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The Effects Of Offender Age And Offender-Victim Relationship On Modus Operandi Strategies To Lure The Victim, Hayley Lauren Tews

Dissertations and Theses

Research on the modus operandi (“method of operation”) of child sexual abuse (CSA) offenders has been useful in informing successful prevention programs (LeClerc, 2009). However, a gap in the literature regarding the strategies offenders use to lure potential CSA victims still remains. The present study seeks to examine the effects of offender-victim relationship and offender age on the use of strategies to lure victims for the purpose of committing CSA. Data for this study is taken from a larger investigation which included 854 identified adolescent and adult CSA offenders from nine different states. A 2 X 2 MANCOVA analysis revealed …

Subset Of Heat-Shock Transcription Factors Required For The Early Response Of Arabidopsis To Excess Light, Hou-Sung Jung, Peter A. Crisp, Gonzalo M. Estavillo, Benjamin Cole

Dartmouth Scholarship

Sunlight provides energy for photosynthesis and is essential for nearly all life on earth. However, too much or too little light or rapidly fluctuating light conditions cause stress to plants. Rapid changes in the amount of light are perceived as a change in the reduced/oxidized (redox) state of photosynthetic electron transport components in chloroplasts. However, how this generates a signal that is relayed to changes in nuclear gene expression is not well understood. We modified redox state in the reference plant, Arabidopsis thaliana, using either excess light or low light plus the herbicide DBMIB (2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone), a well-known inhibitor of photosynthetic …

Dirigent Domain-Containing Protein Is Part Of The Machinery Required For Formation Of The Lignin-Based Casparian Strip In The Root, Prashant S. Hosmani, Takehiro Kamiya, John Danku, Sadaf Naseer, Niko Geldner, Mary Lou Guerinot, David Salt

Dartmouth Scholarship

The endodermis acts as a "second skin" in plant roots by providing the cellular control necessary for the selective entry of water and solutes into the vascular system. To enable such control, Casparian strips span the cell wall of adjacent endodermal cells to form a tight junction that blocks extracellular diffusion across the endodermis. This junction is composed of lignin that is polymerized by oxidative coupling of monolignols through the action of a NADPH oxidase and peroxidases. Casparian strip domain proteins (CASPs) correctly position this biosynthetic machinery by forming a protein scaffold in the plasma membrane at the site where …

Understanding The Support Needs Of People With Intellectual And Related Developmental Disabilities Through Cluster Analysis And Factor Analysis Of Statewide Data, Yuwadee Viriyangkura

Theses and Dissertations

Through a secondary analysis of statewide data from Colorado, people with intellectual and related developmental disabilities (ID/DD) were classified into five clusters based on their support needs characteristics using cluster analysis techniques. Prior latent factor models of support needs in the field of ID/DD were examined to investigate the factor structure of the support needs construct using confirmatory factor analytic procedures.

Science Cafe Focuses On Aquatic Drug Possibilities, Edwin Smith

University of Mississippi News

Professor's research unveils potential of sea organisms for possible medicinal uses

Bax And Bak Function As The Outer Membrane Component Of The Mitochondrial Permeability Pore In Regulating Necrotic Cell Death In Mice, Jason Karch, Jennifer Q. Kwong, Adam R. Burr, Michelle A. Sargent, John W. Elrod, Pablo M. Peixoto, Sonia Martinez-Caballero, Hanna Osinskka, Emily H-Y Cheng, Jeffrey Robbins, Kathleen W. Kinnally, Jeffrey D. Molkentin

Publications and Research

A critical event in ischemia-based cell death is the opening of the mitochondrial permeability transition pore (MPTP). However, the molecular identity of the components of the MPTP remains unknown. Here, we determined that the Bcl-2 family members Bax and Bak, which are central regulators of apoptotic cell death, are also required for mitochondrial pore-dependent necrotic cell death by facilitating outer membrane permeability of the MPTP. Loss of Bax/Bak reduced outer mitochondrial membrane permeability and conductance without altering inner membrane MPTP function, resulting in resistance to mitochondrial calcium overload and necrotic cell death. Reconstitution with mutants of Bax that cannot oligomerize …

Tricellulin Deficiency Affects Tight Junction Architecture And Cochlear Hair Cells, Gowri Nayak, Sue I. Lee, Rizwan Yousaf, Stephanie E. Edelmann, Claire Trincot, Christina M. Van Itallie, Ghanshyam P. Sinha, Maria Rafeeq, Sherri M. Jones, Inna A. Belyantseva, James M. Anderson, Andrew Forge, Gregory I. Frolenkov, Saima Riazuddin

Physiology Faculty Publications

The two compositionally distinct extracellular cochlear fluids, endolymph and perilymph, are separated by tight junctions that outline the scala media and reticular lamina. Mutations in TRIC (also known as MARVELD2), which encodes a tricellular tight junction protein known as tricellulin, lead to nonsyndromic hearing loss (DFNB49). We generated a knockin mouse that carries a mutation orthologous to the TRIC coding mutation linked to DFNB49 hearing loss in humans. Tricellulin was absent from the tricellular junctions in the inner ear epithelia of the mutant animals, which developed rapidly progressing hearing loss accompanied by loss of mechanosensory cochlear hair cells, while …

A Novel Approach For Prognostic Biomarker Identification And Risk Stratification In Multiple Myeloma Using Combined Proteomics And Genomics Analyses, Shweta Shashikant Chavan

Theses and Dissertations

Multiple myeloma is a cancer of antibody-producing plasma B cells with patients presenting heterogeneous progression and survival outcome. Myeloma is currently incurable and the goal of current treatment options, including chemotherapy and stem cell transplantations, is to manage the disease so as to increase overall survival (OS) and/or event-free survival (EFS). Currently, patient risk is assessed using gene expression profiling based on a seventy gene risk signature (GEP70). However, the GEP70 high-risk group has poor prognosis and survival outcome and the low-risk patients with poor survival do exist. Therefore, in order to improve risk stratification, we undertook a mass spectrometry …

Development Of The In Vivo Multicolor Photoacoustic Flow Cytometer, Mustafa Sarimollaoglu

Theses and Dissertations

Flow cytometry is a powerful tool for analysis of cells in artificial flow. This highly accurate technology, using multicolor fluorescent probes and lasers with different wavelengths, provides fast multiparameter quantification of the biological properties of cells. Invasive extraction of cells from an organism, however, leads to changes in cell properties and low sensitivity, and prevents studying cells in their native environment. Challenges to advances in in vivo flow cytometry include fluorescent probe toxicity, strong background, and number of colors, as well as assessment of small vessels. To overcome these limitations, photoacoustic flow cytometry (PAFC) was introduced. PAFC is based on …

Mechanisms Of Estrogen Receptor Α Mediated Transcriptional Repression, Joseph Sin

Journal of Undergraduate Research

In the US, the American Cancer Society estimates that in 2008, breast cancer killed 40,930 people. Breast cancer remains the most common form of cancer among women today and results in almost 1% of all deaths worldwide. Various types of treatment for breast cancer exist today such as surgery, chemotherapy, radiotherapy, etc. Breast cancer treatments are usually selected based on the specific character of breast cancer: estrogen receptor (ER) positive or estrogen receptor negative. Treatment of breast cancer through estrogen modulation is a common form of treatment. Predicting the overall longer cancer-free survival is best done through measuring the levels …

Comparing Riparian Fly Diversity (Diptera) To Environmental And Human Pressures In Mongolia, Joss R. Wertz, Dr. C. Riley Nelson

Journal of Undergraduate Research

Mongolia is as large as the eastern United States with the lowest population density in Asia. This has kept development and its effects at a minimum. Thus, Mongolia retains much of the biota that has been lost in the surrounding countries. In the past 15 years, Mongolia has begun the difficult process of transitioning to a free market system. With this transition have come many pressures to exploit Mongolia’s extensive natural resources, while the number of scientists to monitor the effects of these developments is small. These pressures make an immediate need for biomonitoring methods to be developed. In addition, …

Finding Interactions Between Smpb And Tmrna During Trans-Translation, David Healey, Dr. Allen Buskirk

Journal of Undergraduate Research

During the last year, I have worked in collaboration with Allen Buskirk and DeAnna Cazier to study the interactions between SmpB and tmRNA during a process called bacterial trans-translation. To understand our experiments, it is necessary to know a little about what trans-translation is, and how it works.

Comparative Imaging Of Apoptotic Cell Membrane Morphology As Induced By Cytotoxic And Chemotherapeutic In S49 Lymphoma Cells By Confocal Microscopy, Celestine Yeung, Dr. John Bell

Journal of Undergraduate Research

This project studied and documented the membrane changes of cancer cells undergoing the complex cellular process apoptosis, or programmed cell suicide. More specifically, the purpose of this project was to achieve a visual comparison between S49 mouse lymphoma cells experiencing apoptosis induced by a variety of cytotoxic and chemotherapeutic drugs. This comparison was to be accomplished through cell imaging obtained by merocyanine (MC) 540 fluorescence confocal microscopy. Imaging accomplished in this project is an extension of ongoing research conducted by Dr. Bell and fellow colleagues concerning the action of the secretory phospholipase A2 (sPLA2) enzyme with respect to the effects …

Identifying Selection In The Angptl4 Gene Using Treesaap, Jeffrey Staples, Dr. Keith Crandall

Journal of Undergraduate Research

Geneticists have successfully identified the sources of many diseases that are inherited according to Mendelian rules (e.g. cystic fibrosis and Huntington’s disease). However, not all diseases are caused by one faulty gene; these so-called complex diseases (e.g. asthma, obesity, and diabetes) result from any number of mutated genes, faulty pathways, or environmental conditions. Association studies have identified a particular gene family (Angiopoietin-like proteins or ANGPTL) to be correlated with several of these complex diseases, namely diabetes, obesity, and heart disease1, 2; however, the function and contribution of these genes to these complex diseases is not completely understood.

An Analysis Of Genetic Complexity, Gabriel Proulx, Dr. Keith Crandall

Journal of Undergraduate Research

Sequencing genomes still requires considerable equipment and resources. While a full sequencing of all known species is obviously the end goal, analyzing ESTs, short sequences of expressed genes, can suffice in the meantime as an easier and less resource-intensive method to mapping out a species’ expressed genes. ESTs, however, are limited in both length and quality.

Mice Show Decreased Muscle Strength Bearing A Targeted Inactivation Of Nbmp2, Alina Schmidt, Dr. Laura Bridgewater

Journal of Undergraduate Research

An important secreted growth factor, bone morphogenic protein 2 (Bmp2), is involved in mesoderm formation, heart development, neurogenesis, skeletal development, axis formation, and muscle development 1 and is a member of the TGF-β superfamily of proteins. Members of the TGF-β superfamily are commonly known as secreted growth factors but has recently been discovered in the nucleus, known as nuclear Bmp21. nBmp2 bypasses the secretory pathway by having an alternative start codon downstream of the signal peptide.

Inflammation: A Key Component Of The Immunosuppression Observed In Aggressive Breast Cancer?, Bryan Swanson, Dr. Kim O'Neill

Journal of Undergraduate Research

Chemotherapy, surgery, and radiation are current treatments used to combat cancer. Future treatments may directly involve the cancer patient’s immune system. The immune system has the potential to destroy tumors. This destructive potential is orchestrated by small secreted proteins called cytokines and chemokines. These proteins control communications between immune cells, endothelial cells, and other cell types found within the body. In addition, cytokines and chemokines have growth, differentiation, and activation effects on target cells. Increasing evidence suggests the effects of these proteins may lead to tumor growth, tumor progression, and host immunosuppression in cancer patients.

Sleuthing Through The Rock Cycle: An Online Guided Inquiry Tool For Middle And High School Geoscience Education, Laura Schifman, Dawn Cardace, Karen Kortz, Karen Saul, Amber Gilfert, Anne I. Veeger, Daniel P. Murray

Geosciences Faculty Publications

The rock cycle is a key component of geoscience education at all levels. In this paper, we report on a new guided inquiry curricular module, Sleuthing Through the Rock Cycle, which has a blended online/offline constructivist design with comprehensive teaching notes and has been successful in pilot use in Rhode Island middle and high school classrooms over the past 3 y. The module consists of two overarching activities: (1) SherRock Holmes and the Case of the Mystery Rock Samples, and (2) Cracking the Case of the Changing Rocks. The module encourages hands-on activities, peer collaboration, and real-time teacher review …

Functional Characterization Of Crip1a Knockout Mice, Joanna Jacob

Theses and Dissertations

CB1 cannabinoid receptors are G-protein-coupled receptors that mediate the central nervous system (CNS) effects of marijuana and endocannabinoids. Recently, cannabinoid receptor interacting protein 1a (CRIP1a) was discovered as a novel protein that binds to the CB1 receptor C-terminus and inhibits CB1 receptor activity without affecting CB1 expression. This thesis investigated the functions of CRIP1a by characterizing the first CRIP1a knockout (KO) mouse line. The absence of CRIP1a was confirmed in KO mice using quantitative PCR and immunoblotting. I hypothesized that CRIP1a KO mice would exhibit enhanced CB1 receptor-mediated G-protein activity in the CNS, as well as cannabimemetic phenotypes and enhanced …

Montana Kaimin, August 27, 2013, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

‘Predicting’ Huntington’S Disease In The Heartland, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern Opens Biological Sciences Building

Commonwealth Times 2013-08-26

Commonwealth Times, 1969-

No abstract provided.

Current, August 26, 2013, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

August 26, 2013, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Faculty Senate Executive Committee Agenda, August 26, 2013, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Graduate Council Report
• Research Council Report
• Election of new Committee on Committees Member
• PRPC Section 402, Language on RCDE and USU Eastern
• Post Tenure Review process revision update (e.g. results of straw poll vote)

Bioengineered Lysozyme Reduces Bacterial Burden And Inflammation In A Murine Model Of Mucoid Pseudomonas Aeruginosa Lung Infection, Charlotte C. Teneback, Thomas C. Scanlon, Matthew J. Wargo, Jenna L. Bement, Karl E. Griswold, Laurie W. Leclair

Dartmouth Scholarship

The spread of drug-resistant bacterial pathogens is a growing global concern and has prompted an effort to explore potential adjuvant and alternative therapies derived from nature's repertoire of bactericidal proteins and peptides. In humans, the airway surface liquid layer is a rich source of antibiotics, and lysozyme represents one of the most abundant and effective antimicrobial components of airway secretions. Human lysozyme is active against both Gram-positive and Gram-negative bacteria, ac

New Leadership

News Releases

No abstract provided.

Graduate School's Proctor Named August Employee Of The Month, Traci Bratton

Browse All News

No abstract provided.

The Daily Egyptian, August 26, 2013, Daily Egyptian Staff

August 2013

No abstract provided.