Digital Commons Network^™

Structural Evidence: A Single Charged Residue Affects Substrate Binding In Cytochrome P450 Bm-3, Jaclyn Catalano, Kianoush Sadre-Bazzaz, Gabriele A. Amodeo, Liang Tong, Ann Mcdermott

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Cytochrome P450 BM-3 is a bacterial enzyme with sequence similarity to mammalian P450s that catalyzes the hydroxylation of fatty acids with high efficiency. Enzyme-substrate binding and dynamics has been an important topic of study for cytochromes P450 because most of the crystal structures of substrate-bound structures show the complex in an inactive state. We have determined a new crystal structure for cytochrome P450 BM-3 in complex with N-palmitoylglycine (NPG), which unexpectedly showed a direct bidentate ion pair between NPG and arginine 47 (R47). We further explored the role of R47, the only charged residue in the binding pocket in cytochrome …

Mexican-American Children’S Perspectives: Neighborhood Characteristics And Physical Activity In Texas-Mexico Border Colonias, Nelda Mier, Chanam Lee, Matthew Lee Smith, Xiaohui Wang, David Irizarry, Elias H. Avila-Rodriguez, Laura Trevino, Marcia G. Ory

School of Mathematical & Statistical Sciences Faculty Publications

The qualitative study described in this article investigated perceptions about environmental factors infl uencing physical activity (PA) among children from underserved neighborhoods known as colonias in the U.S.-Mexico border. Ten focus groups were conducted with 67 Mexican-American colonia children ages 8 to 13 living in one of the poorest border counties in the U.S. Analyses indicated that PA among children was influenced by neighborhood characteristics, including litter, speeding cars, unleashed dogs, and dark streets. The children also underlined intrapersonal and social environmental factors. Findings may inform policy makers and public health professionals about ways to promote PA among underserved children …

Stroke Radiology And Distinguishing Characteristics Of Intracranial Atherosclerotic Disease In Native South Asian Pakistanis., Maria Khan, Asif Rasheed, Saman Hashmi, Moazzam Zaidi, Saba Akhtar, Lajpat Bansari, Nabi Shah, Maria Samuel, Sadaf Raza, Umer Rais Khan, Bilal Ahmed, Bilawal Ahmed, Naveeduddin Ahmed, Jamal Ara, Tasnim Ahsan, S. M. Munir, Shoukat Ali, Khalid Mehmood, Karim Ullah Maki, Muhammad Masroor Ahmed, Niaz Sheikh, Abdul Rauf Memon,, Philippe M. Frossard, Ayeesha Kamran Kamal

Department of Medicine

Background: There are no descriptions of stroke mechanisms from intracranial atherosclerotic disease in native South Asian Pakistanis.

Methods: Men and women aged ≥ 18 years with acute stroke presenting to four tertiary care hospitals in Karachi, Pakistan were screened using magnetic resonance angiography/transcranial Doppler scans. Trial of ORG 10172 in Acute Stroke Treatment criteria were applied to identify strokes from intracranial atherosclerotic disease.

Results: We studied 245 patients with acute stroke due to intracranial atherosclerotic disease. Two hundred thirty scans were reviewed. Also, 206/230 (89.0%) showed acute ischaemia. The most frequent presentation was with cortically based strokes in 42.2% (87/206) …

Montana Kaimin, October 1, 2013, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Unf Journal Fall 2013, University Of North Florida

UNF Journal

A university periodical for alumni and friends of the University of North Florida.

Approval And Withdrawal Of New Antibiotics And Other Antiinfectives In The U.S., 1980-2009, Kevin Outterson, John H. Powers, Enrique Seoane, Rosa Rodriguez-Monguio, Aaron S. Kesselheim

Faculty Scholarship

Concerns about a dearth of antibiotic innovation have spurred calls for incentives to speed the development of new antibiotics. Our data demonstrates that many of the new molecular entity (NME) antibioticsintroduced in the last 3 decades were withdrawn from the market, at more than triple the rate of other drug classes. Adjusted for these withdrawals, the net introduction of NME antibiotics is not as troubling of a trend. The reduction in NME antibiotics was partially offset by a surge in the introduction of NME antiretrovirals for HIV/AIDS and other drug classes (such as cardiovascular drugs) posted similar declines.

These data …

The Dangerous Law Of Biological Race, Khiara Bridges

Faculty Scholarship

The idea of biological race -- a conception of race that postulates that racial groups are distinct, genetically homogenous units -- has experienced a dramatic resurgence in popularity in recent years. It is commonly understood, however, that the U.S. Supreme Court has rejected the idea that races are genetically uniform groupings of individuals. Almost a century ago, the Court famously appeared to recognize the socially constructed nature of race. Moreover, the jurisprudence since then appears to reaffirm this disbelief: within law, race is understood to be a social construction, having no biological truth to it at all. Yet upon closer …

Serotonin Transporter Genotype Modulates Functional Connectivity Between Amygdala And Pcc/Pcu During Mood Recovery, Zhuo Fang, Senhua Zhu, Seth J. Gillihan, Marc Korczykowski

Psychology Faculty Scholarship

The short (S) allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) has been associated with increased susceptibility to depression. Previous neuroimaging studies have consistently showed increased amygdala activity during the presentation of negative stimuli or regulation of negative emotion in the homozygous short allele carriers, suggesting the key role of amygdala response in mediating increased risk for depression. The brain default mode network (DMN) has also been shown to modulate amygdala activity. However, it remains unclear whether 5-HTTLPR genetic variation modulates functional connectivity (FC) between the amygdala and regions of DMN. In this study, we re-analyzed our previous imaging dataset …

Ucc Minutes, October 8, 2013, University Curriculum Council

UCC Agendas/Minutes

No abstract provided.

Fall 2013, John M. Pfau Library

Peacock – John M. Pfau Library Newsletter

Contents:

• Against the odds: The Pfau Library team achieves all strategic goals! by Cesar Caballero
• Encore! by Cesar Caballero
• Marginalia by Bonnie Petry
• People in the news
• Kindred spirits by Lisa Bartle
• Another success story! by Iwona Contreras
• The San Bernardino Sun archive by Jill Vassilakos-Long
• A brief history of San Bernardino newspapers by Jill Vassilakos-Long
• Great Horned Owls and a rescue at the Pfau by Pat Rice-Daniels

Patents And The University, Peter Lee

Duke Law Journal

This Article examines the intersection of patent law and academic science. It advances two novel claims about the internalization of academic science within the patent system and the concomitant evolution of “academic exceptionalism.” Historically, relations between patent law and the university were characterized by mutual exclusion, based in part on perceived normative conflicts between academic culture and exclusive rights. These normative distinctions helped inform academic exceptionalism—the notion that the patent system should exclude the fruits of academic science or treat academic entities differently than other actors—in patent doctrine. As universities began to embrace patents and the nature of scientific research …

Intellectual Property And Public Health – A White Paper, Ryan G. Vacca, Jim Chen, Jay Dratler Jr., Tom Folsom, Timothy Hall, Yaniv Heled, Frank Pasquale, Elizabeth Reilly, Jeff Samuels, Kathy Strandburg, Kara Swanson, Andrew Torrance, Katharine Van Tassel

Akron Law Faculty Publications

On October 26, 2012, the University of Akron School of Law’s Center for Intellectual Property and Technology hosted its Sixth Annual IP Scholars Forum. In attendance were thirteen legal scholars with expertise and an interest in IP and public health who met to discuss problems and potential solutions at the intersection of these fields. This report summarizes this discussion by describing the problems raised, areas of agreement and disagreement between the participants, suggestions and solutions made by participants and the subsequent evaluations of these suggestions and solutions.

Led by the moderator, participants at the Forum focused generally on three broad …

Immigration, Nationality, And Xenophobia In Late-19th Century Marseilles, Patrick Mcneill , '14

Senior Theses, Projects, and Awards

This paper investigates the “Vêpres Marseillaises,” a June 1881 anti-Italian riot in Marseilles, in order to discuss the intersection of working class nationalism, immigration, and French political and social discourses. The event is more than a simple manifestation of xenophobic nationalism; it is both a moment that illustrates the unique place of Marseilles as well as the inaugural expression of a discourse that sought to bring the working class under the French republican banner.

Knowing Nothing: Labor, Nativism, And Class Divisions In Turn-Of-The Century Pittsburgh, Jay Kober , '14

Senior Theses, Projects, and Awards

This paper examines the labor movement in Pittsburgh between the years 1892-1919. The labor movement at the turn of the century met new challenges as a new wave of immigrants from Southern and Eastern Europe flooded the industrial sector. Organization was difficult due to class division, nativist depictions of immigrants, and management’s concerted effort to keep labor disorganized. These factors coupled with the extensive reach of management’s influence helped prevent any significant gains for organized labor.

Sowfia Project - Work Package 3 Final Report, D Conley, D Magagna, D Greaves, E Aires, Leitao J Chambel, M Witt, C Embling, Bj Godley, A Bicknell, J-B Saulnier, T Simas, Am O’Hagan, J O’Callaghan, B Holmes, J Sundberg, Y Torre-Enciso, D Marina

School of Biological and Marine Sciences

No abstract provided.

Outdated Dermatologic Drug Samples And Obligations To The Patient., Jordan Wang, Matthew Keller

Department of Dermatology and Cutaneous Biology Faculty Papers

CASE SCENARIO

A 37-year-old man with a slightly raised, red, scaly patch on his left arm is seen in the clinic of an academic teaching hospital by a young dermatologist. Following examination and biopsy, he is found to have squamous cell carcinoma in situ. The patient was recently laid off from work and had lost access to his health insurance. He is struggling to make ends meet for his family, so it would be difficult for him to cover any extraneous health-related expenses. Upon relaying this information to the dermatologist, the patient is provided with a full course of 5-fluorouracil …

Chemokine-Enhanced Dna Vaccination In Cancer Immunotherapy., Olga Igoucheva, Rebecca Jonas, Vitali Alexeev

Department of Dermatology and Cutaneous Biology Faculty Papers

We have demonstrated that priming of intratumoral and intradermal vaccination sites with chemokines enhances cytotoxic immune response against established neoplasms. Additional insights into the molecular mechanisms that underlie these findings and the optimization of such an approach may lead to the development of cost-effective and generic immunotherapeutic regimens against cancer.

Wildflowers & Other Herbaceous Plants Of Utah Rangelands, Mindy Pratt, Chad Reid, Roger Banner, James Bowns

All Current Publications

No abstract provided.

Copley Connects | Fall 2013, Copley Library

Copley Connects Library Newsletter

Reaching Out for Open Access | 1
The Dean's Update | 2
Krakens and Karamazov: A Conversation with Shannon Wheeler | 4
Social Media at Copley Library | 5
Copley Library by the Numbers | 6
JSTOR Alumni Access | 8
The Reference Section in Copley Library | 8
Copley Cataloging Provides Bridges to "New" Collections | 9
Personal Librarian Program | 10
One Book, One San Diego | 10
New Faculty Library Orientation | 11
New Library Faculty Members | 12

Sensitivity To Heat: A Comparative Study Of Phoenix, Arizona And Chicago, Illinois (2003-2006), Wen-Ching Chuang, Patricia Gober, Winston T. L. Chow, Jay Golden

Research Collection School of Social Sciences

Research on how heat impacts human health has increased as climate change threatens to raise temperatures to new extremes. Excessive heat exposure increases death rates, as well as rates of nonfatal, adverse health outcomes. This study used the negative binomial regression model to examine the relationship between daily maximum temperature, heat index, and heat-related emergency calls in Phoenix, Arizona and Chicago, Illinois, from 2003 to 2006. Using model results, we estimated call volumes in a warmer climate, with temperature increase from 1 to 5.5 C. We found that: (1) heat-stress calls increase sharply when the temperature exceeds about 35 C …

October 2013 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Perinatal Outcomes Of Prenatal Probiotic And Prebiotic Administration: An Integrative Review, Leona Vandevusse, Lisa Hanson, Nasia Safdar

College of Nursing Faculty Research and Publications

The purpose of this integrative review was to identify, critique, and synthesize the maternal and neonatal evidence on the prenatal use of probiotics and prebiotics to inform perinatal health professionals. A comprehensive literature search resulted in 37 studies of prenatal probiotics and 1 on antepartal prebiotics published from 1990 through 2011 that reported maternal, fetal, and/or neonatal outcomes. The methodologic quality of the studies reviewed was high, although investigators used different probiotic combinations and inconsistently reported perinatal clinical outcomes. The extraction of perinatal outcome variables resulted in identification of 9 maternal and 5 neonatal categories. Prenatal probiotics significantly reduced the …

Design And Implementation Of Software For Technological Forecasting And Modeling Technological Obsolescence, Gershom Kwaku Obeng

Mechanical & Aerospace Engineering Theses & Dissertations

In a world that is highly infused with technology, it is important that an organization knows how many resources such as manpower, equipment, and funding are needed at what time so that the organization does not suffer unnecessary risks. It is also important to know when to replace equipment. After examining different methods of forecasting, it was determined that manipulation of growth curves was the best way to determine the likelihood of device failure at a specific time. An approach in engineering economics was used to estimate the cost due to the failure of various devices or groups of devices. …

Dimensionless Criteria For Selecting Tidally-Influenced Advective-Dispersive Desalination Brine Mixing Plume Characterization Models, Alireza Shahvari

Civil & Environmental Engineering Theses & Dissertations

The very nature of requirements for implementing a desalination process is highly spatial due to the need to secure both a source for the operation and sink for brine dilution. Thus, the applicable coastal location is bound to natural tidal mixing characteristics and subjected to a near- or a far-field availability for source and sink. Mixing characteristics of coastal waters are very different from one point to another due to the spatiotemporal tidal characteristic in loco in a manner that it can vary from being highly advective to completely dispersive dominant. Once a location is identified, estimation of corresponding water …

Academic And Cultural Bias In The Classroom: A Qualitative Examination Of The Overrepresentation Of African American Students In Special Education, Marcia Molett

McNair Scholars Research Journal

Almost forty percent of African American students are in special education programs, though they constitute only 17% of the general education population (Kunjufu, 2005). A conclusive explanation has yet to be reached as to why this disproportion exists, but multiple suggestions have been made. The ideas that will be presented in this literature review focus on factors such as race, teacher perception and preparation, cultural differences, biases in norm-referenced testing and culturally unresponsive curricula. The purpose of this research review is to gain an understanding of why these issues continue to occur, and what professionals can do to rectify this …

Online Profiles Of Same-Sex Couples Hoping To Adopt: A Communication Analysis, Caprisha Curry

McNair Scholars Research Journal

The number of same-sex couples who are parents has increased dramatically in the last decade (Goldberg & Kinkler 2011). Data from the U.S. Census indicates that approximately 1 in 5 same-sex male couples and 1 in 3 same-sex female couples are raising children (Goldberg & Kinkler, 2011), and many other gays and lesbians are hoping and/or waiting to adopt. This study examines selected online profiles of same-sex couples hoping to adopt. Specifically, I am interested in analyzing how these couples portray themselves online to appeal to pregnant women seeking adoptive families. Same-sex couples must find the means to address the …

From The Gas, Congratulations, Publications, And Presentations, Teresa S. Welsh

SLIS Connecting

Read a highlight from one of the GAs, and all about what our alum, students, and faculty have been doing.

Sylvia Earle: Ocean Life Makes Human Life Possible, Jill Rodrigues

Featured News Story

Legendary oceanographer and marine scientist lauds RWU for marine
biology and aquaculture programs as a leading example of research and conservation efforts.

Recognizing Nonhuman Morality, Simon J. Coghlan

Between the Species

Claims that some sorts of genuine moral behavior exist in nonhuman beings are increasingly common. Many people, however, remain unconvinced, despite growing acceptance of the remarkable behavioral complexity of animals and despite the admission that there may be significant differences between human and nonhuman moral behavior. This paper argues that the rejection of “moral animals” is misplaced. Yet at the same time, it attempts to show how the philosophical task of exhibiting the possibility of nonhuman moral behavior is often misguided, leaving claims about nonhuman morality unnecessarily exposed to philosophical rejection.

High Predation On Small Populations: Avian Predation On Imperiled Salmonids, Ann-Marie Osterback, Danielle Frechette, Andrew Shelton, Sean Hayes, Morgan Bond, Scott A. Shaffer, Jonathan Moore

Faculty Publications, Biological Sciences

Generalist predators can contribute to extinction risk of imperiled prey populations even through incidental predation. Quantifying predation on small populations is important to manage their recovery, however predation is often challenging to observe directly. Recovery of prey tags at predator colonies can indirectly provide minimum estimates of predation, however overall predation rates often remain unquantifiable because an unknown proportion of tags are deposited off‐colony. Here, we estimated overall predation rates on threatened wild juvenile steelhead Oncorhynchus mykiss by generalist adult Western Gulls Larus occidentalis in six central California (USA) watersheds. We estimated predation rates by gulls from the recapture of …