Digital Commons Network^™

Ck1 Is Required For A Mitotic Checkpoint That Delays Cytokinesis, Alyssa E. Johnson, Jun Song Chen, Kathleen L. Gould

Faculty Publications

Failure to accurately partition genetic material during cell division causes aneuploidy and drives tumorigenesis [1]. Cell-cycle checkpoints safeguard cells from such catastrophes by impeding cell-cycle progression when mistakes arise. FHA-RING E3 ligases, including human RNF8 [2] and CHFR [3] and fission yeast Dma1 [4], relay checkpoint signals by binding phosphorylated proteins via their FHA domains and promoting ubiquitination of downstream targets [5]. Upon mitotic checkpoint activation, S. pombe Dma1 concentrates at spindle pole bodies (SPBs) in an FHA-dependent manner and ubiquitinates Sid4, a scaffold of Polo kinase, to suspend cytokinesis [6]. However, the kinase or kinases that phosphoprime Sid4 for …

The Brca Patents: The Good, The Bad, And The Science Excerpt, Amie Gibbons

Cardozo Arts & Entertainment Law Journal (AELJ) Blog

Consider these scenarios: A man on the run from a corporation who has the rights to a specific gene line in his body, and the willingness to take samples from him by force; babies genetically engineered with genes to emphasize height, strength, and intelligence, and jobs granted based on genetic testing instead of proven merit; an airborne biological weapon designed to target members of a specific ethnic group to wipe them out efficiently without worries of killing those the wielder deems worthy to inherit the earth.

This post was originally published on the Cardozo Arts & Entertainment Law Journal website …

Soundings 2013-10-07, N/A N/A

Soundings

No abstract provided.

How I Teach Gender In History (Of Technology), Geoff Zylstra

Publications and Research

No abstract provided.

An Assessment Of The Needs Of Georgian Secondary Agricultural Educators, Jason Peake, Dennis W. Duncan, Brian Parr, John Ricketts, Jennifer Williams

Online Journal for Workforce Education and Development

This purpose of this study was to determine the perception of secondary educators involved in Future Farmers of Georgia (FFG) schools throughout the country of Georgia concerning their needs for furthering the existing framework of agricultural education. The researchers used a modified focus group method to meet the aformentioned purpose of this study. The population for this study consisted of the high school agricultural education teachers and their administrators who were participating in the FFG Program (n=14). Qualitative data collected from the probe (first round) was used to generate a series of 46 statements. In the second round participants were …

Advances In The Redcat Software Package, Chris Schmidt, Stephanie J. Irausquin, Homayoun Valafar

Faculty Publications

Background

Residual Dipolar Couplings (RDCs) have emerged in the past two decades as an informative source of experimental restraints for the study of structure and dynamics of biological macromolecules and complexes. The REDCAT software package was previously introduced for the analysis of molecular structures using RDC data. Here we report additional features that have been included in this software package in order to expand the scope of its analyses. We first discuss the features that enhance REDCATs user-friendly nature, such as the integration of a number of analyses into one single operation and enabling convenient examination of a structural ensemble …

The Free Press Vol 45 Issue 5, 10-07-2013, Kirsten Sylvain

Free Press, The

Veteran student group gets funding for coyote hunt--President announces direction, then switches gears--Late bus connects Gorham--Campus Safety Project still going strong--Faculty Commons opens to mixed reactions

Resolution By Unassisted Top3 Points To Template Switch Recombination Intermediates During Dna Replication, M. Rebecca Glineburg, Alejandro Chavez, Vishesh Agrawal, Steven J. Brill, F. Brad Johnson

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The evolutionarily conserved Sgs1/Top3/Rmi1 (STR) complex plays vital roles in DNA replication and repair. One crucial activity of the complex is dissolution of toxic X-shaped recombination intermediates that accumulate during replication of damaged DNA. However, despite several years of study the nature of these X-shaped molecules remains debated. Here we use genetic approaches and two-dimensional gel electrophoresis of genomic DNA to show that Top3, unassisted by Sgs1 and Rmi1, has modest capacities to provide resistance to MMS and to resolve recombination-dependent X-shaped molecules. The X-shaped molecules have structural properties consistent with hemicatenane-related template switch recombination intermediates (Rec-Xs) but not Holliday …

Cervicothoracic Multisegmental Transpinal Evoked Potentials In Humans, Jonathan Einhorn, Alan Li, Royi Hazan, Maria Knikou

Publications and Research

The objectives of this study were to establish the neurophysiological properties of the transpinal evoked potentials (TEPs) following transcutaneous electric stimulation of the spine (tsESS) over the cervicothoracic region, changes in the amplitude of the TEPs preceded by median nerve stimulation at group I threshold, and the effects of tsESS on the flexor carpi radialis (FCR) H-reflex in thirteen healthy human subjects while seated. Two re-usable self-adhering electrodes, connected to function as one electrode (cathode), were placed bilaterally on the clavicles. A re-usable electrode (anode) was placed on the cervicothoracic region covering from Cervical 4 – Thoracic 2 and held …

The Sexy Issue: Visual Expressions Of Heteronormativity And Gender Identities In Cosmopolitan Magazine, Michael J. Saraceno, Rachel B. Tambling

The Qualitative Report

The current study used a qualitative image analysis to explore observed interactional behaviors communicated through images printed in Cosmopolitan magazine during the calendar year of 2009 as a means to infer social values . Two general inquiries were used to guide the manner with which behavior was observed: is a heteronormative bias present and what values regarding the expressions of sexual orientation and gender identities can be inferred from these images. The sample consisted of 722 individual images depicting groups of two or more persons. Images were coded for group gender composition, activities engaged in, and physical touch . Results …

A Green Chemoselective And Practical Approach Toward N-(2-Azetidinonyl) 25-Disubstituted Pyrroles, Debasish Bandyopadhyay, Elvira Rhodes, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Pyrrole and 2-azetidinone are two essential heterocyclic scaffolds, which are being broadly used in medicinal chemistry and drug discovery field. A green and practical method to synthesize novel N-(2-azetidinonyl) 2,5-disubstituted pyrroles, which are comprised of both pyrrole and 2-azetidinone moieties, has been developed. The classical Paal–Knorr reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful pyrrole derivatives. The present procedure for the synthesis of N-(2-azetidinonyl) 2,5-disubstituted pyrroles (1,2,5-trisubstituted pyrroles) has been accomplished by reacting 3-amino β-lactams and 2,5-hexanedione in the presence of bismuth nitrate pentahydrate as an ecofriendly …

Zach's News, Georgia Southern University, Zach S. Henderson Library

Library Publications (1999-2023)

• America's Music: Latin Rhythms, 10/8 at 7:00PM
• Database trial and evaluation: JoVE Science Education

Emerging Trends For Radioimmunotherapy In Solid Tumors., Maneesh Jain, Suprit Gupta, Sukhwinder Kaur, Moorthy P. Ponnusamy, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

Due to its ability to target both known and occult lesions, radioimmunotherapy (RIT) is an attractive therapeutic modality for solid tumors. Poor tumor uptake and undesirable pharmacokinetics, however, have precluded the administration of radioimmunoconjugates at therapeutically relevant doses thereby limiting the clinical utility of RIT. In solid tumors, efficacy of RIT is further compromised by heterogeneities in blood flow, tumor stroma, expression of target antigens and radioresistance. As a result significant efforts have been invested toward developing strategies to overcome these impediments. Further, there is an emerging interest in exploiting short-range, high energy α-particle emitting radionuclides for the eradication of …

On The Electrodynamics Of Neural Networks, Pb Graben, S Rodrigues

School of Engineering, Computing and Mathematics

We present a microscopic approach for the coupling of cortical activity, as resulting from proper dipole currents of pyramidal neurons, to the electromagnetic field in extracellular fluid in presence of diffusion and Ohmic conduction. Starting from a full-fledged three-compartment model of a single pyramidal neuron, including shunting and dendritic propagation, we derive an observation model for dendritic dipole currents in extracellular space and thereby for the dendritic field potential that contributes to the local field potential of a neural population. Under reasonable simplifications, we then derive a leaky integrate-and-fire model for the dynamics of a neural network, which facilitates comparison …

Points Of Pride, Georgia Southern University

Points of Pride (2013-2023)

• Rankings
• Academics
• Athletics
• Facilities
• Outreach
• Research

Cell-Free Unnatural Amino Acid Incorporation With Alternative Energy Systems And Linear Expression Templates, Prashanta Shrestha, Mark Thomas Smith, Bradley Charles Bundy

Faculty Publications

Site-specific incorporation of unnatural amino acids (uAAs) during protein synthesis expands the proteomic code through the addition of unique residue chemistry. This field provides a unique tool to improve pharmacokinetics, cancer treatments, vaccine development, proteomics and protein engineering. The limited ability to predict the characteristics of proteins with uAA-incorporation creates a need for a low-cost system with the potential for rapid screening. Escherichia coli-based cell-free protein synthesis is a compelling platform for uAA incorporation due to the open and accessible nature of the reaction environment. However, typical cell-free systems can be expensive due to the high cost of energizing …

The Repetitive Component Of The Sunflower Genome As Shown By Different Procedures For Assembling Next Generation Sequencing Reads, Lucia Natali, Rosa Maria Cossu, Elena Barghini, Tommaso Giordani, Matteo Buti, Flavia Mascagni, Michele Morgante, Navdeep Gill, Nolan Kane, Loren Rieseberg, Andrea Cavallini

Biology Faculty Articles

Background

Next generation sequencing provides a powerful tool to study genome structure in species whose genomes are far from being completely sequenced. In this work we describe and compare different computational approaches to evaluate the repetitive component of the genome of sunflower, by using medium/low coverage Illumina or 454 libraries.

Results

By varying sequencing technology (Illumina or 454), coverage (0.55 x-1.25 x), assemblers and assembly procedures, six different genomic databases were produced. The annotation of these databases showed that they were composed of different proportions of repetitive DNA families. The final assembly of the sequences belonging to the six databases …

A Comparison Of The Impact Of A Heart-Healthy Diet Versus Paleolithic Nutrition On Hyperlipidemia In Adults, Robert Pastore

Master's Theses and Doctoral Dissertations

Paleolithic nutrition can optimize serum lipids in adults with hyperlipidemia who have been on a heart-healthy diet based on the current recommendations by the Academy of Nutrition and Dietetics (the Academy) or the American Heart Association (AHA). Twenty subjects (10 male and 10 female) age 40 to 62 were selected based on the criteria of a diagnosis of hypercholesterolemia. Subjects were not taking any cholesterol lowering medication and had followed a calorie-controlled diet, based on either the dietary principles of the Academy or the AHA, for at least four months followed by a Paleolithic diet for four months. Multivariate analysis …

2013 Annual Dinner Program, The O'Callahan Society, College Of The Holy Cross

O'Callahan Society Annual Dinner Program

Thirteenth in a series of speaker events sponsored by the O'Callahan Society at its annual dinner. The keynote speaker is Vice Admiral Barry Costello USN (Ret.) '73.

A Cross-Cultural Health Care Approach To Improve Veteran Health Services In An Academic Community Hospital, Judith Sabino Mph, Eric Johnson Mpsa, Cps, Caama, Chs, Chep, Cdp, James F. Geiger Mpa, Fache

Administration & Leadership

No abstract provided.

Human Rights And Emerging Actors: Indigenous Peoples And Peasants Redefining The Issues, Curtis Kline

Biennial Conference: The Social Practice of Human Rights

As the human rights regime has developed throughout history and especially post WWII, new actors have joined in its promotion. These actors have worked toward expanding identities having claims to human rights and how those claims can be conceptualized. This paper will look at two recent emerging identities. The first will be the identity of Indigenous Peoples and how they have redefined human rights engagement by working to create new UN human rights instruments and bodies. The redefinition of human rights issues will also be looked at in the context of the Indigenous Peoples identity. Issues such as the environment, …

Historical Skeletal Remains From Dundas County, Ontario: A Cautionary Tale Concerning Individual Identification, Lynda Wood, Janet Young

Northeast Historical Archaeology

A single burial dating to the historic period was unexpectedly discovered on a farm in rural Dundas County, Ontario. Based on a preliminary investigation, the remains were believed to be those of Margaret Ellen Bellway, an 8-year-old girl who lived on the property and who died in the year 1881. The objectives of this article are to demonstrate that establishing individual identification of historical remains is possible, to demonstrate the importance of exploring all relevant avenues of research prior to finalizing individual identification, and to demonstrate the means by which this is done. Skeletal analysis of the remains indicated a …

Development Of A Conditional Mesd (Mesoderm Development) Allele For Functional Analysis Of The Low-Density Lipoprotein Receptor-Related Family In Defined Tissues, Andrew V. Taibi, Janet K. Lighthouse, Richard C. Grady, Kenneth R. Shroyer, Bernadette Holdener

Department of Biomedical Engineering Faculty Publications

The Low-density lipoprotein receptor-Related Protein (LRP) family members are essential for diverse processes ranging from the regulation of gastrulation to the modulation of lipid homeostasis. Receptors in this family bind and internalize a diverse array of ligands in the extracellular matrix (ECM). As a consequence, LRPs regulate a wide variety of cellular functions including, but not limited to lipid metabolism, membrane composition, cell motility, and cell signaling. Not surprisingly, mutations in single human LRPs are associated with defects in cholesterol metabolism and development of atherosclerosis, abnormalities in bone density, or aberrant eye vasculature, and may be a contributing factor in …

Winthrop Calls For Volunteers For The 12th Annual Lake Wylie River Sweep, Winthrop University

Winthrop News 2013

• The Winthrop community will focus on the Ebenezer Park site, located at 4490 Boatshore Road.
• The river sweep is from 9 a.m.-noon.

10-04-2013 Life-Long Naturalist, Teacher , Mountain Climber And Artist Speaking At Swosu, Southwestern Oklahoma State University

THE BARK ARCHIVE 2013

Some people discover during childhood their life’s true passions and make of them professional careers. Other people are aware of their true passions but decide not to pursuit them professionally, at least for a while.

The Echo: October 4, 2013, Taylor University

2013-2014 (Volume 101)

Taylor opens doors on campus center plans – Shut down – Enactus returns – Top five news events of the week – Online Teasers – Public health arrives at Taylor – In The Loop – Political, religious overhaul for Italy – Cam Glass: A lucky fame – Melon and Gourd – Ask Angelina – DC Recipe of the week – Echograms #TaylorU -- #TaylorU’s Top Tweets – Kids art classes connect community and college – Taylor goes to Hollywood – The Switchfoot experience – The cost of efficiency – Parents vs. presence – Unity, not uniformity – Runs in the …

Board Of Trustees Meeting Minutes 2013-10-04, Bowling Green State University

Board of Trustees Meeting Minutes

The official meeting minutes of Bowling Green State University's Board of Trustees.

Spring, Summer, Fall 2013 Graduation Survey Responses Master File Without Identifiers, Uno Office Of Institutional Effectiveness

Graduation

Spring, Summer, Fall 2013 Graduation survey responses.

Physics Colloquium | Phonons And Defects In Semiconductors, Oct 4, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

October 4, 2013 Finance & Facilities (F&F) Committee Meeting, Evp For Administration

Finance and Facilities Committee

Documents related to the October 4, 2013 Board of Regents' Finance and Facilities Committee Meeting. (Agenda, Minutes, eBook, Notice)