Digital Commons Network^™

Distributions Of Industry Payments To Massachusetts Physicians, Aaron S. Kesselheim, Christopher Robertson, Kent Siri, Puneet Batra, Jessica M. Franklin

Faculty Scholarship

Some states have mandated systematic public disclosure of payments made by drug- and device-makers to health care practitioners. We used Massachusetts data to characterize the distribution of payment types and the variation among medical specialties.

The 30 months’ of data included 32,227 reported payments to 11,734 Massachusetts physicians, for a total of $76.7 million. The most common form of payment was food. Compensation for bona fide services was the payment type with the highest value.

We found that 25% of currently licensed Massachusetts physicians received at least one payment during the study period. Prevalence ranged by specialties from pediatricians (12%) …

Development And Validation Of A Survey Instrument To Assess Health Information-Seeking Behaviors Among African-Americanyoung Professionals, Shauntice Allen

All ETDs from UAB

The lay public has had more opportunities than ever before to take an active role in their own health care. Despite these opportunities, many questions remain regarding the basis for barriers relating to seeking preventive health information. Following publication of the report of the Secretary’s Task Force of Black and Minority Health, health education researchers have documented health disparities among populations of color, in particular African Americans (United States Department of Health and Human Services, 1985). Brashers, Goldsmith, and Heish (2002) pointed out the complexity of health information-seeking behaviors (HISB) and highlighted the increasing need to clearly understand the process …

Microrna Regulation Of Dlx3 During Odontoblast Differentiation, Hannah Maria Heair

All ETDs from UAB

MicroRNAs are endogenous non-coding RNA (~22nt) that bind to the 3' untranslated region (UTR) of target messenger RNA (mRNA) and facilitate translational repression and degradation. Previous studies have demonstrated the essential role of miRNA in many biological processes, including skeletal development and tooth formation. Dlx3, a homeobox gene, is critical for craniofacial patterning and postnatal skeletal development. Mutations in the Dlx3 gene in humans result in two autosomal dominant phenotypes known as tricho-dento-osseous syndrome (TDO) and amelogenesis imperfecta with taurodontism (AIHHT). Dlx3 expression has been observed in cranial neural crest cells, endochondral osteoblasts, odontoblasts, ameloblasts, hypertrophic chondrocytes, and the developing …

The Role Of Autosomal Dominant Retinitis Pigmentosa Rhodopsin Mutant Ter349glu In Rod Cell Biogenesis And Retinal Inflammation, Tj Hollingsworth

All ETDs from UAB

Retinitis pigmentosa is one of the most common inherited blinding disorders, affecting 1 in 4000 individuals world-wide. Approximately 30% of retinitis pigmentosa cases are dominantly inherited and approximately 30% of these dominant mutations are found in rhodopsin. Most rhodopsin mutations result in misfolded protein aggregates and subsequent apoptosis while others have been shown to result in apoptosis associated with mislocalization, diminished/enhanced activity, or faulty protein-protein interactions. This work serves to test for mechanisms by which the naturally-occurring Ter349Glu rhodopsin mutation causes rod cell death. Ter349Glu rhodopsin was tested for the ability to bind the ligand 11-cis retinal, photoactivate, and activate …

Identification And Biochemical Investigations Of Rhamnose And Glycoprotein In Mycoplasmas, David Jordan

All ETDs from UAB

Mycoplasmas are host-specific human and animal pathogens within the class of wall-deficient bacteria named Mollicutes and have smaller sizes and genomes than the walled bacteria. Mycoplasma genome sequences reveal few if any genes for synthesis of a glycocalyx. Nevertheless, we find that mycoplasmas produce glycolipids, glycoprotein, and polysaccharides. Using gas chromatography and mass spectrometry, glucose, mannose, rhamnose, and galactose were detected in the glycolytic species Mycoplasma pneumoniae and Mycoplasma pulmonis. All of these sugars except galactose was found in Mycoplasma arthritidis. Rhamnose was in the rare D configuration in the glycolytic species and in both D and L forms in …

Modulation Of Intrinsic Activity In Sensory Cortex Facilitates Task Performance, Aburahman Elkhetali

All ETDs from UAB

Due to the changing demands of the environment and our behavioral intentions the brain has to adapt in order to produce task appropriate responses. Part of the challenge is the large amount of sensory information received by the brain. Depending on individu-al goals, the brain must select and react to task appropriate stimuli while ignoring other irrelevant sensory input. Since behavioral intentions are dynamic, this requires the re-sponses within the brain to also be dynamic. Cognitive control, exerted by higher centers on sensory cortex allow for selection of task relevant stimuli. In this study we find that intrinsic, non-stimulus driven …

Characterization Of The Interactions Of Calmodulin With Fas And Death Receptor-5, And Determine The Role Of Calmodulin - Death Receptor-5 Binding In Disc Formation In Breast Cancer., Romone Markel Fancy

All ETDs from UAB

Breast cancer is one of the most commonly diagnosed cancers. Calmodulin (CaM) is involved in regulating breast cancer growth, proliferation, and transformation to malignancy. CaM has been shown to play a role in regulating Fas and DR-5 mediated apoptosis. The Fas receptor apoptotic pathway has been well characterized in cholangiocarcinoma; however, targeting Fas for anti-cancer therapy has shown hepatotoxicity in vivo. Thus, in vitro studies with breast cancer will focus on the DR-5 mediated apoptotic pathway. Targeting DR-5 to regulate breast cancer apoptosis is a promising strategy for breast cancer treatment. Understanding the mechanism of Fas and DR-5 interaction with …

Perceived Food And Labor Equity And School Attendance Among Ugandan Children Living In Kin Care, Jini Roby, Stacey Shaw, Laurel George

Faculty Publications

Emerging research suggests that biological relatedness contributes to differential treatment between children being raised by kin and the biological children in the caregiver’s household. This potential concern may be elevated especially when household resources are stretched thin. In this study, 518 Ugandan youth and their caregivers were interviewed individually, examining the association between relatedness and perceived food and work equity, and school attendance. Household income, but not relatedness, was negatively associated with food inequity. However, relatedness was positively associated with perceived disparity in the distribution of work among children living in the household, and with children’s school attendance. These findings …

Regulation Of Capsule By Cpsa And Global Regulatory Networks In Streptococcus Pneumoniae Type 2, Kanupriya Gupta

All ETDs from UAB

Streptococcus pneumoniae is a major human pathogen that can reside asymptomatically in the nasopharynx before causing invasive disease by entering systemic sites. This involves regulation of colonization and virulence factors including capsule. cps2A, the first gene of the capsule (cps) locus has been proposed to regulate capsule, however its exact role and mechanism is not well understood. A complete deletion of cps2A resulted in enhanced capsule levels, with no alteration in the transcription levels of cps genes. Complementation of Cps2A restored wild type levels of capsule. Expression of the C-terminal tail alone was able to partially complement the deletion strain, …

Comparison Of The Lenstar Optical Biometer And A-Scan Ultrasonography To Measure Ocular Components, Drew W. Gann

All ETDs from UAB

The purpose of this study was to compare ocular component dimensions and treated minus control eye differences measured with the Lenstar optical biometer to those measured with A-scan ultrasound in the tree shrew model of refractive development and induced myopia. A-scan ultrasonographic measures (A-scan) were taken with a 15 MHz focused pulser/receiver and compared with measures made with the Lenstar LS900 optical biometer (Haag-Streit, Basel, Switzerland). Anterior segment depth (ASD), lens thickness (LT), vitreous chamber depth (VCD), and axial length (AL) were measured in treated eyes (30), fellow control eyes (30), and normal eyes (86) in tree shrews (n=146), between …

Potential Roles Of The Immunostimulatory Signals Il-15 And Mica In Oncolytic Hsv-1 Therapy For Malignant Glioma, David Curtis Gaston

All ETDs from UAB

Malignant gliomas are the most frequently diagnosed and the most fatal primary brain tumors. Innovative therapeutic approaches are necessary to combat these devastating cancers, and oncolytic herpes simplex virus type-1 (oHSV) deleted of the γ134.5 neurovirulence gene is a promising adjunctive therapy. The primary mechanism of tumor clearance by oHSV is lytic replication specifically within malignant cells. oHSV also stimulates tumor infiltration of cytotoxic immune effector cells that can participate in tumor clearance. However, cytotoxic immune cells target oHSV as well as tumor, which may limit therapeutic efficacy. Further knowledge regarding the nature of these interactions and how the interactions …

Characterization Of Legal Highs And Their Pyrolysis Products, Emily Denise Bouso

All ETDs from UAB

Legal highs are any mind-altering substance produced and sold in a manner to avoid the legal consequences of illicit substances. They have been advertised and sold as Spice, Bath Salts, plant food, and research chemicals. Not only are these drugs presenting major problems to law enforcement, but also to health care providers. The exact composition for many of these substances is not known. Therefore, treatment for patients who have taken these drugs is limited to symptomatic care. Harmful exposure to these substances is not limited to the primary components within the drugs, but can include potentially toxic by-products that result …

Cell Speed Is Independent Of Force In A Mathematical Model Of Amoeboidal Cell Motion With Random Switching Terms., J. C. Dallon, Emily J. Evans, Christopher Grant, William V. Smith

Faculty Publications

In this paper the motion of a single cell is modeled as a nucleus and multiple integrin based adhesion sites. Numerical simulations and analysis of the model indicate that when the stochastic nature of the adhesion sites is a memoryless and force independent random process, the cell speed is independent of the force these adhesion sites exert on the cell. Furthermore, understanding the dynamics of the attachment and detachment of the adhesion sites is key to predicting cell speed. We introduce a differential equation describing the cell motion and then introduce a conjecture about the expected drift of the cell, …

A Force Based Model Of Individual Cell Migration With Discrete Attachment Sites And Random Switching Terms, J. C. Dallon, Matthew Scott, William V. Smith

Faculty Publications

A force based model of cell migration is presented which gives new insight into the importance of the dynamics of cell binding to the substrate. The main features of the model are the focus on discrete attachment dynamics, the treatment of the cellular forces as springs, and an incorporation of the stochastic nature of the attachment sites. One goal of the model is to capture the effect of the random binding and unbinding of cell attachments on global cell motion. Simulations reveal one of the most important factor influencing cell speed is the duration of the attachment to the substrate. …

O-Linked Beta-N-Acetylglucosamine (O-Glcnac) And The Mitochondrion, Christopher Calderon

All ETDs from UAB

O-linked beta-N-acetylglucosamine (O-GlcNAc) is a dynamic and ubiquitous posttranslational modification of serine and threonine residues on nuclear and cytoplasmic proteins. O-GlcNAc has emerged as an important regulator of cellular processes such as cell signaling, transcription, translation, apoptosis, and cell cycle regulation, among others. O-GlcNAc is thought to be a contributor to pathologies such as hyperglycemia and insulin resistance. O-GlcNAc has been viewed as an indicator of cellular energy levels and is associated with diabetic complications under nutrient excess. Other studies have shown that a variety of stress stimuli increase the levels of protein O-GlcNAc in mammalian cells, and this increase …

Reckless Reevaluated: Containment Theory And Its Ability To Explain Desistance Among Serious Adolescent Offenders, Stephanie Michelle Cardwell

All ETDs from UAB

Social control theorists posit that crime and delinquency occur among members in society because an individuals' behavior is not well regulated. Recent control theories have emphasized the importance of high self-control and strong bonds to society in deterring criminal behavior. However, one of the original theories of self-control has been largely ignored among scholars. Developed by Walter Reckless in the 1960s, containment theory suggests that individuals are pushed and pulled into crime. Pushes are elements that pressure individuals to engage in delinquency while pulls draw individuals away from accepted forms of behavior. The theory states that pushes and pulls are …

The Flow Of The Social: Developing A Constructal Systemic Approach To The Study Of Health Inequalities, William A. Anderson

All ETDs from UAB

Society is a dynamic, living system. People, groups, institutions, and cultures are intricately interconnected. Changes in one area of society create changes in other areas. Causes and results may be closely linked or separated by time and space. Sociologists readily acknowledge this dynamic reality. However, our mainstream theories and methods often fail to account for it. Even after decades of research into social inequalities in health, medical sociology still seems far away from being able to offer any definitive ideas about why such inequalities exist and persist despite efforts to alleviate them. Medical sociology (and sociology in general) is centered …

The Interactional Effects Of Incentive Value And Task Difficulty: A Partial Explanation For Gender Differences In Cardiovascular Response To A Performance Challange., Patricia Barreto

All ETDs from UAB

Participants were presented an impossible or moderately difficult mental addition task; half of them were led to believe that they could win a traditionally masculine incentive by meeting a certain performance standard and half of them were led to believe that they could win a traditionally feminine incentive if they met the same performance standard. In the feminine incentive group, Systolic Blood Pressure (SBP) during the work period was stronger under difficult than impossible conditions among women, but low under both difficulty conditions among men. In the masculine incentive group, blood pressure measures (SBP, diastolic blood pressure, and mean arterial …

Adapter Based Strategies For Adenovirus Vector Retargeting To T Lymphocytes, Matthew S. Beatty

All ETDs from UAB

Adenoviruses are the most commonly used gene therapy vector for cancer therapy clinical trials. While adenovirus has shown a great track record in a variety of cancer therapeutics it has not progressed as a vector system for the modification of T lymphocytes. One of the major roadblocks towards utilizing adenovirus for T cell therapy is the lack of coxsackie virus and adenovirus receptor on the cell surface of T cell lineages. Exploitation of alternative receptors has allowed adenovirus vectors to be utilized in a variety of cell types that native adenovirus type 5 cannot infect. Thus, retargeting adenovirus to an …

In-Vivo Characterization Of Cone Photoreceptor Packing Density With Adaptive Optics Scanning Laser Ophthalmoscopy In Different Racial Groups, Ernesto Blanco Rivero

All ETDs from UAB

Cone photoreceptors are one of the two types of essential light sensitive cells that initiate the visual process in the human retina. A normal database of the cone density of healthy eyes may provide an important measure for diagnosing retinal diseases that cause photoreceptor loss, for monitoring disease progression, and for evaluating treatment out-come. Recent studies revealed that the foveal pit morphology, retina thickness, retinal nerve fiber layer (RNFL) thickness, and optic nerve head structure significantly correlated with racial background. We hypothesize that the cone density may be also modified by racial background. To test this hypothesis, I used a …

Uptake Of Antenatal Care Services And Pregnancy Outcome In Kumasi, Ghana, Asundep Ntui

All ETDs from UAB

A prior study reported a 44.6% prevalence of adverse pregnancy outcomes in Kumasi, Ghana. This study investigated factors that may influence antenatal care (ANC) utilization and their association with adverse pregnancy outcomes; defined as low birth weight, stillbirth, preterm delivery or small for gestational age among pregnant women in Kumasi. A quantitative cross sectional study of 643 women, age 19-48 years who presented for delivery at select public hospitals and private traditional birth attendants from July through November 2011 was conducted. Information on socio-demographic characteristics and other factors associated with ANC attendance was collected using a structured questionnaire. Medical and …

Epigenetic Regulation Of Kir4.1 In Normal And Pathological States: A Focus On Spinal Cord Injury, Sinifunanya Elvee Nwaobi

All ETDs from UAB

Astrocytes are the most numerous cells in the brain and play a critical role in maintaining homeostatic extracellular potassium ([K+]e). This process is mediated, in part, by a glial-specific, inwardly rectifying potassium channel, Kir4.1. Pharmacological inhibition, knock down, or complete knock out of this channel results in astrocytes with increased membrane resistance, depolarized resting membrane potential, and altered extracellular potassium dynamics. Subsequent to the dysregulation of [K+]e, Kir4.1 knockout (KO) animals suffer from ataxia, seizures, and early postnatal death. Interestingly, Kir4.1 has long been characterized as a seizure susceptibility gene. The importance of Kir4.1 is further underscored by recent studies …

New Mouse Models To Aid Studies Of The Role Of Primary Cilia In Limb Patterning And Bone Development, Amber Kathleen O'Connor

All ETDs from UAB

Hedgehog (Hh) signaling is required for many developmental processes, and causes several diseases and cancers. Described in chapter one below, vertebrate Hh sig-naling is dependent on the primary cilium (PC), a small organelle that extends from the surface of most mammalian cell types. A better understanding of how the PC modulates Hh signaling is important, as defects in the structure or function of PC result in severe human disorders termed the ciliopathies. For example, patients with Meckel-Gruber Syndrome have extra digits and neural tube defects, which are Hh both related pheno-types. In chapter two we sought to further understand the …

Obesity, Prediabetes, And Perceived Stress In Municipal Workers, Louise Camilleri O'Keefe

All ETDs from UAB

Obesity and diabetes are major contributors to morbidity and mortality in the United States. According to the American Public Health Association and Partnership for Prevention, obesity is growing faster than any other public health problem in the United States. The prevalence of diabetes has also increased significantly with an estimated 79 million Americans aged 20 years or older suffering from prediabetes. Few studies have examined the influence of perceived stress on obesity and prediabetes among working adults. Investigations are needed to examine factors that can contribute to higher health care costs for both employees and employers. The aims of this …

Environmental Specific Effects On Life History And Energy Metabolism Traits In A Permethrin Resistant Strain Of Anopheles Gambiae, Dennis Otali

All ETDs from UAB

Widespread use of pyrethroids for control of malaria vectors together with use in agriculture for pest control has led to an increase in emergence of populations of pyrethroid resistant phenotypes. Insecticide resistance can likely alter vector development time, reproduction, behavior, and longevity, all of which can affect the potential for disease transmission. In this study we assessed whether the genetic modifications (kdr mutation, cytochrome P450 and esterase detoxification) in a permethrin resistant strain of An. gambiae influence traits related to fitness. The performances of these traits were compared between two strains of An. gambiae, one permethrin susceptible (ASEMBO1) and the …

Computational Studies On Metal Bound Amyloid-Ss Peptide Complexes: Implications For Oligomerization, Lurong Pan

All ETDs from UAB

Amyloid-beta (Abeta) peptide is the primary component of the senile plaques that char-acterize Alzheimer's disease (AD). Numerous studies have shown that small soluble oligomers of Aß have higher neurotoxicity than large, insoluble aggregates and fibrils. Brain tissue analysis has shown that excessive metal ions including zinc, copper and iron are co-localized with the plaques. In addition, in vitro studies suggest that these ions play an important role in the aggregation and toxicity of Abeta. Nevertheless, due to the large number of variables that must be controlled it is difficult to characterize the detailed mechanisms by which metal ions modulate Abeta …

Urban Kindergarten Teachers' Perceptions Of Former Head Start Students And Their Readiness For School, Stephanie Hardy Parker

All ETDs from UAB

The purpose of this qualitative multiple case study was to explore the experiences and instruction of kindergarten teachers in an urban school district who are teaching students who were previously enrolled in a Head Start program. Eleven kindergarten teachers who taught in an urban school district in the southeastern United States participated in this study. Data sources collected for this multiple case study included: (a) semi-structured interviews, (b) observations, and (c) curriculum documents. Results from the study revealed mixed experiences teaching former Head Start students. While some teachers expressed positive experiences teaching former Head Start students, others indicated teaching former …

Phospho-Erk And Amyloid Beta: Targets Of Estrogen In The Brain, Thomas Reed Peavy

All ETDs from UAB

Estrogen replacement therapy (ERT) has been shown to improve memory function in menopausal women, but increases hormone sensitive cancers, prompting a more targeted investigation of estrogen's action in learning and memory to develop more targeted therapeutics. Estrogen improves performance on the novel object recognition task by increasing phosphorylation of extracellular signal-regulated kinase (pERK) within minutes in the hippocampus. Dr. Lori McMahon's lab showed that the improvement in novel object recognition can be seen 24 hours after subcutaneous injection of proestrous levels of estrogen (referred to as E24). Whether a corresponding increase in pERK occurs at the E24 time point had …

Characterization Of The Retina In The Alpha 7 Nicotinic Acetylcholine Receptor Knockout Mouse, Marci Lynn Smith

All ETDs from UAB

Acetylcholine receptors (AChRs) are involved in visual processing and are expressed by inner retinal neurons in all species studied to date (Keyser et al., 2000; Dmitrieva et al., 2007; Liu et al., 2009), but their distribution in the mouse retina remains unknown. Reductions in alpha 7 nicotinic AChRs (nAChRs) are thought to contribute to memory and visual deficits observed in Alzheimer's and schizophrenia (Coyle et al., 1983; Nordberg et al., 1999; Leonard et al., 2006). However, the alpha 7 nAChR knockout (KO) mouse has a mild phenotype (Paylor et al., 1998; Fernandes et al., 2006; Young et al., 2007; Origlia …

Host Genetic Factors Associated With Cervical Human Papillomavirus Clearance, Staci Lynn Sudenga

All ETDs from UAB

This dissertation research focuses on how variants in various host genes are associated with clearance of HPV in three longitudinal cohorts from the United States. I first examined the definition of the intermediate phenotype to cervical cancer, HPV persistence and then I incorporated this phenotype in all my three aims by examining variations in xenobiotic metabolism genes in HIV-1 negative and immune-related genes in HIV-1 positive females and how these contribute to HPV infection outcomes. Several significant variants were associated with HPV clearance for the three aims. For the first aim, in ALTS assessing functional variants within xenobiotic metabolism genes …