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Cancer Quasispecies And Stem-Like Adaptive Aneuploidy, Domenico Napoletani, M. Signore, Daniele C. Struppa

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this paper we develop a theoretical frame to understand self-regulation of aneuploidy rate in cancer and stem cells. This is accomplished building upon quasispecies theory, by leaving its formal mathematical structure intact, but by drastically changing the meaning of its objects. In particular, we propose a novel definition of chromosomal master sequence, as a sequence of physically distinct whole or fragmented chromosomes, whose length is taken to be the sum of the copy numbers of each whole or fragmented chromosome. This fundamental change in the functional objects of quasispecies theory allows us to show that previously measured aneuploidy rates …

Hst 2270 : Community Health, Health Studies

Approved Course Proposals

No abstract provided.

Hst 2000 : Principles Of Human Health, Health Studies

Approved Course Proposals

No abstract provided.

Psy 5970a : Substance Related Disorders: Etiology, Diagnosis, & Treatment, Psychology

Approved Course Proposals

No abstract provided.

Mat 3502 : Differential Equations Ii, Mathematics And Computer Science

Approved Course Proposals

No abstract provided.

Mat 3501 : Differential Equations I, Mathematics And Computer Science

Approved Course Proposals

No abstract provided.

Ele 2050 : The Whole Child: Teaching And Learning In The Educational Environment, Ec/Ele/Mle

Approved Course Proposals

No abstract provided.

Afr 4300 : Capstone Seminar, Africana Studies

Approved Course Proposals

No abstract provided.

Trends Of Intestinal Parasites Prevalence In The Gaza Strip, 1998-2007: The Use Of Government Health Records, Adnan Ibrahim H. Alhindi, Mervat Al-Louh

Turkish Journal of Medical Sciences

To evaluate the amount of intestinal parasite infections over a 10-year period in the Gaza Strip. Materials and methods: Data from the Epidemiology Department, Ministry of Health were collected and analyzed statistically. The prevalence of intestinal parasites was monitored and studied for the period 1998-2007. Results: The present study shows results including the records of 471,688 patients (all ages) who had every provided 1 stool specimen to the laboratories of primary health care centers in one of the 5 governorates of the Gaza Strip. It was found that 116,261 specimens were positive for intestinal parasites, representing an overall prevalence of …

The Effect Of Hypercholesterolemia On The Contractions Of Detrusor Strips In Response To Neural Stimulation In Rats, Serkan Karai̇smai̇loğlu, Zeynep Di̇cle Balkanci, Bi̇lge Pehli̇vanoğlu, Si̇bel Bayrak, İsmai̇l Karabulut, Ayşen Erdem

Turkish Journal of Medical Sciences

To investigate the effect of hypercholesterolemia on in vitro contractions of the detrusor smooth muscle stimulated by an electrical field in rats and the relative contributions of cholinergic and noncholinergic neurotransmission. Materials and methods: Sprague-Dawley rats were fed with standard diet (NC group) or with 4% cholesterol diet (HC group). After 4 weeks, the urinary bladder was excised under anesthesia and 4 detrusor strips were prepared. Blood samples were collected for serum lipid profile, and aortic arches were dissected for histopathological examination. In vitro contractile function of the detrusor smooth muscle was evaluated with: 1) electrical field stimulation (EFS) only, …

Human Papillomavirus Prevalence And Type In Liquid-Based Cervical Samples From Turkish Women In A Selected Risk Group, Işin Akyar, Özlem Aydin, Mustafa Cengi̇z Yakicier, Zühtü Tanil Kocagöz, Ümi̇t İnce, İbrahi̇m Ünsal

Turkish Journal of Medical Sciences

To detect the prevalence and type distribution of human papillomavirus (HPV) in different cytological diagnostic categories. Materials and methods: Between 2007 and 2010, a total of 1014 liquid-based thin preparations of cervical smears were selected and classified according to cytology results. HPV DNA polymerase chain reaction (PCR) was also performed using these samples. HPV DNA-positive samples were genotyped by DNA sequencing. Results: Of those enrolled in the study, 45.3% were negative cytologically, 36.4% had atypical squamous cells of undetermined significance, 0.3% had atypical squamous cells preventing the exclusion of a high-grade squamous intraepithelial lesion, 16.8% showed a low-grade squamous intraepithelial …

Determining The Association Between Turkish Women’S Menopausal Symptoms And Their Marital Adjustment, Asli Si̇s Çeli̇k, Türkan Pasi̇nli̇oğlu

Turkish Journal of Medical Sciences

To determine the association between women's menopausal symptoms and their marital adjustment. Materials and methods: A descriptive cross-sectional study was conducted on 263 Turkish women chosen using an improbable randomized sampling method. A questionnaire, the Menopause Symptom Rating Scale (MSRS), and the Dyadic Adjustment Scale (DAS) were used to collect data. Percentage distributions, the t-test in independent groups, the one-way ANOVA test, Pearson correlation analysis, and the Kruskal-Wallis test were used in the evaluation of the data. Results: The mean of the overall MSRS score for women was 22.67 ± 8.06 and the mean of the overall DAS score for …

Left Atrial Dilatation In Undetermined Group According To Toast Classification: Echocardiographic Assessment Of Stroke Patients, Ahu Takoğlu, Ufuk Can

Turkish Journal of Medical Sciences

To investigate the left atrial dilatation in an undetermined etiological group according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) and to evaluate the relationship between left atrial dilatation and stroke volume and localization. Materials and methods: Files of patients admitted to our hospital (2000-2010) with acute ischemic stroke diagnosis were investigated. The size of their left atrium was registered using the data from transthoracic echocardiogram. Lesion size and localization were registered using brain MRI. Stroke etiology was categorized according to TOAST classification. The relationship between left atrial dilatation and stroke volume and localization in the undetermined group …

The Relationship Between Hla-G Levels And Oxidative Stress Parameters In Patients With Breast Cancer, Sema Bozali̇oğlu, Nedret Kiliç, Zuhal Yildirim, Bi̇lkay Baştürk, Osman Kurukahveci̇oğlu

Turkish Journal of Medical Sciences

To investigate serum HLA-G levels and its correlation with oxidative stress and antioxidant parameters in breast cancer patients. Materials and methods: The patient group consisted of 25 individuals with breast cancer who were operated on in the General Surgery Department of Gazi University’s Faculty of Medicine. Thirty-one individuals who had no history of any kind of cancer, allergic diseases, diabetes, or rheumatic and immunological disease constituted the control group. Results: Results showed that malondialdehyde (MDA), advanced oxidation protein products (AOPPs), and HLA-G levels in the patient group were statistically and significantly high compared to the control group (P < 0.001). While vitamin C levels were significantly lower in the patient group (P < 0.05), an insignificant difference in glutathione peroxidase (GPx) and total sulfhydryl group (R-SH) levels in both groups was observed (P > 0.05). Serum …

Feeling My Way Through: Writing About A Childhood In Foster Care, David Bahr

Reconstruction: Studies in Contemporary Culture

[First paragraph]

I don’t remember when I first began to write about my experience as a foster child; I do know that I had been “writing” it in my head for years. Waiting for a train, walking down the street, standing in an elevator, I would replay scenes, test phrases, and try to imagine the form and structure that my fragmented childhood might take.

Bio 3210 : Immunology, Biological Sciences

Approved Course Proposals

No abstract provided.

The Value Of Apparent Diffusion Coefficient Measurements In The Differential Diagnosis Of Vertebral Bone Marrow Lesions, Gülten Taşkin, Lütfi̇ İncesu, Keri̇m Aslan

Turkish Journal of Medical Sciences

To be able to differentiate benign vertebral bone marrow lesions from malign lesions according to apparent diffusion coefficient (ADC) values, enabling quantitative assessment, and to determine the sensitivity and the specificity in differentiating benign and malign lesions according to the optimal cutoff ADC value. Materials and methods: In 99 patients, 133 lesions in total were included in the study, 59 of which were benign (acute vertebral compression fracture depending on osteoporosis or trauma, spondylitis, atypical hemangioma), and 74 malign (malign compression fracture, metastasis). Each of the benign lesions was compared to the malign lesions. In the statistical analysis, normality tests, …

Rapid Identification Of Aeromonas Species In Stool Samples With Chromogenic Media And Matrix-Assisted Laser Desorption Ionization-Time Of Flight Mass Spectrometry: An Institutional Experience, Işin Akyar, Si̇mge Can

Turkish Journal of Medical Sciences

To evaluate the routine use of chromogenic media together with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) in gastrointestinal infections caused by Aeromonas spp. as rapid, practical, cost-effective and reliable methods. Materials and methods: Between August 2007 and March 2012, a total of 13,194 stool specimens of patients were included in the study. The stool samples and the reference strains were inoculated onto Cefsulodin-Irgasan-Novobiocin agar, sheep blood agar, eosin-methylene blue agar, and Hektoen enteric agar media together with CHROMagar Salmonella Plus. All the Salmonella and Aeromonas suspected colonies were identified with an automated system (Phoenix) and MALDI-TOF. Results: …

The In Vitro Determination Of Genotoxicity In Peripheral Lymphocytes Of Welders Exposed To Fumes From Metal Arc Welding, Ceylan Şener, Hali̇l Erhan Eroğlu

Turkish Journal of Medical Sciences

Gas metal arc welding is a widely used method in many industrial areas. In this study, the peripheral blood lymphocytes of 23 welders and 25 nonexposed subjects were monitored for genotoxicity. Materials and methods: The blood samples obtained from the subjects were incubated with a culture medium at 37 °C for 72 h. Cytochalasin-B and BrdU were added for micronucleus and replication index. After incubation, the cultures were harvested, stained, and examined. Results: The micronucleus rate (2.165 ± 1.645) of the welders was quite higher than that of those not exposed (1.352 ± 0.978) (P < 0.01). There was a significant difference between micronucleus rates of smoking and nonsmoking subjects. It was found that as the time of exposure to welding fumes increased, so did the micronucleus rates (2.938 ± 1.723) (P < 0.05). A positive correlation was observed between micronucleus frequency and age. The replication index rate (1.026 ± 0.020) of the welders was higher than that of those not exposed (1.019 ± 0.016) (P = 0.01). Conclusion: It is advised that welders who work with gas metal arc welding be instructed and that necessary protective measures be taken because of the risk caused by metal arc welding fumes.

Serum Interleukin-8, Ca-125 Levels, Neutrophil-To-Lymphocyte Ratios, And Combined Markers In The Diagnosis Of Endometriosis, Cemi̇le Dayangan Sayan, Müzeyyen Gülnur Özakşi̇t, Esma Sarikaya, Özlem Gün Eryilmaz, Leyla Mollamahmutoğlu, Rüya Deveer

Turkish Journal of Medical Sciences

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis. Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study. Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and …

Asymmetric Dimethylarginine Levels In Allergic Rhinitis And Nasal Polyposis, Mehmet Tosun, Tayfun Apuhan

Turkish Journal of Medical Sciences

Asymmetric dimethylarginine (ADMA) is the major endogenous inhibitor of nitric oxide synthase. We aimed to investigate the ADMA levels in allergic rhinitis (AR) and nasal polyposis (NP). Materials and methods: A total of 29 AR patients, 21 NP patients, and 30 healthy subjects to be used as a control group were enrolled in the study. ADMA was measured in the AR, NP, and control groups with enzyme-linked immunosorbent assay. Any patients or control subjects with coronary artery disease, renal failure, diabetes mellitus, or hypertension were excluded from the study. Results: The mean ADMA serum concentration was 0.52 ± 0.08 µmol/L …

Epidemiology, Clinical Features, And Laboratory Detection Of Mycoplasma Pneumoniae Infection In East Azerbaijan, Iran, Reza Ghotaslou, Simin Sharifi, Mohammad Taghi Akhi, Mohammad Hossein Soroush

Turkish Journal of Medical Sciences

Mycoplasma pneumoniae is involved in the etiology of many respiratory tract infections. This prospective study describes the epidemiology and clinical properties of M. pneumoniae infections in hospitals of the Tabriz University of Medical Sciences. Materials and methods: From May 2009 to November 2010, 200 patients with respiratory tract infections were enrolled into this study. Due to antibiotic use 51 patients were excluded. M. pneumoniae from respiratory infections was detected by culture, enzyme-linked immunosorbent assay (ELISA), and polymerase chain reaction (PCR) assays. Results: M. pneumoniae infection was detected in 9 (6.15%), 8 (5.3%), and 3 (2.01%) of patients by PCR, ELISA, …

Cytokine Associated Neopterin Response Of Peripheral Blood Mononuclear Cells To In Vitro Epstein–Barr Virus Transformation Process Of B Lymphocytes, Lati̇fe Arzu Aral, Ayşegül Atak Yücel

Turkish Journal of Medical Sciences

The Epstein-Barr Virus (EBV) is a human herpes virus that infects B lymphocytes latently and immortalises the cells due to transformation. EBV infection is asymptomatic in childhood, while it may cause a self-limiting lymphoproliferative disorder in adolescence. This study aimed to show the association between in vitro transformation of B lymphocytes via EBV and the levels of neopterin with different accompanying cytokine responses. Materials and methods: Mononuclear cells were isolated from peripheral blood samples of healthy donors and transformed with an EBV secreting cell-line, B95-8. Neopterin, interferon (IFN)-\gamma, tumour necrosis factor (TNF)-\alpha, and interleukin (IL)-6 levels were measured in culture …

Is There Any Effect Of Demographic Features On Development Of Hyperemesis Gravidarum In The Turkish Population?, Zeynep Kamalak, Nermi̇n Köşüş, Aydin Köşüş, Deni̇z Hizli, Ayli̇n Ayrim, Gonca Kurt

Turkish Journal of Medical Sciences

To assess the effect of maternal demographic variables on development of hyperemesis gravidarum (HG) in pregnant Turkish women. Materials and methods: Two hundred consecutive women with HG were defined as the study group, and 200 consecutive pregnant women without any signs or symptoms of HG matched for age, parity, and gestational age were defined as the control group. Personal information, including lifestyle, educational level, occupation, and economic status were obtained via questionnaire. Results: The number of abortions was higher but parity was lower in the HG group. The time interval between 2 pregnancies was significantly shorter in the HG group …

Influence Of Trace Elements And Their Correlation With Semen Quality In Fertile And Infertile Subjects, Vickram Sundaram, Muthugadhalli Srinivas, Jayaraman Gurunathan, Kamini Rao, Ramesh Pathy Maniyan, Sridharan Balasundaram

Turkish Journal of Medical Sciences

There has been increasing curiosity about the appraisal of essential trace elements present in human body fluids and their correlation to human health. Human seminal plasma contains several trace elements that have an imperative role in the normal functioning of the semen. As a result, it is very important to evaluate Zn and other trace elements present in the seminal plasma for the assessment of male infertility. The main objective of this research is to evaluate Zn concentrations and their intercorrelations with semen parameters such as sperm concentration, sperm motility, and normal morphology of the sperm, towards their contribution to …

Notice And Consent In A World Of Big Data, Fred H. Cate, Viktor Mayer-Schönberger

Articles by Maurer Faculty

• Nowadays individuals are often presented with long and complex privacy notices routinely written by lawyers for lawyers, and are then requested to either ‘consent’ or abandon the use of the desired service.
• The over-use of notice and consent presents increasing challenges in an age of ‘Big Data’.
• These phenomena are receiving attention particularly in the context of the current review of the OECD Privacy Guidelines.
• In 2012 Microsoft sponsored an initiative designed to engage leading regulators, industry executives, public interest advocates, and academic experts in frank discussions about the role of individual control and notice and consent in data protection …

Student Perceptions Of Digital Storytelling As A Learning-Tool For Educational Leaders, Jason Lafrance, Jason Blizzard

Leadership, Technology & Human Development: Faculty Publications

: A study regarding students’ perceptions of digital storytelling as a learning tool was conducted in the fall of 2012. The population consisted of 12 students participating in an Administrative Theory course as part of their doctoral program in K-12 or higher education administration at a Carnegie Doctoral Research University in Georgia. During the eight-week course, students created digital stories that synthesized an autoethnography with leadership theory using Bolman and Deal’s (2011) four-framework approach to leadership. This allowed students to demonstrate the practice of continual reflection and assessment, a commitment to technology, diversity, and in-depth understanding of the knowledge and …

Some Legal Considerations For E.U. Based Mnes Contemplating High-Risk Foreign Direct Investments In The Energy Sector After Kiobel V. Royal Dutch Petroleum And Chevron Corporation V. Naranjo, Jeffrey A. Van Detta

South Carolina Journal of International Law and Business

No abstract provided.

The Sex Selection Debate: A Comparative Study Of Sex Selection Laws In The United States And The United Kingdom, Deidre C. Webb

South Carolina Journal of International Law and Business

No abstract provided.

Effects Of Thinning Intensity On The Growth Of Narrow-Leaved Ash (Fraxinus Angustifolia Subsp. Oxycarpa) Plantations, Emrah Çi̇çek, Faruk Yilmaz, Ali̇ Kemal Özbayram, Mehmet Efe, Murat Yilmaz, Ayhan Usta

Turkish Journal of Agriculture and Forestry

Narrow-leaved ash (Fraxinus angustifolia) is one of the important broadleaved tree species, and it is becoming more important in European forestry because of its valuable wood and fast growing ability. Despite its wide natural range and high economic value, there is little or very limited information about the effects of thinning on the growth and development of ash stands, especially in plantations. In this study, 2 thinning experiments were carried out to determine the effects of thinning intensity on the growth of diameter, height, basal area, and volume in narrow-leaved ash plantations over a 6-year period in Adapazarı, Turkey. In …