Digital Commons Network^™

Electromagnetic Properties Of Water In The Presence Of A Protein, Kelly Jeppesen, Travis Oliphant

Journal of Undergraduate Research

Light scattering is a means of detecting certain chemical properties of a sample of material. As a photon (light packet) encounters any material, there is some probability that the photon will be absorbed. The energy from an absorbed photon will either work to heat the sample or be reemitted. When re-emitted, a photon will not necessarily travel in the same direction or with the same phase in which it encountered the material. Also, the amount of energy re-emitted via scattering is dependent on the incident light wavelength and properties of the material, which, for example, is why the sky looks …

Pathogenic Cd4+ T Cells Recognizing An Unstable Peptide Of Insulin Are Directly Recruited Into Islets Bypassing Local Lymph Nodes, James F. Mohan, Boris Calderon, Mark S. Anderson, Emil R. Unanue

Open Access Publications

No abstract provided.

Seeing Triple

News Releases

No abstract provided.

An Investigation Into The Presynaptic Actions By Which Amphetamine Activates Dopamine Signaling Within Striatal Subregions Of The Rat., Dan P. Covey

Theses and Dissertations

Despite decades of intense research and a consensus view in the field, the work presented herein provides strong evidence that the primary mechanism of amphetamine action should be re-evaluated. Rather than depleting vesicular dopamine stores and promoting non-exocytotic efflux through the dopamine transporter in vivo, recent evidence demonstrates that amphetamine augments phasic dopamine signaling instead. This signaling modality is critical for reinforcement learning and is dependent on intact vesicular stores. The new findings support over-activation of phasic dopamine signaling as a common mechanism in the addiction process.

Compressed Property Suffix Trees, Wing Kai Hon, Manish Patil, Rahul Shah, Sharma V. Thankachan

Faculty Publications

Property matching is a biologically motivated problem where the task is to find those occurrences of an online pattern P in a string text T (of size n), such that the matched text part satisfies some conceptual property. The property of a string is a set π of (possibly overlapping) intervals {( s1,f1),(s2,f2),.} corresponding to the part of text and an occurrence of a pattern P=T[i,.,(i+|P|-1)] is a valid output only if T[i,.,(i+|P|-1)] is completely contained in at least one interval (sj,fj)â̂̂π. The indexing version of this problem was introduced by A. Amir (2008), where the text is preprocessed in …

Playing Set® To Discover Qualitative Data Analysis, Jean Scandlyn, Sarah Hautzinger

The Qualitative Report

This article describes the use of an experiential classroom exercise using the card game Set® to introduce concepts related to qualitative approaches to research design and analysis, particularly those based in an interpretive framework. The multiple components of the game, which centers on visual pattern recognition, parallel the “organic” complexity of ethnographic investigation and demonstrate how strong interpretations can be supported with qualitative evidence. The first author adapted the exercise, originally developed by the second author for teaching undergraduate anthropology students, for use in workshops teaching qualitative research to mid - career professionals working on health - related projects in …

The Eastern Echo, October 14, 2013, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Down-Regulation Of Plcγ2-Β-Catenin Pathway Promotes Activation And Expansion Of Myeloid-Derived Suppressor Cells In Cancer, Aude-Helene Capietto, Seokho Kim, Dominic E. Sanford, David C. Linehan, Masaki Hikida, Tomohiro Kumosaki, Deborah V. Novack, Roberta Faccio

Open Access Publications

No abstract provided.

Board Of Directors Meeting Minutes (October 14, 2013), Dmacc

Board of Directors Meeting Minutes

This file contains the minutes from the Des Moines Area Community College Board meeting held on October 14, 2013.

Poets Of Kashmir: A Digital Library, Mudasir Khazer Rather, Bilal Gani Bhat

Library Philosophy and Practice (e-journal)

Abstract

Kashmir has remained a seat of learning and knowledge, religious and philosophical discourses since centuries. Kashmir has a rich and vibrant cultural history and a tradition of learning and scholarly pursuit since times immemorial. Through the ages, it has been a melting pot of ideas, which have been distilled into the finest traditions of learning, tolerance and cultural cohesion. These ideas have been portrayed by different writers, Poets and historians from time to time. Unfortunately, very less information pertaining to these cultural icons is available. The main aim of this work is to build a Digital collection of biographies …

An Expanded View Of The Eukaryotic Cytoskeleton, James B. Moseley

Dartmouth Scholarship

A rich and ongoing history of cell biology research has defined the major polymer systems of the eukaryotic cytoskeleton. Recent studies have identified additional proteins that form filamentous structures in cells and can self-assemble into linear polymers when purified. This suggests that the eukaryotic cytoskeleton is an even more complex system than previously considered. In this essay, I examine the case for an expanded definition of the eukaryotic cytoskeleton and present a series of challenges for future work in this area.

Zebrafish Cytosolic Carboxypeptidases 1 And 5 Are Essential For Embryonic Development, Peter J. Lyons, Matthew R. Sapio, Lloyd D. Fricker

Faculty Publications

The cytosolic carboxypeptidases (CCPs) are a subfamily of metalloenzymes within the larger M14 family of carboxypeptidases that have been implicated in the post-translational modification of tubulin. It has been suggested that at least four of the six mammalian CCPs function as tubulin deglutamylases. However, it is not yet clear whether these enzymes play redundant or unique roles within the cell. To address this question, genes encoding CCPs were identified in the zebrafish genome. Analysis by quantitative polymerase chain reaction indicated that CCP1, CCP2, CCP5, and CCP6 mRNAs were detectable between 2 h and 8 days postfertilization with highest levels 5–8 …

Diffuse Migratory Connectivity In Two Species Of Shrubland Birds: Evidence From Stable Isotopes, Steven T. Knick, Matthias Leu, John T. Rotenberry, Steven E. Hanser, Kurt A. Fesenmyer

Articles

Connecting seasonal ranges of migratory birds is important for understanding the annual template of stressors that influence their populations. Brewer’s sparrows (Spizella breweri) and sagebrush sparrows (Artemisiospiza nevadensis) share similar sagebrush (Artemisia spp.) habitats for breeding but have different population trends that might be related to winter location. To link breeding and winter ranges, we created isoscapes of deuterium [stable isotope ratio (δ) of deuterium; δ ²H] and nitrogen (δ ¹⁵N) for each species modeled from isotope ratios measured in feathers of 264 Brewer’s and 82 sagebrush sparrows and environmental …

The Rootscope: A Simple High-Throughput Screening System For Quantitating Gene Expression Dynamics In Plant Roots, Erin J. Kast , '15, Minh-Duyen T. Nguyen , '13, Rosalie E. Lawrence , '12, Christina Rabeler, Nicholas J. Kaplinsky

Biology Faculty Works

Background: High temperature stress responses are vital for plant survival. The mechanisms that plants use to sense high temperatures are only partially understood and involve multiple sensing and signaling pathways. Here we describe the development of the RootScope, an automated microscopy system for quantitating heat shock responses in plant roots.Results: The promoter of Hsp17.6 was used to build a Hsp17.6(p):GFP transcriptional reporter that is induced by heat shock in Arabidopsis. An automated fluorescence microscopy system which enables multiple roots to be imaged in rapid succession was used to quantitate Hsp17.6p: GFP response dynamics. Hsp17.6(p):GFP signal increased with temperature increases from …

Mutations Of Pdd1 Chromo- And Chromoshadow Domains Reveal Critical Functions For Each During Development Of Tetrahymena Thermophila, Rachel Schwope

All Theses and Dissertations (ETDs)

Pdd1 is a developmentally expressed HP1-like protein of Tetrahymena thermophila that is required during conjugation, when a copy of the cell's transcriptionally silent germline micronucleus differentiates into an active somatic macronucleus. Differentiation of these somatic chromosomes involves genome-wide fragmentation and amplification. These DNA rearrangements are facilitated by an RNAi mechanism, in which small RNAs target silencing histone modifications, H3K9 and H3K27 methylation, to Internal Eliminated Sequences: IESs), which are bound by Pdd1 and later excised from the genome. Pdd1 features two chromodomains, one of which shares homology with that of HP1, and a C-terminal chromoshadow domain. In this study, we …

Identification And Developmental Profiling Of Micrornas In Diamondback Moth, Plutellaxylostella (L.), Pei Liang, Bing Feng, Xuguo Zhou, Xiwu Gao

Entomology Faculty Publications

MicroRNAs (miRNAs) are a group of small RNAs involved in various biological processes through negative regulation of mRNAs at the post-transcriptional level. Although miRNA profiles have been documented in over two dozen insect species, few are agricultural pests. In this study, both conserved and novel miRNAs in the diamondback moth, Plutella xylostella L., a devastating insect pest of cruciferous crops worldwide, were documented. High-throughput sequencing of a small RNA library constructed from a mixed life stages of P. xylostella, including eggs, 1st to 4th (last) instar larvae, pupae and adults, identified 384 miRNAs, of which 174 were P. xylostella specific. …

Homecoming 2013 Booklet, Taylor University

Homecoming & Family Weekend

No abstract provided.

A Framework To Evaluate Wildlife Feeding In Research, Wildlife Management, Tourism And Recreation, Sara Dubois, David Fraser

Wildlife Population Management Collection

Feeding of wildlife occurs in the context of research, wildlife management, tourism and in opportunistic ways. A review of examples shows that although feeding is often motivated by good intentions, it can lead to problems of public safety and conservation and be detrimental to the welfare of the animals. Examples from British Columbia illustrate the problems (nuisance animal activity, public safety risk) and consequences (culling, translocation) that often arise from uncontrolled feeding. Three features of wildlife feeding can be distinguished: the feasibility of control, the effects on conservation and the effects on animal welfare. An evaluative framework incorporating these three …

October 11-12, 2013, Vs. Vermont, University Of North Dakota

UND Athletics Publications: Men's Hockey

Program for the October 11-12, 2013, weekend series against the Vermont Catamounts.

Differential Recruitment Of Coregulators To The Rora Promoter Adds Another Layer Of Complexity To Gene (Dys)Regulation By Sex Hormones In Autism, Tewarit Sarachana, Valerie Wailin Hu

Biochemistry and Molecular Medicine Faculty Publications

Background

Our independent cohort studies have consistently shown the reduction of the nuclear receptor RORA (retinoic acid-related orphan receptor-alpha) in lymphoblasts as well as in brain tissues from individuals with autism spectrum disorder (ASD). Moreover, we have found that RORA regulates the gene for aromatase, which converts androgen to estrogen, and that male and female hormones regulate RORA in opposite directions, with androgen suppressing RORA, suggesting that the sexually dimorphic regulation of RORA may contribute to the male bias in ASD. However, the molecular mechanisms through which androgen and estrogen differentially regulate RORA are still unknown.

Methods

Here we use …

V. 81, Issue 5, October 11, 2013

Archway (1946-2020)

No abstract provided.

Involvement Of Reactive Oxygen Species In A Feed-Forward Mechanism Of Na/K-Atpase Mediated Signaling, Yanling Yan, Anna P. Shapiro, Steven Haller, Vinal Katragadda, Lijun Liu, Jiang Tian, Venkatesha Basrur, Deepak Malhotra, Zi-Jian Xie, Nader G. Abraham, Joseph I. Shapiro Md, Jiang Liu

Biochemistry and Microbiology

Cardiotonic steroids (such as ouabain) signaling through Na/K-ATPase regulate sodium reabsorption in the renal proximal tubule. We report here that reactive oxygen species are required to initiate ouabain-stimulated Na/K-ATPase·c-Src signaling. Pretreatment with the antioxidant N-acetyl-L-cysteine prevented ouabain-stimulated Na/K-ATPase·c-Src signaling, protein carbonylation, redistribution of Na/K-ATPase and sodium/proton exchanger isoform 3, and inhibition of active transepithelial ²²Na⁺ transport. Disruption of the Na/K-ATPase·c-Src signaling complex attenuated ouabain-stimulated protein carbonylation. Ouabain-stimulated protein carbonylation is reversed after removal of ouabain, and this reversibility is largely independent of de novo protein synthesis and degradation by either the lysosome or the proteasome pathways. Furthermore, …

Recruitment Of Tlr Adapter Trif To Tlr4 Signaling Complex Is Mediated By The Second Helical Region Of Trif Tir Domain, Wenji Piao, Lisa W. Ru, Kurt H. Piepenbrink, Eric J. Sundberg, Stefanie N. Vogel, Vladimir Y. Toshchakov

Food for Health: Publications

Toll/IL-1R resistance (TIR) domain–containing adapter-inducing IFN-β (TRIF) is a Toll-like receptor (TLR) adapter that mediates MyD88-independent induction of type I interferons through activation of IFN regulatory factor 3 and NFκB. We have examined peptides derived from the TRIF TIR domain for ability to inhibit TLR4. In addition to a previously identified BB loop peptide (TF4), a peptide derived from putative helix B of TRIF TIR (TF5) strongly inhibits LPS-induced cytokine and MAPK activation in wild-type cells. TF5 failed to inhibit LPS-induced cytokine and kinase activation in TRIF-deficient immortalized bone-marrow–derived macrophage, but was fully inhibitory in MyD88 knockout cells. TF5 does …

Physics Colloquium | The Perfect Fluid The Strongly Coupled Quark Gluon Plasma, Oct 11, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Nominations For Konneker Medal For Commercialization And Entrepreneurship Due, Oct 31, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Bison, October 11, 2013

The Bison Newspapers

No abstract provided.

Carbon Dynamics In The Future Forest: The Importance Of Long-Term Successional Legacy And Climate–Fire Interactions, E. Louise Loudermilk, Robert M. Scheller, Peter J. Weisberg, Jian Yang, Thomas E. Dilts, Sarah L. Karam, Carl Skinner

Environmental Science and Management Faculty Publications and Presentations

Understanding how climate change may influence forest carbon (C) budgets requires knowledge of forest growth relationships with regional climate, long-term forest succession, and past and future disturbances, such as wildfires and timber harvesting events. We used a landscape-scale model of forest succession, wildfire, and C dynamics (LANDIS-II) to evaluate the effects of a changing climate (A2 and B1 IPCC emissions; Geophysical Fluid Dynamics Laboratory General Circulation Models) on total forest C, tree species composition, and wildfire dynamics in the Lake Tahoe Basin, California, and Nevada. The independent effects of temperature and precipitation were assessed within and among climate models. Results …

Harbor Notes, October 11, 2013, Tom Scherberger

Harbor Notes

The October 11, 2013, issue of Harbor Notes.

Ucc Minutes Oct 11, 2013, Undergraduate Curriculum Council

Undergraduate Currirculum Committee Minutes

No abstract provided.

Tanik Named Chair Of Electrical And Computer Engineering At Uab, Staff

Browse All News

No abstract provided.