Digital Commons Network^™

The Persecution Of Homosexuals During The Holocaust, Jennifer Rokakis

Senior Honors Theses and Projects

No abstract provided.

Synthesis Of 1-Pyrenyldiazomethane For Derivatization Of Short-Chain Fatty Acids, Mary E. Kalvaitis

Senior Honors Theses and Projects

Use of I-pyrenyldiazomethane (PDAM) for derivatizing short-chain fatty acids (SCFA) is a successful way to analyze complex SCF A samples quickly and with minimal sample preparation. The costs associated with ordering PDAM from a commercial source can be high, typically more than $300 not including shipping costs. This project developed a simple two-step synthesis procedure that can be used in undergraduate chemistry laboratories. We found that the PDAM produced by this procedure is pure enough to use for our derivatization needs without further purification. This synthesis can be used to further explore the use of PDAM for fast and simple …

To Play Or Not To Play: Using Drama As An Effective Pedagogical Tool To Teach Literature, Maeve Devlin

Senior Honors Theses and Projects

No abstract provided.

Developing First-Year Students' Biological Information Literacy:Collaboration Between Libraries And Disciplinary Faculty In Impact Classrooms, Nancy Pelaez, Clarence Maybee, Maribeth Slebodnik

IMPACT Presentations

This project enabled students in an introductory biology course to learn biological information literacy. The section of the course described utilized a peer-led team learning (PLTL) model in which 50 students met twice a week. The students also divided into teams that met weekly for a workshop facilitated by a peer leader. The first time the course was taught in this way information literacy tasks were added to the weekly problem sets that the students worked on with their teams each week. By examining recorded footage of team meetings, it was determined that the students did not always see the …

Preserving The Bond: Child Welfare Professionals' Perspectives On The Opportunities And Challenges Of Parent-Child Visitation, Lina M. Munoz

Dissertations

The foster care system was designed to be a temporary placement for children when their parents are unable or unwilling to provide proper care and supervision. A permanency plan must be established for all children in care, stating clear goals for a permanent living arrangement to facilitate the child's reunification with his/her family. The current Illinois Child Welfare Practice Model promotes a family-centered, trauma-informed, and strength-based practice approach when providing child welfare services to families in foster care with the caseworker serving as the primary vehicle for facilitating change.

This study explored how this child welfare practice model is reflected …

Novel Role Of Erbb-2 In Inhibition Of Jagged-1-Mediated Trans-Activation Of Notch In Breast Cancer, Kinnari Pandya

Dissertations

The ErbB-2 gene is amplified and the resulting protein product overexpressed in 15-30% of breast tumors, and associated with aggressive behavior and poor overall survival. Currently, there are two FDA approved therapies targeting ErbB-2 for the treatment of ErbB-2 positive breast cancer: trastuzumab, a humanized monoclonal antibody is directed against the extracellular domain of ErbB-2 and lapatinib, a dual EGFR/ErbB-2 tyrosine kinase inhibitor. Unfortunately, anti-ErbB-2 therapy resistance remains a major problem in metastatic breast cancer. Our data suggested that gene amplification or overexpression of ErbB-2 inhibits Notch-1 transcriptional activity and trastuzumab or lapatinib increased

Notch-1 transcriptional activity. Furthermore, Notch-1 is …

Cheerleaders And Performers: Mental Health Courts In A Midwestern State, Monte Staton

Dissertations

"Cheerleaders and Performers: Mental Health Courts in a Midwestern State" by Monte D. Staton

This dissertation presents a statewide study focusing on a recently developed technique for dealing with persons with mental illness in the criminal justice system: mental health court (MHC). This study of nine MHC programs utilized surveys, interviews, and ethnographic observations to examine the work activities and understandings of the criminal justice and mental health professionals who administer and operate the programs in a Midwestern state. Data were analyzed by combining Goffman's dramaturgical analysis with Dorothy E. Smith's institutional ethnography. Findings reveal that MHC professionals engage in …

Significance Of Protein Interactions In Mediating Af9 Function, Bhavna Malik

Dissertations

Rearrangements of the MLL gene at chromosome band 11q23 have been associated with a heterogeneous group of lymphoid, myeloid and mixed lineage leukemias. MLL rearrangements occur approximately in 70% of infant leukemias and are also common in therapy-related leukemias where patients were previously treated with topoisomerase II inhibitors. Unfortunately, these patients have a poor prognosis. MLL gene rearrangements give rise to chimeric proteins that contain the N-terminal portion of MLL fused to the C-terminal portion of over 50 different fusion partners. The chimeric proteins cause constitutive expression of some MLL target genes such as HOXA9 and MEIS1, and enhanced proliferation …

Understanding The Posttranslational Regulation Of The Response Regulator Rcsb And Acetyl Phosphate As An Acetyl Group Donor In E. Coli, Linda Hu

Dissertations

The observation that Nepsilon-lysine acetylation occurs on a hundreds of proteins in bacteria is a recent discovery. To study the mechanisms that regulate acetylation and to determine if acetylation affects physiology, I studied the Escherichia coli response regulator and transcription factor RcsB, which was reported to be acetylated in vitro. To monitor RcsB activity, I measured transcription from the rprA promoter, which requires RcsB. I confirmed that RcsB is activated by phosphorylation through the Rcs phosphorelay and acetyl phosphate and showed that acetyl phosphate could phosphorylate RcsB. However, a mutant that accumulates acetyl phosphate (ackA) exhibited reduced rprA transcription instead …

Psychotherapist Understanding Of Genital Self-Mutilation Amongst Male To Female Transsexuals, Michael Robert Kenney

Dissertations

Self-mutilation of the genitals is a complex phenomenon that can provoke strong countertransference reactions amongst mental health clinician. Transsexuals who engage in self-inflicted mutilation of the genitals face a potentially increased risk of alienation from healthcare providers due to marginalization and lack of understanding by treating clinicians. Frequently, assumptions are made regarding the motivation for the behavior that fails to take into account the complex interplay between contributing psychological, social, and environmental forces.

This qualitative study explored the experience of four psychotherapists who had encountered the behavior in their work with transsexual clients in order to gain a more accurate …

High School Curriculum Tracks As Determinants Of Post-Secondary Outcomes: A Study Of Track Mobility And Its Effects, William Morrison

Dissertations

Despite scores of studies that have shown that tracking and ability grouping perpetuate the academic achievement gap that exists in the United States, the practice continues. The reason for this persistence is a confluence of educational, social, and political factors. As tracking will continue as practice for the foreseeable future, research must help to identify the best and worst of tracking practices so that its negative effects are minimized and positive effects maximized. Oakes (2005) has identified five common elements of tracking policies and practices: extent, pervasiveness, flexibility, mobility, and locus of control. Of these elements, it is my contention …

The Role Of Linker 2 (L2) Region In Rhtrim5Α Assembly And Hiv-1 Restriction, Jayalaxmi Sastri

Dissertations

The cellular restriction factor TRIM5alpha inhibits infection by numerous retroviruses in a species specific manner. TRIM5alpha protein from rhesus macaques (rhTRIM5alpha) and a related protein TRIM-Cyp from Owl monkeys restrict infection by HIV-1 while human TRIM5α (huTRIM5alpha) restricts infection by N-tropic murine leukemia virus (N-MLV) but not HIV-1. Several models have been proposed for retroviral restriction by TRIM5 proteins (TRIM5alpha and TRIMCyp). These models collectively suggest that TRIM5 proteins mediate restriction by recognizing specific determinants in the viral capsid and directly binding the capsid. Following binding, the TRIM5 proteins self-associate into large assemblies around the viral capsid, which leads to …

Draft Genome Sequence Of Marine Alphaproteobacterial Strain Himb11, The First Cultivated Representative Of A Unique Lineage Within The Roseobacter Clade Possessing An Unusually Small Genome, Bryndan P. Durham, Jana Grote, Kerry A. Whittaker, Sara J. Bender, Haiwei Luo, Sharon L. Grim, Julia M. Brown, John R. Casey, Anthony Dron, Lennin Florez-Leiva, Andreas Krupke, Catherine M. Luria, Aric H. Mine, Olivia D. Nigro, Santhiska Pather, Agathe Talarmin, Emma K. Wear, Thomas S. Weber, Jesse M. Wilson, Matthew J. Church, Edward F. Delong, David M. Karl, Grieg F. Steward, John M. Eppley, Nikos C. Krypides, Stephan Schuster, Michael S. Rappé

Graduate School of Oceanography Faculty Publications

Strain HIMB11 is a planktonic marine bacterium isolated from coastal seawater in Kaneohe Bay, Oahu, Hawaii belonging to the ubiquitous and versatile Roseobacter clade of the alphaproteobacterial family Rhodobacteraceae. Here we describe the preliminary characteristics of strain HIMB11, including annotation of the draft genome sequence and comparative genomic analysis with other members of the Roseobacter lineage. The 3,098,747 bp draft genome is arranged in 34 contigs and contains 3,183 protein-coding genes and 54 RNA genes. Phylogenomic and 16S rRNA gene analyses indicate that HIMB11 represents a unique sublineage within the Roseobacter clade. Comparison with other publicly available genome sequences …

Eastern Michigan University Undergraduate Catalog, 2013-2014, Office Of The Registrar

Undergraduate Catalogs

No abstract provided.

Patents At The Supreme Court: It Could Have Been Worse, Gregory Dolin

All Faculty Scholarship

In the last few years in particular, the Court has expanded the zone of exclusion from patent eligibility, limited the availability of injunctive relief for patentees whose patents have been adjudged to be valid and infringed, and broadened the scope of the patent exhaustion doctrine. To be sure, not all of the Supreme Court’s decisions were “anti-patent.” Nonetheless, the overall trajectory of the Court’s patent jurisprudence has been toward a narrower set of patent rights. Thus, there was significant trepidation in the patent bar and the academy when the Supreme Court decided to hear three patent cases in the OT …

Notes On The Biology Of Invasive Lionfish (Pterois Sp.) From The Northcentral Gulf Of Mexico, Nancy J. Brown-Peterson, J. Read Hendon

Gulf and Caribbean Research

The first confirmed sightings of lionfish in the Gulf of Mexico occurred in 2010 (Schofield 2010), where they were reported in the southern GOM off the Yucatan Peninsula, Mexico (Aguilar-Perera and Tuz-Sulub 2010); in 2012 more than 1,500 lionfish were collected from northern GOM locations ranging from Florida to Texas (Fogg et al. 2013). However, other than visual observations (mostly from recreational divers), there is relatively little information on the biology and ecology of lionfish in the northern GOM. The life history of invasive species can vary as they colonize new habitats and areas (Bøhn et al. 2004); thus, biological …

Eastern Michigan University Graduate Catalog, 2013-2014, Office Of The Registrar

Graduate Catalogs

No abstract provided.

Dna, Dogs, The Nickel, And Other Curiosities: Criminal Law Cases In The Supreme Court’S 2012 2013 Term, Charles D. Weisselberg

Court Review: Journal of the American Judges Association

F or readers who would like to review the truly momentous cases of the Supreme Court’s last Term, I heartily recommend Professor Todd E. Pettys’s article, More than Marriage: Civil Cases in the Supreme Court’s 2012-2013 Term, which also appears in this issue of Court Review. During this past Term, like the one before it, the real blockbusters were on the civil side. But the Court’s criminal docket was not without its charms. The justices wrestled with the collection of DNA evidence from arrestees, canine sniffs at the front door, non-custodial suspects’ silence in the face of questioning, and increased …

Effect Of Advanced Age On The Innate Immune Response To Cutaneous Wound Infection, Aleah Lin Brubaker

Dissertations

An estimated 25 billion in US health care expenditure is spent on care of chronic, non-healing wounds. The failure to effectively heal wounds is often compounded by co-morbidities, such as diabetes or obesity. Another major patient population afflicted with chronic wounds are the elderly. Advanced age is associated with a decline in immunologic function that contributes to a poor response to vaccination, infection and tissue injury resulting in prolonged hospital stays and age-related morbidity and mortality. Specifically, clinical observations and laboratory studies have suggested an age-related decline in cutaneous wound healing, marked by protracted wound closure, wound dehiscence and chronic …

Making Something Out Of Nothing: Asexuality And Narrative, Elizabeth Hanna Hanson

Dissertations

The existence of asexuality, the non-experience of sexual attraction, forces us to reconsider a great deal of received wisdom about sexuality, subjectivity, and narrative, which are all closely bound together in modernity. These discourses, whose interactions we find in distilled form in the novel, have both necessitated and facilitated asexual erasure. I read asexuality as a threatening absence or stasis jamming the economy of desire that operates between subjects or propels a narrative forward. Grounding my study of asexuality in narrative theory and queer theory, I explore narratives that confront asexuality at the level of content--its manifestations, misrecognitions, and repudiations …

Molecular Functions Of Mll Phd3 Binding To Its Ligands Cyp33 And H3k4me3, Gayathree Raman

Dissertations

Mixed Lineage Leukemia protein (MLL) is required for proper embryonic development, and hematopoiesis. It is a SET domain containing histone methyl transferase that trimethylates histone H3 on lysine 4 (H3K4Me3), a histone modification that correlates with active transcription. The 3rd PHD finger of MLL binds to H3K4me3. Thus MLL is a "writer" with an embedded "reader" for H3K4Me3. Cyp33 is another known ligand of MLL PHD3. Over expression of Cyp33 results in transcriptional repression of MLL target genes.

The aim of this study is to determine the biological function of MLL PHD3 binding to H3K4Me3 or Cyp33. Cyp33 binding to …

Addressing The Issue Of Meta-Analysis Multiplicity In Education And Psychology, Joshua R. Polanin

Dissertations

The concept of multiplicity, conducting multiple statistical significance tests in one study, has pervaded primary research over the last 7 decades (Hochberg & Tamhane, 1987). This continued discussion was due to the fact that multiplicity increases the probability of committing a Type 1 error (i.e., deriving a false conclusion). Little attention has been paid, unfortunately, to multiplicity in meta-analysis (Tendal, Nuesch, Higgins, Juni, & Gotzsche, 2011) and calls have been made for meta-analysis methodologists to address this critical issue (Bender et al., 2008). As such, the purpose and significance of this project was to answer these calls by formally quantifying …

A Short History Of (Mostly) Western Animal Law: Part Ii, Thomas G. Kelch

Animal Law Review

This Article, presented in two parts, travels through animal law from ancient Babylonia to the present, analyzing examples of laws from the ancient, medieval, Renaissance and Enlightenment, recent modern, and modern historical periods. In performing this analysis, particular attention is focused on the primary motives and purposes behind these laws. What is discovered is that there has been a historical progression in the primary motives underlying animal laws in these different periods. In Part I of this Article, it was discovered that while economic and religious motives dominate the ancient and medieval periods, in the Renaissance and Enlightenment, we see …

Phase Composition Control Of Calcium Phosphate Nanoparticles For Tunable Drug Delivery Kinetics And Treatment Of Osteomyelitis. Part 2: Antibacterial And Osteoblastic Response, Vuk Uskoković, Tejal A. Dasai

Pharmacy Faculty Articles and Research

Osteomyelitis has been traditionally treated by the combination of long-term antibiotic therapies and surgical removal of diseased tissue. The multifunctional material was developed in this study with the aim to improve this therapeutic approach by: (a) enabling locally delivered and sustained release of antibiotics at a tunable rate, so as to eliminate the need for repetitive administration of systemically distributed antibiotics; and (b) controllably dissolving itself, so as to promote natural remineralization of the portion of bone lost to disease. We report hereby on the effect of the previously synthesized calcium phosphates (CAPs) with tunable solubilities and drug release time …

Revisiting The Fundamentals In The Design And Control Of Nanoparticulate Colloids In The Frame Of Soft Chemistry, Vuk Uskoković

Pharmacy Faculty Articles and Research

This review presents thoughts on some of the fundamental features of conceptual models applied in the design of fine particles in the frames of colloid and soft chemistry. A special emphasis is placed on the limitations of these models, an acknowledgment of which is vital in improving their intricacy and effectiveness in predicting the outcomes of the corresponding experimental settings. Thermodynamics of self-assembly phenomena illustrated on the examples of protein assembly and micellization is analyzed in relation to the previously elaborated thesis that each self-assembly in reality presents a co-assembly, since it implies a mutual reorganization of the assembling system …

Non-Motile Primary Cilia As Fluid Shear Stress Mechanosensors, Surya M. Nauli, Xingjian Jin, Wissam A. Aboualaiwi, Wassim El-Jouni, Xuefeng Su, Jing Zhou

Pharmacy Faculty Articles and Research

Primary cilia are sensory organelles that transmit extracellular signals into intracellular biochemical responses. Structural and functional defects in primary cilia are associated with a group of human diseases, known as ciliopathies, with phenotypes ranging from cystic kidney and obesity to blindness and mental retardation. Primary cilia mediate mechano- and chemosensation in many cell types. The mechanosensory function of the primary cilia requires the atypical G-protein-coupled receptor polycystin-1 and the calcium-permeable nonselective cation channel polycystin-2. Mechanical stimulations such as fluid-shear stress of the primary cilia initiate intracellular calcium rise, nitric oxide release, and protein modifications. In this review, we describe a …

Copper Triflate-Mediated Synthesis Of 1,3,5-Triarylpyrazoles In [Bmim][Pf6] Ionic Liquid And Evaluation Of Their Anticancer Activities, V. Kameshwara Rao, Rakesh Tiwari, Bhupender S. Chhikara, Amir Nasrolahi Shirazi, Keykavous Parang, Anil Kumar

Pharmacy Faculty Articles and Research

A simple, efficient, and environment friendly protocol for the synthesis of 1,3,5-triarylpyrazoles and 1,3,5-triarylpyrazolines in [bmim][PF6] ionic liquid mediated by Cu(OTf)2 is described. The reaction protocol gave 1,3,5-triarylpyrazoles in good to high yields (71–84%) via a one-pot addition–cyclocondensation between chalcones and arylhydrazines, and oxidative aromatization without the requirement for an additional oxidizing reagent. The catalyst can be reused for up to four cycles without much loss in the catalytic activity. The pyrazoles (4a–o) and pyrazolines (3a–n) were evaluated for their antiproliferative activity in SK-OV-3, HT-29, and HeLa human cancer cells lines. Among all the compounds, 3b inhibited cell proliferation of …

The Court’S Brain: Neuroscience And Judicial Decision Making In Criminal Sentencing, Kimberly Papillon

Court Review: Journal of the American Judges Association

Cutting-edge neuroscientific studies provide new insights into the inner workings of the human brain. At the same time, innovations in justice-system data collection have allowed researchers to gather and analyze vast quantities of statistical data in criminal-sentencing patterns. The combination of the two genres of study provides us with the first scientifically based demonstration that well-meaning egalitarian judges may have strong neurophysiologic reactions to defendants, victims, experts, and attorneys. These reactions help us explore whether or not race affects judicial decision making.

The Model Code of Judicial Conduct, caselaw, the Fourteenth Amendment, and the constitutions of every state prohibit judges …

The Emotionally Intelligent Judge: A New (And Realistic) Ideal, Terry A. Maroney

Court Review: Journal of the American Judges Association

As a Supreme Court Justice once wrote, “dispassionate judges” are “mythical beings,” like “Santa Claus or Uncle Sam or Easter bunnies.”1 Judges have emotions, and emotions influence decision making. These observations may seem obvious, even banal. But their implications are broad-reaching. Judicial emotion is more common than most people—certainly laypeople, and perhaps judges as well— would like to believe. Further, emotion almost certainly has a substantial impact on judicial decision making and behavior— and that is not necessarily a bad thing.

The ideal of the emotionless, “dispassionate” judge has a very long pedigree. More than three centuries ago, Thomas Hobbes …

Hollingsworth V. Perry, Brief For Foreign And Comparative Law Experts Harold Hongju Koh Et. Al. As Amici Curiae Supporting Respondents, Harold Hongju Koh, Sarah H. Cleveland, Laurence R. Helfer, Ryan Goodman

Faculty Scholarship

No abstract provided.