Digital Commons Network^™

Polymer Micro-Grippers With An Integrated Force Sensor For Biological Manipulation, Re Mackay, Hr Le, S Clark, Ja Williams

School of Biological and Marine Sciences

The development of a novel micro-system integrating SU-8 polymer micro-grippers with a tensile force sensor for handling and characterizing the mechanical properties of delicate biological materials, such as fibrils, is presented. The micro-grippers are actuated by the electro-thermal effect and have gripping forces comparable to the common 'hot-and-cold-arm' grippers. A robust finite element model was developed to investigate system performance and validated experimentally. A new micro-mechanical calibration method using a piezoelectric manipulator with a micro-force measurement system was successfully applied to test the structure. Both FEA simulation and micro-mechanical testing results indicated that the system could fulfil the requirements for …

Event-Driven Visual Attention For The Humanoid Robot Icub, F Rea, G Metta, C Bartolozzi

School of Engineering, Computing and Mathematics

Fast reaction to sudden and potentially interesting stimuli is a crucial feature for safe and reliable interaction with the environment. Here we present a biologically inspired attention system developed for the humanoid robot iCub. It is based on input from unconventional event-driven vision sensors and an efficient computational method. The resulting system shows low-latency and fast determination of the location of the focus of attention. The performance is benchmarked against an instance of the state of the art in robotics artificial attention system used in robotics. Results show that the proposed system is two orders of magnitude faster that the …

An Interactive Channel Model Of The Basal Ganglia: Bifurcation Analysis Under Healthy And Parkinsonian Conditions, R Merrison-Hort, N Yousif, F Njap, Et Al

School of Engineering, Computing and Mathematics

Oscillations in the basal ganglia are an active area of research and have been shown to relate to the hypokinetic motor symptoms of Parkinson's disease. We study oscillations in a multi-channel mean field model, where each channel consists of an interconnected pair of subthalamic nucleus and globus pallidus sub-populations.To study how the channels interact, we perform two-dimensional bifurcation analysis of a model of an individual channel, which reveals the critical boundaries in parameter space that separate different dynamical modes; these modes include steady-state, oscillatory, and bi-stable behaviour. Without self-excitation in the subthalamic nucleus a single channel cannot generate oscillations, yet …

Towards A Consensus View On Understanding Nanomaterials Hazards And Managing Exposure: Knowledge Gaps And Recommendations, G Hunt, I Lynch, F Cassee, Rd Handy, Tf Fernandes, M Berges, Taj Kuhlbusch, M Dusinska, M Riediker

School of Biological and Marine Sciences

No abstract provided.

Critical Comparison Of Intravenous Injection Of Tio2 Nanoparticles With Waterborne And Dietary Exposures Concludes Minimal Environmentally-Relevant Toxicity In Juvenile Rainbow Trout Oncorhynchus Mykiss., D Boyle, Ga Al-Bairuty, Tb Henry, Rd Handy

School of Biological and Marine Sciences

A critical comparison of studies that have investigated tissue accumulation and toxicity of TiO2-NPs in fish is necessary to resolve inconsistencies. The present study used identical TiO2-NPs, toxicological endpoints, and fish (juvenile rainbow trout Oncorhynchus mykiss) as previous studies that investigated waterborne and dietary toxicity of TiO2-NPs, and conducted a critical comparison of results after intravenous caudal-vein injection of 50 μg of TiO2-NPs and bulk TiO2. Injected TiO2-NPs accumulated only in kidney (94% of measured Ti) and to a lesser extent in spleen; and injected bulk TiO2 was found only in kidney. No toxicity of TiO2 was observed in kidney, …

Molecular Approaches For Studying Root Herbivores, Cm Benefer, Rp Blackshaw

School of Geography, Earth and Environmental Sciences

The use of molecular techniques in insect ecology has expanded rapidly, allowing ever more challenging questions to be addressed. Compared to their aboveground equivalents, root herbivore molecular ecology has received less attention, despite essentially the same ecological questions being of importance in both the above- and belowground ecosystems. Studies so far have concentrated on economically important taxa, using mitochondrial and nuclear DNA sequencing and a variety of markers to investigate the species identity and relationships, population dynamics and dispersal, distribution, feeding behaviour and interactions with other organisms. Although this has proved useful for elucidating these aspects of their ecology, there …

The Paradox Of Legal Equivalents And Scientific Equivalence: Reconciling Patent Law's Doctrine Of Equivalents With The Fda's Bioequivalence Requirement, Janet Freilich

Faculty Scholarship

Contrary to popular perception, generic drugs often enter the market before the patents covering their brand name counterparts have expired by making slight changes to the drug to avoid the brand name patent. These generics face a paradox: the U.S. Food and Drug Administration (FDA) requires that the generic "not show a significant difference" from the reference product, while patent law requires that the generic have "substantial differences" as compared to the reference product. The generic must be bioequivalent, but not legally equivalent, to the brand name drug. This paradox occurs frequently in the courts but has never been discussed …

Transsexual And Intersex Athletes, Erin Buzuvis

Faculty Scholarship

In her chapter, the Author examines the impact of both past and present policies enacted by many sport organizations, such as the International Olympic Committee (IOC) on intersex and transsexual athletes. At the root of many of these policies, and therefore the issues, are the binary gender system and the concern that fraudulent competitors could gain an advantage relative to the rest of the field. While no longer mandatory, women athletes are still subject to varying degrees of sex verification testing on a case-by-case basis, as evidenced by the 2009 testing of South African runner, Caster Semenya.

Recent policies point …

"On The Basis Of Sex": Using Title Ix To Protect Transgender Students From Discrimination In Education, Erin E. Buzuvis

Faculty Scholarship

Transgender students are vulnerable to discrimination, exclusion, and harassment, and it is not clear to what extent this discrimination is prohibited by law. Title IX, the federal law prohibiting discrimination "on the basis of sex" in federally-funded schools, does not expressly prohibit discrimination against transgender students. Yet it is possible to interpret the prohibition on sex discrimination in a number of different ways that would make the law available to transgender plaintiffs in some, many, or all cases of discrimination otherwise covered by the statute. Since Title IX has only been invoked in a handful of transgender rights cases, litigants …

“Rugged Vaginas” And “Vulnerable Rectums”: The Sexual Identity, Epidemiology, And Law Of The Global Hiv Epidemic, Aziza Ahmed

Faculty Scholarship

AIDS remains amongst the leading causes of death globally. Identity is the primary mode of understanding HIV and organizing in response to the HIV epidemic. In this Article, I examine how epidemiology and human rights activism co-produce ideas of identity and risk. I call this the "identity/risk narrative ": the commonsense understanding about an identity group's HIV risk. For example, epidemiology offers the biological narrative of risk: anal sex and the weak rectal lining make men who have sex with men more vulnerable to HIV; while the fragility of a woman's vaginal wall provides a biological foundation for women's vulnerability. …

Distributions Of Industry Payments To Massachusetts Physicians, Aaron S. Kesselheim, Christopher Robertson, Kent Siri, Puneet Batra, Jessica M. Franklin

Faculty Scholarship

Some states have mandated systematic public disclosure of payments made by drug- and device-makers to health care practitioners. We used Massachusetts data to characterize the distribution of payment types and the variation among medical specialties.

The 30 months’ of data included 32,227 reported payments to 11,734 Massachusetts physicians, for a total of $76.7 million. The most common form of payment was food. Compensation for bona fide services was the payment type with the highest value.

We found that 25% of currently licensed Massachusetts physicians received at least one payment during the study period. Prevalence ranged by specialties from pediatricians (12%) …

Photochemical Electrocyclic Ring Closure And Leaving Group Expulsion From N-(9-Oxothioxanthenyl)Benzothiophene Carboxamides, Majher I. Sarker, Tasnuva Shahrin, Mark G. Steinmetz, Qadir K. Timerghazin

Chemistry Faculty Research and Publications

N-(9-Oxothioxanthenyl)benzothiophene carboxamides bearing leaving groups (LG⁻ = Cl⁻, PhS⁻, HS⁻, PhCH₂S⁻) at the C-3 position of the benzothiophene ring system photochemically cyclize with nearly quantitative release of the leaving group, LG⁻. The LG⁻ photoexpulsions can be conducted with 390 nm light or with a sunlamp. Solubility in 75% aqueous CH₃CN is achieved by introducing a carboxylate group at the C-6 position of the benzothiophene ring. The carboxylate and methyl ester derivatives regiospecifically cyclize at the more hindered C-1 position of the thioxanthone ring. …

Law, Sexuality, And Transnational Perspectives, Holning S. Lau

Faculty Publications

No abstract provided.

Towards Independent Particle Reconstruction From Cryogenic Transmission Electron Microscopy, W. Lewis Collier, Jean Yves Hervé, Lenore Martin

Cell and Molecular Biology Faculty Publications

Coronary heart disease is the single largest killer of Americans so improved means of detecting risk factors before arterial obstructions appear are expected to lead to a improvement in quality of life with a reduced cost. This paper introduces a new approach to 3-D reconstruction of individual particles based on statistical modeling from a sparse set of 2-D projection images. This paper introduces a new approach to 3-D reconstruction of individual particles based on statistical modeling from a sparse set of 2-D projection images. The method is in contrast to the current state of practice where reconstruction is performed via …

Muscles Flexed And Skin Exposed: Masculinity In The Images Of Hard-Boiled American Pulps, Brennan Falker

Research Papers

No abstract provided.

Appraisal Theory: Old And New Questions, Phoebe C. Ellsworth

Articles

I describe my current thinking on two old questions—the causal role of appraisals and the relationship of appraisal theories to basic emotions theories and constructivist theories, and three (sort of) new questions—the completeness of appraisals, the role of language, and the development of automaticity in emotional responses.

Long-Term Care: An Analysis Of Quality By Rurality In Illinois Nursing Homes, Kimberly M. Brombosz

Research Papers

The purpose of this study was to compare the quality of care rating for long-term care facilities in rural versus urban Illinois locations. Using quality of care data available on medicare.gov, 774 Illinois long-term care facilities were compared to determine if a difference in quality of care existed based on rurality. Each facility was classified as either urban focused, large rural city/town (micropolitan) focused, small rural town focused, or isolated small rural town focused using the Rural Urban Commuting Area (RUCA) codes provided by the Rural Health Research Center. Frequencies, ANOVA, and Scheffe tests were used to analyze the data. …

Models And Theories Of Addiction And The Rehabilitation Counselor, Nora J. See

Research Papers

No abstract provided.

Prometheus Rebound: Diagnostics, Nature, And Mathematical Algorithms, Rebecca S. Eisenberg

Articles

The Supreme Court’s decision last Term in Mayo v. Prometheus left considerable uncertainty as to the boundaries of patentable subject matter for molecular diagnostic inventions. First, the Court took an expansive approach to what counts as an unpatentable natural law by applying that term to the relationship set forth in the challenged patent between a patient’s levels of a drug metabolite and the indication of a need to adjust the patient’s drug dosage. And second, in evaluating whether the patent claims add enough to this unpatentable natural law to be patent eligible, the Court did not consult precedents concerning the …

The Difference A Justice May Make: Remarks At The Symposium For Justice Ruth Bader Ginsburg, Suzanne Baer

Articles

First, I will briefly summarize the state of the art of equality law in Germany today. A distinct dimension of this story from a European Union member state is that we are not just theorizing postnational constitutionalism these days, but that we live it already, since law is not anymore isolated as national but needs to be seen in the context of transnational migration and multinational regimes. Second, I turn to a key feature and key challenge in and to equality law today. It is what I have called the triangle of fundamental rights, referring to the three most prominent …

Remarital Chances, Choices, And Economic Consequences: Issues Of Social And Personal Welfare, Kevin Shafer, Todd M. Jensen

Faculty Publications

Many divorced women experience a significant decline financial, social, physical and psychological well-being following a divorce. Using data from the NLSY79 (n = 2,520) we compare welfare recipients, mothers, and impoverished women to less marginalized divorcees on remarriage chances. Furthermore, we look at the kinds of men these women marry by focusing on the employment and education of new spouses. Finally, we address how remarriage and spousal quality (as defined by education and employment) impact economic well-being after divorce. Our results show that remarriage has positive economic effects, but that is dependent upon spousal quality. However, such matches are …

No One Best Way: Work-Family Strategies, The Gendered Division Of Parenting, And The Contemporary Marriages Of Mothers And Fathers, W. Bradford Wilcox, Jeffrey P. Dew

Faculty Publications

The gender revolution of the last half-century has dramatically reshaped the nature, quality, and stability of marriage and parenthood in the United States. A half-century ago, most married mothers did not work outside the home, and most men and women preferred this arrangement. But over the course of the second half of the twentieth century, mothers streamed into the labor force, fathers devoted more time to childcare and housework, and public opinion largely swung behind these changes, with most Americans expressing normative support for working mothers, as well as for more egalitarian relationships between mothers and fathers in the home …

Orientocreadium Batrachoides Tubangui, 1931 (Orientocreadiidae): The Only Trematode Parasite Of Clarias Gariepinus (Burchell, 1822) (Clariidae) From The Asi River (Southern Turkey), Tayha Tepe, Mehmet Cemal Oğuz, Mark C. Belk, Remzi Özgen

Faculty Publications

Objective: Some information is available about the parasite fauna and incidence for Clarias gariepinus in Turkey, but digenean parasites have received little attention. The purpose of the study is to contribute to the parasite fauna of Turkey.

Methods: From 2007 to 2008, a total 63 Clarias gariepinus that were caught in the Asi River were purchased from the fish market in Hatay and brought on ice to the Parasitology Research Laboratory at Atatürk University. The fish were dissected. The obtained parasites were fixed with AFA, dyed with Mayer’s Carmalum, and mounted with Canada Balsam.

Results: Forty-eight fish were infected with …

Surrogate Mothers: An Exploration Of The Empirical And The Normative, Lina Peng

American University Journal of Gender, Social Policy & the Law

No abstract provided.

The “Federal Law Of Marriage”: Deference, Deviation, And Doma, W. Burlette Carter

American University Journal of Gender, Social Policy & the Law

No abstract provided.

The Forgotten Remedy: A Legal And Theoretical Defense Of Intermediate Scrutiny For Gender-Based Affirmative Action Programs, Ajmel Quereshi

American University Journal of Gender, Social Policy & the Law

No abstract provided.

Transgressions Of Inequality: The Struggle Finding Legal Protections Against Wrongful Employment Termination On The Basis Of The Transgender Identity, Anton Marino

American University Journal of Gender, Social Policy & the Law

No abstract provided.

Reframing The Work-Family Conflict Debate By Rejecting The Ideal Parent Norm, Jennifer H. Sperling

American University Journal of Gender, Social Policy & the Law

No abstract provided.

Cell Speed Is Independent Of Force In A Mathematical Model Of Amoeboidal Cell Motion With Random Switching Terms., J. C. Dallon, Emily J. Evans, Christopher Grant, William V. Smith

Faculty Publications

In this paper the motion of a single cell is modeled as a nucleus and multiple integrin based adhesion sites. Numerical simulations and analysis of the model indicate that when the stochastic nature of the adhesion sites is a memoryless and force independent random process, the cell speed is independent of the force these adhesion sites exert on the cell. Furthermore, understanding the dynamics of the attachment and detachment of the adhesion sites is key to predicting cell speed. We introduce a differential equation describing the cell motion and then introduce a conjecture about the expected drift of the cell, …

A Force Based Model Of Individual Cell Migration With Discrete Attachment Sites And Random Switching Terms, J. C. Dallon, Matthew Scott, William V. Smith

Faculty Publications

A force based model of cell migration is presented which gives new insight into the importance of the dynamics of cell binding to the substrate. The main features of the model are the focus on discrete attachment dynamics, the treatment of the cellular forces as springs, and an incorporation of the stochastic nature of the attachment sites. One goal of the model is to capture the effect of the random binding and unbinding of cell attachments on global cell motion. Simulations reveal one of the most important factor influencing cell speed is the duration of the attachment to the substrate. …