Digital Commons Network^™

Sibyl 2013, Otterbein University

Otterbein University Yearbooks

No abstract provided.

Mapping Our Future: The Impact Of Gene Patents On Scientific Research And Health Care In The United States, Caitlin E. Lanning

Journal of Law and Health

In September, 2011, the Senate passed H.R. 1249, the Leahy-Smith America Invents Act (“AIA”), which President Barrack Obama signed into law on September 16th. The AIA is the largest transformation to U.S. patent law since 1952. While the new legislation implements numerous, positive changes to the U.S. patent system, it fails to address any of the concerns raised by gene patent critics over the past few decades. Gene patents should be categorized as patentable subject matter within the AIA, but under a separate patent category with specifically engineered regulations designed to promote scientific research and collaboration that will in turn …

Utah Shrubland Management, Kari E. Veblen, R. K. Mann, Thomas A. Monaco, J. R. Williams

Wildland Resources Faculty Publications

No abstract provided.

Candida Albicans Czf1 And Efg1 Coordinate The Response To Farnesol During Quorum Sensing, White-Opaque Thermal Dimorphism, And Cell Death, Melanie L. Langford, Jessica C. Hargarten, Krista D. Patefield, Elizabeth Marta, Jill R. Blankenship, Saranna Fanning, Kenneth W. Nickerson, Audrey L. Atkin

Kenneth Nickerson Papers

Quorum sensing by farnesol in Candida albicans inhibits filamentation and may be directly related to its ability to cause both mucosal and systemic diseases. The Ras1-cyclic AMP signaling pathway is a target for farnesol inhibition. However, a clear understanding of the downstream effectors of the morphological farnesol response has yet to be unraveled. To address this issue, we screened a library for mutants that fail to respond to farnesol. Six mutants were identified, and the czf1/czf1 mutant was selected for further characterization. Czf1 is a transcription factor that regulates filamentation in embedded agar and also whiteto- opaque switching. We found …

Five Year Carbon Storage Analysis In The Gordon Natural Area, Joy Fritschle, Chad Hudson, Catherine Spahr, Andy Tamez

Forest Carbon Storage Study Documents

The Gordon Natural Area (GNA) serves as a natural laboratory for a range of class research projects. In a Geography Field Methods course led by Dr. Fritschle, students established five permanent carbon-study plots in 2008. Since then, students have returned to these plots to measure the carbon stock of standing trees in five plots located along a topographic gradient: floodplain, ridge-top, lower mid-slope, mid-slope and upper mid-slope. Using U.S. Forest Service established guidelines, all trees greater than 5 cm and up to 73 cm in diameter at breast height (DBH) were measured and identified within each 40 m circular plot. …

Uis Bulletin, Volume 55, No. 1 & 2, 2012, Fadi Nader

UIS Bulletin

Contents: Message from the President of the UIS -- Minutes of the 2012 Annual UIS Bureau Meeting -- UIS Code of Ethics: Proposed Revision -- Internal Regulations of the UIS: Proposed Modifications -- UIS Department of Karst and Caves Protection -- The France Habe Prize 2013: Proposed Regulations -- UIS Commission on Artificial Caves: Torino 2012 Workshop -- UIS Commission on "Pseudokarst": Tui 2012 Assembly -- UIS Commission on "Pseudokarst": Tui 2012 Report -- UIS Permanent Commission on Speleotherapy: XIVth Int. Symposium -- Tribute to Victor Dublyansky (1930-2012) -- UIS Bureau 2009-2013 -- National Delegates and Substitutes -- UIS Departments, …

Book Review: Colonization After Emancipation: Lincoln And The Movement For Black Resettlement, Allen C. Guelzo

Civil War Era Studies Faculty Publications

“There is a clause in the Act which is likely to meet with misconstruction in Europe,” wrote Frederick Milnes Edge about the legislation that emancipated the slaves of the District of Columbia in April 1862, “namely the appropriation for colonizing the freed slaves.” Ignore it, Edge advised. It only “was adopted to silence the weak-nerved, whose name is legion—and to enable any of the slaves who see fit to emigrate to more genial climes.” And this, for a long time, has been the way that most commentators have understood colonization—a plan ostensibly designed to expatriate any emancipated blacks to …

Euryhalinity In An Evolutionary Context, Eric T. Schultz, Stephen D. Mccormick

EEB Articles

This chapter focuses on the evolutionary importance and taxonomic distribution of euryhalinity. Euryhalinity refers to broad halotolerance and broad halohabitat distribution. Salinity exposure experiments have demonstrated that species vary tenfold in their range of tolerable salinity levels, primarily because of differences in upper limits. Halotolerance breadth varies with the species’ evolutionary history, as represented by its ordinal classification, and with the species’ halohabitat. Freshwater and seawater species tolerate brackish water; their empirically-determined fundamental haloniche is broader than their realized haloniche, as revealed by the halohabitats they occupy. With respect to halohabitat distribution, a minority of species (<10%) are euryhaline. Habitat-euryhalinity is prevalent among basal actinopterygian fishes, is largely absent from orders arising from intermediate nodes, and reappears in the most derived taxa. There is pronounced family-level variability in the tendency to be halohabitat-euryhaline, which may have arisen during a burst of diversification following the Cretaceous-Palaeogene extinction. Low prevalence notwithstanding, euryhaline species are potent sources of evolutionary diversity. Euryhalinity is regarded as a key innovation trait whose evolution enables exploitation of new adaptive zone, triggering cladogenesis. We review phylogenetically-informed studies that demonstrate freshwater species diversifying from euryhaline ancestors through processes such as landlocking. These studies indicate that some euryhaline taxa are particularly susceptible to changes in halohabitat and subsequent diversification, and some geographic regions have been hotspots for transitions to freshwater. Comparative studies on mechanisms among multiple taxa and at multiple levels of biological integration are needed to clarify evolutionary pathways to, and from, euryhalinity.

Direct And Indirect Selection On Floral Pigmentation By Pollinators And Seed Predators In A Color Polymorphic South African Shrub, Jane E. Carlson, Kent E. Holsinger

EEB Articles

The coexistence of different color morphs is often attributed to variable selection pressures across space, time, morph frequencies or selection agents, but the routes by which each morph is favored are rarely identified. In this study we untangle the interactions and trait pleiotropisms that influence floral color polymorphisms on a local scale in Protea, within which ~40% of species are polymorphic. Previous work shows that seed predators and reproductive differences likely influence polymorphism maintenance in four Protea species. Here, we explore whether selection acts on floral color directly or indirectly in Protea aurea, using path analysis of pollinator …

Preclinical Development Of Phytocannabinoid- And Endocannabinoid- Based Pharmacotherapies For The Treatment Of Ethanol-Induced Neurodegeneration, Daniel J. Liput

Theses and Dissertations--Pharmacy

Excessive ethanol consumption, characteristic of alcohol use disorders (AUDs), is associated with widespread neurodegeneration and cognitive and behavioral impairments that may contribute to the chronic and relapsing nature of alcoholism. Therefore, identifying novel targets that can afford neuroprotection will undoubtedly aid current treatment strategies for AUDs. The cannabinoids have been shown to provide neuroprotection in a variety of preclinical models of neurodegeneration; however minimal data is available regarding the use of cannabinoid-based pharmacotherapies for treating ethanol-induced neurodegeneration. Therefore, the current dissertation examined the overarching hypothesis: the cannabinoids are a therapeutic strategy to afford neuroprotection in the context of ethanol-induced neurodegeneration. …

Tennessee Folklore Society Bulletin - Volume 69, No. 1, Tennessee Folklore Society

Tennessee Folklore Society Bulletin

No abstract provided.

Shifting Paradigms Transform Environmental And Land Use Law: The Emergence Of The Law Of Sustainable Development, John R. Nolan

Fordham Environmental Law Review

No abstract provided.

Kids Count: The State Of The Child In Tennessee, 2013, Tennessee Commission On Children And Youth

Kids Count/State of the Child in Tennessee Reports

This report provides an overview of information on healthy infants, children and teens; child/teen well-being; education; economic security; and demographics.

Hydraulic Fracturing Wastewater: Making The Case For Treating The Environmentally Condemned, Inessa Abayev

Fordham Environmental Law Review

No abstract provided.

Environmental Monitoring Plan: January Through December 2013, Tennessee. Department Of Environment And Conservation.

Environmental Monitoring Plans

The Tennessee Department of Environment and Conservation (TDEC), Department of Energy (DOE) Oversight Office (the office), is providing an annual environmental monitoring plan for the calendar year 2013 under terms of the Tennessee Oversight Agreement (TOA) Section A.7.2.1. Individual work plans describing independent environmental monitoring and surveillance make up the 2013 Environmental Monitoring Plan.

Calculation Of Non-Adiabatic Coupling Vectors In A Local-Orbital Basis Set, Enrique Abad, James P. Lewis, Vladmír Zobač, Prokop Hapala, Pavel Jelínek, José Ortega

Faculty & Staff Scholarship

No abstract provided.

The Sad Story Of The Northern Rocky Mountain Gray Wold Reintroduction Program, Hope M. Babcock

Fordham Environmental Law Review

No abstract provided.

Learning To Think About Complex Environmental Systems In Environmental And Natural Resource Law And Legal Scholarship: A Twenty-Year Retrospective

Fordham Environmental Law Review

No abstract provided.

Google Vs. The Library: Student Preferences And Perceptions When Doing Research Using Google And A Federated Search Tool, Helen Georgas

Publications and Research

Federated searching was once touted as the library world’s answer to Google, but ten years since federated searching technology’s inception, how does it actually compare? This study focuses on undergraduate student preferences and perceptions when doing research using both Google and a federated search tool. Students were asked about their preferences using each search tool and the perceived relevance of the sources they found using each search tool. Students were also asked to self-assess their online searching skills. The findings show that students believe they possess strong searching skills, are able to find relevant sources using both search tools, but …

Identity And The Sexual Minority Refugee: A Discussion Of Conceptions And Preconceptions In The United Kingdom And Ireland, Samantha K. Arnold

Human Rights Brief

No abstract provided.

Technology For Social Inclusion, Hugh Lacey

Philosophy Faculty Works

No abstract provided.

Nature, Nurture, Narrative, Law: The Wellesley Case, Oliver Twist, And The Victorian Anxiety About Parentage, Sarah Abramowicz

Studio for Law and Culture

Charles Dickens’s Oliver Twist heralded the popularity in Victorian England of a new type of novel, the novel of child development, that traced the experience of displaced child protagonists as they found their place in the world by working out their relationships with a series of parents and parent-figures. At the same time, the newly prominent field of English child custody law began to articulate why and how parentage matters for a developing child. An examination of one of the first highly publicized English custody disputes, Wellesley v. Beaufort, brings out some of the concerns about parentage at work …

March-In Rights Under The Bayh-Dole Act: The Nih’S Paper Tiger?, William O'Brien

Seton Hall Law Review

No abstract provided.

(A)Filiaciones Femeninas: Gorriti Y La Genealogía De La Escritura En Lima, Rocío Del Águila

Decimonónica

La presencia de varias mujeres escritoras a finales del siglo XIX en el Perú no es producto del azar, sino del esfuerzo de ciertos intelectuales en promover un discurso que admitiera esta posibilidad y en elevar a algunas figuras femeninas de las letras. Aunque en medio de una coyuntura política compleja, Lima se dio abasto para tener un ambiente intelectual activo en el que se discutían temas de actualidad a la par que se componían versos.1 En esta época, Juana Manuela Gorriti (Argentina, 1818-1892) regentó las veladas literarias en su hogar en el que participaron destacados personajes y que se …

Volume 67 Issue 2 (Fall/Winter 2013)

Utah Science

2 People in the Water Planning Picture

People have always had an impact on how water interacts with the landscape, but social scientists have long been absent from water policy discussions and decisions. Sociologist Douglas Jackson-Smith and his colleagues are working to change that and to shape our water future.

8 Designing Where the Water Goes

Streets, sidewalks, rooftops and patios all affect what happens when the rain falls, and what happens to stormwater effects every community. The design of streets and other landscape elements has a big impact on this important part of the water cycle and can help …

Volume 67 Issue 1 (Spring/Summer 2013)

Utah Science

2 Utah 's Connection To Cleft Palate Nutritional epidemiologist Ron Munger has traveled to distant, developing countries to study the causes of cleft lip and cleft palate, but he also has a large population of people to study right here at home. Utah has the highest incidence of clefts in the nation, double the average for Caucasian Americans and Munger wants to know why.

8 Nutrition Research : Science Goes Beyond Gut Instinct Our diets are tangled webs of vitamins, fats, fibers, sugars, proteins and minerals, so teasing out the role (or roles) of each component can be difficult. That’s …

Building Kcnq1/Kcne1 Channel Models And Probing Their Interactions By Molecular-Dynamics Simulations, Yu Xu, Yuhong Wang, Xuan-Yu Meng, Mei Zhang, Min Jiang, Meng Cui, Gea-Ny Tseng

Physiology and Biophysics Publications and Presentations

The slow delayed rectifier (I_Ks) channel is composed of KCNQ1 (pore-forming) and KCNE1 (auxiliary) subunits, and functions as a repolarization reserve in the human heart. Design of I_Ks-targeting anti-arrhythmic drugs requires detailed three-dimensional structures of the KCNQ1/KCNE1 complex, a task made possible by Kv channel crystal structures (templates for KCNQ1 homology-modeling) and KCNE1 NMR structures. Our goal was to build KCNQ1/KCNE1 models and extract mechanistic information about their interactions by molecular-dynamics simulations in an explicit lipid/solvent environment. We validated our models by confirming two sets of model-generated predictions that were independent from the spatial restraints used …

S3-S4 Linker Length Modulates The Relaxed State Of A Voltage-Gated Potassium Channel, Michael F. Priest, Jérôme J. Lacroix, Carlos A. Villalba-Galea, Fancisco Bezanilla

Physiology and Biophysics Publications and Presentations

Abstract

Voltage-sensing domains (VSDs) are membrane protein modules found in ion channels and enzymes that are responsible for a large number of fundamental biological tasks, such as neuronal electrical activity. The VSDs switch from a resting to an active conformation upon membrane depolarization, altering the activity of the protein in response to voltage changes. Interestingly, numerous studies describe the existence of a third distinct state, called the relaxed state, also populated at positive potentials. Although some physiological roles for the relaxed state have been suggested, little is known about the molecular determinants responsible for the development and modulation of VSD …

The Compromised Cargo Container: Terror In A Box, Taylor Simpson-Wood

Faculty Scholarship

No abstract provided.

Cutting The Cord To Private Cord Blood Banking: Encouraging Compensation For Public Cord Blood Donations After Flynn V. Holder, Seema Mohapatra

Faculty Scholarship

No abstract provided.