Digital Commons Network^™

Comparison And Contrast Of Genes And Biological Pathways Responding To Marek’S Disease Virus Infection Using Allele-Specific Expression And Differential Expression In Broiler And Layer Chickens., Sudeep Perumbakkam, William M. Muir, Alexis Black-Pyrkosz, Ron Okimoto, Hans H. Cheng

Department of Animal Sciences Faculty Publications

Background

Marek’s disease (MD) is a commercially important neoplastic disease of chickens caused by the Marek’s disease virus (MDV), a naturally occurring oncogenic alphaherpesvirus. Enhancing MD genetic resistance is desirable to augment current vaccines and other MD control measures. High throughput sequencing was used to profile splenic transcriptomes from individual F₁ progeny infected with MDV at 4 days of age from both outbred broilers (meat-type) and inbred layer (egg-type) chicken lines that differed in MD genetic resistance. The resulting information was used to identify SNPs, genes, and biological pathways exhibiting allele-specific expression (ASE) in response to MDV infection in …

The Effects Of Continuing Bond On Posttraumatic Stress Disorder And Complicated Grief Among Parents Bereaved By The Suicide Of Their Child, Carol Capitano

Nursing ETDs

There is a paucity of research on the effect of parents maintaining a continuing bond with their child who died by suicide. Furthermore, there is a gap in the research literature regarding differences among the parental continuing bond, posttraumatic stress, and complicated grief between parents who directly witnessed the suicide or found the body of their child and parents who were notified of the suicide by indirect methods (police, clergy, family, media, etc). This quantitative study included a convenience sample of 219 participants (response rate = 63.29%) who self-identified as parents whose child died by suicide 6 or more months …

The Spinnaker [Vol. 33 No. 113], University Of North Florida

Spinnaker

Student newspaper for the UNF community.

A Novel Fast Solver For Poisson's Equation With Neumann Boundary Condition, Zuhui Ma, Weng Cho Chew, Lijun Jiang

Electrical and Computer Engineering Faculty Research & Creative Works

In this paper, we present a novel fast method to solve Poisson's equation in an arbitrary two dimensional region with Neumann boundary condition, which are frequently encountered in solving electrostatic boundary problems. The basic idea is to solve the original Poisson's equation by a two-step procedure. In the first stage, we expand the electric field of interest by a set of tree basis functions and solve it with a fast tree solver in O(N) operations. The field such obtained, however, fails to expand the exact field because the tree basis is not curl-free. Despite of this, we can retrieve the …

Exogenous Delivery Of Chaperonin Subunit Fragment Apicct1 Modulates Mutant Huntingtin Cellular Phenotypes, Emily M. Sontag, Lukasz A. Joachimiak, Zhiqun Tan, Anthony Tomlinson, David E. Housman, Charles G. Glabe, Steven G. Potkin, Judith Frydman, Leslie M. Thompson

Biological Sciences Faculty Research and Publications

Aggregation of misfolded proteins is characteristic of a number of neurodegenerative diseases, including Huntington disease (HD). The CCT/TRiC (chaperonin containing TCP-1/TCP-1 ring) chaperonin complex can inhibit aggregation and cellular toxicity induced by expanded repeat Huntingtin (mHtt) fragments. The substrate-binding apical domain of CCT/TRiC subunit CCT1, ApiCCT1, is sufficient to inhibit aggregation of expanded repeat mHtt fragments in vitro, providing therapeutic promise for HD. However, a key hurdle in considering ApiCCT1 as a potential treatment is in delivery. Because ApiCCT1 has a region of similarity to the HIV Tat protein cell-transduction domain, we tested whether recombinant ApiCCT1 (ApiCCT1r) protein could enter …

Asian Primate Species Richness Correlates With Rainfall, Yi-Chen Wang, Amrita Srivathsan, Chen-Chieh Feng, Agus Salim, Myron Shekelle

Biology Faculty Publications and Presentations

Previous studies of meta-analyses found significantly positive correlations between primate species richness and rainfall for Africa, Madagascar and the Neotropics, with the exception of Asia, leaving the open question whether that anomaly is the result of sampling bias, biogeography, or some other factor. This study re-examines the question using modelled data, with primate species richness data from the Southeast Asian Mammals Databank and rainfall data from the Climatic Research Unit. Data processing with Geographical Information Systems resulted in 390 sample points. Reduced major axis and ordinary least squares regressions were employed to examine the relationship for six regions, including the …

Nanomechanical Characterization Of Asphalt, Hasan Faisal

Civil Engineering ETDs

In this study, asphalt binder and asphalt concrete (AC) materials are characterized using laboratory nanoindentation testing and mechanical models. Traditionally, laboratory nanoindentation test data is analyzed using the Oliver-Pharr method to determine elastic modulus and hardness of materials. In a nanoindentation test, a test sample surface is indented or loaded by a hard indenter tip and then unloaded. In the past, several studies of the polymer materials area have selected a loading rate and dwell time (i.e., the peak load is kept constant for a few seconds before unloading) to avoid or minimize the viscous effect of a material. No …

01-29-2013 Brown Bag Lunch This Friday To Feature The Swosu Neuroscience Lab, Southwestern Oklahoma State University

THE BARK ARCHIVE 2013

A research interest group brown bag lunch at Southwestern Oklahoma State University will take place this Friday, February 1, and will feature a presentation on the SWOSU Neuroscience Lab.

Nanotubes As Mitochondrial Uncouplers, Patrick G. Sullivan

Neuroscience Faculty Patents

A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A method of decreasing reactive oxygen species and decreasing detrimental loading of Ca²⁺ into mitochondria is provided, including administering a pharmaceutically effective amount of nanotubes into the subject. A method of reducing weight, treating cancer, reducing the effects of traumatic brain injury, or reducing the effects of ageing, in a subject including administering a pharmaceutically effective amount of nanotubes into the subject is also provided.

Role Of Deregulated Micrornas In Breast Cancer Progression Using Ffpe Tissue, Liang Chen, Youhuai Li, Yebo Fu, Jin Peng, Meng-Hsuan Mo, Michael Stamatakos, Christine B. Teal, Rachel F. Brem, Alexander Stojadinovic, Michael Grinkemeyer, Timothy A. Mccaffrey, Yan-Gao Man, Sidney W. Fu

Pathology Faculty Publications

MicroRNAs (miRNAs) contribute to cancer initiation and progression by silencing the expression of their target genes, causing either mRNA molecule degradation or translational inhibition. Intraductal epithelial proliferations of the breast are histologically and clinically classified into normal, atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). To better understand the progression of ductal breast cancer development, we attempt to identify deregulated miRNAs in this process using Formalin-Fixed, Paraffin-Embedded (FFPE) tissues from breast cancer patients. Following tissue microdissection, we obtained 8 normal, 4 ADH, 6 DCIS and 7 IDC samples, which were subject to RNA isolation …

Mesenchymal Stem Cells With Increased Developmental Potency By Expressing Nanog, Kiminobu Sugaya, Angel Alvarez

UCF Patents

CON filing for non-elected claims 7 and 12

Voices From Behind Bars: A Working Alliance?, Mariaimee Gonzalez

Dissertations

Prisons have become a primary location for mental health services, yet little research has been done to investigate the clinical relationships experienced by a growing population of female inmates. This qualitative study was based upon intersectional theory and explored the experiences of 12 female inmates through in-depth interviews about receiving mental health services in prison and the quality of the working alliance with mental health professionals. Additionally, suggestions for improving mental health services in the prison system are documented. Through 12 semi-structured interviews the researcher listened to narratives of these participants and their mental health journeys. Using open and axial …

The Daily Egyptian, January 29, 2013, Daily Egyptian Staff

January 2013

No abstract provided.

A Phylogeny Of Birds Based On Over 1,500 Loci Collected By Target Enrichment And High-Throughput Sequencing, John E. Mccormack, Michael G. Harvey, Brant C. Faircloth, Nicholas G. Crawford, Travis C. Glenn, Robb T. Brumfield

Faculty Publications

Evolutionary relationships among birds in Neoaves, the clade comprising the vast majority of avian diversity, have vexed systematists due to the ancient, rapid radiation of numerous lineages. We applied a new phylogenomic approach to resolve relationships in Neoaves using target enrichment (sequence capture) and high-throughput sequencing of ultraconserved elements (UCEs) in avian genomes. We collected sequence data from UCE loci for 32 members of Neoaves and one outgroup (chicken) and analyzed data sets that differed in their amount of missing data. An alignment of 1,541 loci that allowed missing data was 87% complete and resulted in a highly resolved phylogeny …

January 29, 2013 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Emu Today, January 29, 2013, Eastern Michigan University

EMU Today

No abstract provided.

Patriot Talon (Jan. 29, 2013), Archives Account

The Patriot Talon/The Patriot

The official newspaper for the University of Texas at Tyler before it was changed back to the UT Tyler Patriot. Articles in this issue include: New Owners Look to Boost Varsity Place’s Safety, Image; Texas Lawmakers Talk Guns, Education Funding; A Glimpse at Possible Policy Changes that Could Affect Students; Police Still Investigating Robbery Near University; University Globetrotters Study Around the World; Holidays are Over, Get Ready for Change; A reasonable Discussion About Guns; Something in the Water?; Biology Department Uses Grant To Strengthen Mussel Research; Field Collection of Freshwater Mussels; Art and Innovation Center Awaits Approval; Engineering Society Named …

The Advocate, January 29, 2013, Minnesota State University Moorhead

The Advocate

No abstract provided.

Growth Factor Binding Molecules, Said M. Sebti, Andrew D. Hamilton

USF Patents

Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growth factors and are suitable for treating a subject having tumors or restinosis. In one embodiment a platelet-derived growth factor binding molecule is disclosed that is used to inhibit tumor growth and angiogenesis in solid tumors.

Compounds And Methods To Dysregulate Ca2+ Homeostasis For Cancer Treatment, Javier Cuevas

USF Patents

Disclosed is a novel composition and method for chemotherapy in leukemia. Activation of the calcium ion channel by tipifarnib increases intracellular calcium and triggers cell death in leukemia cell lines. Increasing the activity of this channel with 2-aminoethoxydiphenyl borate (2-APB) enhances both the intracellular calcium elevations and cell death, whereas decreasing the activity of the channel with gadolinium or lanthanum blocks the calcium increases and promotes cell survival. The protein target was able to overcome cell adhesion-mediated drug resistance, which often limits the usefulness of other targets. This protein is expressed in other immortalized cell lines, but has limited expression …

Multimodal Nanoparticles For Non-Invasive Bio-Imaging, Swadeshmukul Santra, Niclas Bengtsson, Scott Brown, Stephen Grobmyer, Huabei Jiang, Brij Moudgil, Edward Scott, Parvesh Sharma, Glenn Walter, Qizhi Zhang

UCF Patents

The present teachings provide multimodal nanoparticles that can act simultaneously as contrast agents for one or more of PAT, fluorescence imaging, x-ray imaging, and/or MRI. Exemplary multimodal nanoparticles can have a size between 50-100 nm and can be tunable to large sizes. In various embodiments, these nanoparticles can also be used for therapeutic purposes.

Cubic Semiconductor Alloys For Deep Uv Applications, Winston Schoenfeld

UCF Patents

Disclosed are progestin agonists having the following formula: ##STR1## W is absent or --CH-CH--; R1 are independently selected from the group consisting of halogen, --CF3, and NO2, or both R1 may be joined to form a bi-radical which is --CH-CHCH-CH--;R3 are independently selected from the group consisting of hydrogen, C1-6 branched or linear alkyl, halogen and --CF3, with the proviso that R3 at the 3-position must be H where R3 at the 4-position is H, or both R3 may be joined to form a bi-radical selected from the group consisting of --CH-CHCH-CH--, --C(NC1-4 alkyl2)=CHCH-CH-- and --(CH2)4 --; R5 is selected …

Acaricide, Fungicide And Drug Interactions In Honey Bees (Apis Mellifera), Reed M. Johnson, Lizette Dahlgren, Blair D. Siegfried, Marion D. Ellis

Department of Entomology: Faculty Publications

Background: Chemical analysis shows that honey bees (Apis mellifera) and hive products contain many pesticides derived from various sources. The most abundant pesticides are acaricides applied by beekeepers to control Varroa destructor. Beekeepers also apply antimicrobial drugs to control bacterial and microsporidial diseases. Fungicides may enter the hive when applied to nearby flowering crops. Acaricides, antimicrobial drugs and fungicides are not highly toxic to bees alone, but in combination there is potential for heightened toxicity due to interactive effects.

Methodology/Principal Findings: Laboratory bioassays based on mortality rates in adult worker bees demonstrated interactive effects among acaricides, as …

Design, Syntheses, And Biological Evaluation Of 14-N-Substituted Naltrexone Derivatives As Opioid Receptor Ligands, Orgil Elbegdorj

Theses and Dissertations

Opium, the dried resin obtained from the unripe seedpods of the poppy flower, has been used for medicinal and euphoric purposes since ancient times. Morphine, the main active ingredient of opium, and other clinically useful opioid analgesics all mediate their effects through activating the mu opioid receptor. Studies involving the mu opioid receptor knockout mice showed that the interaction with the mu opioid receptor is also responsible for many notorious side effects associated with these drugs including dependence and addiction. Therefore, selective antagonists for the mu opioid receptor are needed to study its function in drug abuse and addiction. Previously, …

Volume 110, Number 15 - Tuesday, January 29, 2013, Saint Mary's College Of California

The Collegian

No abstract provided.

Investigating The Electrostatic Role Of A Critical Arginine For The Catalysis Of E. Coli Adp-Glucose Pyrophosphorylase, Angela Mahaffey, Saleh Aiyash, Miguel Ballicora, Ligin Solamen

Chemistry: Faculty Publications and Other Works

ADP-glucose pyrophosphorylase (ADP-Glc PPase) is the regulatory enzyme of the pathway for starch synthesis in plants and glycogen in mammals and enteric bacteria. It exists as a 200 kDa homotetramer (α4) in enteric bacteria, and as a heterotetramer (α2β2) in plants. In both in vivo and in vitro the substrates (Glucose 1-Phosphate; Glc-1P and Adenosine 5'-Triphosphate; ATP) are converted into a glucose donor ADP-Glucose and a pyrophosphate (PPi) via the ADP-Glc PPase enzyme. It has been noted that some residues are conserved in homotetrameric bacterial ADP-Glc PPases, but are not in some plant forms. One of them is …

Control Of Candida Albicans Metabolism And Biofilm Formation By Pseudomonas Aeruginosa Phenazines, Diana K. Morales, Nora Grahl, Chinweike Okegbe, Lars E. P. Dietrich, Nicholas J. Jacobs, Deborah A. Hogan

Dartmouth Scholarship

Candidaalbicanshasdevelopmentalprogramsthatgoverntransitionsbetweenyeastandfilamentousmorphologies and between unattached and biofilm lifestyles. Here, we report that filamentation, intercellular adherence, and biofilm develop- ment were inhibited during interactions between Candida albicans and Pseudomonas aeruginosa through the action of P. aeruginosa-produced phenazines. While phenazines are toxic to C. albicans at millimolar concentrations, we found that lower concentrations of any of three different phenazines (pyocyanin, phenazine methosulfate, and phenazine-1-carboxylate) allowed growth but affected the development of C. albicans wrinkled colony biofilms and inhibited the fungal yeast-to-filament transition. Phenazines impaired C. albicans growth on nonfermentable carbon sources and led to increased production of fer- mentation products (ethanol, glycerol, and …

Simplifying Federal Criminal Laws , Robert H. Joost

Pepperdine Law Review

No abstract provided.

Curricular Affairs Committee Minutes January 28, 2013, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

No abstract provided.

Commonwealth Times 2013-01-28

Commonwealth Times, 1969-

No abstract provided.