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2013

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Graduate Record 2013: Bulldog Adventures, Southwestern Oklahoma State University Jan 2013

Graduate Record 2013: Bulldog Adventures, Southwestern Oklahoma State University

SWOSU Yearbooks

The 2013 Graduate Record was produced by the Communications Department.

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The Teacher-Student Writing Conference Reimaged: Entangled Becoming-Writingconferencing, Donna Kalmbach Phillips, Mindy Legard Larson Jan 2013

The Teacher-Student Writing Conference Reimaged: Entangled Becoming-Writingconferencing, Donna Kalmbach Phillips, Mindy Legard Larson

Faculty Publications

This analysis is experimental: we attempt to read data with the work of Karen Barad and in doing so ‘see’ teacher-student writing conferences (a common pedagogy of US elementary school writing) as intra-activity. Data were gathered during teacher-student writing conferences in a grade five US classroom over a six week period. One conference between a researcher and a male Latino student, a Student of Labels, is diffracted. Reading and writing and thinking with Barad disrupts our habitual ways of privileging language as representational. Rather, we consider the material-discursive practices of schooling that produce what comes to matter, leading …

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Antioxidant And Cytoprotective Activities Of Piper Betle, Areca Catechu, Uncaria Gambir And Betel Quid With And Without Calcium Hydroxide, N.N. Sazwi, T. Nalina, Z.H.A. Rahim Jan 2013

Antioxidant And Cytoprotective Activities Of Piper Betle, Areca Catechu, Uncaria Gambir And Betel Quid With And Without Calcium Hydroxide, N.N. Sazwi, T. Nalina, Z.H.A. Rahim

Research Publications (2011 to 2015)

Background: Betel quid chewing is a popular habit in Southeast Asia. It is believed that chewing betel quid could reduce stress, strengthen teeth and maintain oral hygiene. The aim of this study was to investigate the antioxidant and cytoprotective activities of each of the ingredients of betel quid and compared with betel quid itself (with and without calcium hydroxide). The correlation of their cytoprotective and antioxidant activities with phenolic content was also determined. Methods: Five samples (betel leaf, areca nut, gambir, betel quid and betel quid containing calcium hydroxide) were extracted in deionized distilled water for 12 hours at 37 …

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Beta-Glucan-Rich Extract From Pleurotus Sajor-Caju (Fr.) Singer Prevents Obesity And Oxidative Stress In C57bl/6j Mice Fed On A High-Fat Diet, G. Kanagasabapathy, S.N.A. Malek, A.A. Mahmood, Kek Heng Chua, S. Vikineswary, Umah Rani Kuppusamy Jan 2013

Beta-Glucan-Rich Extract From Pleurotus Sajor-Caju (Fr.) Singer Prevents Obesity And Oxidative Stress In C57bl/6j Mice Fed On A High-Fat Diet, G. Kanagasabapathy, S.N.A. Malek, A.A. Mahmood, Kek Heng Chua, S. Vikineswary, Umah Rani Kuppusamy

Research Publications (2011 to 2015)

Mushrooms have been used in folk medicine for thousands of years. In this study, the effect of beta-glucan-rich extract of P. sajor-caju (GE) on lipid lowering and antioxidant potential was assessed in C57BL/6J mice fed on a high-fat diet. Obesity was induced in C57BL/6J mice by feeding a high-fat diet. The control groups in this study were ND (for normal diet) and HFD (for high-fat diet). The treated groups were ND 240 (for normal diet) (240 mg/kg b.w) and HFD60, HFD120, and HFD240 (for high-fat diet), where the mice were administrated with three dosages of GE (60, 120, and 240 …

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Apoptosis Effect Of Girinimbine Isolated From Murraya Koenigii On Lung Cancer Cells In Vitro, S. Mohan, S.I. Abdelwahab, Shiau Chuen Cheah, M.A. Sukari, S. Syam, N. Shamsuddin, Mohd Rais Mustafa Jan 2013

Apoptosis Effect Of Girinimbine Isolated From Murraya Koenigii On Lung Cancer Cells In Vitro, S. Mohan, S.I. Abdelwahab, Shiau Chuen Cheah, M.A. Sukari, S. Syam, N. Shamsuddin, Mohd Rais Mustafa

Research Publications (2011 to 2015)

Murraya koenigii Spreng has been traditionally claimed as a remedy for cancer. The current study investigated the anticancer effects of girinimbine, a carbazole alkaloid isolated from Murraya koenigii Spreng, on A549 lung cancer cells in relation to apoptotic mechanistic pathway. Girinimbine was isolated from Murraya koenigii Spreng. The antiproliferative activity was assayed using MTT and the apoptosis detection was done by annexin V and lysosomal stability assays. Multiparameter cytotoxicity assays were performed to investigate the change in mitochondrial membrane potential and cytochrome c translocation. ROS, caspase, and human apoptosis proteome profiler assays were done to investigate the apoptotic mechanism of …

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Common Oncogenic Mutations Are Infrequent In Oral Squamous Cell Carcinoma Of Asian Origin, S.N. Zanaruddin, P.S. Yee, S.Y. Hor, Y.H. Kong, W.M. Ghani, W.M. Mustafa, R.B. Zain, S.S. Prime, Z.A. Rahman, S.C. Cheong Jan 2013

Common Oncogenic Mutations Are Infrequent In Oral Squamous Cell Carcinoma Of Asian Origin, S.N. Zanaruddin, P.S. Yee, S.Y. Hor, Y.H. Kong, W.M. Ghani, W.M. Mustafa, R.B. Zain, S.S. Prime, Z.A. Rahman, S.C. Cheong

Research Publications (2011 to 2015)

OBJECTIVES: The frequency of common oncogenic mutations and TP53 was determined in Asian oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: The OncoCarta(™) panel v1.0 assay was used to characterize oncogenic mutations. In addition, exons 4-11 of the TP53 gene were sequenced. Statistical analyses were conducted to identify associations between mutations and selected clinico-pathological characteristics and risk habits. RESULTS: Oncogenic mutations were detected in PIK3CA (5.7%) and HRAS (2.4%). Mutations in TP53 were observed in 27.7% (31/112) of the OSCC specimens. Oncogenic mutations were found more frequently in non-smokers (p = 0.049) and TP53 truncating mutations were more common in …

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Effects Of Cocktail Of Four Local Malaysian Medicinal Plants (Phyllanthus Spp.) Against Dengue Virus 2, S.H. Lee, Y.Q. Tang, A. Rathkrishnan, S.M. Wang, K.C. Ong, R. Manikam, B.J. Payne, I.B. Jaganath, S.D. Sekaran Jan 2013

Effects Of Cocktail Of Four Local Malaysian Medicinal Plants (Phyllanthus Spp.) Against Dengue Virus 2, S.H. Lee, Y.Q. Tang, A. Rathkrishnan, S.M. Wang, K.C. Ong, R. Manikam, B.J. Payne, I.B. Jaganath, S.D. Sekaran

Research Publications (2011 to 2015)

Background: The absence of commercialized vaccines and antiviral agents against dengue has made the disease a major health concern around the world. With the current dengue virus transmission rate and incidences, the development of antiviral drugs is of vital need. The aim of this project was to evaluate the possibility of developing a local medicinal plant, Phyllanthus as an anti-dengue agent. Methods: Cocktail (aqueous and methanolic) extracts were prepared from four species of Phyllanthus (P. amarus, P. niruri, P. urinaria, and P. watsonii) and their polyphenolic compounds were identified via HPLC and LC-MS/MS analysis. MTS assay was then carried out …

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Effect Of Compositions In Nanostructured Lipid Carriers (Nlc) On Skin Hydration And Occlusion, C.H. Loo, M. Basri, R. Ismail, H.L.N. Lau, B.A. Tejo, M.S. Kanthimathi, H.A. Hassan, Y.M. Choo Jan 2013

Effect Of Compositions In Nanostructured Lipid Carriers (Nlc) On Skin Hydration And Occlusion, C.H. Loo, M. Basri, R. Ismail, H.L.N. Lau, B.A. Tejo, M.S. Kanthimathi, H.A. Hassan, Y.M. Choo

Research Publications (2011 to 2015)

Purpose: To study the effects of varying lipid concentrations, lipid and oil ratio, and the addition of propylene glycol and lecithin on the long-term physical stability of nanostructured lipid nanocarriers (NLC), skin hydration, and transepidermal water loss. Methods: The various NLC formulations (A1-A5) were prepared and their particle size, zeta potential, viscosity, and stability were analyzed. The formulations were applied on the forearms of the 20 female volunteers (one forearm of each volunteer was left untreated as a control). The subjects stayed for 30minutes in a conditioned room with their forearms uncovered to let the skin adapt to the temperature …

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Effects Of Tamarindus Indica Fruit Pulp Extract On Abundance Ofhepg2 Cell Lysate Proteins And Their Possible Consequential Impact On Metabolism And Inflammation, U.R.W. Chong, P.S. Abdul-Rahman, A. Abdul-Aziz, Onn Haji Hashim, Sarni Mat Junit Jan 2013

Effects Of Tamarindus Indica Fruit Pulp Extract On Abundance Ofhepg2 Cell Lysate Proteins And Their Possible Consequential Impact On Metabolism And Inflammation, U.R.W. Chong, P.S. Abdul-Rahman, A. Abdul-Aziz, Onn Haji Hashim, Sarni Mat Junit

Research Publications (2011 to 2015)

The fruit pulp extract of Tamarindus indica has been reported for its antioxidant and hypolipidemic properties. In this study, the methanol extract of T. indica fruit pulp was investigated for its effects on the abundance of HepG2 cell lysate proteins. Cell lysate was extracted from HepG2 cells grown in the absence and presence of the methanol extract of T. indica fruit pulp. Approximately 2500 spots were resolved using two-dimensional gel electrophoresis and the abundance of 20 cellular proteins was found to be significantly reduced. Among the proteins of reduced abundance, fourteen, including six proteins involved in metabolism (including ethanolamine phosphate …

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Fruit Development, Pigmentation And Biochemical Properties Of Wax Apple As Affected By Localized Application Of Ga(3) Under Field Conditions, M.M. Khandaker, A.N. Boyce, N. Osman, F. Golam, M.M. Rahman, Mohd Sofian-Azirun Jan 2013

Fruit Development, Pigmentation And Biochemical Properties Of Wax Apple As Affected By Localized Application Of Ga(3) Under Field Conditions, M.M. Khandaker, A.N. Boyce, N. Osman, F. Golam, M.M. Rahman, Mohd Sofian-Azirun

Research Publications (2011 to 2015)

This study investigated the effects of gibberellin (GA(3)) on the fruit development, pigmentation and biochemical properties of wax apple. The wax apple trees were rubbing treated with 0, 20, 50 and 100 mgGA(3)/l under field conditions. The localized application (rubbing) of 50 mg GA(3)/l significantly increased the fruit set, fruit length and diameter, color development, weight and yield compared to the control. In addition, GA(3) treatments significantly reduced the fruit drop. With regard to the fruit quality, 50 mg/l GA(3) treatment increased the juice content, K+, TSS, total sugar and sugar acid ratio of wax apple fruits. In addition, higher …

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Honey-Induced Protein Stabilization As Studied By Fluorescein Isothiocyanate Fluorescence, Y.H. Wong, H. Abdul Kadir, S. Tayyab Jan 2013

Honey-Induced Protein Stabilization As Studied By Fluorescein Isothiocyanate Fluorescence, Y.H. Wong, H. Abdul Kadir, S. Tayyab

Research Publications (2011 to 2015)

Protein stabilizing potential of honey was studied on a model protein, bovine serum albumin (BSA), using extrinsic fluorescence of fluorescein isothiocyanate (FITC) as the probe. BSA was labelled with FITC using chemical coupling, and urea and thermal denaturation studies were performed on FITC-labelled BSA (FITC-BSA) both in the absence and presence of 10% and 20% (w/v) honey using FITC fluorescence at 522 nm upon excitation at 495 nm. There was an increase in the FITC fluorescence intensity upon increasing urea concentration or temperature, suggesting protein denaturation. The results from urea and thermal denaturation studies showed increased stability of protein in …

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Genetic Assemblage Of Sarcocystis Spp. In Malaysian Snakes, Yee Ling Lau, P.Y. Chang, V. Subramaniam, Y.H. Ng, Rohela Mahmud, A.F. Ahmad, Mun Yik Fong Jan 2013

Genetic Assemblage Of Sarcocystis Spp. In Malaysian Snakes, Yee Ling Lau, P.Y. Chang, V. Subramaniam, Y.H. Ng, Rohela Mahmud, A.F. Ahmad, Mun Yik Fong

Research Publications (2011 to 2015)

Background: Sarcocystis species are protozoan parasites with a wide host range including snakes. Although there were several reports of Sarcocytis species in snakes, their distribution and prevalence are still not fully explored. Methods: In this study, fecal specimens of several snake species in Malaysia were examined for the presence of Sarcocystis by PCR of 18S rDNA sequence. Microscopy examination of the fecal specimens for sporocysts was not carried as it was difficult to determine the species of the infecting Sarcocystis. Results: Of the 28 snake fecal specimens, 7 were positive by PCR. BLASTn and phylogenetic analyses of the amplified 18S …

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Genetic Diversity Analysis Of Agro-Morphological And Quality Traits In Populations Of Sainfoin (Onobrychis Sativa), S. Mohajer, A.A. Jafari, R.M. Taha, J.S. Yaacob, A. Saleh Jan 2013

Genetic Diversity Analysis Of Agro-Morphological And Quality Traits In Populations Of Sainfoin (Onobrychis Sativa), S. Mohajer, A.A. Jafari, R.M. Taha, J.S. Yaacob, A. Saleh

Research Publications (2011 to 2015)

In order to study the variations and relations among morphological and quality traits, 12 populations (accessions) of sainfoin (Onobrychis sativa), were assessed under sward growth condition using split plot design with two replications for three years. In this regard, each variety was cultivated in plot area directly and different traits were assessed when 50 of plants produced flowers. Results of combined analyses showed that there were significant differences among 3 years for all of traits except plant density. Based on these results, the average values of 6.47 and 10.31 ton ha-1 dry matter (DM) yield were obtained in the first …

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In Vivo Antioxidant And Antiulcer Activity Of Parkia Speciosa Ethanolic Leaf Extract Against Ethanol-Induced Gastric Ulcer In Rats, R.A. Batran, F. Al-Bayaty, M.M.J. Al-Obaidi, A.M. Abdualkader, H.A. Hadi, H.M. Ali, M.A. Abdulla Jan 2013

In Vivo Antioxidant And Antiulcer Activity Of Parkia Speciosa Ethanolic Leaf Extract Against Ethanol-Induced Gastric Ulcer In Rats, R.A. Batran, F. Al-Bayaty, M.M.J. Al-Obaidi, A.M. Abdualkader, H.A. Hadi, H.M. Ali, M.A. Abdulla

Research Publications (2011 to 2015)

Background: The current study was carried out to examine the gastroprotective effects of Parkia speciosa against ethanolinduced gastric mucosa injury in rats. Methodology/Principal Findings: Sprague Dawley rats were separated into 7 groups. Groups 1–2 were orally challenged with carboxymethylcellulose (CMC); group 3 received 20 mg/kg omeprazole and groups 4–7 received 50, 100, 200 and 400 mg/kg of ethanolic leaf extract, respectively. After 1 h, CMC or absolute ethanol was given orally to groups 2–7. The rats were sacrificed after 1 h. Then, the injuries to the gastric mucosa were estimated through assessment of the gastric wall mucus, the gross appearance …

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Panduratin A, A Possible Inhibitor In Metastasized A549 Cells Through Inhibition Of Nf-Kappa B Translocation And Chemoinvasion, Shiau Chuen Cheah, Siew Li Lai, Sui Ting Lee, A. Hamid A. Hadi, Mohd Rais Mustafa Jan 2013

Panduratin A, A Possible Inhibitor In Metastasized A549 Cells Through Inhibition Of Nf-Kappa B Translocation And Chemoinvasion, Shiau Chuen Cheah, Siew Li Lai, Sui Ting Lee, A. Hamid A. Hadi, Mohd Rais Mustafa

Research Publications (2011 to 2015)

In the present study, we investigated the effects of panduratin A (PA), isolated from Boesenbergia rotunda, on apoptosis and chemoinvasion in A549 human non-small cell lung cancer cells. Activation of the executioner procaspase-3 by PA was found to be dose-dependent. Caspase-3 activity was significantly elevated at the 5 µg/mL level of PA treatment and progressed to a maximal level. However, no significant elevated level was detected on procaspase-8. These findings suggest that PA activated caspase-3 but not caspase-8. Numerous nuclei of PA treated A549 cells stained brightly by anti-cleaved PARP antibody through High Content Screening. This result further confirmed that …

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Nigella Sativa And Its Protective Role In Oxidative Stress And Hypertension, Xin-Fang Leong, Mohd Rais Mustafa, K. Jaarin Jan 2013

Nigella Sativa And Its Protective Role In Oxidative Stress And Hypertension, Xin-Fang Leong, Mohd Rais Mustafa, K. Jaarin

Research Publications (2011 to 2015)

Hypertension increases the risk for a variety of cardiovascular diseases, including stroke, coronary artery disease, heart failure, and peripheral vascular disease. The increase in oxidative stress has been associated with the pathogenesis of hypertension. Increase of blood pressure is due to an imbalance between antioxidants defence mechanisms and free radical productions. Excessive production of reactive oxygen species reduces nitric oxide bioavailability leading to an endothelial dysfunction and a subsequent increase in total peripheral resistance. Hypertension can cause few symptoms until it reaches the advanced stage and poses serious health problems with lifelong consequences. Hypertensive patients are required to take drugs …

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Optimization Of Extraction Parameters By Using Response Surface Methodology, Purification, And Identification Of Anthocyanin Pigments In Melastoma Malabathricum Fruit, Nordiyanah Anuar, Ahmad Faris Mohd Adnan, Naziz Saat, Norkasmani Aziz, Rosna Mat Taha Jan 2013

Optimization Of Extraction Parameters By Using Response Surface Methodology, Purification, And Identification Of Anthocyanin Pigments In Melastoma Malabathricum Fruit, Nordiyanah Anuar, Ahmad Faris Mohd Adnan, Naziz Saat, Norkasmani Aziz, Rosna Mat Taha

Research Publications (2011 to 2015)

Anthocyanins not just have various benefits in food industry but also have been used as natural colourants in cosmetic, coating products and as potential natural photosensitizers in solar cell. Thus, the main purpose of this study was to obtain information on the maximum yield of anthocyanin that can be recovered from Melastoma malabathricum fruit. Factors such as extraction temperature, extraction time, and solid to liquid ratio were identified to be significantly affecting anthocyanin extraction efficiency. By using three-level three-factor Box-Behnken design, the optimized conditions for anthocyanin extraction by acidified methanol (R (2) = 0.972) were temperature of 60°C, time of …

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Preliminary Analysis Of Knee Stress In Full Extension Landing, M.D. Makinejad, Noor Azuan Abu Osman, Wan Abu Bakar Wan Abas, M. Bayat Jan 2013

Preliminary Analysis Of Knee Stress In Full Extension Landing, M.D. Makinejad, Noor Azuan Abu Osman, Wan Abu Bakar Wan Abas, M. Bayat

Research Publications (2011 to 2015)

OBJECTIVE: This study provides an experimental and finite element analysis of knee-joint structure during extended-knee landing based on the extracted impact force, and it numerically identifies the contact pressure, stress distribution and possibility of bone-to-bone contact when a subject lands from a safe height. METHODS: The impact time and loads were measured via inverse dynamic analysis of free landing without knee flexion from three different heights (25, 50 and 75 cm), using five subjects with an average body mass index of 18.8. Three-dimensional data were developed from computed tomography scans and were reprocessed with modeling software before being imported and …

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Response Of Nitrogen Fertilizer And Legumes Residues On Biomass Production And Utilization In Rice-Legumes Rotation, M.M. Rahman, Mohd Sofian-Azirun, A.N. Boyce Jan 2013

Response Of Nitrogen Fertilizer And Legumes Residues On Biomass Production And Utilization In Rice-Legumes Rotation, M.M. Rahman, Mohd Sofian-Azirun, A.N. Boyce

Research Publications (2011 to 2015)

A cropping sequence including rice after winged bean, rice after bush bean, rice after corn, and rice after fallow with varying rates of nitrogen (N) fertilizer were carried out to investigate the effects of legume residues and N fertilizer to clarify dynamics of soil N supply, N utilization in soil-plant system and grain yield of rice. Nitrogen fertilizer was applied in both legumes at rates of 0, 2, 4 and 6 g m(-2). The first crop cycle for rice and corn were fertilized with N fertilizer at rates of 0, 4, 8 and 12 g m(-2) with no chemical fertilizer …

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Testosterone Level And Histological Features Of Tualang Honey And Nicotine Treated Male Rats., R. Noorhafiza, A.M. Majid, N.H. Hashida Jan 2013

Testosterone Level And Histological Features Of Tualang Honey And Nicotine Treated Male Rats., R. Noorhafiza, A.M. Majid, N.H. Hashida

Research Publications (2011 to 2015)

Forty-four Sprague-Dawley rats were divided into honey (1.0ml/100g honey), honey control (1.0ml/100g 0.9% NaCl), nicotine (0.5mg/100g nicotine), nicotine control (0.1ml/100g 0.9% NaCl) and nicotine-honey (0.5mg/100g nicotine and 1.0ml/100g honey) groups and treated for 60 days. On day 61, the rats were sacrificed and blood was drawn for blood hormone analysis. The testes were fixed in Bouin’s solution followed by Hematoxylin and Eosin (H&E) staining technique. This treatment did not significantly affect the testosterone level for all five groups (p≥0.05). The N (263.79±2.17μm) group showed significantly lower diameter of seminiferous tubules compared to the other four groups. The NH (135.02±1.66μm) and …

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The Effect Of Contact Angles And Capillary Dimensions On The Burst Frequency Of Super Hydrophilic And Hydrophilic Centrifugal Microfluidic Platforms, A Cfd Study, A. Kazemzadeh, P. Ganesan, Fatimah Ibrahim, S. He, M.J. Madou Jan 2013

The Effect Of Contact Angles And Capillary Dimensions On The Burst Frequency Of Super Hydrophilic And Hydrophilic Centrifugal Microfluidic Platforms, A Cfd Study, A. Kazemzadeh, P. Ganesan, Fatimah Ibrahim, S. He, M.J. Madou

Research Publications (2011 to 2015)

This paper employs the volume of fluid (VOF) method to numerically investigate the effect of the width, height, and contact angles on burst frequencies of super hydrophilic and hydrophilic capillary valves in centrifugal microfluidic systems. Existing experimental results in the literature have been used to validate the implementation of the numerical method. The performance of capillary valves in the rectangular and the circular microfluidic structures on super hydrophilic centrifugal microfluidic platforms is studied. The numerical results are also compared with the existing theoretical models and the differences are discussed. Our experimental and computed results show a minimum burst frequency occurring …

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Theoretical Development And Critical Analysis Of Burst Frequency Equations For Passive Valves On Centrifugal Microfluidic Platforms, T.H.G. Thio, S. Soroori, F. Ibrahim, W. Al-Faqheri, N. Soin, L. Kulinsky, M. Madou Jan 2013

Theoretical Development And Critical Analysis Of Burst Frequency Equations For Passive Valves On Centrifugal Microfluidic Platforms, T.H.G. Thio, S. Soroori, F. Ibrahim, W. Al-Faqheri, N. Soin, L. Kulinsky, M. Madou

Research Publications (2011 to 2015)

This paper presents a theoretical development and critical analysis of the burst frequency equations for capillary valves on a microfluidic compact disc (CD) platform. This analysis includes background on passive capillary valves and the governing models/equations that have been developed to date. The implicit assumptions and limitations of these models are discussed. The fluid meniscus dynamics before bursting is broken up into a multi-stage model and a more accurate version of the burst frequency equation for the capillary valves is proposed. The modified equations are used to evaluate the effects of various CD design parameters such as the hydraulic diameter, …

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Towards An Effective Control Programme Of Soil-Transmitted Helminth Infections Among Orang Asli In Rural Malaysia. Part 1: Prevalence And Associated Key Factors, N.A. Nasr, H.M. Al-Mekhlafi, A. Ahmed, M.A. Roslan, Awang Bulgiba Jan 2013

Towards An Effective Control Programme Of Soil-Transmitted Helminth Infections Among Orang Asli In Rural Malaysia. Part 1: Prevalence And Associated Key Factors, N.A. Nasr, H.M. Al-Mekhlafi, A. Ahmed, M.A. Roslan, Awang Bulgiba

Research Publications (2011 to 2015)

Background: Despite the continuous efforts to improve the quality of life of Orang Asli (Aborigines) communities, these communities are still plagued with a wide range of health problems including parasitic infections. The first part of this study aimed at determining the prevalence of soil-transmitted helminth (STH) infections and identifying their associated factors among rural Orang Asli children. Methods: A cross-sectional study was carried out among 484 Orang Asli children aged <= 15 years (235 females and 249 males) belonging to 215 households from 13 villages in Lipis district, Pahang, Malaysia. Faecal samples were collected and examined by using formalin-ether sedimentation, Kato Katz and Harada Mori techniques. Demographic, socioeconomic, environmental and behavioural information were collected by using a pre-tested questionnaire. Results: Overall, 78.1 of the children were found to be infected with one or more STH species. The prevalence of trichuriasis, ascariasis and hookworm infections were 71.7, 37.4 and 17.6, respectively. Almost all, three quarters and one fifth of trichuriasis, ascariasis and hookworm infections, respectively, were of moderate-to-heavy intensities. Multiple logistic regression analysis showed that age of >= 6 years (school-age), using unsafe water supply as a source for drinking water, absence of a toilet in the house, large family size (>= 7 members), not washing …

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Verrucous Papillary Lesions: Dilemmas In Diagnosis And Terminology, T.G. Kallarakkal, A. Ramanathan, R.B. Zain Jan 2013

Verrucous Papillary Lesions: Dilemmas In Diagnosis And Terminology, T.G. Kallarakkal, A. Ramanathan, R.B. Zain

Research Publications (2011 to 2015)

Verrucous papillary lesions (VPLs) of oral cavity are diagnostically challenging as they include a spectrum of benign, potentially malignant, and frankly malignant lesions. A majority of the benign VPLs have viral aetiology and include commonly occurring squamous papilloma along with verruca vulgaris, focal epithelial hyperplasia, and condyloma. Current understanding of potentially malignant VPLs is perplexing and is primarily attributed to the use of confusing and unsatisfactory terminology. Clinically and histologically oral verrucous hyperplasia, a potentially malignant disorder, resembles oral verrucous carcinoma and may be indistinguishable from one another. The most reliable way to separate these entities on routine haematoxylin-eosin stained …

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Towards An Effective Control Programme Of Soil-Transmitted Helminth Infections Among Orang Asli In Rural Malaysia. Part 2: Knowledge, Attitude, And Practices, N.A. Nasr, H.M. Al-Mekhlafi, A. Ahmed, M.A. Roslan, Awang Bulgiba Jan 2013

Towards An Effective Control Programme Of Soil-Transmitted Helminth Infections Among Orang Asli In Rural Malaysia. Part 2: Knowledge, Attitude, And Practices, N.A. Nasr, H.M. Al-Mekhlafi, A. Ahmed, M.A. Roslan, Awang Bulgiba

Research Publications (2011 to 2015)

Background In the first part of this study, we investigated the prevalence and associated key factors of soil-transmitted helminth (STH) infections among Orang Asli children in rural Malaysia; an alarming high prevalence and five key factors significantly associated with infections were reported. Part 2 of this study aims to evaluate the knowledge, attitude and practices (KAP) on STH infections among Orang Asli in Peninsular Malaysia. Methods A cross-sectional study was carried out among 215 households from 13 villages in Lipis district, Pahang, Malaysia. Demographic and socioeconomic information of the participants and their KAP on STH were collected by using a …

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Development Of 11 Polymorphic Microsatellite Markers For Xylocarpus Granatum (Meliaceae) Using Next-Generation Sequencing Technology, Yuki Tomizawa, Yoshimi Shinmura, Alison K S Wee, Koji Takayama, Takeshi Asakawa, Orlex Baylen Yllano, Severino G. Salmo Iii, Erwin Riyanto Ardli, Nguyen Xuan Tung, Norhaslinda Binti Malekal, Onrizal Onrizal, Sankararamasubramanian H. Meenakshisundaram, Sarawood Sungkaew, Mohd Nazre Saleh, Bayu Adjie, Khin Khin Soe, Emiko Oguri, Noriaki Murakami, Yasuyuki Watano, Shigeyuki Baba, Edward L. Webb, Tadashi Kajita Jan 2013

Development Of 11 Polymorphic Microsatellite Markers For Xylocarpus Granatum (Meliaceae) Using Next-Generation Sequencing Technology, Yuki Tomizawa, Yoshimi Shinmura, Alison K S Wee, Koji Takayama, Takeshi Asakawa, Orlex Baylen Yllano, Severino G. Salmo Iii, Erwin Riyanto Ardli, Nguyen Xuan Tung, Norhaslinda Binti Malekal, Onrizal Onrizal, Sankararamasubramanian H. Meenakshisundaram, Sarawood Sungkaew, Mohd Nazre Saleh, Bayu Adjie, Khin Khin Soe, Emiko Oguri, Noriaki Murakami, Yasuyuki Watano, Shigeyuki Baba, Edward L. Webb, Tadashi Kajita

Environmental Science Faculty Publications

Human impacts have seriously damaged mangroves, and conservation of mangroves will require information on local and regional population genetic structures. Here, we report the development and polymorphism of eleven novel microsatellite markers, developed using next- generation sequencing on 56 samples of widespread man- grove species Xylocarpus granatum (Meliaceae) from nine populations across the Indo-West Pacific region. All loci were found to be polymorphic, with the number of alleles per locus ranging from four to 19. In a population from Sabah (Malaysia), the mean observed and expected heterozygosity per locus was 0.59 and 0.58, respectively. No null allele, significant linkage disequilibrium …

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Husserl And Foucault On The Subject: The Companions, Harry Nethery Iv Jan 2013

Husserl And Foucault On The Subject: The Companions, Harry Nethery Iv

Electronic Theses and Dissertations

In this text, I argue for the revision of Husserlian phenomenology through a dialogue with the work of Michel Foucault. Specifically, I argue that Foucault's critical project, in which we isolate the contingent limits of thought so as to pass beyond them, and thus think new ways of being, can be filled out by the work of Edmund Husserl and differentiated into two lines of inquiry: a critical ontology and a critical phenomenology. This is accomplished by bringing these two philosophers, commonly held to be diametrically opposed, into dialogue such that together they say something that neither could say on …

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Differential Expressions Of Nodal-Signal Transducers And Global Transcriptional Repression Commit Vegetal Cells In Eleutherodactylus Coqui To Form Nutritional Endoderm, Suman Chatterjee Jan 2013

Differential Expressions Of Nodal-Signal Transducers And Global Transcriptional Repression Commit Vegetal Cells In Eleutherodactylus Coqui To Form Nutritional Endoderm, Suman Chatterjee

Electronic Theses and Dissertations

The vegetal core cells of a Xenopus laevis embryo commit to mesendoderm via the Nodal-signaling pathway. In Eleutherodactylus coqui, a direct developing frog, mesendoderm is specified at the marginal zone of the early gastrulae and vegetal core cells transform into nutritional endoderm. It is a novel tissue consisting of transient, yolk rich cells that provide nutrition, but do not differentiate into adult tissues. We hypothesized that a disruption of Nodal-signaling is responsible for committing vegetal core cells to nutritional endoderm. I report a dual regulation involved in the generation of nutritional endoderm. First, differential expression of Nodal-signaling components like Smad2 …

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Phlip Peptide Targets Nanogold Particles To Tumors, Lan Yao, Jennifer Daniels, Anna Moshnikova, Sergey Kuznetsov, Aftab Ahmed, Donald M. Engelman, Yana Reshetnyak, Oleg A. Andreev Jan 2013

Phlip Peptide Targets Nanogold Particles To Tumors, Lan Yao, Jennifer Daniels, Anna Moshnikova, Sergey Kuznetsov, Aftab Ahmed, Donald M. Engelman, Yana Reshetnyak, Oleg A. Andreev

Physics Faculty Publications

Progress in nanomedicine depends on the development of nanomaterials and targeted delivery methods. In this work, we describe a method for the preferential targeting of gold nanoparticles to a tumor in a mouse model. The method is based on the use of the pH Low Insertion Peptide (pHLIP), which targets various imaging agents to acidic tumors. We compare tumor targeting by nonfunctionalized nanogold particles with nanogold–pHLIP conjugates, where nanogold is covalently attached to the N terminus of pHLIP. Our most important finding is that both intratumoral and i.v. administration demonstrated a significant enhancement of tumor uptake of gold nanoparticles conjugated …

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Antiproliferative Effect Of Phlip-Amanitin, Anna Moshnikova, Valentina Moshnikova, Oleg A. Andreev, Yana Reshetnyak Jan 2013

Antiproliferative Effect Of Phlip-Amanitin, Anna Moshnikova, Valentina Moshnikova, Oleg A. Andreev, Yana Reshetnyak

Physics Faculty Publications

Toxins could be effective anticancer drugs, if their selective delivery into cancer cells could be achieved. We have shown that the energy of membrane-associated folding of water-soluble membrane peptides of the pHLIP (pH low insertion peptide) family could be used to move cell-impermeable cargo across the lipid bilayer into the cytoplasm of cancer cells. Here we present the results of a study of pHLIP-mediated cellular delivery of a polar cell-impermeable toxin, α-amanitin, an inhibitor of RNA polymerase II. We show that pHLIP can deliver α-amanitin into cells in a pH-dependent fashion and induce cell death within 48 h. Translocation capability …

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