Digital Commons Network^™

Mismatch Repair Genes Mlh1 And Mlh3 Modify Cag Instability In Huntington's Disease Mice: Genome-Wide And Candidate Approaches, Ricardo Mouro Pinto, Ella Dragileva, Andrew Kirby, Alejandro Lloret, Edith Lopez, Jason St. Claire, Gagan B. Panigrahi, Caixia Hou, Kim Holloway, Tammy Gillis, Jolene R. Guide, Paula E. Cohen, Guo-Min Li, Christopher E. Pearson, Mark J. Daly, Vanessa C. Wheeler

Toxicology and Cancer Biology Faculty Publications

The Huntington's disease gene (HTT) CAG repeat mutation undergoes somatic expansion that correlates with pathogenesis. Modifiers of somatic expansion may therefore provide routes for therapies targeting the underlying mutation, an approach that is likely applicable to other trinucleotide repeat diseases. Huntington's disease Hdh(Q111) mice exhibit higher levels of somatic HTT CAG expansion on a C57BL/6 genetic background (B6.Hdh(Q111) ) than on a 129 background (129.Hdh(Q111) ). Linkage mapping in (B6x129).Hdh(Q111) F2 intercross animals identified a single quantitative trait locus underlying the strain-specific difference in expansion in the striatum, implicating mismatch repair (MMR) gene Mlh1 as the most likely candidate modifier. …

Otter Realm, October 31, 2013, California State University, Monterey Bay

The Otter Realm

Dia de los Muertos: When Life and Death Go Hand in Hand -- What You Otter Be Doing October 31 - November 14 -- Shifting Priorities and Making Decisions -- Giving for the Sake of Sharing: "Really, Really Free Market" a Success in North Quad -- Volunteering for the Youth of the Nations: Village Project in Seaside Provides Opportunities for Service Learning -- Campus Prepares for New Business and Information Technology Building: Parking Options Subject to Change with New Construction -- No Privacy in Public Locations: City of Seaside May Install New Surveillance Cameras -- Gatorade Pong A Splash: Otter …

Quantitative Relationship Of Soil Texture With The Observed Population Density Reduction Of Heterodera Glycines After Annual Corn Rotation In Nebraska, Oscar Perez-Hernandez, Loren J. Giesler

Department of Plant Pathology: Faculty Publications

Soil texture has been commonly associated with the population density of Heterodera glycines (soybean cyst nematode: SCN), but such an association has been mainly described in terms of textural classes. In this study, multivariate analysis and a generalized linear modeling approach were used to elucidate the quantitative relationship of soil texture with the observed SCN population density reduction after annual corn rotation in Nebraska. Forty-five commercial production fields were sampled in 2009, 2010, and 2011 and SCN population density (eggs/100 cm3 of soil) for each field was determined before (Pi) and after (Pf) annual corn rotation from ten 3 3 …

The Bees And Dinosaurs Connection, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Preliminary Assessment Of Diabetic Youth’S Acceptance Of Cinnamon In Treating Diabetes: A Telephone Interview, Valerie Amend, Dawn Vincent, Valerie Amend, Kimberli Pike

Journal of Human Sciences and Extension

Medications in treatment and control of diabetes can be costly for pediatric patients and families. Therefore, individuals may seek complementary and alternative therapies, such as cinnamon, in addition to traditional treatments. The objective of this study was to determine acceptability of using cinnamon in treatment of diabetes in a pediatric population with diabetes. Seventy-six pediatric diabetes patients at a diabetes clinic participated in a one-time telephone interview using an 18-item, validated questionnaire. Descriptive statistics were utilized to determine cinnamon acceptability and preferences. The majority of the subjects were between 16-18 years (43%, n = 33), Caucasian (62%, n = 47), …

Conversations About The Weight Of America's Children: Barriers Which Prevent Healthcare Providers From Discussing Childhood Obesity, Catherine Blow, Alisa Allicock, Carolynn Desandre, Chandra Cooper-Samuels

Journal of Human Sciences and Extension

A systematic review of the literature was conducted to identify the barriers that prevent practitioners from identifying and counseling parents and caregivers of overweight or obese children. Once identified, barriers were organized into thematic categories (parental, provider, and professional barriers) and recommendations were generated to facilitate discussion about childhood obesity between professionals and parents. Childhood obesity is a significant public health problem. Healthcare providers must be able to effectively communicate with caregivers and put childhood obesity at the front of healthcare discussions. This article provides a synthesis of the relevant literature and makes recommendations for healthcare providers to overcome the …

Killerflip: A Novel Lytic Peptide Specifically Inducing Cancer Cell Death, B Pennarun, G. Gaidos, O Bucur, A Tinari

Dartmouth Scholarship

One of the objectives in the development of effective cancer therapy is induction of tumor-selective cell death. Toward this end, we have identified a small peptide that, when introduced into cells via a TAT cell-delivery system, shows a remarkably potent cytoxicity in a variety of cancer cell lines and inhibits tumor growth in vivo, whereas sparing normal cells and tissues. This fusion peptide was named killer FLIP as its sequence was derived from the C-terminal domain of c-FLIP, an anti-apoptotic protein. Using structure activity analysis, we determined the minimal bioactive core of killerFLIP, namely killerFLIP-E. Structural analysis of cells using …

The Eastern Echo, October 31, 2013, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Determinan Perilaku Perawatan Kehamilan, Elviera Gamelia, Colti Sistiarani, Siti Masfiah

Kesmas

Peningkatan status derajat kesehatan. Indikator derajat kesehatan masyarakat terkait erat dengan Angka Kematian Ibu (AKI). Kabupaten Banyumas memiliki AKI di bawah standar pelayanan minimal (SPM), salah satunya adalah wilayah kerja Puskesmas I Ajibarang. Peningkatan status kesehatan ibu pada saat kehamilan merupakan salah satu langkah yang dapat dilakukan untuk menurunkan kasus kematian ibu. Status kesehatan ibu hamil dipengaruhi oleh perawatan kehamilan yang baik oleh ibu hamil untuk mencegah terjadinya komplikasi dan kematian ketika persalinan, di samping itu juga untuk pertumbuhan dan kesehatan janin. Penelitian ini bertujuan untuk mengetahui faktor-faktor apakah yang dominan mempengaruhi perilaku perawatan kehamilan. Penelitian ini adalah potong lintang. …

Laser Vaporization Methods For The Synthesis Of Metal And Semiconductor Nanoparticles; Graphene, Doped Graphene And Nanoparticles Supported On Graphene, Parichehr Afshani

Theses and Dissertations

The major objective of the research described in this dissertation is the development of new laser vaporization methods for the synthesis of metal and semiconductor nanoparticles, graphene, B- and N-doped graphene, and metal and semiconductor nanoparticles supported on graphene. These methods include the Laser Vaporization Controlled Condensation (LVCC) approach, which has been used in this work for the synthesis of: (1) gold nanoparticles supported on ceria and zirconia nanoparticles for the low temperature oxidation of carbon monoxide, and (2) graphene, boron- and nitrogen-doped graphene, hydrogen-terminated graphene (HTG), metal nanoparticles supported on graphene, and graphene quantum dots. The gold nanoparticles supported …

Neratinib Overcomes Trastuzumab Resistance In Her2 Amplified Breast Cancer, A Canonici, M Gijsen, M Mullooly, R Bennett, Et Al

Peninsula Medical School

Trastuzumab has been shown to improve the survival outcomes of HER2 positive breast cancer patients. However, a significant proportion of HER2-positive patients are either inherently resistant or develop resistance to trastuzumab. We assessed the effects of neratinib, an irreversible panHER inhibitor, in a panel of 36 breast cancer cell lines. We further assessed its effects with or without trastuzumab in several sensitive and resistant breast cancer cells as well as a BT474 xenograft model. We confirmed that neratinib was significantly more active in HER2-amplified than HER2 non-amplified cell lines. Neratinib decreased the activation of the 4 HER receptors and inhibited …

Kenyon Collegian - October 31, 2013

The Kenyon Collegian

No abstract provided.

It's A "Love/Hate Relationship": Developing Research Affinity For The Non-Researcher, Bridgette M. Brawner Phd

Research Day

No abstract provided.

The Reality Of Disaster: An Educational Template That Brings Community Into The Classroom, Mary T. Bouchaud Phd, Msn, Cns, Rn, Crrn, Edward H. Jasper Md

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Population Health Matters, Fall 2013, Download Full Text Pdf

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Fine-Scale Distributions Of Plankton And Larval Fishes: Implications For Predator-Prey Interactions Near Coastal Oceanographic Features, Adam Tyler Greer

Open Access Dissertations

Describing the distributions of organisms on scales relevant to individuals (1-100 m) is critical to understanding predator-prey interactions within the plankton. This has driven the development of plankton imaging technology with synoptic physical parameters (temperature, salinity, depth), which facilitates high-resolution taxonomic and spatial descriptions. We utilized a novel In Situ Ichthyoplankton Imaging System (ISIIS) that addressed some shortcomings of other imaging systems by allowing for the simultaneous sampling of both abundant (e.g., copepods, appendicularians, marine snow) and rare (e.g., fish larvae, medusae, ctenophores) members of the plankton community. The main objectives of this study were 1) to describe the physical …

Apoptotic Regulation Of B Cell Development And Autoimmunity, Jacqueline A. Wright

Open Access Dissertations

Misguided immune reactions against self can cause autoimmunity. Although multiple factors are likely involved, a common feature is altered lymphocyte homeostasis due to dyregulated apoptosis. Here, we show that the integration of signals from the BCR and BAFF-R promotes survival of T2 cells that have passed the self-reactivity checkpoint. BCR engagement produces NF-κB2 protein, a substrate used by the BAFF-R for the activation of the alternative NF-κB pathway. In contrast, pre-checkpoint T1 cells fail to integrate BCR and BAFF-R signals and remain sensitive to BCR-mediated-apoptosis. Btk and c-Rel are critical in this signal integration and B-cell survival. Importantly, BAFF-R promotes …

Weekly News Digest 10/30/2013, Jenna Ray

Weekly Bulletin Archive

In this issue:

● Performing Arts Series Continues with Zenon Dance Company

● Gloria Ladson-Billings Will Conclude Visit to Morris

● Students Awarded Dr. Nancy “Rusty” Barceló Scholarship

● Nic McPhee Featured in the Minneapolis Star Tribune

Spartan Daily, October 30, 2013, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 141, Issue 27

Including Capabilities Of Local Actors In Regional Economic Development: Empirical Results Of Local Seaweed Industries In Sulawesi, Mark T. J. Vredegoor, Bartjan W. Pennink

The South East Asian Journal of Management

Stimson, et al. (2009) developed one of the most relevant and well known model for Regional Economic Development. This model covers the most important factors related to economic development question. However, this model excludes the social components of development. Local community should be included in terms of the development of a region. This paper introduced to the Stimson model “Skills” and “Knowledge” at the individual level for local actors indicating the capabilities at the individual level and introduced “Human Coordination” for the capabilities at the collective level. In our empirical research we looked at the Indonesian seaweed market with a …

The Lumberjack, October 30, 2013, The Lumberjack Staff

2013

The student newspaper of Humboldt State University

The Anchor, Volume 127.08: October 30, 2013, Hope College

The Anchor: 2013

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

Campus Chronicle, Alex Payne, Anna Duran, Megan Miras, Ann Voight, Mike Kelsey, Morgan Meier, Buddy Jackson, Miriah Masching, Alex Roth, Ryan Meier, Andy Langager

Campus Chronicle

No abstract provided.

The Daily Gamecock, Wednesday, October 30, 2013, University Of South Carolina, Office Of Student Media

October

No abstract provided.

The Parthenon, October 30, 2013, Bishop Nash

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

Distinct Balance Of Excitation And Inhibition In An Interareal Feedforward And Feedback Circuit Of Mouse Visual Cortex, Weiguo Yang, Yarimar Carrasquillo, Bryan M. Hooks, Jeanne M. Nerbonne, Andreas Burkhalter

Open Access Publications

No abstract provided.

Volume 51, Number 11: October 30, 2013, University Of North Dakota

University Letter Archive

No abstract provided.

Daily Eastern News: October 30, 2013, Eastern Illinois University

October

No abstract provided.

The Daily Egyptian, October 29, 2013, Daily Egyptian Staff

October 2013

No abstract provided.

As-771-13 Resolution On Proposal For The Establishment Of The Kenneth N. Edwards Western Coatings Technology Center, Dr. Raymond Fernando, Arthur C. Edwards, Ednowed Chair, Director: Polymers And Coatings Program, Chemistry And Biochemistry Department, Cal Poly

Academic Senate Resolutions

That The Academic Senate endorses the proposal for the Kenneth N. Edwards Western Coatings Technology Center.