Digital Commons Network^™

Enacting Privacy Rules And Protecting Disclosure Recipients: Parents’ Communication With Children Following The Death Of A Family Member, Paige W. Toller, M. Chad Mcbride

Communication Faculty Publications

Given the probability that the death of a family member will occur before a child has reached adulthood, the purpose of this project was to understand what motivates parents to either talk or not talk about a loved one's death with their children. Using Communication Privacy Management to inductively analyze interviews, we found parents were motivated to talk to their children about death because they wanted their children to be informed. This is reflected in the first primary theme, Recalibrating Family of Origin Privacy Orientation Rules: Motivations for Revealing. Two secondary themes further explained parents' motivations to reveal: death as …

Characterization Of The Asian Citrus Psyllid Transcriptome, Justin Reese, Matthew K. Christenson, Nan Leng, Surya Saha, Brandi Cantarel, Magdalen Lindeberg, Cecilia Tamborindeguy, Justin Maccarthy, Andrew J. Trease, Steven V. Ready, Vincent M. David, Courtney Mccormick, Christian Haudenschild, Shunsheng Han, Shannon L. Johnson, Kent S. Shelby, Hong Huang, Blake R. Bextine, Robert G. Shatters, David G. Hall, Paul H. Davis, Wayne B. Hunter

Biology Faculty Publications

The Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Psyllidae) is a vector for the causative agents of Huanglongbing, which threatens citrus production worldwide. This study reports and discusses the first D. citri transcriptomes, encompassing the three main life stages of D. citri, egg, nymph and adult. The transcriptomes were annotated using Gene Ontology (GO) and insecticide-related genes within each life stage were identified to aid the development of future D. citri insecticides. Transcriptome assemblies and other sequence data are available for download at the International Asian Citrus Psyllid Genome Consortium website [http://psyllid.org/download] and at NCBI [http://www.ncbi.nlm.nih.gov/bioproject/29447].

The Effect Of A Short Duration, High Intensity Exercise Intervention On Gait Biomechanics In Patients With Copd: Findings From A Pilot Study, Jenna M. Yentes, Daniel Blanke, Stephen I. Rennard, Nikolaos Stergiou

Journal Articles

Previous work has shown that patients with chronic obstructive pulmonary disease (COPD) demonstrate changes in their gait biomechanics as compared to controls. This pilot study was designed to explore the possibility that biomechanical alterations present in COPD patients might be amenable to treatment by exercise training of skeletal muscle. This study investigated the effect of a 6-week exercise intervention on gait biomechanics in patients with COPD under both a rest and a non-rested condition. Seven patients with COPD underwent a supervised cardio-respiratory and strength training protocol 2-3 times per week for 6-weeks for a total of 16-sessions. Spatiotemporal, kinematic and …

Serialization, Ethnographic Drag, And The Ineffable Authenticity Of Nikki S. Lee, Todd Richardson

English Faculty Publications

This essay reads the photographer Nikki S Lee’s Projects, a series of pictures in which the artist poses as a member of various subcultures and folk groups from an ethnographic perspective. Focusing on how folklore scholars might employ Lee’s representational strategies, the essay suggests that two aspects of Projects are especially instructive for folkloristic ethnography. First, Lee’s use of drag as camp highlights the performative aspects of identity, showing how individuals express themselves both through and against shared expressive standards. Second, the serialized presentation of the photographs provides a model for the ethnographic representation of multiple folk identities performed …

Lomustine Analogous Drug Structures For Intervention Of Brain And Spinal Cord Tumors: The Benefit Of In Silico Substructure Search And Analysis, Ronald Bartzatt

Chemistry Faculty Publications

Lomustine is a nitrosourea anticancer agent shown to be effective for treatment of childhood medulloblastoma. In silico substructure searches produced 17 novel nitrosourea agents analogous to lumustine and retaining activity for DNA alkylation and cytotoxic activity. The mean values for Log P, polar surface area, formula weight, number of oxygens & nitrogens, and rotatable bonds were 2.524, 62.89 Anstroms2, 232.8, 5, and 2, respectively. All 17 agents have formula weight less than 450 and Log P less than 5, two criteria preferred for blood-brain barrier penetration.These agents have a polar surface area less than 90 Angstroms2. Each show zero violations …

A Structure-Preserving Hybrid-Chordal Filter For Sampling In Correlation Networksa Structure-Preserving Hybrid-Chordal Filter For Sampling In Correlation Networks, Kathryn Dempsey Cooper, Tzu-Yi Chen, Sriram Srinivasan, Sanjukta Bhowmick, Hesham Ali

Interdisciplinary Informatics Faculty Proceedings & Presentations

Biological networks are fast becoming a popular tool for modeling high-throughput data, especially due to the ability of the network model to readily identify structures with biological function. However, many networks are fraught with noise or coincidental edges, resulting in signal corruption. Previous work has found that the implementation of network filters can reduce network noise and size while revealing significant network structures, even enhancing the ability to identify these structures by exaggerating their inherent qualities. In this study, we implement a hybrid network filter that combines features from a spanning tree and near-chordal subgraph identification to show how a …

In Vivo Analysis Of Highly Conserved Nef Activities In Hiv-1 Replication And Pathogenesis, Richard L. Watkins, Wei Zou, Paul W. Denton, John F. Krisko, John L. Foster, J. Victor Garcia

Biology Faculty Publications

Background: The HIV-1 accessory protein, Nef, is decisive for progression to AIDS. In vitro characterization of the protein has described many Nef activities of unknown in vivo significance including CD4 downregulation and a number of activities that depend on Nef interacting with host SH3 domain proteins. Here, we use the BLT humanized mouse model of HIV-1 infection to assess their impact on viral replication and pathogenesis and the selection pressure to restore these activities using enforced in vivo evolution.

Results: We followed the evolution of HIV-1LAI (LAI) with a frame-shifted nef (LAINeffs) during infection of BLT mice. LAINeffs …

A Perspective On Human Movement Variability With Applications In Infancy Motor Development, Nikolaos Stergiou, Yawen Yu, Anastasia Kyvelidou

Journal Articles

Movement variability is considered essential to typical motor development. However, multiple theoretical perspectives and measurement tools have limited interpretation of the importance of movement variability in biological systems. The complementary use of linear and nonlinear measures have recently allowed for the evaluation of not only the magnitude of variability but also the temporal structure of variability. As a result, the theoretical model of optimal movement variability was introduced. The model suggests that the development of healthy and highly adaptable systems relies on the achievement of an optimal state of variability. Alternatively, abnormal development may be characterized by a narrow range …

Prosthesis Preference Is Related To Stride-To-Stride Fluctuations At The Prosthetic Ankle, Shane R. Wurdeman, Sara A. Myers, Adam L. Jacobsen, Nikolaos Stergiou

Journal Articles

The purpose of this study was to determine the relationship between stride-to-stride fluctuations and prosthesis preference. Thirteen individuals with unilateral, transtibial amputation consented to participate. Individuals walked on a treadmill for 3 min with their prescribed and an alternate prosthesis. Stride-to-stride fluctuations were quantified with the largest Lyapunov exponent (LyE) of each joint flexion/extension time series. The change in the LyE was calculated for each major lower-limb joint for both conditions. Participants indicated preference between the prostheses on a continuous visual analog scale. The change in the LyE was correlated with the degree of preference between the two prostheses at …

Disentangling Function From Topology To Infer The Network Properties Of Disease Genes, Dario Ghersi, Mona Singh

Interdisciplinary Informatics Faculty Publications

Background: The topological features of disease genes within interaction networks are the subject of intense study, as they shed light on common mechanisms of pathology and are useful for uncovering additional disease genes. Computational analyses typically try to uncover whether disease genes exhibit distinct network features, as compared to all genes. Results: We demonstrate that the functional composition of disease gene sets is an important confounding factor in these types of analyses. We consider five disease sets and show that while they indeed have distinct topological features, they are also enriched in functions that a priori exhibit distinct network properties. …

A Parallel Template For Implementing Filters For Biological Correlation Networks, Kathryn Dempsey Cooper, Vladimir Ufimtsev, Sanjukta Bhowmick, Hesham Ali

Interdisciplinary Informatics Faculty Publications

High throughput biological experiments are critical for their role in systems biology – the ability to survey the state of cellular mechanisms on the broad scale opens possibilities for the scientific researcher to understand how multiple components come together, and what goes wrong in disease states. However, the data returned from these experiments is massive and heterogeneous, and requires intuitive and clever computational algorithms for analysis. The correlation network model has been proposed as a tool for modeling and analysis of this high throughput data; structures within the model identified by graph theory have been found to represent key players …

Phase Composition Control Of Calcium Phosphate Nanoparticles For Tunable Drug Delivery Kinetics And Treatment Of Osteomyelitis. Part 1: Preparation And Drug Release, Vuk Uskoković, Tejal A. Dasai

Pharmacy Faculty Articles and Research

Developed in this study is a multifunctional material for simultaneous osseoinduction and drug delivery, potentially applicable in the treatment of osteomyelitis. It is composed of agglomerates of nanoparticles of calcium phosphate (CAP) with different monophasic contents. The drug loading capacity and the release kinetics were investigated on two model drug compounds with different chemical structures, sizes and adsorption propensities: bovine serum albumin and fluorescein. Loading of CAP powders with small molecule drugs was achieved by physisorption and desiccation-induced agglomeration of nanoparticulate subunits into microscopic blocks. The material dissolution rate and the drug release rate depended on the nature of the …

Major Depressive Disorder And Measures Of Cellular Aging: An Integrative Review, Patricia Anne Kinser, Debra E. Lyon

School of Nursing Publications

Major depressive disorder (MDD) affects millions of individuals and causes significant suffering worldwide. It has been speculated that MDD is associated with accelerated aging-related biological and functional decline. To examine the accelerated aging hypothesis, one of the biomarkers under study is leukocyte telomeres, and specifically the measure of telomere length and telomerase activity. This review integrates findings from eleven human studies which evaluated telomere length and telomerase activity, in order to synthesize the state of the current science and to inform the development of new knowledge and enhance nursing research of depression using appropriate biobehavioral measures. Although preliminary, the findings …

A Study Of The Sensitivity Of Plethodon Cinereus (Caudata: Plethodontidae) To Damage-Released Cues From Conspecifics, Aaron M. Sullivan, Gregory Jensen

Faculty Publications - Department of Biological & Molecular Science

Some prey species vary the intensity of antipredator responses according to the perceived level of threat associated with different concentrations of chemical cues related to predation. Here, we examine whether Red-Backed Salamanders (Plethodon cinereus) respond to different concentrations of damage-released cues from the tails of conspecifics in a threat-sensitive manner. We exposed salamanders either to a control or to damage-released cues from conspecifîcs at one of three different concentrations. We found that salamanders exposed to damage released cues significantly decreased their activity compared to salamanders exposed to a control. However, the intensity of the responses was not related to the …

The European Union's Response To The Sovereign Debt Crisis: Its Effect On Labor Relations In Greece, Joanna Pagones

Fordham International Law Journal

No abstract provided.

Effects Of Discrete Time Delays And Parameters Variation On Dynamical Systems, Ibrahim Oumar Diakite

Mathematics Dissertations - Archive

To understand the effects of discrete time delays and of parameters variation on certain biological system models, we first consider a Delay Differential Equation model of human immunodeficiency virus (HIV). We investigate the effects of the discrete time on the virulence of the HIV strain, and present sufficient and necessary condition for the virulence of the pathogen to change as the time delay changes. We also consider the same delay differential model for HIV infection, and we investigate analytically and numerically the stability of the endemically infected equilibrium. Our analysis shows that certain key parameters, such as the rate of …

Occurrence Of An Intersexual Blacktip Shark In The Northern Gulf Of Mexico, With Notes On The Standardization Of Classifications For This Condition In Elasmobranchs, Jill M. Hendon, David M. Koester, Eric R. Hoffmayer, William B. Driggers Iii, Angela M. Cicia

Faculty Publications

An intersexual Blacktip Shark Carcharhinus limbatus with a testis, immature female reproductive tracts (embedded), and claspers was caught in the Gulf of Mexico. Histology of the single gonad revealed that all stages of spermatogenesis were occurring; however, the absence of ovaries and a male duct system suggests that neither sex would have been functional in this individual. Intersexuality has been reported in 17 families and 36 species of elasmobranchs. The degree to which the different sexes are present in a given individual is often difficult to categorize by normal hermaphroditic standards, as this is typically an anomalous presentation in elasmobranchs. …

Adaptation, Steven Luper

Philosophy Faculty Research

Some ways of dealing with a threatened evil will be self-defeating, in the sense that the response is no better for us, or even worse, than the evil it prevents. A way of adapting to death might be self-defeating in precisely the same way. Perhaps, however, we can adapt to death by suitably modifying our interests, and do so in a way that is not self-defeating. I will call this claim the adaptation thesis. Elsewhere, I have argued against it. In this chapter, I reinforce that conclusion.

A New Way Of Living: Bioeconomic Models In Post-Apocalyptic Dystopias, Margaret A. Wells

Theses and Dissertations--English

The objective of this thesis is to explore the relationship between moralities and bioeconomies in post-apocalyptic dystopias from the Victorian era to contemporary Young Adult Fiction. In defining the terms bioeconomy and biopolitics, this works examines the ways in which literature uses food and energy systems to explore morality and immorality in social orders and systems, including capitalism and our modern techno-industrial landscapes. This work examines science fiction portrayals of apocalypses and dystopias, including After London: Or, Wild England and The Hunger Games, as well as their medieval and contextual influences. These works are analyzed in light of genre …

Randomness, Uncertainty, And Economic Behavior: The Life Of Money In Eighteenth-Century Fiction, Devjani Roy

Theses and Dissertations--English

My dissertation argues that fiction produced in England during the frequent financial crises and political volatility experienced between 1770 and 1820 both reflected and shaped the cultural anxiety occasioned by a seemingly random and increasingly uncertain world. The project begins within the historical framework of the multiple financial crises that occurred in the late eighteenth century: seven crises took place between 1760 and 1797 alone, appearing seemingly out of nowhere and creating a climate of financial meltdown. But how did the awareness of economic turbulence filter into the creative consciousness? Through an interdisciplinary focus on cultural studies and behavioral economics, …

Counting On The Environment: Measuring And Marketing Ecosystem Services In Oregon, Eric Nost

Theses and Dissertations--Geography

New markets for the conservation of so-called ecosystem services, like the ability of a wetland to mitigate floods, are emerging worldwide. According to environmental economists, these markets require some metric - ecological or otherwise - that names the relevant characteristics of the service to be traded as a commodity. But while this is often assumed to be a simple task of science, I argue that the environmental regulators, eco-entrepreneurs, and conservationists who actually design and implement metrics are not so easily brought into agreement. In “rolling-out” revamped metrics and protocols, regulators and their conservationist allies in one market in Oregon …

The Effect Of Augmented Reality Treatment On Learning, Cognitive Load, And Spatial Visualization Abilities, Nedim Slijepcevic

Theses and Dissertations--Curriculum and Instruction

This study investigated the effects of Augmented Reality (AR) on learning, cognitive load and spatial abilities. More specifically, it measured learning gains, perceived cognitive load, and the role spatial abilities play with students engaged in an astronomy lesson about lunar phases. Research participants were 182 students from a public university in southeastern United States, and were recruited from psychology research pool. Participants were randomly assigned to two groups: (a) Augmented Reality and Text Astronomy Treatment (ARTAT); and (b) Images and Text Astronomy Treatment (ITAT). Upon entering the experimental classroom, participants were given (a) Paper Folding Test to measure their spatial …

Examining The Influence Of Parents, Teachers, And Neighborhood Safety On African American Adolescents’ Motivation And Achievement, Clarissa R. Roan-Belle

Theses and Dissertations--Educational, School, and Counseling Psychology

Guided by the theoretical frameworks of Baumrind’s parenting style theory, interpersonal expectations, Self Determination Theory, and self-efficacy, this study examines factors that influence African American students’ GPA and motivation, specifically associations between parents’ and teachers’ control, warmth, and educational expectations and African American adolescents’ GPA, self-efficacy, and intrinsic motivation were examined. The moderating effects of neighborhood safety on the aforementioned associations were also assessed. Using data from the Educational Longitudinal Study of 2002, this study found that parents’ warmth and expectations were positive predictors of all educational variables, while parents control was a negative predictor of GPA and intrinsic motivation. …

Support Services And Programmatic Interventions Four-Year Institutions Have In Place To Assist And Graduate Students With Low Academic Credentials: A Mixed Methods Study, Nada El Majzoub

Theses and Dissertations--Educational Leadership Studies

This mixed methods study investigates the influence of student characteristics and institutional support services and interventions on graduation rates. Regression analysis was conducted using a dataset constructed from multiple publically available resources to estimate graduation rates. Regression results showed High School Grade Point Average to be the highest estimator of graduation rates, among other student and institutional characteristics. The results confirmed existing findings on the influence of student pre-college and demographic characteristics on graduation rates for students with academic needs. Content analysis of survey data from office of support service personnel at public four-year institutions shows institutions implement a wide …

Behavioral Intentions And Nonmedical Anabolic Steroid Use Among Non Intercollegiate Athlete Males Ages 18-30, Vitesh Enaker

Theses and Dissertations--Kinesiology and Health Promotion

The purpose of this study was to increase understanding of factors associated with nonmedical anabolic steroid use among males ages 18-30 who do not participate in intercollegiate athletics. The Behavioral Intentions and Ergogenic Aid/Performance Enhancer use among non-intercollegiate athlete males survey instrument was developed, reviewed for content validity by a jury of experts, and pilot tested. The pilot testing results (n=25) demonstrated acceptable reliability (Cronbach’s alpha= 0.74). The final version of the Behavioral Intentions and Ergogenic Aid/Performance Enhancer use among non-intercollegiate athlete males survey instrument was administered at two distribution sites which included Ford’s Fitness Center in Lexington, Kentucky and …

Biological Control Of Manganese In Water Supplies In The Presence Of Humic Acids, Michael S. Snyder

Theses and Dissertations--Civil Engineering

The main objective of this study was to improve our understanding of biological filtration (biofilm type) treatment for manganese (Mn) removal in drinking water. Biological filtration treatment involves biofilms of Mn(II)-oxidizing microorganisms attached to solid filter material that remove and immobilize dissolved Mn(II) in raw water by conversion to black MnO_2(s) precipitates. Mn-biological filtration is an emerging green technology that can serve as an alternative to conventional physicochemical treatments but its full potential is hindered by various factors. These include lack of understanding the: (1) optimal removal conditions for Mn, (2) mechanisms for Mn releases of the accumulated Mn …

Noninvasive Near-Infrared Diffuse Optical Monitoring Of Cerebral Hemodynamics And Autoregulation, Ran Cheng

Theses and Dissertations--Biomedical Engineering

Many cerebral diseases are associated with abnormal cerebral hemodynamics and impaired cerebral autoregulation (CA). CA is a mechanism to maintain cerebral blood flow (CBF) stable when mean arterial pressure (MAP) fluctuates. Evaluating these abnormalities requires direct measurements of cerebral hemodynamics and MAP. Several near-infrared diffuse optical instruments have been developed in our laboratory for hemodynamic measurements including near-infrared spectroscopy (NIRS), diffuse correlation spectroscopy (DCS), hybrid NIRS/DCS, and dual-wavelength DCS flow-oximeter. We utilized these noninvasive technologies to quantify CBF and cerebral oxygenation in different populations under different physiological conditions/manipulations. A commercial finger plethysmograph was used to continuously monitor MAP. For investigating …

Water Quality Sensor Placement Guidance For Small Water Distribution Systems, Stacey L. Schal

Theses and Dissertations--Civil Engineering

Water distribution systems are vulnerable to intentional, along with accidental, contamination of the water supply. Contamination warning systems (CWS) are strategies to lessen the effects of contamination by delivering early indication of an event. Online quality monitoring, a network of sensors that can assess water quality and alert an operator of contamination, is a critical component of CWS, but utilities are faced with the decision of what locations are optimal for deployment of sensors. A sensor placement algorithm was developed and implemented in a commercial network distribution model (i.e. KYPIPE) to aid small utilities in sensor placement. The developed sensor …

Indiana's Southern Senator: Jesse Bright And The Hoosier Democracy, John J. Wickre

Theses and Dissertations--History

Without northern doughface Democrats, and northern states like Indiana, the South could not have held dominance in American politics during the sectional crisis. Anchoring the extreme end of the doughface North was Indiana’s slaveholding senator Jesse Bright (his holdings were in Kentucky). Yet, he was no flailing radical pushed to the margins of northern politics. Bright was the chief party boss who by the mid to late 1850s controlled the state of Indiana. He was one of the most influential leaders getting James Buchanan into the presidency. He did this, in part, because Indiana was a conservative state that disliked …

More Than An "Immoderate Superstition": Christian Identity In The First Three Centuries, Edward Mason

Theses and Dissertations--History

Only recently have scholars given particular attention to the development of the racial discourse present in early Christian apologetics. This study is aimed at understanding the Latin and Greek literary antecedents to the development of a Christian discourse on race and identity and examining in detail the apex of this discourse in the work of third century apologist Origen of Alexandria. Origen’s work represented the apex of an evolving discourse that, while continuing to use traditional vocabulary, became increasingly universalizing with the growth of the Roman Empire. By understanding how Christians in the first three centuries shaped their attitudes on …