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2013

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Microevolution Of Capsule Synthesis Genes Contributes To Pneumococcal Capsule Diversity, Melissa Beth Oliver Jan 2013

Microevolution Of Capsule Synthesis Genes Contributes To Pneumococcal Capsule Diversity, Melissa Beth Oliver

All ETDs from UAB

Streptococcus pneumoniae (pneumococcus) is an important human pathogen that expresses a capsular polysaccharide (PS) to shield underlying antigenic structures from complement-mediated opsonophagocytosis. Thus, capsular PS is the major virulence factor, the target of primary immune responses to pneumococcal infections, and the antigenic component of pneumococcal vaccines. Pneumococci have diverse capsular PS synthesis (cps) loci and express over 90 different capsule types. Such diversity helps pneumococci escape immune detection and adapt to changing environments. Recombination of cps genes has been recognized as the main driver of capsule diversity. However, we show point mutations in cps genes encoding glycosyltransferases can broaden enzymes' …

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Understanding The Relation Between Routines And Problem Behaviors In Children With Clinical Diagnoses, Mark Ryan Pennick Jan 2013

Understanding The Relation Between Routines And Problem Behaviors In Children With Clinical Diagnoses, Mark Ryan Pennick

All ETDs from UAB

The current study investigated the impact of routines on problem behaviors in children with the clinical diagnoses of either PDD, ADHD, or depression/anxiety. Previous research has identified negative relations between externalizing behaviors and routines as well as a link between using routines and having positive parenting. The study extends these findings to children with these various diagnoses and also to internalizing symptoms. In our sample negative relations were found between routines, as measured by the Child Routines Inventory (CRI), and both internalizing and externalizing symptoms when all groups were examined together. Additionally routines were found to moderate the relation between …

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Msx1 Mutations And Their Binding Interactions, Divakar Prakash Jan 2013

Msx1 Mutations And Their Binding Interactions, Divakar Prakash

All ETDs from UAB

Orofacial clefting (OFC), also called cleft lip and/or palate, is the most common congenital birth anomaly that involve the craniofacial region in humans. The etiology of Non-Syndromic OFC (NS-OFC) is complex and multifactorial; a slew of genetic mutations, standing alone or in combinations, along with several environmental factors, play a major role in the disease process. Numerous linkage and association studies in humans, as well as expression studies and knockout mouse models, have implicated Muscle segment homeobox gene 1 (MSX1), which encodes a homeodomain/DNA binding domain (HD) containing transcription factor as a strong candidate contributing to NS-OFC and Tooth Agenesis …

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High Density Genotyping For Immunogenetic Polymorphisms Associated With Transmission And Control Of Hiv-1 Infection In Zambian Heterosexual Serodiscordant Couples, Heather Prentice Jan 2013

High Density Genotyping For Immunogenetic Polymorphisms Associated With Transmission And Control Of Hiv-1 Infection In Zambian Heterosexual Serodiscordant Couples, Heather Prentice

All ETDs from UAB

Understanding host genetic correlates of HIV-1 outcomes in sub-Saharan African populations is of continued importance due to the disproportionate disease burden in this population. We sought to identify genetic variants associated with HIV-1 acquisition in a sample of 439 initially seronegative individuals enrolled in the Zambia-Emory HIV Research Project, as well as novel variants associated with viral load (VL) in a sample of 172 seroconverters (SCs) with an estimated date of infection and 449 seroprevalent individuals (SPs). We were unable to detect any statistically significant associations in our analysis of HIV-1 acquisition, though one signal in the HLA-DOA gene associated …

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Plant Selection, Community Dynamics, Ecophysiology, And Stormwater Mitigation On Green Roofs In The Southeastern U.S., Julie G. Price Jan 2013

Plant Selection, Community Dynamics, Ecophysiology, And Stormwater Mitigation On Green Roofs In The Southeastern U.S., Julie G. Price

All ETDs from UAB

Green roofs offer the opportunity to transform impervious surfaces into multifunctional constructed ecosystems. Plant selection for green roofs is often limited to drought-tolerant succulent species, but more diverse assemblages enhance habitat and biodiversity in urban areas and have the potential to improve green roof performance. Nineteen taxa were evaluated under irrigated and non-irrigated conditions over three growing seasons. Individual taxa were evaluated for survival and amount and mechanism of colonization, and the effect of irrigation on plant community structure and vegetation coverage was examined. Only succulent species survived under non-irrigated conditions. Irrigated plots had more taxa, higher diversity index, less …

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The Role Of Complement In Experimental Cerebral Malaria, Theresa N. Ramos Jan 2013

The Role Of Complement In Experimental Cerebral Malaria, Theresa N. Ramos

All ETDs from UAB

Cerebral malaria (CM) is one of the most severe clinical complications of P. falciparum malaria with a fatality rate of 15-30%, and 10% of CM survivors have permanent neurological sequelae. Since inflammation is a central pathophysiological tenet of CM, we began examining the role of the complement system in pathogenesis of experimental cerebral malaria (ECM) using Plasmodium berghei ANKA (PbA) model. Previous studies using this model indicated that mice naturally deficient in complement component C5 were protected from cerebral complications, and wild type mice treated with anti-C5aR antibody were also protected. To determine the protective mechanism of naturally-C5 deficient mice, …

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Mesocorticolimbic Abnormalities In Schizophrenia: A Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging Study, Meredith A. Reid Jan 2013

Mesocorticolimbic Abnormalities In Schizophrenia: A Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging Study, Meredith A. Reid

All ETDs from UAB

Schizophrenia is a complex, often debilitating chronic mental disorder that affects approximately 1% of people worldwide. Recently, there has been growing interest in identifying non-invasive biomarkers of schizophrenia. Understanding the molecular and structural mechanisms underlying clinical features of schizophrenia and patients' drug response is an important step in identifying biomarkers and potential targets for novel medications, treatment strategies, and interventions. The primary objective of this dissertation research was to use non-invasive magnetic resonance imaging techniques, specifically magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI), to examine the neurochemical and structural correlates of symptoms, cognition, and treatment response to antipsychotic …

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Characterization Of Emergent Spatial-Temporal Orders In Transcription Regulatory Networks Using Phase Locking Analysis, Herbert Keith Roberts Jan 2013

Characterization Of Emergent Spatial-Temporal Orders In Transcription Regulatory Networks Using Phase Locking Analysis, Herbert Keith Roberts

All ETDs from UAB

The study of gene regulatory networks (GRNs) is paramount for continued breakthroughs in understanding the genetic architecture of life and how alterations thereof contribute to disease. The complex spatio-temporal orders within GRNs are studied primarily through the modeling of time-course gene expression data. Recently, gene expression profiling technology has improved greatly in regards to accuracy and resolution, enabling novel methodology development and characterization of GRNs. Many methods have been utilized to model GRNs from gene expression data (correlational measures, time-warping, coherence, and/or causality, etc). In this study, we propose a new approach based on phase locking analysis that compliments existing …

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Commensal Microbiota And Its Impact On Health And Autoimmune Diabetets, Kyle James Wolf Jan 2013

Commensal Microbiota And Its Impact On Health And Autoimmune Diabetets, Kyle James Wolf

All ETDs from UAB

Environmental exposures such as diet, use of antibiotics, and lifestyle have significant impact on the health of an individual. One mechanism that acts as a major pathway in these environmental exposures is the role intestinal commensal microbiota play in both metabolic and immunological responses. Metabolic pathways are altered through changes in metabolites provided by commensal microbiota; alterations in microbial make-up can have drastic impacts on metabolic function. Similarly, the development and maturation of the immune system is dependent on the intestinal microbes to induce tolerance and act as both an immune modulator as well as a barrier against pathogens. We …

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A Study Of Multi-Group And Multivariate Tests Of Equivalence With Application To Microarray And, Celeste Yang Jan 2013

A Study Of Multi-Group And Multivariate Tests Of Equivalence With Application To Microarray And, Celeste Yang

All ETDs from UAB

In this dissertation we have adapted two multi-group equivalence tests to be performed on high-dimensional data. The F and Range test for multi-group equivalence were applied to the public microarray dataset GSE11291 to detect equivalently expressed genes. They were also evaluated in terms of type I error and power using single gene simulation and a high-dimension simulation. The F test has higher power than the Range for the same simulated data and parameter settings, in the single gene simulations. The power of the two tests is similar in the high-dimension simulation. The multi-group equivalence tests that were applied to the …

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Characterization Of The Mumps Virus Replicase, Robert Marsden Cox Jan 2013

Characterization Of The Mumps Virus Replicase, Robert Marsden Cox

All ETDs from UAB

Negative strand RNA viruses (NSV) are unique because their nucleocapsids are used directly as the template for both transcription and replication. The viral genomic RNA is coated by the nucleoprotein (N) for the entirety of the NSV replication cycle. The viral polymerase, which is composed of the L and P proteins, can only recognize encapsidated RNA as the template for RNA synthesis. Our previous studies have solved the EM structure of the MuV N-RNA complex at 25Ņ. This structure revealed how the nucleocapsid is assembled and provides an initial model for examining how the viral polymerase may recognize the …

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Using A Mixed Methods Sequential Design To Identify Factors Associated With African American Mothers' Intention To Vaccinate Their Daughters Aged 9 To 12 For Hpv With A Purpose Of Informing A Culturally-Relevant, Theory-Based Intervention, Jennifer Cunningham Jan 2013

Using A Mixed Methods Sequential Design To Identify Factors Associated With African American Mothers' Intention To Vaccinate Their Daughters Aged 9 To 12 For Hpv With A Purpose Of Informing A Culturally-Relevant, Theory-Based Intervention, Jennifer Cunningham

All ETDs from UAB

The purpose of this sequential, explanatory mixed methods research study was to understand what factors influenced African American maternal intentions to get their daughters aged 9 years to 12 years vaccinated in Alabama. In the first, quantitative phase of the study, the research questions focused on identifying the predictive power of eleven variables, representing selected factors associated with maternal intentions to vaccinate their daughters. The data were collected via a self-developed instrument that used a mixed mode survey design that was web-based (N = 14) and paper-based (N = 228). Participant demographics were analyzed using descriptive statistics. A binary, logistic …

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Sulindac Sulfide Amide As A Novel Agent For The Prevention And Treatment Of Lung Cancer, Evrim Gurpinar Jan 2013

Sulindac Sulfide Amide As A Novel Agent For The Prevention And Treatment Of Lung Cancer, Evrim Gurpinar

All ETDs from UAB

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac sulfide (SS) have shown promising antineoplastic activity in multiple tumor types, but toxicities resulting from cyclooxygenase (COX) inhibition limit their use in cancer prevention. We recently described a N,N-dimethylethyl amine derivative of SS, sulindac sulfide amide (SSA), that does not inhibit COX-1 or -2, yet displays potent tumor cell growth inhibitory activity. Here, we studied the basis for the growth inhibitory effects of SSA on human lung adenocarcinoma cell lines and evaluated its preclinical pharmacology. SSA potently inhibited the growth of lung tumor cells with IC50 values of 2-5 μ compared with 44-52 …

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The Effects Of Sleep Restriction On Adolescents' Pedestrian Safety, Aaron Leah Davis Jan 2013

The Effects Of Sleep Restriction On Adolescents' Pedestrian Safety, Aaron Leah Davis

All ETDs from UAB

Introduction. Over 8,000 American adolescents ages 14 and 15 require medical attention due to pedestrian injury annually. Psychosocial factors contributing to pedestrian safety include reaction time, impulsivity, risk-taking, attention, and decision-making. These characteristics are also influenced by sleep restriction. Adolescents require 8.5 hours of uninterrupted sleep each night. Despite requiring more sleep than other children, adolescents often do not obtain adequate sleep due to delayed circadian, academic demands, extracurricular activities, media use, and minimal parental supervision. This combination of factors may place adolescents at risk for pedestrian injury. Method. This study investigated whether sleep restriction reduces adolescents' pedestrian safety. Using …

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Clinical Consequences Of Micrornas In Colorectal Cancer, Liselle C. Bovell Jan 2013

Clinical Consequences Of Micrornas In Colorectal Cancer, Liselle C. Bovell

All ETDs from UAB

Colorectal cancer (CRC) is a heterogeneous disease, and factors such as tumor location, the environment, genetics, and ethnic differences, can influence its development and progression. Over the last few decades, overall CRC mortality rates have declined; however, racial disparities in mortality rates have increased. The discovery of biomarkers that focus on identifying individual differences based on confounders such as tumor stage and patient race/ethnicity is needed, for such biomarkers can lead to development of personalized therapeutic approaches to target these molecules. MicroRNAs (miRNAs) are a class of small molecules that regulate genes at the post-transcriptional level. Altered miRNA expression levels …

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Therapeutic Potential Of Genetically-Engineered Mesenchymal Stem Cells In Multiple Myeloma, Jerome T. Higgs Jan 2013

Therapeutic Potential Of Genetically-Engineered Mesenchymal Stem Cells In Multiple Myeloma, Jerome T. Higgs

All ETDs from UAB

ABSTRACT Multiple Myeloma (MM) remains the second most common hematologic malig-nancy occurring in adults, which primarily affects the skeletal system causing severe bone destruction, spinal cord compression and hypercalcemia. Current therapies, which include chemotherapy, radiotherapy, autologouos stem cell transplantation and in some cases surgery, have extended the median survival between 3 and 10 years. However, MM is still incurable and therefore improving current therapies or developing newer ones to reduce the burden of osteolytic damage and extend survival rate will be highly beneficial for patient management. The long-term goal of this study is to develop a novel therapeutic approach to …

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Regulation Of Glioma Cell Migration And Proliferation By A Non-Selective Cation Channel., Arun Kumar Rooj Jan 2013

Regulation Of Glioma Cell Migration And Proliferation By A Non-Selective Cation Channel., Arun Kumar Rooj

All ETDs from UAB

Two of the most striking features of brain tumors are their unusual ability to robustly proliferate and migrate in the brain. Previous results from our laboratory suggest that glioma cells express a non-selective cation channel that is composed of Epithelial Sodium Channel (ENaC) and Acid Sensing Ion Channel (ASIC) subunits. We hypothesize that this glioma specific current regulates glioma cell migration and proliferation by modulating an intracellular signaling pathway. To test our hypothesis, we have attenuated this cationic conductance by either pharmacological blockers (psalmotoxin-1 and benzamil), or by knocking down expression of a particular subunit of this cross-clade ion channel …

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Determinant Of G-Chain Mediated Fc Receptor Signaling, Spandan Shah Jan 2013

Determinant Of G-Chain Mediated Fc Receptor Signaling, Spandan Shah

All ETDs from UAB

Fc receptors provide an interface between humoral immunity and cellular immunity by binding to the Fc portion of immunoglobulin and mediating effector functions. Cells expressing Fc receptors play a major role in immune complex clearance via phagocytosis, leading to a context dependent pro- or anti-inflammatory environment. Signaling by multi-chain Fc receptor complexes, including FcgRI, FcgRIII, FceRI and FcaRI is mediated by the ITAM-containing common FceRIg (g-chain) subunit. However, despite the use of a common g-chain, different Fc receptor complexes elicit specific cellular programs, suggesting additional layers of regulation of tyrosine based signaling by g-chain. We hypothesized that the unique g-chain …

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Neuropathological Alterations In Alzheimer's Disease: An Up Close Look At Sympathetic Sprouting, Amy Renee Nelson Jan 2013

Neuropathological Alterations In Alzheimer's Disease: An Up Close Look At Sympathetic Sprouting, Amy Renee Nelson

All ETDs from UAB

Pathological hallmarks of AD include neurofibrillary tau tangles, amyloid beta (Abeta) accumulation and cholinergic degeneration. Cholinergic degeneration can be mimicked in rats by lesioning cholinergic neurons in medial septum. Hippocampal cholinergic denervation disrupts retrograde transport of nerve growth factor (NGF), leading to its accumulation, which subsequently triggers sprouting of noradrenergic sympathetic fibers from the superior cervical ganglia into hippocampus. Dr. McMahon's lab previously reported that coincident with this sprouting, there is an increase in cholinergic innervation that correlates with a recovery of M1 muscarinic receptor dependent plasticity at CA3-CA1 synapses and visual cortex. These findings suggest that noradrenergic sympathetic sprouting …

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Repellency Efficacy Of Essential Oils Of Selected Plants Growing In Western Kenya And Their Eag-Active Constituent Blends Against Anopheles Gambiae, David Otieno Ywaya Jan 2013

Repellency Efficacy Of Essential Oils Of Selected Plants Growing In Western Kenya And Their Eag-Active Constituent Blends Against Anopheles Gambiae, David Otieno Ywaya

All Master’s Theses

Control of disease vectors by use of synthetic chemical pesticides has been associated with a series of problems, including resistance development, environmental pollution, and safety risks for humans and domestic animals. Plant-based products have been used for generations in traditional practices to control different arthropods. These have been used in space or personal protection either to repel the arthropods from distance or to deter them from blood-feeding on contact. In the present study, the repellence of essential oils of three plants (Ocimum gratissimum L., Vitex keniensis Turill and Hyptis suaveolens (L.) Poit used in Siaya County in western Kenya were …

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Structure Of The 40 S Ribosomal Subunit From Plasmodium Falciparum By Homology And De Novo Modeling, Harrison N. Mwangi Jan 2013

Structure Of The 40 S Ribosomal Subunit From Plasmodium Falciparum By Homology And De Novo Modeling, Harrison N. Mwangi

All Master’s Theses

Generation of the three dimensional structures of macromolecules using in silico structural modeling technologies such as homology and de novo modeling has improved dramatically and increased the speed in which tertiary structures of organisms of interest can be generated. This is especially the case if a homologous crystal structure is already available. High resolution structures can be rapidly created using only their sequence information as input and thus increasing the speed of scientific discoveries. In this study, a host of homology modeling and structure prediction tools such as RNA123 and SWISS MODEL among others, were used to generate the 40S …

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Work And Life Harmony: An Exploratory Case Study Of Entrepinays, Divina M. Edralin Jan 2013

Work And Life Harmony: An Exploratory Case Study Of Entrepinays, Divina M. Edralin

DLSU Business & Economics Review

This study aims to explore how Filipina entrepreneurs (EntrePinays) harmonize their work demands with their family responsibilities and personal needs in order to sustain their business and at the same time live a meaningful and happy life. As an exploratory study utilizing nine participants, the case study approach based on the multiple case dimensions was used. Findings revealed that there are positive and negative spillover effects of work-life relationships. The negative spillover induces stress among the EntrePinays and the positive spillover can lead to their high levels of life satisfaction. Results also showed that EntrePinays are able to harmonize their …

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Federalism, Liberty, And Equality In United States V. Windsor, Ernest A. Young, Erin C. Blondel Jan 2013

Federalism, Liberty, And Equality In United States V. Windsor, Ernest A. Young, Erin C. Blondel

Faculty Scholarship

This essay argues that federalism played a profoundly important role in the Supreme Court's decision in United States v. Windsor, which struck down the federal Defense of Marriage Act. Arguments to the contrary have failed to appreciate how Justice Kennedy's opinion employed federalism not as a freestanding argument but as an essential component of his rights analysis. Far from being a "muddle," as many have claimed, Justice Kennedy's analysis offered one of the most sophisticated examples to date of the interconnections between federalism, liberty, and equality.

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Dynamic Diatom Response To Changing Climate 0-1.2 Ma At Lake El'gygytgyn, Far East Russian Arctic, Jeffrey Allan Snyder, M. V. Cheraponova, A. Bryan Jan 2013

Dynamic Diatom Response To Changing Climate 0-1.2 Ma At Lake El'gygytgyn, Far East Russian Arctic, Jeffrey Allan Snyder, M. V. Cheraponova, A. Bryan

School of Earth, Environment and Society Faculty Publications

The Lake El' gygytgyn sediment record contains an abundant diatom flora through most intervals of the lake's history, providing a means to create and test hypotheses concerning the lake's response to changing climates. The 0 1.2 Ma core interval is characterized by shifts in the dominant planktonic genera and events of exceptional concentration and diversity. Warm interglacial intervals have enhanced concentration and diversity of the plankton. This response is most extreme during exceptional events corresponding to marine isotope stages (MIS) 11 and 31. Diatom concentration and diversity also increase during some cold intervals (e.g., MIS 2), suggesting conditions of lake …

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Sensitivity Analysis For Optimal Parameters For Marine Radar Data Processing, Amin Jarrah, Mohsin Jamali, Jeremy Ross, Peter Gorsevski, Joesph P. Frizado, Verner Peter Bingman Jan 2013

Sensitivity Analysis For Optimal Parameters For Marine Radar Data Processing, Amin Jarrah, Mohsin Jamali, Jeremy Ross, Peter Gorsevski, Joesph P. Frizado, Verner Peter Bingman

School of Earth, Environment and Society Faculty Publications

A bird and bat monitoring system has been developed that uses marine radar, IR camera and acoustic recorders for wind farm applications. IR video recording is used to monitor birds and bats activity which will be useful for wildlife biologists in developing mit igation techniques to minimize impact of wind turbines on birds and bats. The goal is to quantify birds and bats activity near wind turbines. Radar will provide z-coordinate (alt itude) and IR camera will provide (x, y) coordinates of birds/bats. Acous tic monitoring is used to identify birds and bats at their species level. This paper deals …

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Students’ Crisis In Nigerian Tertiary Educational Institutions: A Review Of The Causes And Management Style, Ajibade David Jan 2013

Students’ Crisis In Nigerian Tertiary Educational Institutions: A Review Of The Causes And Management Style, Ajibade David

Khazar Journal of Humanities and Social Sciences

Students’ crisis is one of the challenges confronting Nigerian educational system in the recent past. The level of disruption and closures that has bedeviled Nigerian tertiary institutions is unprecedented in the History/ Archaeology of higher education in Nigeria. However, realizing the importance of tertiary education in national development, this paper is conceived to identify the factors responsible for the occurrence of students’ crisis and the management style adopted by the individuals and groups involved in tertiary education system. Secondary source of data collection was used in the study. Data were generated from textbooks, published and unpublished materials, including the internet. …

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Characterization Of Ichthyoplankton In The Northeastern Gulf Of Mexico From Seamap Plankton Surveys, 1982-1999, Joanne Lyczkowski-Shultz, David S. Hanisko, Kenneth J. Sulak, Malgorzata Konieczna, Pamela J. Bond Jan 2013

Characterization Of Ichthyoplankton In The Northeastern Gulf Of Mexico From Seamap Plankton Surveys, 1982-1999, Joanne Lyczkowski-Shultz, David S. Hanisko, Kenneth J. Sulak, Malgorzata Konieczna, Pamela J. Bond

Gulf and Caribbean Research

Data for 61 selected ichthyoplankton taxa from 1,166 bongo and neuston net samples at 72 stations comprising the USGS Northeastern Gulf of Mexico Ichthyoplankton Synopsis (UNIS) study area were analyzed. These data were taken during annual spring and fall Southeast Area Monitoring and Assessment Program (SEAMAP) Gulfwide plankton surveys over the period 1982-1999. The UNIS study area contributed disproportionately more fish eggs, total larvae and net-caught zooplankton biomass to survey totals than would be expected from the number of samples taken in the study area. This pattern was more evident during spring than fall surveys and is probably related to …

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A History Of Place: Using Phytolith Analysis To Discern Holocene Vegetation Change On Sanak Island, Western Gulf Of Alaska, Cricket C. Wilbur Jan 2013

A History Of Place: Using Phytolith Analysis To Discern Holocene Vegetation Change On Sanak Island, Western Gulf Of Alaska, Cricket C. Wilbur

Antioch University Dissertations & Theses

This study investigated a terrestrial climate proxy, phytoliths, as a complimentary approach to documenting the dynamics of present and past vegetation on Sanak Island, the largest island in a small island group in the eastern Aleutian archipelago, and as a new basis by which to interpret Holocene environmental variability in Alaska. A phytolith reference collection was established from 59 selected plant species of maritime tundra belonging to 27 families. The grass species and a sedge species produced abundant phytolith forms whereas the majority of dicotyledons in this study were trace producers of phytoliths. A paleoenvironmental reconstruction from fossil phytoliths recovered …

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A History Of Peer-Led Team Learning, 1990-2012, A.E. Dreyfuss Jan 2013

A History Of Peer-Led Team Learning, 1990-2012, A.E. Dreyfuss

Publications and Research

From Workshop Chemistry in 1991 at the City College of New York, CUNY, to implementation in other disciplines and development of Peer-Led Team Learning and its Six Critical Components, this paper reviews the contributions of faculty at a variety of higher education institutions to the dissemination and growth of PLTL as a successful model of student engagement with the position of the student Peer Leader.

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Wavelet Based Automated Postural Event Detection And Activity Classification With Single Imu (Tempo), Thurmon E. Lockhart, Rahul Soangra, Jian Zhang, Xuefang Wu Jan 2013

Wavelet Based Automated Postural Event Detection And Activity Classification With Single Imu (Tempo), Thurmon E. Lockhart, Rahul Soangra, Jian Zhang, Xuefang Wu

Physical Therapy Faculty Articles and Research

Mobility characteristics associated with activity of daily living such as sitting down, lying down, rising up, and walking are considered to be important in maintaining functional independence and healthy life style especially for the growing elderly population. Characteristics of postural transitions such as sit-to-stand are widely used by clinicians as a physical indicator of health, and walking is used as an important mobility assessment tool. Many tools have been developed to assist in the assessment of functional levels and to detect a person’s activities during daily life. These include questionnaires, observation, diaries, kinetic and kinematic systems, and validated functional tests. …

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