Digital Commons Network^™

Smokers' Neurological Responses To Imagery From Cigarette Package Warning Labels, Johann Fridrik Fridriksson

Theses and Dissertations

Tobacco use is the leading cause of preventable death in the United States. The Family Smoking Prevention and Tobacco Control Act was signed into law in 2009 and gave the U.S. Food and Drug Administration (FDA) the authority to implement pictorial health warning labels (HWLs) on cigarette packages. Multiple studies investigating self-reported affective, cognitive and behavioral impacts of HWLs suggest that the most effective warnings include imagery that depicts physical damage to the body due to smoking. However, self-report methods of assessment used in these studies may be biased. Far less is known about how HWLs directly modulate brain activity. …

General Genetics Lab, Steelman Library, Todd D. Schraw Dr.

Syllabus Repository

No abstract provided.

Biol 4903: Senior Capstone, Steelman Library, Jerm J. Day-Storms Dr.

Syllabus Repository

No abstract provided.

Maternal Depletion Of Piwi, A Component Of The Rnai System, Impacts Heterochromatin Formation In Drosophila, Tingting Gu, Sarah C.R. Elgin

Biology Faculty Research

A persistent question in epigenetics is how heterochromatin is targeted for assembly at specific domains, and how that chromatin state is faithfully transmitted. Stable heterochromatin is necessary to silence transposable elements (TEs) and maintain genome integrity. Both the RNAi system and heterochromatin components HP1 (Swi6) and H3K9me2/3 are required for initial establishment of heterochromatin structures in S. pombe. Here we utilize both loss of function alleles and the newly developed Drosophila melanogaster transgenic shRNA lines to deplete proteins of interest at specific development stages to dissect their roles in heterochromatin assembly in early zygotes and in maintenance of the silencing …

Differential Gene Expression Patterns In Hpv-Positive And Hpv-Negative Oropharyngeal Carcinomas, Swati Tomar

Theses and Dissertations

Head and neck (HN) cancer is the fifth most prevalent malignancy worldwide with 90% of them categorized as squamous cell carcinomas (SCC). Carcinomas of the oropharynx, pharynx and the oral cavity, comprise a subset of HNSCC and are referred to as oropharyngeal squamous cell carcinomas (OPSCC). Up to 60% of OPSCC and 25% of HNSCC are positive for high-risk human papillomavirus (HR-HPV), primarily HPV16. HPV positive and HPV negative OPSCC’s are molecularly and biologically distinct with differences in risk factors, age of presentation and clinical behavior. The precise molecular signatures of each have been well studied with respect to gene …

Quasinovo: Algorithms For De Novo Peptide Sequencing, James Paul Cleveland

Theses and Dissertations

High-throughput proteomics analysis involves the rapid identification and characterization of large sets of proteins in complex biological samples. Tandem mass spectrometry (MS/MS) has become the leading approach for the experimental identification of proteins. Accurate analysis of the data produced is a computationally challenging process that relies on a complex understanding of molecular dynamics, signal processing, and pattern classification. In this work we address these modeling and classification problems, and introduce an additional data-driven evolutionary information source into the analysis pipeline.

The particular problem being solved is peptide sequencing via MS/MS. The objective in solving this problem is to decipher the …

The Molecular Basis Of Antibody Mediated Neutralization Of Hepatitis C Virus, Michelle Catherine Sabo

All Theses and Dissertations (ETDs)

Hepatitis C virus: HCV) is positive strand, blood-borne, hepatotropic RNA virus that causes chronic infection in ~170 million people worldwide and is the leading cause of liver transplantation in the United States. HCV entry and attachment is mediated by the envelope protein E2 through interaction with several cellular receptors including CD81, scavenger receptor B1: SRB-1), claudin-1, and occludin, although the exact mechanism by which these receptors facilitate infection remains unclear, largely due to the absence of a structural model of E2. The production of neutralizing antibodies against E2 is thought to be important for controlling HCV infection, likely by blocking …

Bio-Inspired Design, Fabrication And Testing Of Bipolar Plates For Pem Fuel Cells, Nannan Guo

Doctoral Dissertations

"The flow field of a bipolar plate distributes reactants for polymer electrolyte membrane (PEM) fuel cells and removes the produced water from the fuel cells. It greatly influences the performance of fuel cells, especially the concentration losses. Two approaches were developed to improve flow field designs in this dissertation. One is inspired by the biological circulatory structures and called bio-inspired designs, which have great potential to transport reactant efficiently and hence improve fuel cell performance. Another way is using a network-based optimization model to optimize the conventional flow field configurations, i.e., pin-type, parallel and serpentine designs, to improve flow distributions …

A New Social Gene In Dictyostelium Discoideum, Chtb, Lorenzo A. Santorelli, Adam Kuspa, Gad Shaulsky, David C. Queller, Joan E. Strassmann

Biology Faculty Research

BACKGROUND:

Competitive social interactions are ubiquitous in nature, but their genetic basis is difficult to determine. Much can be learned from single gene knockouts in a eukaryote microbe. The mutants can be competed with the parent to discern the social impact of that specific gene. Dictyostelium discoideum is a social amoeba that exhibits cooperative behavior in the construction of a multicellular fruiting body. It is a good model organism to study the genetic basis of cooperation since it has a sequenced genome and it is amenable to genetic manipulation. When two strains of D. discoideum are mixed, a cheater strain …

Aaron Gillette , Eugenics And The Nature Nurture Debate In The Twentieth Century, Garland E. Allen

Biology Faculty Research

Aaron Gillette, Eugenics and the Nature–Nurture Debate in the Twentieth Century, Palgrave Studies in the History of Science and Technology [2007], digital reprint (New York, NY: Palgrave Macmillan, 2010), pp. ix, 239, index, £18.99, paperback, ISBN: 9780230108455. This book treats an important subject – the history of the nature–nurture debate (focused on the US but with references to European players and movements) – and its implications for current theories of evolutionary psychology.

Behind The Mask: An Analysis Of Women's Perceptions And Rationale Toward The Purchase And Use Of Anti-Aging Products, Clair Maureen Williams

Dissertations and Theses @ UNI

An exploratory study was done to unveil a more contemporary and intimate look at women and aging in U.S. society. This qualitative research explored what women do, if anything, to confront pressures associated with aging. Purposeful sampling was used to homogenize the participant sample for increased richness of data. Criterion was as follows: women, 50’s age range, married with children, Caucasian, from the Midwest, and who currently use one or more anti‐aging products. In total, 17 women of similar status and background participated in this research. Data collection consisted of in‐depth audio taped interviews followed by immediate transcription. The analysis …

Quantum Phase Transitions In Impurity Models And Percolating Lattices, Manal M. Al-Ali

Doctoral Dissertations

"This thesis investigates the influence of random disorder and dissipation on zero-temperature quantum phase transitions. Both phenomena can fundamentally change the character of the phases of a quantum many-particle system and of the transitions between them. If dissipation and disorder occur simultaneously in a system undergoing a quantum phase transition, particularly strong effects can be expected. In the first paper reproduced in this thesis, we study a single quantum rotor coupled to a sub-Ohmic dissipative bath. We find that this system undergoes a quantum phase transition from a delocalized phase to a localized phase as the dissipation strength is increased. …

Phytoforensics On Energetics: Novel Plant Tissue Measure Approach And Modeling, Yuan Yuan

Doctoral Dissertations

"Explosives and energetics are common soil and groundwater pollutions. This research was to develop novel phytoforensics approaches on energetics. Four different plants species, including woody perennial trees and monocot grasses, were planted both in soil and sand reactors with continuous exposure to a mixture of explosives in the greenhouse. Time dependent assessments were carried out to determine kinetic mechanisms of uptake, transport and accumulation. Plant concentrations were analyzed by both traditional solvent extraction and novel sap analysis methods. A dynamic soil-plant system model was developed to quantify the relationship between tissue concentration and soil pore water concentration for non-volatile organic …

Comparative Evaluation Of N-Acetylcysteine And N-Acetylcysteine Amide In Acetaminophen-Induced Oxidative Stress, Ahdab Naeem Khayyat

Masters Theses

"Acetaminophen (APAP) is the most widely used pharmaceutical analgesic-antipyretic agent in the world, but its toxicity is a common cause of drug-induced hepatotoxicity. With APAP toxicity, cellular glutathione (GSH) is depleted. This results in the availability of N-acetyl-p-benzoquinone imine (NAPQI), is a toxic metabolite of APAP that binds to cellular macromolecules, which leads to cell necrosis. N-acetyl cysteine (NAC), a GSH precursor, is the only approved antidote for an acetaminophen overdose. It is a negatively charged molecule that diminishes its penetration into the cells, thereby requiring fairly high doses that increase the severity of side effects. In addition, oral and …

Water Management Capabilities Of Bio-Inspired Flow Field Configurations For Polymer Electrolyte Membrane Fuel Cells, Nicholas Warren Freer

Masters Theses

"Fuel cells have received an increasing amount of attention over the past decade for their power production capabilities. Polymer electrolyte membrane (PEM) fuel cells in particular are researched because of their high power density, large range of operating conditions, green products, and ease of scalability. PEM fuel cells do have a number of issues that reduce their overall performance. These issues include variations in reactant distribution, materials issues for the bipolar plate, and flooding caused by poor water management. Variations in the reactant distribution causes lower overall power output due to regions of low reactant density. This means that optimizing …

A Computational Study Of Driven Micro-Cavities In Supersonic Flat Plate Flow, Thomas Ryan Rehmeier

Masters Theses

"Driven micro-cavities embedded in the wall beneath turbulent supersonic boundary layers are analyzed using two-dimensional computational fluid dynamics. This concept is a passive flow control technique in which very small cavities formed by arrays of thin vertical walls are oriented transverse to the flow direction and underlie the boundary layer. The purpose is to reduce or eliminate skin friction drag. Various micro-cavity configurations were analyzed at locations (0.1 m and 1 m) downstream of the leading edges of flat plates, for free-stream Mach numbers of 1.2, 2.0, and 3.0. Results focus on net drag reduction achieved, cavity flow-field effects, perforation …

A Case Study Of The Impact Of An Intervention Scheduling Model On Academic Achievement In English And Mathematics By Students In Need Of Remediation, Dora Harvey

College of Graduate Studies: Theses & Dissertations

This case study explored the impact of a scheduling intervention on the Georgia High School Graduation Test standardized achievement test scores of students identified as in need of remediation in the content areas of English and mathematics, paired with the perception of this scheduling model from key informants in the study. Students in the scheduling intervention were enrolled in a year-long, alternating content-day block scheduling model. The quantitative portion reviewed Georgia High School Graduation Test score data for students who participated in a modified block (referred to as Schedule Two) results were analyzed, indicating passing percentages, and number for each …

The Cultural Studies Of Science Education, Karen D. Chassereau

College of Graduate Studies: Theses & Dissertations

In an age of accountability, the demands and constraints placed on science teachers seem insurmountable. Teachers are challenged to provide students with authentic scientific experiences, yet the need to prepare students for high-stakes tests remains. The problem of attrition and job stress in the field of science teaching is growing. As pressures rise, it becomes necessary to understand what the culture of science education is like from the perspective of the science teacher. This study sought to define the culture of science education and determine how this culture informs teacher practice in the secondary science classroom. This qualitative case study …

Scanner: An Efficient And Accurate Trimming Tool For Illumina Next Generation Sequencing Reads, Xiang Zhou

All Computer Science and Engineering Research

Recent advances in High-Throughput Sequencing (HTS) technology have greatly facilitated the researches in bioinformatics field. With the ultra-high sequencing speed and improved base-calling accuracy, Illumina Genome Analyzer is currently the most widely used platform in the field. To use the raw reads generated from the sequencing machine, the 3’ adapter sequence attached to the real read in the process of ligation needs to be correctly trimmed. This is often done by some inhouse scripts or different packages with various parameters. They either use the Smith-Waterman algorithm or search for an exact match of the 3’ adapter sequence. In this report, …

Adding Data Parallelism To Streaming Pipelines For Throughput Optimization, Peng Li, Kunal Agrawal, Jeremy Buhler, Roger D. Chamberlain

All Computer Science and Engineering Research

The streaming model is a popular model for writing high-throughput parallel applications. A streaming application is represented by a graph of computation stages that communicate with each other via FIFO channels. In this report, we consider the problem of mapping streaming pipelines — streaming applications where the graph is a linear chain — in order to maximize throughput. In a parallel setting, subsets of stages, called components can be mapped onto different computing resources. The through-put of an application is determined by the throughput of the slowest component. Therefore, if some stage is much slower than others, then it may …

Urban American Indians: A Comparison Of Father Involvement Predictors Across Race, Jonathan Padilla, Peter Ward, Gordon E. Limb

Faculty Publications

Father involvement in families of urban American Indians has been a neglected area of research. In this study, the authors examined the associations among parental relationship quality, father involvement, and coresidence. The authors conducted a multiple group analysis through structural equation modeling comparing 107 American Indian fathers with fathers of the general population in the Fragile Families and Child Wellbeing Study. Although the results were similar between groups, findings indicated two key differences for urban American Indians. First, emotional supportiveness had a stronger relationship with physically active engagement for American Indian fathers. Second, parental relationship quality had greater total standardized …

Polymer Micro-Grippers With An Integrated Force Sensor For Biological Manipulation, Re Mackay, Hr Le, S Clark, Ja Williams

School of Biological and Marine Sciences

The development of a novel micro-system integrating SU-8 polymer micro-grippers with a tensile force sensor for handling and characterizing the mechanical properties of delicate biological materials, such as fibrils, is presented. The micro-grippers are actuated by the electro-thermal effect and have gripping forces comparable to the common 'hot-and-cold-arm' grippers. A robust finite element model was developed to investigate system performance and validated experimentally. A new micro-mechanical calibration method using a piezoelectric manipulator with a micro-force measurement system was successfully applied to test the structure. Both FEA simulation and micro-mechanical testing results indicated that the system could fulfil the requirements for …

Tolerance Of Sponge Assemblages To Temperature Anomalies: Resilience And Proliferation Of Sponges Following The 1997-8 El-Niño Southern Oscillation., Francisco Kelmo, James J. Bell, Martin J. Attrill

School of Biological and Marine Sciences

Coral reefs across the world are under threat from a range of stressors, and while there has been considerable focus on the impacts of these stressors on corals, far less is known about their effect on other reef organisms. The 1997-8 El-Niño Southern Oscillation (ENSO) had notable and severe impacts on coral reefs worldwide, but not all reef organisms were negatively impacted by this large-scale event. Here we describe how the sponge fauna at Bahia, Brazil was influenced by the 1997-8 ENSO event. Sponge assemblages from three contrasting reef habitats (reef tops, walls and shallow banks) at four sites were …

Yellowstone Over-Snow Vehicle Emission Tests – 2012, John D. Ray, Gary A. Bishop, Brent G. Schuchmann, Chris Frey, Gurdas Sandhu, Brandon Graver

Fuel Efficiency Automobile Test Publications

No abstract provided.

Embedding Student Research Publication Opportunities: Strategies For Widening Engagement With Undergraduate Research Journals, H Walkington, A Edwards-Jones, K Gresty

Professional Services

No abstract provided.

Midterm Results Of Bovine Jugular Vein Conduit For Right Ventricular Outflow Tract Reconstruction, Shazia Samad Mohsin, Maria Tariq Siddiqui, Abdul Sattar Shaikh, Mehnaz Atiq, Muneer Amanullah

Department of Paediatrics and Child Health

Objective: To evaluate the midterm results of Contegra conduit.
Methods: The retrospective study comprised patient record at Aga Khan University Hospital, Karachi, of conduits implanted between May 2007 and June 2012. Data collection was made from the clinical notes and from serial echocardiograms by a single cardiologist. The last followup echocardiography was done at the time of data collection in June 2012. SPSS 19 was used for statistical analysis.
Results: A total of 18 conduits had been implanted (16-22mm) during the study period. Median age at the time of surgery was 9 years (range: 2.5-16 years). Early mortality was seen …

Frequency And Outcome Of Graft Versus Host Disease After Stem Cell Transplantation: A Six-Year Experience From A Tertiary Care Center In Pakistan, Natasha Ali, Salman Naseem Adil, Mohammad Usman Shaikh, Nehal Masood

Department of Pathology and Laboratory Medicine

Objective: The objective of this study was to evaluate the frequency and outcome of graft versus host disease after stem cell transplantation for various haematological disorders in Pakistan.
Materials and Methods: Pretransplant workup of the patient and donor was performed. Mobilization was done with G-CSF 300 mu g twice daily for five day. Standard GvHD prophylaxis was done with methotrexate 15mg/m(2) on day +1 followed by 10mg/m(2) on days +3 and +6 and cyclosporine. Grading was done according to the Glucksberg classification.
Results: A total of 153 transplants were done from April 2004 to December 2011. Out of these were …

The Role Of Focal Adhesion Kinase In Nonmuscle Cell Contraction, Kimberly M. Arnold

Graduate Theses, Dissertations, and Problem Reports (ETD)

Focal adhesions are specialized cell contact sites of distinct molecular composition and structure that bridge the actin cytoskeleton to the extracellular matrix and provide for efficient bidirectional transmission of biochemical and mechanical signals between the intra- and extracellular compartment. Many proteins within the focal adhesion have been discovered to be an integral component of the adhesion structure and function; however, a key molecule in the organization and physiological activity of focal adhesions is focal adhesion kinase (FAK). FAK is a nonreceptor tyrosine kinase that is essential for cell processes including cell migration, growth, and survival. Due to its connection between …

Towards Direct Fabrication Of Functional Patterns On Large-Area Substrates For Flexible Devices, Sean D. Cronin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nowadays there is a growing interest to develop flexible devices that can be used in applications spanning from displays to energy harvesting. This is due to the potential of such devices to be integrated onto various-shaped surfaces and also to be roll-to-roll processed. However, there are still a few challenges to be tackled before their full commercialization. In particular, the direct fabrication of micro/nano-scale functional features on a large-area flexible substrate remains a critical challenge. This is because it requires both low temperature processing and precise control of the feature size.;During this study an investigation of different fabrication methods, such …

Novel Techniques For Automated Dental Identification, Nourdin Al-Sherif

Graduate Theses, Dissertations, and Problem Reports (ETD)

Automated dental identification is one of the best candidates for postmortem identification. With the large number of victims encountered in mass disasters, automating the process of postmortem identification is receiving an increased attention. This dissertation introduces new approaches for different stages of Automated Dental Identification system: These stages include segmentations, classification, labeling, and matching:;We modified the seam carving technique to adapt the problem of segmenting dental image records into individual teeth. We propose a two-stage teeth segmentation approach for segmenting the dental images. In the first stage, the teeth images are preprocessed by a two-step thresholding technique, which starts with …