax were compared in T. castaneum. homothorax/extradenticle RNAi and Hox RNAi produced similar body wall phenotypes but different appendage phenotypes. These results suggest that Hox genes …

Investigating The Metabolic And Pathophysiological Ramifications Of Elevated Dietary Cholesterol And Macronutrient Manipulation In Guinea Pigs (Cavia Porcellus) With Non-Alcoholic Fatty Liver Disease (Nafld), Ryan C. Deogburn

Doctoral Dissertations

Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological entity that includes a spectrum of histological and biochemical anomalies. NAFLD begins with excessive lipid accumulation within hepatocytes (hepatic steatosis) and can transition to non-alcoholic steatohepatitis (NASH), characterized by hepatic inflammation and injury that can render the liver vulnerable to bridging fibrosis, cirrhosis, and hepatocellular carcinoma. Dietary cholesterol has been proposed as a potential mediator of the transition from steatosis to NASH. Guinea pigs are similar to humans in terms of hepatic cholesterol metabolism and were implemented in three studies to explore its contribution to NAFLD. In study one male guinea pigs …

Probabilistic And Dynamical Models Of Belief Update: Effects Of Experimentally Induced Implicit Bias, Stephanie Petrusz

Doctoral Dissertations

Organisms undertake actions on the basis of perceptions. Perceptions serve as the basis for what an agent takes to be the case; that is, for the agent’s beliefs. However, the idea of belief is freighted with notions of fallibility and subjectivity, since belief is often considered insofar as it is distinct from knowledge. Here, an attempt is made to link belief more closely with perception and action. This linkage is shown by considering the role belief plays in determining behavior, which is distinct from the role belief plays in language-based philosophical accounts of content and intention. These two notions …

Individual And Community Factors Associated With Thriving Among African American Adolescents In The Context Of Stressors, Adia Shani Gooden

College of Science and Health Theses and Dissertations

This dissertation used the transactional-ecological framework along with principles from positive youth development literature to examine naturally occurring individual and contextual factors

that promote thriving among African American adolescents. Specifically, this study examined how religiosity, religious support, racial identity, and communalism relate to thriving. This study

also assessed the negative influence of stressors on thriving in order to understand how thriving manifests in the context of risk factors. This cross-sectional study included 152 youth

participants who were surveyed at five Black churches on the south side of Chicago. Structural equation modeling was used to assess whether the proposed model fit …

Ecological And Behavioral Interactions Between Two Closely Related North American Frogs (Rana Clamitans And R. Catesbeiana), Susan Z. Herrick

Doctoral Dissertations

Abstract

Resource partitioning within the ecological niche space in which there is a high level of overlap between species can alleviate the tendency toward competitive exclusion. When competitive ability is asymmetrical due to predation or other ecological factors, it may be more effective for the less competitive species to lessen direct competition by contracting their use of local resources. Species occurring in mixed assemblages may come into direct contact with each other throughout their respective breeding seasons. Where competition for breeding habitat and acoustic space exists, the level of interference is expected to vary widely, depending upon the ecological and …

Investigation Of Bond-Coat Rumpling In Thermal Barrier Coatings Using Advanced 3d Imaging Techniques, Sina Shahbazmohamadi

Doctoral Dissertations

Thermal barrier coatings (TBCs) are used in gas turbines to reduce the metal temperature for a given operating condition. The temperature drop in the TBC can be exploited by running the engine at a higher firing temperature leading to greater fuel efficiency and/or increased durability. Eventually TBCs spall off. One of the contributing factors to the failure in any TBC system is the surface geometry change of the interface commonly known as Bond-coat rumpling. Though rumpling is a three dimensional behavior, previous efforts of studying rumpling were mainly two-dimensional and/or lacked the 3D quantification of surface geometry change. In this …

Assessing The Exposure Risk And Impacts Of Pharmaceuticals In The Environment On Individuals And Ecosystems, Ke Arnold, Aba Boxall, Ar Brown, Rj Cuthbert, S Gaw, Th Hutchinson, S Jobling, Jc Madden, Cd Metcalfe, V Naidoo, Rf Shore, Je Smits, Ma Taggart, Hm Thompson

School of Geography, Earth and Environmental Sciences

The use of human and veterinary pharmaceuticals is increasing. Over the past decade, there has been a proliferation of research into potential environmental impacts of pharmaceuticals in the environment. A Royal Society-supported seminar brought together experts from diverse scientific fields to discuss the risks posed by pharmaceuticals to wildlife. Recent analytical advances have revealed that pharmaceuticals are entering habitats via water, sewage, manure and animal carcases, and dispersing through food chains. Pharmaceuticals are designed to alter physiology at low doses and so can be particularly potent contaminants. The near extinction of Asian vultures following exposure to diclofenac is the key …