Digital Commons Network^™

The Regulation And Packaging Of Synaptic Vesicles Related To Recruitment Within Crayfish And Fruit Fly Neuromuscular Junctions: Variations In Low- And High-Output Terminals, Wenhui Wu

Theses and Dissertations--Biology

Glutamate is the main excitatory neurotransmitter in the CNS and at the neuromuscular junctions (NMJs) of invertebrate. The characteristic similarities to CNS glutamatergic synapses in vertebrate and the anatomical simplicity of invertebrate NMJs favor the investigation of glutamatergic synaptic functions in this system. This dissertation mainly aimed to physiologically separate two functional vesicle groups, the reserve pool (RP) and readily releasable pool (RRP) within presynaptic nerve terminals of Procambarus Clarkii and Drosophila melanogaster. This was addressed in part by blocking the vesicular glutamate transporter (VGlut) with bafilomycin A1. Various frequencies of motor nerve stimulation, exposure time, and concentration of …

Factors Influencing The Establishment And Survival Of Native Hardwood Tree Seedlings Of The Kentucky Inner Bluegrass Blue Ash-Oak Savanna-Woodland, James D. Shaffer

Theses and Dissertations--Biology

Historically, the Kentucky Inner Bluegrass blue ash-oak savanna-woodland was the primary ecosystem of the Inner Bluegrass Region (IBR) of Kentucky. After European settlement, the majority (>99%) of Bluegrass savanna was converted to agricultural and urban land uses. Currently remnant savanna tree species are failing to recruit. Therefore, a long-term restoration ecology project researching competition and disturbance on seedling establishment, survival, and growth has been established at Griffith Woods (the largest remaining savanna in Kentucky) in Harrison Co., KY. Fourteen native hardwood tree species (a total of 6,168 seedlings) have been experimentally planted. Light, soil, surrounding vegetation, and herbivory, factors …

Physical Dormancy In Seeds, With Special Reference To Geraniaceae: Morpho-Anatomy, Development, Physiology, Biomechanics And Classification Of Water-Gap Complexes, Nalin Suranjith Gama Arachchige

Theses and Dissertations--Biology

The primary aims of this dissertation were to (1) identify and characterize the water-gap complex in seeds of Geraniaceae, (2) investigate its role in physical dormancy (PY) break and (3) develop a new classification system for water-gap complexes in seeds of angiosperms. The winter annuals Geranium carolinianum and G. dissectum were selected as the main representative species for the study, and seeds of an additional 29 species from the Geraniaceae were used to compare the water-gap complex within the family. A new classification system for water-gap complexes in species with PY was developed by comparing the morpho-anatomical features of PY …

Self-Replicating Technologies And The Challenge For The Patent And Antitrust Laws, Daryl Lim

Cardozo Arts & Entertainment Law Journal

Few patented inventions challenge the traditional boundaries of the patent and antitrust laws like those that are capable of multiplying as they are used. These self-replicating technologies are embedded in our food, fortify our vaccines, and form the computer code upon which the information age is based. These inventions create an inherent conflict between patentees and their customers. The conflict arises because every customer could become competitors as the product replicates, potentially making every first sale the patentee's last. They also challenge how we think about fundamental issues of ownership as well as innovation and market competition, and make it …

The Relationship Between Time Estimation And An Individual's Ability To Delay Gratification, Erin Kamien

EWU Masters Thesis Collection

"This study examines the relationship between an individual's ability to accurately estimate the passage of time and his or her ability to delay gratification. In this study, undergraduate students were asked to estimate time intervals using a time estimation computer program and to provide a verbal estimation of time intervals. These scores were then correlated with delay of gratification measures, designated by their score on a delay of gratification inventory, and their decision to receive extra credit points immediately and end their participation, or to return and collect an additional half of their reward a day later. It was expected …

Grand Bargains For Big Data: The Emerging Law Of Health Information, Frank Pasquale

Faculty Scholarship

No abstract provided.

Parsing Parenthood, Cynthia Godsoe

Faculty Scholarship

No abstract provided.

Family Law Equality At A Crossroads, David D. Meyer

Faculty Scholarship

No abstract provided.

Analysis Of Dna Methylation And Copy Number Variation In Renal Cell Carcinoma, Brittany N. Lasseigne

Dissertations

Renal cell carcinoma (RCC) is the 10th most commonly diagnosed cancer in the United States and its incidence is increasing. It is difficult to detect early and is relatively non-responsive to traditional radiation and chemotherapies. Previous work demonstrates the value of measuring copy number variation (CNV) and DNA methylation changes in RCC, but diagnostic biomarkers and additional treatment options in the clinic are still needed. This study examined genome-wide DNA methylation and CNV in RCC tumor and benign adjacent kidney tissues from 101 clinically-annotated patients. Analyses revealed widespread DNA methylation and copy number differences between tumor and benign tissues, particularly …

Chemical Investigation Of Opuntia Species And Stenocereus Thurberi, Cacti Native To North America : A Search To Identify Essential Oil Compositions And To Characterize Cyclic Siloxane Compounds, Cynthia Rena Wright

Dissertations

This study investigates the essential oil compositions of certain cacti species native to southern Arizona and the California Channel Islands. The species studied are Opuntia littoralis (Engelm.) Cockerell., Opuntia ficus-indica L. (Mill), Opunita prolifera Engelm., Opuntia acanthocarpa var. major (Engelm. & J.M. Begelow) L.D. Benson, Opuntia phaeacantha var. discata, and Stenocereus thurberi Engelm. Drosophila mojavensis, a cactus fly, utilizes the necrotic rots of O. littoralis and S. thurberi, which have been shown to be toxic to fruit flies, Drosophila melanogaster. The oil compositions of both O. littoralis and S. thurberi was characterized at differing states of necrosis and compared to …

Uncommon Approaches To Commons Problems: Nested Governance Commons And Climate Change, Blake Hudson, Jonathan Rosenbloom

Journal Articles

Natural capital resources crucial to combatting climate change are potentially subject to tragic overconsumption absent a requisite degree of vertical government regulation of resource appropriators and/or horizontal collective action among resource appropriators. In federal systems, these vertical and horizontal approaches may (or may not) take place in any one of four scales — local, state, national, and global — “nested” one within another. Prior research has described how natural capital in federal systems of government, though privatized and/or subject to government regulation, may nonetheless remain in a tragic plight due to the allocation of governance authority in federal systems — …

Cladistic Analysis Of Extant And Fossil African Papionins Using Craniodental Data, Christopher C. Gilbert

Publications and Research

No abstract provided.

The Role Of Gender In Intergenerational Transmissions Of Education And Occupational Promotion, Si Wang

Theses and Dissertations

While several studies have suggested the importance of maternal schooling to children's outcomes during childhood, less is known about the role when the child is older. In the first chapter, I estimate the relationship between maternal education and children's college attendance. After developing a theoretical model to consider the transmission of education across generations, I use the NLSY79 Child and Young Adult Surveys for empirical analysis. College proximity is used as an instrument for mother's schooling. All else equal, results suggest that maternal schooling significantly increases a child's probability of attending college by about 2 to 3 percentage points. The …

Improved Limits And Portability Over Currently Employed Cadmium Monitoring Systems Through Preconcentration For Detection By Way Of Micro-/Nanofluidic Mechanisms, Paul F. Wach

Theses and Dissertations

Due to risk of environmental and biological accumulation of Cadmium (Cd), improved methods of early detection and monitoring must be explored as a preventative measure. Listed as one of the top three toxic heavy metals by the Environmental Protection Agency (EPA), the effects on ecological and human systems have well documented side-effects of physical mutation, reproductive sterility, kidney failure, liver disease, bone loss, and death. Found in batteries, metal plating, pigments, plastics, and cigarettes, Cd is also used as a neutron absorber in the nuclear industry as well as having 3 known radioactive isotopes. Urine Cd levels, which have been …

The Effect Of Thymidylate Synthase Inhibitors On Bone Marrow Derived Cells In The Intestinal Tumor Microenvironment, Grishma Acharya

Theses and Dissertations

Tumors have come to be known as independently functioning complex organs consisting of cancer cells coexisting with a heterogeneous mixture of host-derived non-neoplastic cells that form the tumor stroma. Tumor survival, progression, and metastasis depend on multiple close interactions between the cancer cells and the tumor stromal cells. These tumor stromal cells are mainly bone marrow derived cells (BMDCs) that are recruited to the primary tumor and sites of metastasis by a variety of signals secreted by the cancer cells. Because of the close interaction between the tumor and the tumor stroma, we propose that tumor stromal cells play an …

Growth Of Silver Nanoparticles On Transparent Substrates From Liquid Precursors: Improvements And Applications, Carlos Andrés Jarro Sanabria

Theses and Dissertations--Electrical and Computer Engineering

Interest in controlling the synthesis of silver nanoparticles in colloidal solutions has increased during the last two decades. There is also growing interest in forming layers of silver nanoparticles on substrates, particularly for surface-enhanced Raman spectroscopy applications. However, methods to grow silver nanoparticles directly on substrates have not been studied extensively, and there are few techniques for controlling the size, shape, density, and location of the particles. This work presents a simple and reliable method to photodeposit silver nanoparticles onto transparent substrates. The size, shape and deposition density of the nanoparticles are influenced by the precursor solution, light intensity, and …

Multi-Mode Self-Referencing Surface Plasmon Resonance Sensors, Jing Guo

Theses and Dissertations--Electrical and Computer Engineering

Surface-plasmon-resonance (SPR) sensors are widely used in biological, chemical, medical, and environmental sensing. This dissertation describes the design and development of dual-mode, self-referencing SPR sensors supporting two surface-plasmon modes (long- and short-range) which can differentiate surface binding interactions from bulk index changes at a single sensing location. Dual-mode SPR sensors have been optimized for surface limit of detection (LOD). In a wavelength interrogated optical setup, both surface plasmons are simultaneously excited at the same location and incident angle but at different wavelengths. To improve the sensor performance, a new approach to dual-mode SPR sensing is presented that offers improved differentiation …

Providing A Persistent Space Plug-And-Play Avionics Network On The International Space Station, Zachary A. Jacobs

Theses and Dissertations--Electrical and Computer Engineering

The CubeLab is a new payload standard that greatly improves access to the International Space Station (ISS) for small, rapid turn-around microgravity experiments. CubeLabs are small (less than 16”x8”x4” and under 10kg) modular payloads that interface with the NanoRacks Platform aboard the ISS. CubeLabs receive power from the station and transfer data using the standard terrestrial plug-and-play Universal Serial Bus (USB). The Space Plug-and-play Avionics (SPA) architecture is a modular technology for spacecraft that provides an infrastructure for modular satellite components to reduce the time to orbit and development costs for satellites. This paper describes the development of a bus …

An Attitude Determination System With Mems Gyroscope Drift Compensation For Small Satellites, Maxwell Bezold

Theses and Dissertations--Electrical and Computer Engineering

This thesis presents the design of an attitude determination system for small satellites that automatically corrects for attitude drift. Existing attitude determination systems suffer from attitude drift due to the integration of noisy rate gyro sensors used to measure the change in attitude. This attitude drift leads to a gradual loss in attitude knowledge, as error between the estimated attitude and the actual attitude increases.

In this thesis a Kalman filter is used to complete sensor fusion which combines sensor observations with a projected attitude based on the dynamics of the satellite. The system proposed in this thesis also utilizes …

Expanding The Vienna Convention On Consular Relations, Sarah G. Mccroskey

Vanderbilt Journal of Transnational Law

Article 37 of the Vienna Convention on Consular Relations (VCCR) aims to protect the interests of foreign national children by requiring consular notification whenever these children come into the custody of the state. Consular assistance can be invaluable for foreign national parents and children who may not understand the language or the culture and who may be subject to discrimination based on their nationality. However, the VCCR is currently inadequate in two major ways. First, the protections of Article 37 are only triggered when the child in custody is a foreign national, leaving vulnerable to unfair treatment families in which …

Red, Yellow, Blue, Lauren Elizabeth Eyler

Theses and Dissertations

Red, Yellow, Blue is a hybrid, metafictional novel/autobiography. The work explores the life of Ellis, Lotte, Diana John-John and Lauren as they wander through a variety of circumstances, which center on loss and grief. As the novel develops, the author loses control over her intentionality; the character's she claims to know fuse together, leaving the reader to wonder if Lauren is synonymous with Ellis or if Diana is actually Lotte disguised by a signifier. Red, Yellow, Blue questions the author's as well as the reader's ability to understand the transformation that occurs in an individual during long periods of grief …

Removal Of Synthetic Organic Compounds And Nom By Single-Walled Carbon Nanotubes-Ultrafiltration And Forward Osmosis Membrane System, Jiyong Heo

Theses and Dissertations

This overall theme of this dissertation is to investigate the potential engineered application of low pressure membranes incorporated with single-walled carbon nanotubes (SWNTs) and forward osmosis (FO) membrane systems for the removal of synthetic organic compounds (SOCs) and natural organic matter (NOM) from drinking water sources. The focus is on the use of SWNTs-ultrafiltration (UF) and FO membrane systems to facilitate the removal of these compounds and potential applications of these membrane system designs for reducing the energy demands and membrane fouling in environmental water filtration process and seawater desalination. The SWNTs-UF results indicate that SOCs transport is influenced by …

Heirlooms, Candace Gayle Wiley

Theses and Dissertations

This creative thesis is a collection of poems and an essay that explores the concept of defining the self through the influence of personal and cultural heirlooms. It is particularly concerned with the inheritances that children receive, whether they are a pair of stockings or a political atmosphere. This collection consists of five sections, submitted in partial fulfillment of University of South Carolina's Master of Fine Arts degree in Creative Writing.

Thermal Infrared Imaging: Instrumentation And Method Development, Wayne O'Brien

Theses and Dissertations

A recently development thermal infrared camera system was improved by designing new components to downsize physical aspect and improve the instrument's performance. A new thermal infrared light source was developed and characterized. It is designed from a custom-made Macor backpiece that holds an alumina screw. High resistance wire is coiled around the screw. The coiled wire is covered with an alumina coating. Most light sources have a spectral emissivity similar to that of a blackbody emitter. This source has a spectral irradiance profile that is not similar to a blackbody source. Thus, the lamp has an improved efficiency in the …

Longitudinal Effects Of Depression And Sexual Dysfunction On Glycemic Control In Veterans With Diabetes, Adrian Laseter

Theses and Dissertations

Diabetes rates are on the rise, particularly among members of racial and ethnic minority groups. Individuals with diabetes are more vulnerable to developing depressive symptoms when compared to those without diabetes. While there appear to be no racial and ethnic differences in depression prevalence estimates among individuals with diabetes, members of racial and ethnic minority groups are less likely to achieve glycemic control over time, and may be at greater risk for diabetes related health issues. One such health issue is sexual dysfunction, with individuals with diabetes being more vulnerable to sexual dysfunction than those without diabetes. Sexual dysfunction may …

Malnutrition In Sickle Cell Anemia: Implications For Infection, Growth And Maturation, Hyacinth I. Hyacinth, Oluwatoyosi A. Adekeye, Christopher S. Yilgwan

Journal of Social, Behavioral, and Health Sciences

Sickle cell anemia (SCA) is a genetic disease that affects mostly individuals of African and/or Hispanic descent, with the majority of cases in sub-Saharan Africa. Individuals with this disease show slowed growth, delayed sexual maturity, and poor immunologic function. These complications could partly be explained by the state of undernutrition associated with the disease. Proposed mechanism of undernutrition include protein hypermetabolism, decreased dietary intake possibly from interleukin-6-related appetite suppression, increased cardiac energy demand/expenditure, and increased red cell turnover. All the above mechanisms manifest as increased resting energy expenditure. Nutritional intervention utilizing single or multiple nutrient supplementation has led to improved …

The Road To “Severe Obesity”: Weight Loss Surgery Candidates Talk About Their Histories Of Weight Gain, Julia Temple Newhook, Deborah Gregory, Laurie Twells

Journal of Social, Behavioral, and Health Sciences

Much research focuses on the causes of weight gain, but few studies examine the perspectives of those who have been categorized as “severely obese.” This paper discusses the findings of 54 interviews with weight loss surgery candidates in Newfoundland and Labrador, Canada. We explore participants’ perspectives on their histories of weight gain, focusing on their explanations for weight gain as well as the emotions surrounding their weight gain experiences. We find that the dominant individualized, medicalized construction of obesity both (1) adds to the burden of blame for weight loss surgery candidates, with potential emotional health implications, and (2) overlooks …

Flagellar Waveform Dynamics Of Freely Swimming Algal Cells, H. Kurtuldu, D. Tam, A. E. Hosoi, Karl A. Johnson

Biology Faculty Scholarship

We present quantitative measurements of time-dependent flagellar waveforms for freely swimming biflagellated algal cells, for both synchronous and asynchronous beating. We use the waveforms in conjunction with resistive force theory as well as a singularity method to predict a cell's time-dependent velocity for comparison with experiments. While net propulsion is thought to arise from asymmetry between the power and recovery strokes, we show that hydrodynamic interactions between the flagella and cell body on the return stroke make an important contribution to enhance net forward motion.

Cholera Outbreaks In Nigeria Are Associated With Multidrug Resistant Atypical El Tor And Non-O1/Non-O139 Vibrio Cholerae., M. A. Marin, Cristiane C. Thompson, F. S. Freitas, E. L. Fonseca, Iruka N. Okeke

Biology Faculty Scholarship

Background

The current millennium has seen a steep rise in the number, size and case-fatalities of cholera outbreaks in many African countries. Over 40,000 cases of cholera were reported from Nigeria in 2010. Variants of Vibrio cholerae O1 El Tor biotype have emerged but very little is known about strains causing cholera outbreaks in West Africa, which is crucial for the implementation of interventions to control epidemic cholera.

Methodology/Principal Findings

V. cholerae isolates from outbreaks of acute watery diarrhea in Nigeria from December, 2009 to October, 2010 were identified by standard culture methods. Fifteen O1 and five non-O1/non-O139 strains were …

The Carbon Isotope Organic Geochemistry Of Early Ordovician Rocks From The Annascaul Formation, County Kerry, A. H. Jahren, Brian A. Schubert, Leszek Marynowski, Jonathan P. Wilson

Biology Faculty Scholarship

Ireland is well known to geologists as containing some of the thickest successions of Early Ordovician (485-470 Ma; Walker et al. 2012) sedimentary rocks in the world. The carbon stable isotope compositions (δ¹³C value) of similarly aged rocks have been reported for only very few places in the world (i.e., Argentina, southern China, and southern France), and no such analyses have been performed on the Early Ordovician, organic-rich rocks of Ireland. Here we report the δ¹³C values of bulk organic material and organic isolates recovered from the Annascaul Formation of Southwestern Ireland. Members of the Annascaul …