Digital Commons Network^™

Retinal Angiogenesis Suppression Through Small Molecule Activation Of P53, Sai H. Chavala, Younghee Kim, Laura Tudisco, Valeria Cicatiello, Till Milde, Nagaraj Kerur, Nidia Claros, Susan Yanni, Victor H. Guaiquil, William W. Hauswirth, John S. Penn, Shahin Rafii, Sandro De Falco, Thomas C. Lee, Jayakrishna Ambati

Ophthalmology and Visual Science Faculty Publications

Neovascular age-related macular degeneration is a leading cause of irreversible vision loss in the Western world. Cytokine-targeted therapies (such as anti-vascular endothelial growth factor) are effective in treating pathologic ocular angiogenesis, but have not led to a durable effect and often require indefinite treatment. Here, we show that Nutlin-3, a small molecule antagonist of the E3 ubiquitin protein ligase MDM2, inhibited angiogenesis in several model systems. We found that a functional p53 pathway was essential for Nutlin-3-mediated retinal antiangiogenesis and disruption of the p53 transcriptional network abolished the antiangiogenic activity of Nutlin-3. Nutlin-3 did not inhibit established, mature blood vessels …

Vegetable Production Guide For Commercial Growers, 2014-15, Ricardo Bessin, Kenneth W. Seebold, Shubin Saha, Shawn Wright, John Strang

Agriculture and Natural Resources Publications

Successful vegetable production generally requires the grower to make daily decisions regarding pest management, irrigation, and cultural practices. Would-be growers unwilling to make serious investments of time (and money) should not attempt to expand beyond a space at the farmers’ market. It is important for vegetable growers to have a market outlet for their product before they choose to start production. Good marketing plans start with the customer and work backward to production. Potential growers should first determine exactly what buyers want, how they want it, and when they want it. They then must determine how these crops should be …

Sailing In The Shadow Of The Vietnam War: The Gdr Government And The "Vietnam Bonus" Of The Early 1970s, Gerd Horten

CUP Faculty Research

In concert with the Soviet Union and Warsaw Pact countries, the East German government vigorously opposed the Vietnam War in the 1960s and early 1970s and supported North Vietnam politically and economically. Concurrently, it sponsored ongoing solidarity campaigns in support of the Democratic Republic of Vietnam (DRV) against the US-led coalition. As the American war effort deteriorated, the East German government reaped a significant boost both internationally and domestically as a result of these campaigns. This "Vietnam Bonus" helped to enhance the international stature of the GDR and increased the domestic stability of the SED government in the early 1970s.

Great Plains Research, Volume 23, Number 2, Fall 2013 (Complete Issue)

Great Plains Research: A Journal of Natural and Social Sciences (through 2013)

CONTENTS

Introduction — Richard Edwards and Peter Longo

School Consolidation and Community Development — Gary Paul Green

The Importance of Being Emily: Lessons from Legislative Battles over

Forced School Consolidation — Marty Strange

Tiebout in the Country: The Inevitable Politics of Rural School Consolidation — Steven L. Willborn

Place-Based Civic Education and the Rural Leadership Crisis in Nebraska — Christie L. Maloyed and J. Kelton Williams

Considering Native American Students in Rural School Consolidation — Andrea Miller

Photo Essay: Atmosphere for Learning Undistracted: Rural Schools of Nebraska — Charles W. Guildner

Economic Issues in School District Consolidation in Nebraska — …

Stress And Eating: A Dual Role For Bombesin-Like Peptides, Zul Merali, S. Graitson, J. C. Mackay, P. Kent

Brain and Mind Institute

The current obesity "epidemic" in the developed world is a major health concern; over half of adult Canadians are now classified as overweight or obese. Although the reasons for high obesity rates remain unknown, an important factor appears to be the role stressors play in overconsumption of food and weight gain. In this context, increased stressor exposure and/or perceived stress may influence eating behavior and food choices. Stress-induced anorexia is often noted in rats exposed to chronic stress (e.g., repeated restraint) and access to standard Chow diet; associated reduced consumption and weight loss. However, if a similar stressor exposure takes …

Saharasia: Geographical Comparisons Of World Cultures And Civilizations, James Demeo

Comparative Civilizations Review

No abstract provided.

Laina Farhat-Holzman: Worldchangers: Ten Inventions That Changed Everything., George Von Der Muhll

Comparative Civilizations Review

No abstract provided.

Uni Grad Student News, V9n1, October 2013, University Of Northern Iowa. Graduate College.

UNI Grad Student News

Inside this issue:

-- Message from the Dean
-- May 2013 Commencement Speaker: Darrina Bledsoe
-- Graduate Student Profile: Michelle Czarnecki
-- Graduate Student Profile: Steve Przymus
-- Graduate College Graduate Assistant Profile: Anthony Roth, Scotti Hagensick and Raeann Swanson
-- Seventh Annual Graduate Student Symposium
-- UNI MBA Teams Provide Valuable Work to Area Companies
-- 7th Annual Graduate Student Research in the Humanities Symposium
-- Graduate Student Information Meeting
-- Psychology Department Student Updates
-- Thinking About Graduate School (TAGS)
-- Thinking About Doctoral Studies (TADS)
-- Graduate Student Advisory Board
-- New Look for the Graduate College …

Modeling And Control Of Nanoparticle Bloodstream Concentration For Cancer Therapies, Scarlett S. Bracey

Doctoral Dissertations

Currently, the most commonly used treatments for cancerous tumors (chemotherapy, radiation, etc.) have almost no method of monitoring the administration of the treatment for adverse effects in real time. Without any real time feedback or control, treatment becomes a "guess and check" method with no way of predicting the effects of the drugs based on the actual bioavailability to the patient's body. One particular drug may be effective for one patient, yet provide no benefit to another. Doctors and scientists do not routinely attempt to quantifiably explain this discrepancy. In this work, mathematical modeling and analysis techniques are joined together …

Illinois State University Salaries Fy2014, Illinois State University

Illinois State University Salaries

Includes two sections: merit eligible continuing academic personnel and civil service salaries and merit eligible faculty increases.

Ecology Of Musk Thistle (Carduus Nutans) Seed Germination For Grasslands Of Temperate Climates, Chengchou Han, Stephen L. Young

West Central Research and Extension Center, North Platte

Musk thistle is an invasive weed that is widely distributed throughout much of North America, including grasslands in temperate climates of the midwest USA. A series of laboratory and greenhouse experiments were conducted to determine the effect of various environmental factors on germination of musk thistle seeds. In temperature-fluctuation experiments, seed germination was greater than 65% in both alternating (30/20 C) and constant (20 or 25 C) temperature regimes with an 8-h day but less (33%) in warmer regimes (35/20 C). Germination of musk thistle seeds was 37% in alternating temperature regimes of 30/20 C in total darkness, but less …

Virginia Academy Of Science, 2013, Fall Undergraduate Research Meeting

Virginia Journal of Science

Article about the 2013 Virginia Academy of Science Fall Undergraduate Research Meeting

Plant Community Composition And Structure Monitoring In Scotts Bluff National Monument, 2013 Annual Report, Isabel Ashton, Michael Prowatzke

United States National Park Service: Publications

Introduction

During the last century, much of the prairie within the Northern Great Plains has been plowed for cropland, planted with non-natives to maximize livestock production, or otherwise developed, making it one of the most threatened ecosystems in the United States. Within Nebraska, greater than 77% of the area of native mixed grass prairie has been lost since European settlement (Samson and Knopf 1994). The National Park Service (NPS) plays an important role in preserving and restoring some of the last pieces of intact prairies within its boundaries. The stewardship goal of the NPS is to “preserve ecological integrity and …

“Breastfeeding Perceptions And Practices” A Comparative Study Of Two Opposing Socio-Economic Level Quarters Within Yaoundé, Cameroon, Alexandria J. Ross

Independent Study Project (ISP) Collection

This research project aims to identify and analyze the conditions that influence breastfeeding perceptions and practices within two opposing socioeconomic level quarters of Yaoundé, Cameroon: Bastos and Madagascar. According to the World Health Organization recommendations for optimal infant and young child nutrition, mothers are advised to exclusively breastfeed for the first six months of life after birth before introducing complimentary feeding. Cameroon since 2005 has adhered to the International Code of Marketing of Breastmilk Substitutes. It is classified as a Category 1 as a country which discourages commercial pressures to feed alternative forms of nutrition known as breastmilk substitutes.

This …

National Trends In C. Difficileinfections In Hospitalized Children And Young Adults With Inflammatory Bowel Disease, 2001 –2010, Kelly C. Sandberg, Matthew M. Davis, Achamyeleh Gebremariam, Jeremy Adler, Child Health Evaluation And Research Unit, University Of Michigan, C.S. Mott Children's Hospital, Pediatric Gastroenterology, University Of Michigan

Pediatrics Faculty Publications

Clostridium difficile infection complicates inflammatory bowel disease in children and adults. Increased hospitalizations have been reported due to recent hypervirulent c. difficile strains. National trends of c. difficile infections in hospitalized children and young adults with inflammatory bowel disease (IBD) are currently incomplete.

An Empirical Study Of Home Healthcare Robots Adoption Using The Utuat Model, Ahmad Alaiad, Lina Zhou, Gunes Koru

Transactions of the International Conference on Health Information Technology Advancement

Home healthcare initiatives are aimed to reduce readmission costs, transportation costs, and hospital medical errors, and to improve post hospitalization healthcare quality, and enhance patient home independency. Today, it is almost unimaginable to consider this initiative without information technology. Home healthcare robots are one type of the emerging technologies that hold promise for making clinical information available at the right place and right time. Several robots have been developed to facilitate home healthcare such as remote presence robots (e.g., RP2) and Paro. Most previous research focus on technical and implementation issues of home healthcare robots, there is a need to …

An Analysis Of The Impact Of Storage Temperature, Moisture Content & Duration Upon The Chemical Components & Bioprocessing Of Lignocellulosic Biomass, Arun Athmanathan

Open Access Dissertations

The successful utilization of lignocellulosic biomass as a feedstock for fuels and chemicals necessitates storage for 2-6 months. It is correspondingly important to understand the impact of storage parameters - moisture concentration, temperature and duration - on biomass quality.

As aerobic storage is the most viable large-scale solution, aerobic storage experiments were carried out with three projected bioenergy feedstocks - sweet sorghum (Sorghum bicolor) bagasse, corn (Zea mays) stover and switchgrass (Panicum virgatum). Stored samples of each were examined for dry matter loss and composition change to develop a material balance around carbohydrates and lignin.

A mean dry matter loss …

Hybrid Opto-Electrokinetic Technique For Micro/Nanomanipulation: Towards Application Of A Novel Non-Invasive Manipulation Technique In Microbiological Assay, Jae-Sung Kwon

Open Access Dissertations

This dissertation explores various physical mechanisms of the Rapid Electrokinetic Patterning (REP) technique suggested for rapid and precise on-chip manipulation of colloids and fluids, and bio-compatibility of the technique for biological applications. REP is a hybrid opto-electrokinetic technique that is driven by the simultaneous application of an AC electric field and a heating source. It can not only effectively transport and manipulate a fluid but also concentrate and pattern particles suspended in the fluid through the combined effect of an electrohydrodynamic flow, electrostatic colloidal interactions and an electrothermal microfluidic flow. These capabilities make REP a promising tool which can provide …

Academic Affairs Report, Fall 2013, University Of Northern Iowa. Office Of The Provost And Executive Vice President For Academic Affairs.

Academic Affairs Update

Inside this issue:

-- UNI: New Beginnings on a Strong Foundation
-- New Faces at UNI
-- Re-Envisioning Rod Library
-- Information Technology Services
-- Lippens Joins Office of Executive Vice President and Provost
-- Office of Academic Affairs Initiatives: Communication
-- Lamberti Appointed Administrative Fellow
-- Office of Academic Affairs Initiatives: Diversity
-- The Return of the Center for Excellence in Teaching and Learning
-- Office of Academic Affairs Initiatives: Funding
-- SEEDing the Future
-- The National Coalition Building Institute
-- Bridging American Indians and Taiwan's Indigenous Tribes
-- Award-Winning Innovations in Teaching, Scholarship, and Creative Activity

Synthesis And Antiproliferative Activities Of Quebecol And Its Analogs, Kasiviswanadharaju Pericherla, Amir Nasrolahi Shirazi, V. Kameshwara Rao, Rakesh Tiwari, Nicholas Dasilva, Kellen Mccaffrey, Yousef A. Beni, Antonio González- Sarrías, Navindra P. Seeram, Keykavous Parang, Anil Kumar

Pharmacy Faculty Articles and Research

Simple and efficient synthesis of quebecol and a number of its analogs was accomplished in five steps. The synthesized compounds were evaluated for antiproliferative activities against human cervix adenocarcinoma (HeLa), human ovarian carcinoma (SK-OV-3), human colon carcinoma (HT-29), and human breast adenocarcinoma (MCF-7) cancer cell lines. Among all the compounds, 7c, 7d, 7f, and 8f exhibited antiproliferative activities against four tested cell lines with inhibition over 80% at 75 mu M after 72 h, whereas, compound 7b and 7g were more selective towards MCF-7 cell line. The IC50 values for compounds 7c, 7d, and 7f were 85.1 mu M, 78.7 …

Vermiremediation And Mycoremediation Of Polycyclic Aromatic Hydrocarbons In Soil And Sewage Sludge Mixture: A Comparative Study, A.B. Azizi, K.Y. Liew, Z.M. Noor, N. Abdullah

Research Publications (2011 to 2015)

Polycyclic aromatic hydrocarbons-contaminated soil and sewage sludge mixtures in microcosms were tested separately in triplicate with two types of biological agents, namely earthworms (Lumbricus rubellus) and spent fungal mycelia of Pleurotus sajor-caju (SPC) for 60 days. The results indicated that vermiremediation (VMR) and mycoremediation (MYC) showed degradation result of 99.99 PAHs i.e. Anth, Phen and BaP removal. Ten earthworms and 750 g of SPC depicted optimum results in nutrient element content among respective treatments. Treatment of MYC resulted a consistence increment of soil macronutrients except for TP and TKN (500 g treatment) compared to VMR. Hence, sixty days incubation of …

Let Ivf Take Its Course: Reconceiving Procreative Liberty For The Twenty-First Century, Christine E. White

Student Articles and Papers

No abstract provided.

The Decline And (Possible) Renewal Of Aspiration In The Clean Water Act, Robert W. Adler

Washington Law Review

In the approximately four decades since Congress adopted sweeping amendments to the Federal Water Pollution Control Act—creating what is commonly known as the Clean Water Act (CWA)—the United States has made significant progress in reducing many kinds of water pollution. It is clear, however, that the United States has not attained the most ambitious of the statutory goals and objectives, including the overarching objective to “restore and maintain the chemical, physical, and biological integrity of the nation’s waters.”1 Indeed, although discrete water quality improvements continue in some places and for some forms of pollution, on a national scale progress toward …

Exploring The Lived Experiences Of Participants In Simulation-Based Learning Activities, Rachael Beard

Dissertations

There is currently a small body of research on the experiences of participants, both facilitators and learners, during simulated mock codes (cardiac arrest) in the healthcare setting. This study was based on a practitioner’s concerns that mock codes are facilitated differently among educators, mock codes are not aligned with andragogy theory of adult learning, and there is no standardized method to evaluate participant reflection achieved during the debriefings immediately after mock codes. The study took place in a large federal government healthcare organization. The qualitative study method, interpretive inquiry, was used to explore the lived experiences of clinicians and facilitators …

Phases And Phase Transitions In Disordered Quantum Systems, Thomas Vojta

Physics Faculty Research & Creative Works

These lecture notes give a pedagogical introduction to phase transitions in disordered quantum systems and to the exotic Griffiths phases induced in their vicinity. We first review some fundamental concepts in the physics of phase transitions. We then derive criteria governing under what conditions spatial disorder or randomness can change the properties of a phase transition. After introducing the strong-disorder renormalization group method, we discuss in detail some of the exotic phenomena arising at phase transitions in disordered quantum systems. These include infinite-randomness criticality, rare regions and quantum Griffiths singularities, as well as the smearing of phase transitions. We also …

Course Offerings, Fall 2013 [Difficult Dialogues], Clark University

Difficult Dialogues (2006-2013)

Difficult Dialogues course offerings for the Fall 2013 semester. While each semester's Difficult Dialogues programming centered around a theme, the initiative's course offerings covered a broader range of topic approaching the process of dialogues in a variety of ways and across a number of disciplines.

Clark University's Difficult Dialogues initiative was launched in 2006 and ran through 2013. The initiative aimed to raise awareness and develop skills of dialogue as a distinct approach to discourse, as well as encourage its practice among faculty, staff, and students.

Qbi Colloquium | Nonlinear Dynamics Oscillations Chaos And Noise From Shark Electroreceptors To Mental Disorders, Oct 29, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Role Of Soil Microorganisms In The Resistance Of Giant Ragweed, Horseweed, And Common Lambsquarters To Glyphosate, Jessica Renee Schafer-Bugg

Open Access Dissertations

Continuous glyphosate use has contributed to an increasing number of problematic glyphosate-resistant (GR) weeds. The mechanism of resistance in many GR weeds is poorly understood, in part, due to a poor understanding of how exactly glyphosate kills a plant. In previous research, the efficacy of glyphosate was demonstrated to be strongly influenced by root invading soil-borne microorganisms. However, this interaction among plants, glyphosate, and soil microorganisms has only been studied in a number of crop plants, but not in weed species. This is surprising since the soil biotic environment has a strong impact on the activity of this important herbicide. …

Development Of Isotags For Nmr Based Metabolite Profiling And Applications, Fariba Tayyari

Open Access Dissertations

NMR spectroscopy is a powerful analytical tool for both qualitative and quantitative metabolite profiling analysis. However, accurate quantitative analysis of biological systems especially using one dimensional NMR has been challenging due to signal overlap. In contrast, the enhanced resolution and sensitivity offered by chemoselective isotope tags have enabled new and enhanced methods for detecting hundreds of quantifiable metabolites in biofluids using NMR spectroscopy or mass spectrometry. In this thesis we show improved sensitivity and resolution of NMR experiments imparted by 15N and 13C isotope tagging which enables the accurate analysis of plasma metabolites. To date, isotope tagging has been used …

Construction And Demonstration Of A Tandem Mass Spectrometer Based Instrument For Cold Ion Spectroscopy, James Gerhardt Redwine

Open Access Dissertations

A new instrument incorporating ion trap based tandem mass spectrometry and cold ion UV and UV-IR double resonance spectroscopy has been developed at Purdue University for the study of gas phase, biologically relevant ions. The instrument incorporates multiple quadrupole linear ion trap mass analyzers to prepare and isolate the precursor ions as well as to analyze the resultant photofragments. A 22-pole ion trap cooled to 5 K via a closed cycle helium cryostat is used to cool the ions for spectroscopic interrogation. Results show the vibrational and rotational temperature of a wide assortment of ions to be 12±2 K.

The …